LOCUS       NM_181386               3690 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus sphingomyelin synthase 1 (Sgms1), mRNA.
ACCESSION   NM_181386
VERSION     NM_181386.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3690)
  AUTHORS   Filippenkov,I.B., Kolomin,T.A., Limborska,S.A. and Dergunova,L.V.
  TITLE     Developmental stage-specific expression of genes for sphingomyelin
            synthase in rat brain
  JOURNAL   Cell Tissue Res 372 (1), 33-40 (2018)
   PUBMED   29294205
  REMARK    GeneRIF: in contrast to Sgms1, Sgms2 does not contain the
            multi-exon 5'-UTR but encodes circRNAs, which are composed of the
            coding region of the gene and are expressed at a low level.
REFERENCE   2  (bases 1 to 3690)
  AUTHORS   Ding,T., Kabir,I., Li,Y., Lou,C., Yazdanyar,A., Xu,J., Dong,J.,
            Zhou,H., Park,T., Boutjdir,M., Li,Z. and Jiang,X.C.
  TITLE     All members in the sphingomyelin synthase gene family have ceramide
            phosphoethanolamine synthase activity
  JOURNAL   J Lipid Res 56 (3), 537-545 (2015)
   PUBMED   25605874
REFERENCE   3  (bases 1 to 3690)
  AUTHORS   Filippenkov,I.B., Sudarkina,O.Y., Limborska,S.A. and Dergunova,L.V.
  TITLE     Circular RNA of the human sphingomyelin synthase 1 gene: Multiple
            splice variants, evolutionary conservatism and expression in
            different tissues
  JOURNAL   RNA Biol 12 (9), 1030-1042 (2015)
   PUBMED   26274505
REFERENCE   4  (bases 1 to 3690)
  AUTHORS   Subathra,M., Qureshi,A. and Luberto,C.
  TITLE     Sphingomyelin synthases regulate protein trafficking and secretion
  JOURNAL   PLoS One 6 (9), e23644 (2011)
   PUBMED   21980337
  REMARK    GeneRIF: SMS1 and SMS2 are capable of regulating TGN-mediated
            protein trafficking and secretion
REFERENCE   5  (bases 1 to 3690)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3690)
  AUTHORS   Yang,Z., Jean-Baptiste,G., Khoury,C. and Greenwood,M.T.
  TITLE     The mouse sphingomyelin synthase 1 (SMS1) gene is alternatively
            spliced to yield multiple transcripts and proteins
  JOURNAL   Gene 363, 123-132 (2005)
   PUBMED   16226406
REFERENCE   7  (bases 1 to 3690)
  AUTHORS   Yamaoka,S., Miyaji,M., Kitano,T., Umehara,H. and Okazaki,T.
  TITLE     Expression cloning of a human cDNA restoring sphingomyelin
            synthesis and cell growth in sphingomyelin synthase-defective
            lymphoid cells
  JOURNAL   J Biol Chem 279 (18), 18688-18693 (2004)
   PUBMED   14976195
REFERENCE   8  (bases 1 to 3690)
  AUTHORS   Huitema,K., van den Dikkenberg,J., Brouwers,J.F. and Holthuis,J.C.
  TITLE     Identification of a family of animal sphingomyelin synthases
  JOURNAL   EMBO J 23 (1), 33-44 (2004)
   PUBMED   14685263
REFERENCE   9  (bases 1 to 3690)
  AUTHORS   Rabinovici,R., Zhang,D., Su,Y., Luo,X., Zhao,Q. and Yang,J.H.
  TITLE     MOB-1 and TNF-alpha interact to induce microvascular lung injury
  JOURNAL   Shock 18 (3), 261-264 (2002)
   PUBMED   12353928
  REMARK    GeneRIF: mob-1 and TNF-alpha interact to promote lung inflammation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 3, 2020 this sequence version replaced NM_181386.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081693.1, SRR26360194.163841.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               JAXUCZ010000001.1  239672608-239672893 c
            287-365             JAXUCZ010000001.1  239640153-239640231 c
            366-454             JAXUCZ010000001.1  239576457-239576545 c
            455-497             JAXUCZ010000001.1  239531236-239531278 c
            498-579             JAXUCZ010000001.1  239505693-239505774 c
            580-1419            JAXUCZ010000001.1  239447044-239447883 c
            1420-1537           JAXUCZ010000001.1  239433116-239433233 c
            1538-1691           JAXUCZ010000001.1  239416748-239416901 c
            1692-1858           JAXUCZ010000001.1  239412511-239412677 c
            1859-3690           JAXUCZ010000001.1  239409991-239411822 c
FEATURES             Location/Qualifiers
     source          1..3690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3690
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /note="sphingomyelin synthase 1"
                     /db_xref="GeneID:353229"
                     /db_xref="RGD:727912"
     exon            1..286
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            287..365
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            366..454
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            455..497
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            498..579
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            580..1419
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     CDS             779..2038
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /EC_number="2.7.8.27"
                     /note="protein Mob; transmembrane protein 23"
                     /codon_start=1
                     /product="phosphatidylcholine:ceramide
                     cholinephosphotransferase 1"
                     /protein_id="NP_852051.2"
                     /db_xref="GeneID:353229"
                     /db_xref="RGD:727912"
                     /translation="MLSASTMKEVVYWSPKKVADWLLENAMPEYCEPLGHFTGQDLIN
                     LTQEDFTKPPLCRVSSDNGQRLLDMIETLKMEHHIEAHKNGHANGHLSIGVDIPNPDG
                     SFSIKIKPNGMPNGFRKEMIKIPMPEPERSQYPMEWGKTLLAFLYALSCFVLTTVMIS
                     VVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLFQWLLLKYKSIIS
                     RRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQVRRIMKLIAGGGLSI
                     TGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDH
                     YTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVP
                     RSYHWPLPWPVVHLSRQVKYSRLVNDT"
     exon            1420..1537
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1691
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1858
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..3690
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaaagca tggaggaggg cgacggctgt ccaaacaact tcagcaacct tcatcctctg
       61 tccccgggaa tgggtcagaa cagggaagcg gcaggaggag cgatgcgggc gccttaggaa
      121 cgggaactcc tttccccaac ttccgcccct ggggaaaagc tgaagccatc agctccagga
      181 gagcggctct ccaattctca gcctttaggt tctggctctg gagacagcct gtcctcccgg
      241 tatcgccggc gccgctgtac ccccgctgta gactagcgga ttgcaggttg aaggcagggt
      301 gagtggtgcc ggaggacaga cctcgccatt cgatcgtatt tagaagatag ccacccactc
      361 ggaagggaaa gctacagtgg ccgaagaagc tgtgatcttt caagcagggc gctgccactg
      421 gagcacagag gagggtatac agaagacagc acggactgga agaaagactg atgaagagaa
      481 gtaacggcat gattgaggtg atggagatga acgggaacac acggagaagc tagtatcctg
      541 caggaagcca agatgaggag agtcttttta aaataatcca aggaagaaac ctgtccagaa
      601 atgaggcgac ttaatgttcg gacaccattg catcaagcgt tttaaaactg ccctgaccat
      661 cttgtcaaat gagtctctgc tcatgagacc caacaagatg aaccagccaa ggagggatgg
      721 tgtcttgccc tgtcggaaca gtgactgctg acgtctgaga gcgagctggg ggcgccaaat
      781 gttgtctgcc agtaccatga aggaagtggt ttactggtca cccaagaagg tggcagactg
      841 gctgctggag aatgctatgc cagaatactg tgaacctctg gggcatttca caggccagga
      901 cctaatcaac ctaacccaag aggatttcac aaagcctcct ctgtgccgag tctcctctga
      961 caatgggcag cggctcttag acatgataga gaccctgaag atggagcacc atatcgaagc
     1021 gcacaagaat ggccacgcca acggacacct cagcattggc gtcgacattc ccaaccctga
     1081 cggcagcttc agcatcaaga ttaaacccaa cggaatgcca aatggcttca ggaaagagat
     1141 gatcaagatc cccatgccgg aacccgagcg ctcccagtac cccatggagt ggggcaagac
     1201 tttgctggcc tttctttacg cactgtcctg ttttgttctc actacagtga tgatctcggt
     1261 cgtccatgaa cgagtgcctc ctaaggaggt acagcctccg ctaccggaca cgttttttga
     1321 ccattttaac cgggtgcagt gggcgttttc tatttgcgaa attaacggca tgatccttgt
     1381 aggactctgg ttatttcagt ggctgctctt aaaatacaag tctattatta gcagaagatt
     1441 tttctgcata gttggcacgc tgtacctgta ccggtgtatt acaatgtatg taactacact
     1501 cccagtaccc ggcatgcact tcaactgttc tccgaagctc tttggagact gggaagctca
     1561 agtgcggagg ataatgaagc tcattgctgg aggtggcttg tccatcacgg gctcgcacaa
     1621 catgtgtggg gactatctgt acagtggaca cacagtcatg ctaacgctca cctacctgtt
     1681 tatcaaggag tattcccctc ggcggctctg gtggtaccac tggatttgct ggctcctcag
     1741 cgtcgttgga atcttctgta ttctcttagc gcatgaccac tacactgtgg acgtggtggt
     1801 agcatattac atcaccacaa gactcttctg gtggtatcac acgatggcca atcagcaagt
     1861 gctgaaggaa gcttcccaga tgaacctcct ggccagagtg tggtggtaca ggccatttca
     1921 gtactttgaa aagaacgtcc aagggattgt acctcgatct taccattggc cccttccctg
     1981 gccggtagtc caccttagta ggcaagttaa atatagccgg ctggtaaacg acacctaaca
     2041 gcctcgccgc ctaggggaac gaacgaggaa tggtccgaag tgctaagaac tccgtgagag
     2101 aagacgccat agagtaacca cctcccctgc tatctctcaa gttaccttga ctgaacccat
     2161 tgagttatct gctcagcact gtgatctttt tttttctctc caaaggaccc gcgttggaca
     2221 acaataaaga aaatttacca tatcatgcac tgtacacatt tcctgttgtt aagcttgggg
     2281 cttctatacc gggcagccac catgtccctt gtgtcatcca gccgcgccac cgtgcgcgtc
     2341 tgtatcctaa gcgctggcct ttccagccac atctggaaat aaagtgtgtt attttcttgg
     2401 gaaaacatac ttttcatata tctctcgccc caaagacagg gctgtaagcc attttctagt
     2461 aaatgtctct atgaagggtc ctatttgtct gaatgggagt tgactcagaa tctctgccaa
     2521 ttacaccgag gctcggctga agacgctagg tgcagagagg tttggtacct ggggttttat
     2581 acagtcagca gagatggtgt atcaaaaagt gcaaaaaagg attctgttat aaagcgattt
     2641 ttctaagtat ttcctaactt tatttttcaa aatgatgtta tgaaaaccaa atttaaagat
     2701 ttttacatgt cacagaaaag agagttaaac tttaaagatg cttcttggga gagaaatttg
     2761 tctatgtttc tagtgccttt cttgtcttga ttgtatggtc ggttggtagg caatcttaaa
     2821 tgtttttatt tattccatga aaatataaat gtatgtatac actactaaat ttcgcattta
     2881 tagctaaatt aaagcgaaag actgctaatg gtttgaaaac ggttttgaac tgaagaacag
     2941 gggtatgaat tagagtctgc gtctattcac atattgtgag cagacagcac tgacaagtgc
     3001 cactgaaatt cttctatgga tttggtagtt cggttttaac tactcaataa aaacagccat
     3061 gaatattttt ttttaaaaaa gagagtttcg aaaatgatca cttacctgaa acttgaaagc
     3121 tataaattag ttatccacac tctcatgaca ggtttgctgg tgggcaacaa cagcaaaaag
     3181 agagctattt ctttacaata tatttgtgca gaaagcgcat gtaactctga gttttactcc
     3241 tgacatacgt atgtttgggg aagtattcta ctctatactt gccaacgtgg agaacaaaat
     3301 agttttctaa gagtgaagaa gtatatatat atataaatat aaatataaat ataatatcct
     3361 ttctgtattt tatgtgcagc aggattacct tctgtaggtt tcgtgtgtgt gcacgcgcgt
     3421 gcaagagtgt gtgtatgcgc gtgcatgtat gtgtgcgtgt gtgtgtgtgc gtgtatgtgt
     3481 gcgtgtgtat gtgtgtgtgt agtgtctact cacaaggtga tatttgtatt gtaaaacaat
     3541 aatggtgaag gaaataaaaa ggcttttaaa tttttgtttg ttttaaatct ttgtaaagtt
     3601 attattccag agagtatact gataatctta caacttacct aaatcataaa ttaatcaaaa
     3661 tgcacttttt aataaaaact tatactgaaa
//
