LOCUS       NM_001271191            3779 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus shugoshin 2 (Sgo2), mRNA.
ACCESSION   NM_001271191 XM_001068385 XM_237176
VERSION     NM_001271191.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3779)
  AUTHORS   Kim J, Ishiguro K, Nambu A, Akiyoshi B, Yokobayashi S, Kagami A,
            Ishiguro T, Pendas AM, Takeda N, Sakakibara Y, Kitajima TS, Tanno
            Y, Sakuno T and Watanabe Y.
  TITLE     Meikin is a conserved regulator of meiosis-I-specific kinetochore
            function
  JOURNAL   Nature 517 (7535), 466-471 (2015)
   PUBMED   25533956
  REMARK    Erratum:[Nature. 2018 Nov;563(7731):E23. PMID: 30275477]
REFERENCE   2  (bases 1 to 3779)
  AUTHORS   Parra MT, Gomez R, Viera A, Llano E, Pendas AM, Rufas JS and Suja
            JA.
  TITLE     Sequential assembly of centromeric proteins in male mouse meiosis
  JOURNAL   PLoS Genet 5 (3), e1000417 (2009)
   PUBMED   19283064
REFERENCE   3  (bases 1 to 3779)
  AUTHORS   Llano E, Gomez R, Gutierrez-Caballero C, Herran Y, Sanchez-Martin
            M, Vazquez-Quinones L, Hernandez T, de Alava E, Cuadrado A, Barbero
            JL, Suja JA and Pendas AM.
  TITLE     Shugoshin-2 is essential for the completion of meiosis but not for
            mitotic cell division in mice
  JOURNAL   Genes Dev 22 (17), 2400-2413 (2008)
   PUBMED   18765791
REFERENCE   4  (bases 1 to 3779)
  AUTHORS   Lee J, Kitajima TS, Tanno Y, Yoshida K, Morita T, Miyano T, Miyake
            M and Watanabe Y.
  TITLE     Unified mode of centromeric protection by shugoshin in mammalian
            oocytes and somatic cells
  JOURNAL   Nat Cell Biol 10 (1), 42-52 (2008)
   PUBMED   18084284
REFERENCE   5  (bases 1 to 3779)
  AUTHORS   Huang H, Feng J, Famulski J, Rattner JB, Liu ST, Kao GD, Muschel R,
            Chan GK and Yen TJ.
  TITLE     Tripin/hSgo2 recruits MCAK to the inner centromere to correct
            defective kinetochore attachments
  JOURNAL   J Cell Biol 177 (3), 413-424 (2007)
   PUBMED   17485487
REFERENCE   6  (bases 1 to 3779)
  AUTHORS   Gomez R, Valdeolmillos A, Parra MT, Viera A, Carreiro C, Roncal F,
            Rufas JS, Barbero JL and Suja JA.
  TITLE     Mammalian SGO2 appears at the inner centromere domain and
            redistributes depending on tension across centromeres during
            meiosis II and mitosis
  JOURNAL   EMBO Rep 8 (2), 173-180 (2007)
   PUBMED   17205076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000214.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001271191.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001271191.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JACYVU010000214.1  15545622-15545745
            125-300             JACYVU010000214.1  15547506-15547681
            301-378             JACYVU010000214.1  15548574-15548651
            379-464             JACYVU010000214.1  15550191-15550276
            465-706             JACYVU010000214.1  15556589-15556830
            707-3322            JACYVU010000214.1  15558098-15560713
            3323-3473           JACYVU010000214.1  15562351-15562501
            3474-3779           JACYVU010000214.1  15567815-15568120
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..3779
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /note="shugoshin 2"
                     /db_xref="GeneID:316425"
                     /db_xref="RGD:1308450"
     CDS             1..3489
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /note="shugoshin-like 2"
                     /codon_start=1
                     /product="shugoshin 2"
                     /protein_id="NP_001258120.1"
                     /db_xref="GeneID:316425"
                     /db_xref="RGD:1308450"
                     /translation="MEYPGIEDDSVSSGIKRRVKDRIAKTKLNVSLASKIKTKILNNS
                     SIFKISLKHNNRALARALSKEKENSRRITTEKVQLQKEVEKLNFENTFLRLKLNNLNK
                     KLIEIESQVSNSLLTAIEMSSLSEFHQSSFLLSANKKKRVSKQCKPAHLPYARVLITS
                     ENDDDDDDGDDDKWKTKCNNRTVSKTSPDSTSSVSRQSLSLHQCNLEVFLPQEDNQKT
                     CESGHSEYTSSVDVLPNESHYHSDQSPKSFLSKMKDAPSPSPIKEKLSLGNVTKRKKC
                     VSSAADILHVADLDHQSISSPGSNWNNEINGCTNETSNNVQRNTECFPDLPSESSSGP
                     NVKCMEQVQKNTDTFHLQKTVYEDADMELTATDIGKIVTISKSNKSQNKKKADCRKET
                     FRKVKGPSSDRKKERSKRKCKASSEGAEGKTENRPERGSGVLDGRGDSEDPNCISNSE
                     QPSQVNMQKEITFQKSSDQENVQNQRRRQTYTTDEQEETNPFSRCSVKFLQDGKFDPY
                     QNTLHCDLSKPSRQTFVIQTSEKDNLLPNQDNKENISENLEDANEFHIAHLSIKDNEN
                     VCDHETQTILDLKKNVNAQQNQTKINKTKQKINRRTKIISITNQINEDNDKDIHVLEK
                     GNFPFQTQANKETTSGNLEASKEFETPLYTRDSGSLHDCNTQNVLDLHKQITSIYPGQ
                     NKSQISKIPRQKLSRKTEVISEVNCFSNDRDVLCSEKDESFLLQKDKEIPGTLKDVSE
                     FDKPAFYNKDSVKSCDFKAEPLLGLKRHDPNMPPACQADSKVDKKLRQKVKRKTEIIS
                     KINQIHKNDEGSAHDPLNKELRQKVSISKIISEMNQIYETINEDGNAFKSSLKHCQDV
                     MSCDFGKKTSNEEENHDLTPDLCSLVKKPRKKVSCKAGNSLTGDKNRCILQLTGSSQE
                     SVTLDSGLKHGPNEADSGPGEQTNLPKKQKPSTVSTLGDAFSLSVVREGSHPAQTGSK
                     VTSKSKKRKTPLRSSDTRGAVERTPNTDGITAVYFQQTEKENYLENEKIAKSKPDFRS
                     KVLKPLSEICSSNIKNSSLGSMCESSVPLSTFSSKPLMLEESSSLDSTCIFPVGDGAH
                     EKLKEGTPTSHRRTQKSRPGSRTSLVLVDNSSVSSNTANPENESERHSSHQMRRKRQC
                     TPLNLTEPSLRSKMRR"
     exon            1..124
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..300
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..378
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..464
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..706
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..3322
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3473
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3779
                     /gene="Sgo2"
                     /gene_synonym="Sgol2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtacc cagggataga agatgactct gtttcctctg gaattaagag acgagtgaag
       61 gatagaattg caaagacaaa gttgaatgtt tctcttgctt caaagatcaa aacaaaaata
      121 ttaaacaatt cttctatttt caagatctct ctaaagcaca acaacagagc attagctcgg
      181 gcccttagta aagagaaaga gaattctcga agaatcacta ccgaaaaggt gcaattacag
      241 aaagaagtag agaaactgaa ttttgagaat acctttcttc gcttaaaact aaataatctg
      301 aataagaagc tgatagaaat agaatcacaa gtgagcaata gtttgttaac tgcaattgaa
      361 atgagcagtc tttctgagtt ccatcaaagt tcttttctcc tgtcagctaa caagaaaaaa
      421 agggtcagta aacaatgcaa gcctgcacac cttccatatg caagagttct aataacttca
      481 gaaaatgatg atgatgatga tgatggtgat gatgataaat ggaaaacaaa atgtaacaac
      541 agaactgtat caaagacatc acctgatagt acctcttctg tatcaagaca gtctttatcc
      601 ttacatcagt gtaatttgga agtattcctt cctcaagaag ataatcagaa aacatgtgaa
      661 tcaggtcatt cagaatatac ttcaagtgtt gatgtacttc ctaatgagag ccattaccac
      721 tcagatcaaa gtcctaagag ttttctgagt aagatgaaag atgctccgtc tcccagcccc
      781 ataaaggaaa aattgtcact tggtaatgtg actaagagga agaagtgtgt gtcttcagct
      841 gcagacattc tgcatgtggc agatttagat caccaatcaa tttcaagtcc aggatcaaat
      901 tggaataatg agataaatgg ttgtactaat gaaaccagta ataacgtgca aagaaataca
      961 gagtgttttc ctgacttacc ttctgagtct tccagtggtc ctaatgtaaa gtgcatggaa
     1021 caagtacaga agaacactga tacctttcac ttgcagaaaa ctgtgtatga agacgctgac
     1081 atggagttaa ctgctactga cataggcaag attgtaacaa tttcaaaaag caataaaagt
     1141 caaaataaga aaaaggcaga ttgtagaaag gagactttca gaaaagtgaa aggtccaagc
     1201 tctgatagga agaaagaaag atcaaagaga aaatgtaaag ctagttcgga aggtgctgag
     1261 ggaaagactg aaaacagacc agagagaggc tctggtgtcc tagatggcag aggggattca
     1321 gaagatccaa actgtatttc caatagtgaa cagccatctc aggtaaacat gcagaaggaa
     1381 ataaccttcc agaagagctc agatcaggag aacgttcaaa atcaaaggag gaggcaaacg
     1441 tatacgacag atgagcagga ggaaacaaac cctttctcca gatgttcagt caaattcctt
     1501 caagatggta aatttgatcc gtatcagaac accctacact gtgatttaag taagccttct
     1561 cggcagacat ttgtgattca aacatcagaa aaagataact tactgccaaa ccaagacaat
     1621 aaagagaaca tttctgaaaa cctagaagat gcaaatgaat ttcatatagc tcatctttcc
     1681 atcaaagata atgaaaatgt atgtgaccat gaaactcaaa caattttgga cttgaaaaag
     1741 aatgtcaatg ctcagcaaaa tcaaacaaaa ataaataaga ctaagcagaa aataaatcga
     1801 agaaccaaaa taatttctat tacaaaccaa ataaatgagg ataatgataa agatattcac
     1861 gtcctagaaa aaggcaactt tcccttccaa acccaagcaa ataaagaaac caccagtgga
     1921 aacctagaag cttcaaaaga atttgaaaca cctctttaca caagagacag tggaagctta
     1981 catgactgta acacccagaa tgttctggat ctgcacaagc aaatcactag tatataccct
     2041 ggtcagaata agtcccaaat tagcaaaatc cctagacaga agctaagtcg caagacagaa
     2101 gtaatttctg aagtgaattg ttttagtaat gacagagatg tcctttgttc agaaaaggat
     2161 gagtctttct tgctacaaaa ggataaagag atccctggaa ccttgaaaga cgtaagcgag
     2221 tttgataagc ctgcttttta taacaaagat agtgtgaagt catgtgattt taaggctgaa
     2281 ccgttgttgg ggttgaaaag acatgaccct aatatgccac ctgcttgtca agctgactca
     2341 aaggtagata agaagcttag acaaaaggtg aagcgaaaga cagaaataat ttctaaaatc
     2401 aaccagatac ataaaaatga tgaaggaagt gcacatgacc cattaaataa ggagctccgt
     2461 cagaaggtta gtatatcaaa aatcatttct gaaatgaacc aaatatatga gactattaat
     2521 gaagatggga atgcctttaa aagctcgctc aaacattgcc aagatgttat gagttgtgac
     2581 tttgggaaaa aaaccagtaa cgaagaggaa aatcatgatc tgactccaga tctttgctca
     2641 ctagttaaga aaccaaggaa aaaggtatca tgtaaagcag ggaacagttt gacaggagat
     2701 aagaacaggt gtattttgca gttaacaggt tcttcacagg agtccgtcac cttggactct
     2761 ggcttaaaac acggtccaaa tgaagcagat tctggccctg gagagcagac taacctgcca
     2821 aagaagcaga aaccaagcac tgtgagtaca ctgggagacg ccttctctct gagtgtggta
     2881 agagaaggaa gccacccagc ccagacaggt agtaaagtga catccaagtc aaagaaaaga
     2941 aagacccctc taagatcctc tgatacccgt ggagcagtgg agagaacacc aaacactgat
     3001 ggcattacgg cagtttactt ccaacagact gagaaggaga actatttgga gaatgagaaa
     3061 attgccaaga gtaagccaga ctttcgctca aaggtgttga aacctttatc tgagatatgt
     3121 tcatctaaca taaagaattc ttccttgggc agtatgtgtg agagttctgt gcctttgagt
     3181 actttttcta gtaaacccct gatgctagaa gaaagttctt ccctggacag tacatgcatc
     3241 tttccagtag gtgatggtgc ccatgaaaag ttaaaggaag gcactcctac atcccaccgc
     3301 aggacacaga agtcaagacc aggtagcaga acatccctgg tcttggtgga taacagttct
     3361 gtttctagta acactgctaa ccctgaaaat gagtcagaaa ggcactcttc acaccagatg
     3421 aggaggaaaa gacagtgcac ccctctcaac ctgaccgaac caagccttag aagcaagatg
     3481 agaagatgaa gtgcaggtga agtggataca gatcctagtt tttccaagtt cccaaagcac
     3541 aagtcagagc agaagtataa gtagaacatg aaacaagtat tcggttgctt gagttttgta
     3601 catgaagaag tattctgtta ccttttcttt tctttttttt tttttttttt tttttttttt
     3661 tttttttttt ttttggcctt tcatggatta atgctttctc tattcttaca ttgagatgta
     3721 tgtgcataaa atagctgtat cttagataat aaactttttt aaaaaacatt tgtcatcac
//
