LOCUS       NM_173116               2033 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus sphingosine-1-phosphate lyase 1 (Sgpl1), mRNA.
ACCESSION   NM_173116
VERSION     NM_173116.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Hahn,C., Tyka,K., Saba,J.D., Lenzen,S. and Gurgul-Convey,E.
  TITLE     Overexpression of sphingosine-1-phosphate lyase protects
            insulin-secreting cells against cytokine toxicity
  JOURNAL   J Biol Chem 292 (49), 20292-20304 (2017)
   PUBMED   29070677
  REMARK    GeneRIF: the relatively low endogenous Spl expression level in
            insulin-secreting cells contributes to their extraordinary
            vulnerability to proinflammatory cytokine toxicity
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Lovric,S., Goncalves,S., Gee,H.Y., Oskouian,B., Srinivas,H.,
            Choi,W.I., Shril,S., Ashraf,S., Tan,W., Rao,J., Airik,M.,
            Schapiro,D., Braun,D.A., Sadowski,C.E., Widmeier,E.,
            Jobst-Schwan,T., Schmidt,J.M., Girik,V., Capitani,G., Suh,J.H.,
            Lachaussee,N., Arrondel,C., Patat,J., Gribouval,O., Furlano,M.,
            Boyer,O., Schmitt,A., Vuiblet,V., Hashmi,S., Wilcken,R.,
            Bernier,F.P., Innes,A.M., Parboosingh,J.S., Lamont,R.E.,
            Midgley,J.P., Wright,N., Majewski,J., Zenker,M., Schaefer,F.,
            Kuss,N., Greil,J., Giese,T., Schwarz,K., Catheline,V., Schanze,D.,
            Franke,I., Sznajer,Y., Truant,A.S., Adams,B., Desir,J., Biemann,R.,
            Pei,Y., Ars,E., Lloberas,N., Madrid,A., Dharnidharka,V.R.,
            Connolly,A.M., Willing,M.C., Cooper,M.A., Lifton,R.P., Simons,M.,
            Riezman,H., Antignac,C., Saba,J.D. and Hildebrandt,F.
  TITLE     Mutations in sphingosine-1-phosphate lyase cause nephrosis with
            ichthyosis and adrenal insufficiency
  JOURNAL   J Clin Invest 127 (3), 912-928 (2017)
   PUBMED   28165339
  REMARK    GeneRIF: Mutations in sphingosine-1-phosphate lyase cause nephrosis
            with ichthyosis and adrenal insufficiency
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Schumann,J., Grevot,A., Ledieu,D., Wolf,A., Schubart,A., Piaia,A.,
            Sutter,E., Cote,S., Beerli,C., Pognan,F., Billich,A., Moulin,P. and
            Walker,U.J.
  TITLE     Reduced Activity of Sphingosine-1-Phosphate Lyase Induces
            Podocyte-related Glomerular Proteinuria, Skin Irritation, and
            Platelet Activation
  JOURNAL   Toxicol Pathol 43 (5), 694-703 (2015)
   PUBMED   25630683
  REMARK    GeneRIF: Studied pathological alterations associated with only
            partially reduced activity of S1P lyase (as may be encountered upon
            pharmacological inhibition).
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Weiler,S., Braendlin,N., Beerli,C., Bergsdorf,C., Schubart,A.,
            Srinivas,H., Oberhauser,B. and Billich,A.
  TITLE     Orally active 7-substituted
            (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles
            as active-site inhibitors of sphingosine 1-phosphate lyase for the
            treatment of multiple sclerosis
  JOURNAL   J Med Chem 57 (12), 5074-5084 (2014)
   PUBMED   24809814
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Schmahl,J., Rizzolo,K. and Soriano,P.
  TITLE     The PDGF signaling pathway controls multiple steroid-producing
            lineages
  JOURNAL   Genes Dev 22 (23), 3255-3267 (2008)
   PUBMED   19056881
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
REFERENCE   7  (bases 1 to 2033)
  AUTHORS   Reiss,U., Oskouian,B., Zhou,J., Gupta,V., Sooriyakumaran,P.,
            Kelly,S., Wang,E., Merrill,A.H. Jr. and Saba,J.D.
  TITLE     Sphingosine-phosphate lyase enhances stress-induced ceramide
            generation and apoptosis
  JOURNAL   J Biol Chem 279 (2), 1281-1290 (2004)
   PUBMED   14570870
REFERENCE   8  (bases 1 to 2033)
  AUTHORS   Van Veldhoven,P.P. and Mannaerts,G.P.
  TITLE     Subcellular localization and membrane topology of
            sphingosine-1-phosphate lyase in rat liver
  JOURNAL   J Biol Chem 266 (19), 12502-12507 (1991)
   PUBMED   2061324
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ512838.1.
            
            [WARNING] On Nov 14, 2024 this sequence was replaced by
            NM_173116.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ512838.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2033
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /note="sphingosine-1-phosphate lyase 1"
                     /db_xref="GeneID:286896"
                     /db_xref="RGD:628599"
     exon            1..86
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            87..156
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1836
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /EC_number="4.1.2.27"
                     /note="sphingosine-1-phosphate aldolase; SPL 1; SP-lyase
                     1; sphingosine phosphate lyase 1"
                     /codon_start=1
                     /product="sphingosine-1-phosphate lyase 1"
                     /protein_id="NP_775139.1"
                     /db_xref="GeneID:286896"
                     /db_xref="RGD:628599"
                     /translation="MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIA
                     GSVLCTLLVVWVYELIFQPESLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKN
                     MPFLKLDKDYVKTLPAQGLSTAEVLERLKEYSSMDVFWQEGKASGAVYSGEPKLTELL
                     VQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMAC
                     KAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVAQKKNMEVDVRAMKRAI
                     SRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGGFLIVFMEKAGYPLE
                     KPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQGGIYASPSI
                     AGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQLSV
                     IALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESV
                     TQIMKNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPK
                     PR"
     exon            157..322
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            323..390
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            391..538
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            539..615
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            616..744
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            745..833
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            834..939
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1038
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1188
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1427
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1574
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1695
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2033
                     /gene="Sgpl1"
                     /gene_synonym="S1PL; Spgl1; spl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgcttgcag aaccgaggcg cgtgaggtgg gcggcggcca gctgagcccc tgcgaggaag
       61 aaggcgcggg tccacggctt gtggagacgc agtagcagag gagccctgag gagccatctg
      121 cagaggaaga tgccgagtac cgaccttctc aagttgaagg acttcgagcc ttatttggag
      181 attttggaag catattccac aaaagccaag aattacgtga atgggtactg caccaaatac
      241 gagccctggc agctcattgc ggggagtgtc ctgtgtactc tgctggtagt ctgggtatat
      301 gagcttatct tccagccaga gagtttatgg tctcggttta aaaataaatt atttaggctt
      361 ataaggaaga tgccatttat tggacgtaag atacaacagc agcttaccaa agccaagaag
      421 gatcttgtca agaacatgcc attcctgaag ttggacaaag attatgtgaa aaccctgcct
      481 gctcagggtc tgagcacagc tgaggttctg gagagactca aggagtacag ctccatggat
      541 gtcttctggc aagaagggaa agcctcagga gctgtgtaca gtggggagcc gaagctcacc
      601 gagctgctgg tgcaggctta cggagaattc acgtggagca atccactgca cccagatatc
      661 ttccccggac tacggaagtt agaggcagaa atcgtgagga tgacttgctc cctcttcaat
      721 ggggggccag actcctgtgg atgtgtgact tctgggggaa cagaaagcat cctaatggcc
      781 tgcaaagcat atcgggactt ggccttagag aaggggatca aaactccaga aattgtggct
      841 cctgagagtg cccacgccgc attcgacaaa gcagctcatt atttcggaat gaagattgta
      901 cgcgttgcgc agaaaaagaa catggaggtg gatgtgcggg caatgaaaag agccatctcc
      961 aggaacacag ccatgctggt ctgttctgcc ccacagtttc ctcatggtgt gatagatcct
     1021 atccccgaag tggccaagct ggctgtcaaa tataaaatcc cattccatgt ggatgcttgt
     1081 cttgggggct tcctcattgt cttcatggag aaagcagggt acccactgga gaaaccattt
     1141 gatttccggg tgaaaggtgt gaccagcatt tcagcagata ctcataagta cggctatgct
     1201 cccaaaggtt catcagtggt gatgtactct aacgagaagt acaggaagta ccagttcttt
     1261 gttgatgcag attggcaagg tggcatctac gcatctccaa gcatagctgg ctcacggcct
     1321 ggtggcatca ttgcagcctg ttgggccgcc ttgatgcact ttggtgagaa cggctatgtt
     1381 gaagctacca aacagatcat caaaactgct cgcttcctca agtcagaact ggaaaacatc
     1441 aaaaacatct tcattttggg ggatcctcaa ttgtcagtta ttgctctggg ctccaacgat
     1501 tttgacatct accgactatc taatatgatg tctgctaagg ggtggaattt taactacttg
     1561 cagttcccaa gaagcattca tttctgcatt acgttagtac atactcggaa gcgagtggca
     1621 atccagttcc taaaggatat ccgggaatcg gtcacacaaa tcatgaagaa tcctaaagct
     1681 aagaccacag gaatgggtgc catctatggc atggcccagg caaccattga caggaagatg
     1741 gttgcagaaa tatcctccgt cttcttggac agcctttata gtacagaccc tgtgactcag
     1801 ggtaaccaga tgaacggttc tccaaagccc cgctgaactt tgacccttga tagatccatg
     1861 gaacttcagg ccttcagaag gttcttggca tttagaaccc accacacaca acttgacatc
     1921 tggactggct ccttagagca caaataggat aaaccgtaag atagcttcag cctcaggact
     1981 cctttgtctc cttttggggc ttttagtttg aagaccctga aggatcccac tgc
//
