LOCUS       NM_030874               3321 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sphingosine-1-phosphate phosphatase 1 (Sgpp1),
            mRNA.
ACCESSION   NM_030874 XM_001080791 XM_343081
VERSION     NM_030874.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Allende,M.L., Sipe,L.M., Tuymetova,G., Wilson-Henjum,K.L., Chen,W.
            and Proia,R.L.
  TITLE     Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte
            differentiation and epidermal homeostasis
  JOURNAL   J Biol Chem 288 (25), 18381-18391 (2013)
   PUBMED   23637227
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Giussani,P., Maceyka,M., Le Stunff,H., Mikami,A., Lepine,S.,
            Wang,E., Kelly,S., Merrill,A.H. Jr., Milstien,S. and Spiegel,S.
  TITLE     Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic
            reticulum-to-golgi trafficking of ceramide
  JOURNAL   Mol Cell Biol 26 (13), 5055-5069 (2006)
   PUBMED   16782891
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Pyne,S., Kong,K.C. and Darroch,P.I.
  TITLE     Lysophosphatidic acid and sphingosine 1-phosphate biology: the role
            of lipid phosphate phosphatases
  JOURNAL   Semin Cell Dev Biol 15 (5), 491-501 (2004)
   PUBMED   15271294
  REMARK    Review article
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Le Stunff,H., Galve-Roperh,I., Peterson,C., Milstien,S. and
            Spiegel,S.
  TITLE     Sphingosine-1-phosphate phosphohydrolase in regulation of
            sphingolipid metabolism and apoptosis
  JOURNAL   J Cell Biol 158 (6), 1039-1049 (2002)
   PUBMED   12235122
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   Le Stunff,H., Peterson,C., Thornton,R., Milstien,S., Mandala,S.M.
            and Spiegel,S.
  TITLE     Characterization of murine sphingosine-1-phosphate phosphohydrolase
  JOURNAL   J Biol Chem 277 (11), 8920-8927 (2002)
   PUBMED   11756451
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Mandala,S.M., Thornton,R., Galve-Roperh,I., Poulton,S.,
            Peterson,C., Olivera,A., Bergstrom,J., Kurtz,M.B. and Spiegel,S.
  TITLE     Molecular cloning and characterization of a lipid phosphohydrolase
            that degrades sphingosine-1- phosphate and induces cell death
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7859-7864 (2000)
   PUBMED   10859351
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   Brindley,D.N., Xu,J., Jasinska,R. and Waggoner,D.W.
  TITLE     Analysis of ceramide 1-phosphate and sphingosine-1-phosphate
            phosphatase activities
  JOURNAL   Methods Enzymol 311, 233-244 (2000)
   PUBMED   10563330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 2, 2021 this sequence version replaced NM_030874.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1846133.1,
                                           SRR26643285.24997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-805               JAXUCZ010000006.1  100181410-100182214 c
            806-895             JAXUCZ010000006.1  100169126-100169215 c
            896-3321            JAXUCZ010000006.1  100161024-100163449 c
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3321
                     /gene="Sgpp1"
                     /gene_synonym="Spp1"
                     /note="sphingosine-1-phosphate phosphatase 1"
                     /db_xref="GeneID:81536"
                     /db_xref="RGD:727829"
     exon            1..805
                     /gene="Sgpp1"
                     /gene_synonym="Spp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1447
                     /gene="Sgpp1"
                     /gene_synonym="Spp1"
                     /note="sphingosine-1-phosphate phosphohydrolase; SPPase1;
                     sphingosine-1-phosphatase 1"
                     /codon_start=1
                     /product="sphingosine-1-phosphate phosphatase 1"
                     /protein_id="NP_110501.2"
                     /db_xref="GeneID:81536"
                     /db_xref="RGD:727829"
                     /translation="MSLGQRLALLAIRLQEPQRVASFQRLCGVEVPLGSPAAGEDAET
                     EVRGAPGDPRRRPRQSGADGSPAKPDCCGAPNGVRNGLAAEPGPTGPRRAGSLRRNSL
                     TGEEGELAKVSNLPLYYLFCFGTELGNELFYIIFFPFWIWNLDPFVGRRLVIIWVLVM
                     YLGQCTKDIIRWPRPASPPVIKLEIFYNSEYSMPSTHAMSGTAIPIAMILLTYGRWQY
                     PLIYGLILIPCWSSLVCLSRIYMGMHSILDVIAGFLYTILILIIFYPLVDLIDNFNQT
                     YKYAPLIIIGLHLILGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHAAYNLGISLDP
                     SLHTLPLAIPPLTVTLFGKAILRVVIGMLLVLFVRDIMKKVTIPLACKLFGIPCHDLR
                     QARQHMEVELPYRYITYGTVGFSITFLIPYIFSFIGIS"
     exon            806..895
                     /gene="Sgpp1"
                     /gene_synonym="Spp1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..3321
                     /gene="Sgpp1"
                     /gene_synonym="Spp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaggggc gcgcggagcg cagggcgcgc gcggcggccg ctgcggcctg ttggcgcggt
       61 cgccggcagc ctcgagcgag tcgagctagg caccgtggcg gctgtggctg gcggggagcg
      121 cgtggccgga tcaattcccg agtggcccgc gaccatgtcc ctggggcagc gactggctct
      181 gctagccatc cgtctgcagg agccgcagcg ggtggcgagc ttccagcgtc tgtgtggggt
      241 ggaggtgccg ctcggcagcc cggcggcggg cgaggatgca gagaccgagg ttcgcggagc
      301 cccgggagac ccccggcgac ggccacggca gtcgggcgct gacggcagcc cggccaagcc
      361 cgactgctgc ggtgcaccga acggcgtgcg aaacgggctg gcggccgagc cgggcccgac
      421 cgggccccgc cgcgcgggct cgctgcggcg caactcgttg acgggcgagg agggcgagct
      481 ggccaaagtg agcaacttgc cgctctacta cctgttctgc ttcggcaccg aactgggcaa
      541 cgagctcttc tacatcatct tcttcccctt ctggatctgg aatctggacc cctttgtggg
      601 ccggaggctg gtgatcatct gggtgctggt catgtacctg ggccagtgca ccaaggacat
      661 catccgttgg ccgcggccgg cctcgccgcc ggtcatcaag ctggagatct tctacaattc
      721 ggaatacagc atgccttcca cgcatgccat gtccggcacc gccatcccca tcgccatgat
      781 cctgctcacc tatggccgct ggcagtatcc tcttatatat gggctgattc tcattccctg
      841 ttggagttct ctagtttgcc taagtagaat ctacatggga atgcattcca tcctggacgt
      901 cattgctgga ttcttgtata ccattttaat ccttattatc ttctacccat tggtggacct
      961 gattgacaac ttcaaccaaa cttacaaata tgccccgctc atcatcatcg ggcttcactt
     1021 gattttgggc attttttctt tcacccttga cacctggagc acatcccgag gagacacggc
     1081 tgagattctg gggagtggtg ctgggattgc ctgtggctcg cacgccgctt ataacctggg
     1141 tatatcctta gacccttctc tgcacacgtt acccttagct atcccccctc ttacggtaac
     1201 tctgtttgga aaagccatat tacgggtcgt catagggatg ttgcttgtac tgttcgtaag
     1261 agatatcatg aagaaggtca ccattcctct agcctgcaaa ctcttcggta ttccgtgtca
     1321 tgaccttcgc caagcaaggc agcacatgga agtggagctg ccctaccggt atattaccta
     1381 cgggacggtt ggtttctcca tcacgttttt gatcccctac atattttcct ttatcggtat
     1441 ctcttgatgg aggaacactg gttattataa gaaaggaggc taccagctat atctaaagct
     1501 attctctagg taaaacttgg atcagaggct tttgcaagaa tttatcttaa agaaggaagt
     1561 tctgcagcca gtgcattgtc attgcatacc agacgctgtt ttaggtgggc ggagctctct
     1621 cagtactgag aaatgacacg cccatttaga atgttcacaa aatgtttggg gagttccggt
     1681 ctgttacaaa ttgcagttct atatactata tattaaggtg cacagtgtgc aagtgtgtat
     1741 ctagtatata ttatatgtac aactctttac ctacgaacag tggggtgaat tgaaaaatca
     1801 gtaacattat gcagttgtgc ccaggtcttt ggaattaagg caggcatgtt gttagtaaca
     1861 aataggttga atgtttcttt cctatgggag ccattttctc attgaattgg taattaccag
     1921 acagaaatcc acatgctacc acacactgat ttactgcctc ttcctacact gccatccccc
     1981 ttcttgttat ccatgacgtt gaacatgaga ggcattttta atggaccaag ttttggggga
     2041 aatttgcttt tttggatttc ttctttctta aagttctgta cactgtgttg aatgtacttt
     2101 tttttttcct caaccatttt ggtcaccaat ttaataattc aggtactgaa ttttattgct
     2161 tgctaactgt gcctttcttt tcctgaatca agagacacca tgtatactgt gatgtaaaag
     2221 tgacactcta attctatctt aagccacatc atcaggaaag tattttaaaa atatatatca
     2281 aactaacaga attaaaagta aacgacccat aacttttaag tcggtttttt gttttttgtt
     2341 tttttagaac aaaatgtgga gtcgctaagt tttctcacta atttattgga aagctaaatg
     2401 gataagtatt tccatttttg taagtatttt tctgtgcatt gcaagttata ggaacagtat
     2461 atatctatgt acatcatctt gactgtatag tacaagtaaa tatttccagt gagtgaaaag
     2521 gtaactgaaa tttatagatg agacagtgca caccctttct atgtgcacaa gccatttttc
     2581 taaattattt gaaaaggatt agatttccca ctgttaactt ttaatacccc actctttagc
     2641 aacctaaggt agattatcaa atccagacgt gaaggatcgg tagcttagat tctgttattt
     2701 tcccaactaa ttatttttac agtggaaaat ttgagtgtag tattaaacta ttcttttcct
     2761 gtctgtgcct ttctattttg aagtgtgatt gcaactaggt taacttacat tcatgcgcgg
     2821 taagcttttt gtaaagaaga gaattgattt ccatgtgaat ggccgtcagg ggtggaggta
     2881 gcgacttcag tgcaataacc tcttggtcat tcagaaggaa aatgctccta ctgtggacaa
     2941 cataagtatt tgagctcata tttttataat tctgattgga agcttagggg cctggtagtt
     3001 tttacccaaa cagagtctga tcaactttaa gcaagtaaat ttgaaccctt tggccaatgg
     3061 gagactaaag cgaggtgctt agaaaagaat cggtacgcag ggagcttgga agctgcaaaa
     3121 agtggggatt cctcatcaga tgtgctctgt gaattgagct ataaaaaggg tcccacactt
     3181 tgggtctgtt atcctattaa tttttgtgtg tagcttaaaa agaattagaa aatattctat
     3241 ctctttgtgt ttatgttttg tttgatgaca gttctatgct aaatgtattt taaaataaaa
     3301 gccaagatca atacgaaaat c
//
