LOCUS       NM_001399345            3296 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus shugoshin 1 (Sgo1), transcript variant 2, mRNA.
ACCESSION   NM_001399345 XM_008766787
VERSION     NM_001399345.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3296)
  AUTHORS   Liu,D., Song,A.T., Qi,X., van Vliet,P.P., Xiao,J., Xiong,F.,
            Andelfinger,G. and Nattel,S.
  TITLE     Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4
            pacemaker channel
  JOURNAL   Nat Commun 12 (1), 2551 (2021)
   PUBMED   33953173
  REMARK    GeneRIF: Cohesin-protein Shugoshin-1 controls cardiac automaticity
            via HCN4 pacemaker channel.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3296)
  AUTHORS   Liu,H., Jia,L. and Yu,H.
  TITLE     Phospho-H2A and cohesin specify distinct tension-regulated Sgo1
            pools at kinetochores and inner centromeres
  JOURNAL   Curr Biol 23 (19), 1927-1933 (2013)
   PUBMED   24055156
REFERENCE   3  (bases 1 to 3296)
  AUTHORS   Porter,I.M., Schleicher,K., Porter,M. and Swedlow,J.R.
  TITLE     Bod1 regulates protein phosphatase 2A at mitotic kinetochores
  JOURNAL   Nat Commun 4, 2677 (2013)
   PUBMED   24157919
REFERENCE   4  (bases 1 to 3296)
  AUTHORS   Gambe,A.E., Matsunaga,S., Takata,H., Ono-Maniwa,R., Baba,A.,
            Uchiyama,S. and Fukui,K.
  TITLE     A nucleolar protein RRS1 contributes to chromosome congression
  JOURNAL   FEBS Lett 583 (12), 1951-1956 (2009)
   PUBMED   19465021
REFERENCE   5  (bases 1 to 3296)
  AUTHORS   Wang,X., Yang,Y., Duan,Q., Jiang,N., Huang,Y., Darzynkiewicz,Z. and
            Dai,W.
  TITLE     sSgo1, a major splice variant of Sgo1, functions in centriole
            cohesion where it is regulated by Plk1
  JOURNAL   Dev Cell 14 (3), 331-341 (2008)
   PUBMED   18331714
REFERENCE   6  (bases 1 to 3296)
  AUTHORS   Pouwels,J., Kukkonen,A.M., Lan,W., Daum,J.R., Gorbsky,G.J.,
            Stukenberg,T. and Kallio,M.J.
  TITLE     Shugoshin 1 plays a central role in kinetochore assembly and is
            required for kinetochore targeting of Plk1
  JOURNAL   Cell Cycle 6 (13), 1579-1585 (2007)
   PUBMED   17617734
REFERENCE   7  (bases 1 to 3296)
  AUTHORS   Fu,G., Ding,X., Yuan,K., Aikhionbare,F., Yao,J., Cai,X., Jiang,K.
            and Yao,X.
  TITLE     Phosphorylation of human Sgo1 by NEK2A is essential for chromosome
            congression in mitosis
  JOURNAL   Cell Res 17 (7), 608-618 (2007)
   PUBMED   17621308
REFERENCE   8  (bases 1 to 3296)
  AUTHORS   Watrin,E., Schleiffer,A., Tanaka,K., Eisenhaber,F., Nasmyth,K. and
            Peters,J.M.
  TITLE     Human Scc4 is required for cohesin binding to chromatin,
            sister-chromatid cohesion, and mitotic progression
  JOURNAL   Curr Biol 16 (9), 863-874 (2006)
   PUBMED   16682347
REFERENCE   9  (bases 1 to 3296)
  AUTHORS   Tang,Z., Shu,H., Qi,W., Mahmood,N.A., Mumby,M.C. and Yu,H.
  TITLE     PP2A is required for centromeric localization of Sgo1 and proper
            chromosome segregation
  JOURNAL   Dev Cell 10 (5), 575-585 (2006)
   PUBMED   16580887
REFERENCE   10 (bases 1 to 3296)
  AUTHORS   Wang,X., Yang,Y. and Dai,W.
  TITLE     Differential subcellular localizations of two human Sgo1 isoforms:
            implications in regulation of sister chromatid cohesion and
            microtubule dynamics
  JOURNAL   Cell Cycle 5 (6), 635-640 (2006)
   PUBMED   16582621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 6, 2022 this sequence version replaced XM_008766787.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.34447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000009.1  6924295-6924415     c
            122-252             JAXUCZ010000009.1  6923000-6923130     c
            253-400             JAXUCZ010000009.1  6922738-6922885     c
            401-597             JAXUCZ010000009.1  6922135-6922331     c
            598-698             JAXUCZ010000009.1  6917056-6917156     c
            699-742             JAXUCZ010000009.1  6915176-6915219     c
            743-1525            JAXUCZ010000009.1  6912603-6913385     c
            1526-1709           JAXUCZ010000009.1  6910449-6910632     c
            1710-3296           JAXUCZ010000009.1  6908661-6910247     c
FEATURES             Location/Qualifiers
     source          1..3296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..3296
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /note="shugoshin 1"
                     /db_xref="GeneID:363174"
                     /db_xref="RGD:1593238"
     exon            1..121
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..252
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..400
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1809
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /note="shugoshin-like 1"
                     /codon_start=1
                     /product="shugoshin 1"
                     /protein_id="NP_001386274.1"
                     /db_xref="GeneID:363174"
                     /db_xref="RGD:1593238"
                     /translation="MVKERCQKRSFQDTLEDIKKRMKEKRNKNLAEVGKRKSFIVAPC
                     QVSTNTSTLLKYYQDNNRLLVLALENEKSKVREAQDIILQLRRECYHLTCQLCTLKEK
                     LTSRQRDEGAQQNWKERPSEVVSSSENMTRDFDNSTRDLSVKTLQQTALEETDCPFQT
                     TEASPTVTPETLGCDFDSDKVNSTDEVLPRTVSSRQHLRRDFSNVSKASSREEPSLEV
                     KRSRCKDLTVTLHRLDNIEQNVYLWNKEQINLCPRLISPAKITKTQEAISSSKPEQKE
                     IKHKRAQKRRAEHRRTNQRCKSNFSLRSKGSRGKEKRALPRNSLDGCVGSSDAYDFNL
                     KERVHHTPFRQKMKDGSNRETDSINSEVSACSTSEGESDDDDPYLPPYKRLQDYTGSE
                     EPVTRPRSKRGSTYPDEKAVEEVLPPTAPTGTPPETQESPHRGLKDVTNSLRRPIVKS
                     RKLSLAPKRHEDSPAVSLRRCTTIISYKEPTLNSKLRRGDPFTDLCFLNSPIFKQKKE
                     MRHRKRTK"
     exon            401..597
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..698
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..742
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1525
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1709
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..3296
                     /gene="Sgo1"
                     /gene_synonym="Sgol1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacgcagga tttcgaatgt ggcggcggta gctgcgggct gcgcggcgga gccggaggct
       61 gcatcgactt gtaggacttg agcggccgag gtacggagcg gtacgggcgg cgacaaagga
      121 gatgagtttc actatgtagc ccaagcttga gtctatgatc cacctgcctt agccttttag
      181 tagcttggat tattctgcaa cacctgacta ttaatatttc taagctgaaa aatcaaaatt
      241 actgcttttg aaacaaagat ggttaaggaa aggtgtcaga aaaggtcctt tcaagatact
      301 cttgaagaca ttaagaagcg aatgaaagaa aaaaggaata aaaacctggc ggaggttggc
      361 aaacgcaagt cctttattgt tgcaccgtgc caagtatcca ctaacacttc tacactacta
      421 aaatattacc aagataacaa caggttgtta gttttggctt tggaaaatga gaagtccaaa
      481 gtgagagaag cacaagatat catcctacag ctgagaagag agtgctacca cctcacctgc
      541 cagctgtgta cactgaaaga gaagctaacc tcccgacaac gtgacgaagg tgcccagcag
      601 aactggaaag aacgtccctc agaagtggtc tccagcagtg aaaatatgac cagggacttt
      661 gacaattcga ccagggactt gtctgtgaag accttacagc aaactgctct tgaagaaact
      721 gactgtccct tccaaaccac agaagcaagt cctactgtta caccagagac actgggttgt
      781 gattttgatt cggataaagt caactctact gatgaagtct tacctagaac tgtatcttcc
      841 cgtcagcact taaggagaga ctttagtaat gtaagtaaag ccagttcaag agaggagccg
      901 tccttggagg ttaaaagaag tagatgtaaa gacctaactg taaccctgca tagacttgac
      961 aacatagaac aaaatgttta tctgtggaac aaagagcaaa ttaacttatg ccctagactg
     1021 attagcccag caaagattac taaaacacaa gaagccattt catcatctaa acctgaacaa
     1081 aaagagatca agcataaacg agcacaaaaa agaagagcag agcatagaag aaccaaccag
     1141 agatgcaagt caaacttctc attgaggagt aagggcagca gaggcaaaga aaagcgggct
     1201 ttaccccgga attcactgga tgggtgtgtt ggttccagtg atgcttacga ttttaatcta
     1261 aaagaacgtg ttcaccacac ccctttccga caaaaaatga aggatggctc caatagagaa
     1321 accgacagca tcaactcaga agtgagtgca tgcagtacct ctgagggcga gtctgacgac
     1381 gacgacccct atctgcctcc ttacaagcgc ttgcaagact acacagggtc agaggaacca
     1441 gttaccaggc ctcgctctaa aagaggctct acctacccag acgagaaagc ggtggaggag
     1501 gtgctgccac ccacagctcc cactggtacc ccacctgaga ctcaagagtc acctcaccga
     1561 ggccttaagg atgtcaccaa tagcttgcgg cgtccaatag tgaaaagcag gaagctttct
     1621 ctggctccaa aacggcatga agacagccca gcagtgtctc tgcgcaggtg taccaccatc
     1681 ataagctata aagagccgac actcaattcg aagctaagaa gaggggaccc ttttacagac
     1741 ttgtgtttct tgaattctcc tattttcaag cagaaaaagg aaatgagaca tcgtaaaaga
     1801 acaaagtaaa cacaataact gctttcattg gatactgttg gaggtgatcc ttctcttttg
     1861 cctaatagag tgttgtgaga gtgcgcaatg ggcagagcca tcccgtgtca ggctttgggt
     1921 caggagtgtc ccttggacct agactttgta tggattacta ccaacatcta aaacttctct
     1981 ggcatctgta ttttttcctt aagcaggaga cttgcagagt agaaaactta aatatgatgt
     2041 agctacttca taaatcctta acaccacagt aagacatacc ataagtgggt aaggatccct
     2101 tctgtcattg tgattcttcc tggaaaaatg catatggaat tgtgattaag agaatgaatg
     2161 aattgggttc cagaacaagg taactgttgt gaactgtgaa tacagtgcta ttcctcagca
     2221 gaataatacc atgtcatgaa cctcgggcta gtgcttcgtg tggtcagtct acagtgtaaa
     2281 tgtgtaaata aagggggctt ctggttttga tctatgggga aaatataagt atccagttca
     2341 gaaaagtgaa tctctacctg tgtatgtatg tctttaaaac taaagcattg taactggtcc
     2401 gtttttaaag aaagatgaag tctatgatga ccagcttctg ctcttaatca ggtaatcgtg
     2461 attatcttcc tttctggcct ttgccactcc cagcttagct ggaccctctt ctgtcttccc
     2521 tgccaacgtt cccttctttt cccattagat ttgtccgtca agttttccca cctgggcctc
     2581 cagggccaac atcaagacat ttcaattttc attaattcag tagtagaaca tttgcctcac
     2641 atgggcaagg cccagggata aatcccaccg caaacaggag atttttctaa cttatcagaa
     2701 gggccatctg gtgttcatct cagatttgcc ccacatctgc attacttcct acatctgcca
     2761 tcaaactgag agtcctttct ttgtcactca tgtgcatccc tctcacccat cacagccttt
     2821 tagctgctgg tttttatagt gctgaggata ggacccacaa ccctgtgtgt gataggagta
     2881 gtcatagcag tcgtcagcca ctacatttat cattttctaa tgtcatggta ccttgaaagc
     2941 aaccatttta gctaaaaata aatgcaatta aaagtccagt ctcagtctca gttgtcctca
     3001 tgtagctgtg attaccttag tgaagcctat gtagagatag gctatgtcta tttaaagctg
     3061 gtgctagacc tttagttttc ttcgcctttt cctattcttg ctgtagtgct tactcatggg
     3121 ctattaagga gtttgtgtca acatttttat aaaatatgta ttgtattata tatgttgtac
     3181 ataccattta tgatggactt aagagttcga gacctccctg gttgttagat aaagttattt
     3241 ctgttgttgt ataatattat ataaataaac cagacttaat gaccactttt gagaaa
//
