LOCUS       NP_852051                419 aa            linear   ROD 29-MAR-2024
DEFINITION  phosphatidylcholine:ceramide cholinephosphotransferase 1 [Rattus
            norvegicus].
ACCESSION   NP_852051
VERSION     NP_852051.2
DBSOURCE    REFSEQ: accession NM_181386.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Filippenkov,I.B., Kolomin,T.A., Limborska,S.A. and Dergunova,L.V.
  TITLE     Developmental stage-specific expression of genes for sphingomyelin
            synthase in rat brain
  JOURNAL   Cell Tissue Res 372 (1), 33-40 (2018)
   PUBMED   29294205
  REMARK    GeneRIF: in contrast to Sgms1, Sgms2 does not contain the
            multi-exon 5'-UTR but encodes circRNAs, which are composed of the
            coding region of the gene and are expressed at a low level.
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Ding,T., Kabir,I., Li,Y., Lou,C., Yazdanyar,A., Xu,J., Dong,J.,
            Zhou,H., Park,T., Boutjdir,M., Li,Z. and Jiang,X.C.
  TITLE     All members in the sphingomyelin synthase gene family have ceramide
            phosphoethanolamine synthase activity
  JOURNAL   J Lipid Res 56 (3), 537-545 (2015)
   PUBMED   25605874
REFERENCE   3  (residues 1 to 419)
  AUTHORS   Filippenkov,I.B., Sudarkina,O.Y., Limborska,S.A. and Dergunova,L.V.
  TITLE     Circular RNA of the human sphingomyelin synthase 1 gene: Multiple
            splice variants, evolutionary conservatism and expression in
            different tissues
  JOURNAL   RNA Biol 12 (9), 1030-1042 (2015)
   PUBMED   26274505
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Subathra,M., Qureshi,A. and Luberto,C.
  TITLE     Sphingomyelin synthases regulate protein trafficking and secretion
  JOURNAL   PLoS One 6 (9), e23644 (2011)
   PUBMED   21980337
  REMARK    GeneRIF: SMS1 and SMS2 are capable of regulating TGN-mediated
            protein trafficking and secretion
REFERENCE   5  (residues 1 to 419)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (residues 1 to 419)
  AUTHORS   Yang,Z., Jean-Baptiste,G., Khoury,C. and Greenwood,M.T.
  TITLE     The mouse sphingomyelin synthase 1 (SMS1) gene is alternatively
            spliced to yield multiple transcripts and proteins
  JOURNAL   Gene 363, 123-132 (2005)
   PUBMED   16226406
REFERENCE   7  (residues 1 to 419)
  AUTHORS   Yamaoka,S., Miyaji,M., Kitano,T., Umehara,H. and Okazaki,T.
  TITLE     Expression cloning of a human cDNA restoring sphingomyelin
            synthesis and cell growth in sphingomyelin synthase-defective
            lymphoid cells
  JOURNAL   J Biol Chem 279 (18), 18688-18693 (2004)
   PUBMED   14976195
REFERENCE   8  (residues 1 to 419)
  AUTHORS   Huitema,K., van den Dikkenberg,J., Brouwers,J.F. and Holthuis,J.C.
  TITLE     Identification of a family of animal sphingomyelin synthases
  JOURNAL   EMBO J 23 (1), 33-44 (2004)
   PUBMED   14685263
REFERENCE   9  (residues 1 to 419)
  AUTHORS   Rabinovici,R., Zhang,D., Su,Y., Luo,X., Zhao,Q. and Yang,J.H.
  TITLE     MOB-1 and TNF-alpha interact to induce microvascular lung injury
  JOURNAL   Shock 18 (3), 261-264 (2002)
   PUBMED   12353928
  REMARK    GeneRIF: mob-1 and TNF-alpha interact to promote lung inflammation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 28, 2005 this sequence version replaced NP_852051.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081693.1, SRR26360194.163841.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     Protein         1..419
                     /product="phosphatidylcholine:ceramide
                     cholinephosphotransferase 1"
                     /EC_number="2.7.8.27"
                     /note="protein Mob; transmembrane protein 23"
                     /calculated_mol_wt=48883
     Region          7..78
                     /region_name="SAM_SGMS1"
                     /note="SAM domain of sphingomyelin synthase; cd09514"
                     /db_xref="CDD:188913"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86VZ5; propagated from
                     UniProtKB/Swiss-Prot (Q7TSX5.2)"
     Site            142..162
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSX5.2)"
     Site            190..210
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSX5.2)"
     Site            221..241
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSX5.2)"
     Region          282..355
                     /region_name="PAP2_C"
                     /note="PAP2 superfamily C-terminal; pfam14360"
                     /db_xref="CDD:464150"
     Site            282..302
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSX5.2)"
     Site            310..330
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSX5.2)"
     CDS             1..419
                     /gene="Sgms1"
                     /gene_synonym="Mob; mob-1; Tmem23"
                     /coded_by="NM_181386.3:779..2038"
                     /db_xref="GeneID:353229"
                     /db_xref="RGD:727912"
ORIGIN      
        1 mlsastmkev vywspkkvad wllenampey ceplghftgq dlinltqedf tkpplcrvss
       61 dngqrlldmi etlkmehhie ahknghangh lsigvdipnp dgsfsikikp ngmpngfrke
      121 mikipmpepe rsqypmewgk tllaflyals cfvlttvmis vvhervppke vqpplpdtff
      181 dhfnrvqwaf siceingmil vglwlfqwll lkyksiisrr ffcivgtlyl yrcitmyvtt
      241 lpvpgmhfnc spklfgdwea qvrrimklia ggglsitgsh nmcgdylysg htvmltltyl
      301 fikeysprrl wwyhwicwll svvgifcill ahdhytvdvv vayyittrlf wwyhtmanqq
      361 vlkeasqmnl larvwwyrpf qyfeknvqgi vprsyhwplp wpvvhlsrqv kysrlvndt
//
