LOCUS       NM_001014043            1924 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus sphingomyelin synthase 2 (Sgms2), mRNA.
ACCESSION   NM_001014043 XM_227679
VERSION     NM_001014043.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Pekkinen,M., Terhal,P.A., Botto,L.D., Henning,P., Makitie,R.E.,
            Roschger,P., Jain,A., Kol,M., Kjellberg,M.A., Paschalis,E.P., van
            Gassen,K., Murray,M., Bayrak-Toydemir,P., Magnusson,M.K., Jans,J.,
            Kausar,M., Carey,J.C., Somerharju,P., Lerner,U.H., Olkkonen,V.M.,
            Klaushofer,K., Holthuis,J.C. and Makitie,O.
  TITLE     Osteoporosis and skeletal dysplasia caused by pathogenic variants
            in SGMS2
  JOURNAL   JCI Insight 4 (7), 126180 (2019)
   PUBMED   30779713
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Filippenkov,I.B., Kolomin,T.A., Limborska,S.A. and Dergunova,L.V.
  TITLE     Developmental stage-specific expression of genes for sphingomyelin
            synthase in rat brain
  JOURNAL   Cell Tissue Res 372 (1), 33-40 (2018)
   PUBMED   29294205
  REMARK    GeneRIF: in contrast to Sgms1, Sgms2 does not contain the
            multi-exon 5'-UTR but encodes circRNAs, which are composed of the
            coding region of the gene and are expressed at a low level.
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Bickert,A., Ginkel,C., Kol,M., vom Dorp,K., Jastrow,H., Degen,J.,
            Jacobs,R.L., Vance,D.E., Winterhager,E., Jiang,X.C., Dormann,P.,
            Somerharju,P., Holthuis,J.C. and Willecke,K.
  TITLE     Functional characterization of enzymes catalyzing ceramide
            phosphoethanolamine biosynthesis in mice
  JOURNAL   J Lipid Res 56 (4), 821-835 (2015)
   PUBMED   25667419
  REMARK    Erratum:[J Lipid Res. 2017 Apr;58(4):820. doi:
            10.1194/jlr.M055269ERR.. PMID: 28365667]
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Ding,T., Kabir,I., Li,Y., Lou,C., Yazdanyar,A., Xu,J., Dong,J.,
            Zhou,H., Park,T., Boutjdir,M., Li,Z. and Jiang,X.C.
  TITLE     All members in the sphingomyelin synthase gene family have ceramide
            phosphoethanolamine synthase activity
  JOURNAL   J Lipid Res 56 (3), 537-545 (2015)
   PUBMED   25605874
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Subathra,M., Qureshi,A. and Luberto,C.
  TITLE     Sphingomyelin synthases regulate protein trafficking and secretion
  JOURNAL   PLoS One 6 (9), e23644 (2011)
   PUBMED   21980337
  REMARK    GeneRIF: SMS1 and SMS2 are capable of regulating TGN-mediated
            protein trafficking and secretion
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   Lee,N.P., Mruk,D.D., Xia,W. and Cheng,C.Y.
  TITLE     Cellular localization of sphingomyelin synthase 2 in the
            seminiferous epithelium of adult rat testes
  JOURNAL   J Endocrinol 192 (1), 17-32 (2007)
   PUBMED   17210739
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Huitema,K., van den Dikkenberg,J., Brouwers,J.F. and Holthuis,J.C.
  TITLE     Identification of a family of animal sphingomyelin synthases
  JOURNAL   EMBO J 23 (1), 33-44 (2004)
   PUBMED   14685263
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085803.1.
            
            On Apr 1, 2005 this sequence version replaced XM_227679.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085803.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1924
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /note="sphingomyelin synthase 2"
                     /db_xref="GeneID:310849"
                     /db_xref="RGD:1305778"
     exon            1..219
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /inference="alignment:Splign:2.1.0"
     exon            220..884
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..1527
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /EC_number="2.7.8.27"
                     /codon_start=1
                     /product="phosphatidylcholine:ceramide
                     cholinephosphotransferase 2"
                     /protein_id="NP_001014065.1"
                     /db_xref="GeneID:310849"
                     /db_xref="RGD:1305778"
                     /translation="MDIIETAKLEGHLESQTNNSTNTYTSPTEAVEEEDKNGKGKPKT
                     LSNGLRKGAKKYPDYIQISMPNDSRNKLPLEWWKTGIAFVYALFNLILTTVMITVVHE
                     RVPPKELSPPLPDKFFDYVDRVKWAFSVSEINGMVLVGLWLTQWLFLRYKSIVGRRFF
                     FIMGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKIQRILRLLSGGGLSITGSH
                     ILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIVCILVAHEHYTVD
                     VIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFS
                     WPLSWPPGCFKSSCKKYSRVQKIGEDNEKST"
     exon            885..1002
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1156
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1323
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1897
                     /gene="Sgms2"
                     /gene_synonym="RGD1305778; Sms2; spermatin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgagggc ctgggtatct tcctcaaaag gaggagtcca tggtggagag gtttgctgtt
       61 ggactcacct ggctgaggcc tctcctcagg acacttactc ttcccacggc cttttctaag
      121 gcactgaaga gaacactggt caggctggag gaacgctggc ttccccactc cctctagtgt
      181 cttggtactt tgggagattg tcacagggac aagaggaaga agggacaata ccatcctctg
      241 tgggaaggag aaccagcttc cttgtggtga ctacacagca gaccagaagg ccaccgtcta
      301 cgattcatat cagcacacac agtctatcct aagagtccat gttgatcttg gaagtagaga
      361 ggtttaaaag aagttcccac agaaaccaag agccttacca tctcctttag ctccgaaggc
      421 tggcggacaa tggatatcat agagacagca aaacttgaag gtcatttgga aagtcaaacc
      481 aacaactcta ccaacactta cacaagcccc actgaagctg tagaagagga ggacaaaaat
      541 ggcaagggta aacccaagac cttatccaac gggctacgaa agggtgccaa gaaatacccg
      601 gactacatcc agatttccat gcccaatgac tccaggaaca agcttcccct agagtggtgg
      661 aaaacaggca ttgcctttgt gtacgctctc ttcaacctta tcctgacaac agtcatgatc
      721 accgttgtgc acgagagggt ccctcccaag gaactcagcc ctccactccc agacaagttt
      781 tttgattacg tcgaccgggt caaatgggca ttttctgtat cagaaataaa tgggatggta
      841 ttagttgggc tatggctcac ccagtggctc tttctgagat acaagtcaat agtgggacgc
      901 agattcttct ttatcatggg aactttatac ctgtatcgct gtataactat gtacgtcact
      961 acgttacctg tgcccggaat gcacttccag tgtgctccaa agctcaatgg agactctcag
     1021 gcaaaaatac aacggattct ccggttgctt tctggtggtg gattgtccat cacgggatca
     1081 cacatcctgt gtggagactt cctcttcagc ggccatacag ttgtgctgac acttacttac
     1141 ttgttcatca aagaatattc acctcgtcac ttctggtggt accacttggt ctgctggctg
     1201 ctgagcgccg ctgggatcgt ctgcatcctc gtggcgcacg aacactacac ggtcgatgtc
     1261 atcattgcgt attacatcac aacacggctg ttttggtggt accactccat ggccaatgaa
     1321 aagaacttga aggtctcttc ccagactaat ttcttgtctc gggcttggtg gttccccatc
     1381 ttctattttt ttgaaaagaa tgtgcaaggc tccattcctt gctgtttctc ctggccgctg
     1441 tcctggcccc ctggctgctt caagtcatcg tgcaaaaagt attctcgagt ccagaagatc
     1501 ggggaggata atgagaagtc tacctgagcg gccgacacga cagccgcttt tccacccaaa
     1561 gagtccgtgc tgtaaccaaa ggcacagctt cctatttatt ttcagagaac tgactggtga
     1621 aacgaagtgg accaaatttt atgcaaaaga ttggagcagt gaagtattac ctttcggctt
     1681 tttttcttca ttcatcccaa gaaacatata ttttcctgta gctctccatt cagggaggac
     1741 aaggccccaa gctggagttc tgcagaggca aaagagaaca cgctaagcct ctcctcatct
     1801 tccttcactt ccacactctt tccagattgc tttttttcct cccttcaagg tcagaagagt
     1861 ttgctaatgt tttgaataaa atgtccggat atatacaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaa
//
