LOCUS       NM_001376043            3168 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serum/glucocorticoid regulated kinase family,
            member 3 (Sgk3), mRNA.
ACCESSION   NM_001376043 XM_003753981
VERSION     NM_001376043.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3168)
  AUTHORS   Liu,S., Zhu,B., Sun,Y. and Xie,X.
  TITLE     MiR-155 modulates the progression of neuropathic pain through
            targeting SGK3
  JOURNAL   Int J Clin Exp Pathol 8 (11), 14374-14382 (2015)
   PUBMED   26823753
  REMARK    GeneRIF: MiR-155 modulates the progression of neuropathic pain
            through SGK3 signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3168)
  AUTHORS   Lamothe,S.M. and Zhang,S.
  TITLE     The serum- and glucocorticoid-inducible kinases SGK1 and SGK3
            regulate hERG channel expression via ubiquitin ligase Nedd4-2 and
            GTPase Rab11
  JOURNAL   J Biol Chem 288 (21), 15075-15084 (2013)
   PUBMED   23589291
  REMARK    GeneRIF: SGK1,3 enhances the expression level of mature hERG
            channels by inhibiting Nedd4-2 as well as by promoting
            Rab11-mediated hERG recycling.
REFERENCE   3  (bases 1 to 3168)
  AUTHORS   Liu,D., Yang,X. and Songyang,Z.
  TITLE     Identification of CISK, a new member of the SGK kinase family that
            promotes IL-3-dependent survival
  JOURNAL   Curr Biol 10 (19), 1233-1236 (2000)
   PUBMED   11050396
REFERENCE   4  (bases 1 to 3168)
  AUTHORS   Dai,F., Yu,L., He,H., Zhao,Y., Yang,J., Zhang,X. and Zhao,S.
  TITLE     Cloning and mapping of a novel human serum/glucocorticoid regulated
            kinase-like gene, SGKL, to chromosome 8q12.3-q13.1
  JOURNAL   Genomics 62 (1), 95-97 (1999)
   PUBMED   10585774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 7, 2019 this sequence version replaced XM_003753981.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.20761.1,
                                           SRR26643287.12601.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000005.1  14198225-14198331   c
            108-327             JAXUCZ010000005.1  14177267-14177486   c
            328-411             JAXUCZ010000005.1  14173513-14173596   c
            412-484             JAXUCZ010000005.1  14169432-14169504   c
            485-560             JAXUCZ010000005.1  14168841-14168916   c
            561-648             JAXUCZ010000005.1  14162987-14163074   c
            649-698             JAXUCZ010000005.1  14161317-14161366   c
            699-756             JAXUCZ010000005.1  14159341-14159398   c
            757-840             JAXUCZ010000005.1  14154958-14155041   c
            841-972             JAXUCZ010000005.1  14154711-14154842   c
            973-1085            JAXUCZ010000005.1  14151732-14151844   c
            1086-1122           JAXUCZ010000005.1  14151583-14151619   c
            1123-1209           JAXUCZ010000005.1  14150222-14150308   c
            1210-1305           JAXUCZ010000005.1  14149824-14149919   c
            1306-1461           JAXUCZ010000005.1  14147021-14147176   c
            1462-1551           JAXUCZ010000005.1  14142338-14142427   c
            1552-3168           JAXUCZ010000005.1  14128902-14130518   c
FEATURES             Location/Qualifiers
     source          1..3168
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..3168
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /note="serum/glucocorticoid regulated kinase family,
                     member 3"
                     /db_xref="GeneID:171498"
                     /db_xref="RGD:620242"
     exon            1..107
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            108..327
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1722
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /EC_number="2.7.11.1"
                     /note="serum/glucocorticoid-regulated kinase 3;
                     cytokine-independent survival kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk3"
                     /protein_id="NP_001362972.1"
                     /db_xref="GeneID:171498"
                     /db_xref="RGD:620242"
                     /translation="MQRDCTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSE
                     WFVFRRYAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLV
                     RYPELYNHPDVRAFLQMDSPRHQSDPSEDEDERSTPKPHSTSRNINLGPTGNPHAKPS
                     DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNV
                     KHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGY
                     LHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIR
                     KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSIL
                     EELLEKNRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFD
                     AVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL"
     exon            328..411
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            412..484
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            485..560
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            561..648
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            649..698
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            699..756
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            757..840
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            841..972
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1085
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1122
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1209
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1305
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1461
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1551
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..3168
                     /gene="Sgk3"
                     /gene_synonym="Cisk; Sgkl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgccggc aggcgccctg ggggcaggtg gagaggcccg ctgggatcgg gtggcgccga
       61 agagtggcgc tttcagcttg ccacgctcaa gggtagggtc ccggaaggtt ccatgatgga
      121 gtttgaacat tacctcaaga ggtttcatat tttggactag ttaatcatat ttaccttctg
      181 ctgagacctt ggaaacttca gactcaattt ctgtgtcctt caagacatta aatgcagaga
      241 gactgtacta tggactacaa ggagagctgc ccaagtgtga gcattcccag ctctgacgaa
      301 cacagagaga aaaagaagag gttcacggtt tataaagttc tggtctctgt gggaagaagc
      361 gaatggttcg tcttcaggag atatgcagag tttgacaaac tttacaattc tttgaagaaa
      421 cagtttcctg ctatggctct gaagatcccg gccaagagaa tatttggtga taattttgat
      481 ccagatttta ttaaacaaag aagagcagga ttgaacgagt tcattcagaa cttagtcaga
      541 tatccagagc tttacaacca tccagacgtc cgagcattcc ttcaaatgga cagcccgaga
      601 catcagtcag atccatctga agatgaggat gaaagaagta ctccgaagcc acattctacc
      661 tcacggaaca tcaacctggg tccaactgga aatcctcatg ccaaaccaag tgacttcgat
      721 tttttaaaag ttattggaaa gggcagcttt ggcaaggttc ttcttgcaaa acggaaactg
      781 gatggaaaat tttatgctgt caaagtgtta cagaaaaaaa tagttctcaa cagaaaagag
      841 caaaaacata ttatggctga acgcaatgtg ctcttgaaaa atgtgaagca cccgtttctg
      901 gttggattgc actattcttt ccagacaact gaaaagcttt attttgttct ggattttgtt
      961 aatggagggg agctcttctt tcacctacaa agagaaaggt cttttcctga acccagagcg
     1021 aggttttatg ctgctgagat tgccagtgcc ttgggttatc tgcactccat caaaatagtg
     1081 tacagagact tgaagccaga aaatatcctt ttggattcta tgggacatgt tgtcttaacg
     1141 gattttgggc tttgcaaaga aggaatcgct atttctgata ccaccacaac cttttgtggt
     1201 acaccagagt accttgcacc tgaagtgatc agaaaacagc cgtatgacaa cactgtggac
     1261 tggtggtgcc tgggagctgt tctgtacgag atgctgtatg ggctgccccc tttttactgc
     1321 cgagatgttg ctgaaatgta tgacaatatt cttcacaagc ccctgaactt gagaccagga
     1381 gtgagcctca cagcctggtc catcctggag gaactcctag aaaaaaacag acaaaatcga
     1441 cttggtgcca aagaagactt tcttgaaatc cagaatcatc ctttttttga gtcactcagc
     1501 tggactgacc ttgtacaaaa aaagatccca ccgccattta accctaatgt ggctggacca
     1561 gacgatatca gaaacttcga tgccgtcttc actgaagaaa cggtgcccta ttctgtgtgc
     1621 gtgtcttctg actattctat agtgaatgcc agtgttctgg aggcagacga tgcatttgtt
     1681 ggtttttctt acgcccctcc ttcagaagac ttatttttgt gaacactcta tcattcagaa
     1741 accgaggagc aacctctagc ctgcagaaga gttggaaaca cttatttgtg tgaatatatt
     1801 caactttgta taacagtgcc tcatttttat atgtaacagt gaaaactatg aaatacatat
     1861 tttctgctgt atgcaagaaa taatagggca tttcaaagag ctaagttttg aacttaaatt
     1921 tgtattcttg tttattaagc ttatttttaa acaaaaattt aaagctatta ttcttagcat
     1981 taacctattt ttaaagataa ctttttgcta ttgactgttt ttctttcctg ttaagtttac
     2041 actaacacat ccaagataga ctgttttaat agtctgttac agttaagatg tattaatatc
     2101 tgtaattcta tgccttttat catagcgaaa ctatgcaaat ggtacatgat ggtttgtgat
     2161 ggtttatgat gaaaccctat cttcccatga taatttactc tttgcttctt agtcagactc
     2221 cagcacagag gcagatgagc tgacgccccg gctgctagtg ggcattcgca gccactcatt
     2281 tgcagcccca taagaaaaag cagaaggcag ccatttgctt ttggaatacc cagatcccat
     2341 ccatgcatca ctttcctcta aaggaaaaga aaatacttaa catccaggaa tttttagaat
     2401 tctcaacgaa ctgagaagta ataaaatgct accagatatt ttttttaagg tggtgccaaa
     2461 catagatgtc tctgtcacgt gtttatatta gaaatgtttt ctatttatgt tccttctgac
     2521 ccttggaagg tttagtagac accactaagc cttggtgtct gtttttgcag atagctattt
     2581 caaaactgcc ttcttaattg atcatgtttt taaagtgaca gaaaagaagt agccttctgt
     2641 aatgtttact tagttgtgaa ttaagtagta aaaccgcaag tctgggtcag tgtgagtgtg
     2701 tgtccccacc acattccaac aaaaggtaac agtaatttag tgtaacgttt tcagtattac
     2761 tcgtgttgta gtgcagggat cagacatgca tgaggcctcg tgaatgctaa tcagagcatt
     2821 ccctatctct gacgtgcaca catgcctctt gctatcttta tgtgtcttag aagtagttca
     2881 gaacaacctg tcggttacca tctgcactca tgatggtaaa atgttaggtt cagagggtgc
     2941 ttcttgggac tccagctcct ggaggacagc ttcccaggtc cttaagggga cagcagcatg
     3001 agcttagctg cgctaagaac aaactttcct tggatgtgtt accttggcaa gtgagaaata
     3061 tttctcgtca gtaccctttg gctaaaatac gttcagcagg atggggacag gcggtgcttc
     3121 agtgtgacag gtagtctttg tgtgcatgca gtacactgga tctccctc
//
