LOCUS       NM_134463               2708 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serum/glucocorticoid regulated kinase 2 (Sgk2),
            mRNA.
ACCESSION   NM_134463 XM_001070075 XM_342570
VERSION     NM_134463.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Pao,A.C., Bhargava,A., Di Sole,F., Quigley,R., Shao,X., Wang,J.,
            Thomas,S., Zhang,J., Shi,M., Funder,J.W., Moe,O.W. and Pearce,D.
  TITLE     Expression and role of serum and glucocorticoid-regulated kinase 2
            in the regulation of Na+/H+ exchanger 3 in the mammalian kidney
  JOURNAL   Am J Physiol Renal Physiol 299 (6), F1496-F1506 (2010)
   PUBMED   20926631
  REMARK    GeneRIF: results suggest that pattern of expression, regulation,
            and role of sgk2 within mammalian kidney are distinct from sgk1 and
            that sgk2 may play previously unrecognized role in control of
            transtubular Na(+) transport through NHE3 in the proximal tubule.
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Won,M., Park,K.A., Byun,H.S., Kim,Y.R., Choi,B.L., Hong,J.H.,
            Park,J., Seok,J.H., Lee,Y.H., Cho,C.H., Song,I.S., Kim,Y.K.,
            Shen,H.M. and Hur,G.M.
  TITLE     Protein kinase SGK1 enhances MEK/ERK complex formation through the
            phosphorylation of ERK2: implication for the positive regulatory
            role of SGK1 on the ERK function during liver regeneration
  JOURNAL   J Hepatol 51 (1), 67-76 (2009)
   PUBMED   19447520
  REMARK    GeneRIF: SGK1 expression during liver regeneration is a part of a
            signaling pathway that is necessary for enhancing ERK signaling
            activation through modulating the MEK/ERK complex formation.
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   Gamper,N., Fillon,S., Feng,Y., Friedrich,B., Lang,P.A., Henke,G.,
            Huber,S.M., Kobayashi,T., Cohen,P. and Lang,F.
  TITLE     K+ channel activation by all three isoforms of serum- and
            glucocorticoid-dependent protein kinase SGK
  JOURNAL   Pflugers Arch 445 (1), 60-66 (2002)
   PUBMED   12397388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_001070075.1, XM_342570.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2708
                     /gene="Sgk2"
                     /note="serum/glucocorticoid regulated kinase 2"
                     /db_xref="GeneID:171497"
                     /db_xref="RGD:620232"
     exon            1..268
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            269..512
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..572
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..1640
                     /gene="Sgk2"
                     /EC_number="2.7.11.1"
                     /note="SGK2, serine/threonine kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk2"
                     /protein_id="NP_604458.1"
                     /db_xref="GeneID:171497"
                     /db_xref="RGD:620232"
                     /translation="MASSPVGVPSPQPSRANGNINLGPSANPNARPTDFDFLKVIGKG
                     NYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQSHIMAERNVLLKNVRHPFLVGLRYS
                     FQTPEKLYFVLDYVNGGELFFHLQREHRFLEPRARFYTAEVASAIGYLHSLNIIYRDL
                     KPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWW
                     CLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLHKDQRQR
                     LGSKEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLKHFDPEFTQEAVSKS
                     IGCTPDTMSSSSGASSAFLGFSYAQDDDDILDS"
     exon            573..622
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..680
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..764
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..896
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1009
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1046
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1133
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1229
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1385
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1475
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..2708
                     /gene="Sgk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgtccg ggagccagtg gtacagcaac cacggtgatt cagtccagca gttaattagt
       61 aaccggaagg tctcgaagct ggctgtcagc tggcagggct gggaggctgg acctgtgctg
      121 gtttgagagt caggcgagtg ggtgacaggt cactcctgct taggaaggtt gtagggtgag
      181 tcaggattgg gtttcaggtc agaaggacgg tgcaaaggga gagaaccttt attctccagg
      241 acctgcgctg gaacctgggg gtttccaggg agaaatggtg accccgtggg aacagaggtc
      301 tcccatccca tcctaagctg ctggatcctg cgtgacatca ccagtcccct cgctgctgcc
      361 actgttggaa gctctgagct ctgtgctggg ggcaccaggc actgacactt ggctcttgtt
      421 gagagaacag tgagagtctc tcttgtccac ggcctgtgct ccgctccaac tgctgcatct
      481 cccagaggct ctgctctgcc caggctgcat agagcctatc agatcatagc tacagaatgg
      541 cctccagccc agttggagtt cctagccccc agccctctag ggccaatggg aacatcaacc
      601 tggggccatc agccaaccca aatgcccgac ccacagactt tgatttcctc aaagtcattg
      661 gcaaagggaa ctatgggaag gtcctactgg ccaagcgcaa gtcagacgga gccttctatg
      721 ccgtgaaggt gctgcagaag aagtccatct taaaaaacaa agagcagagc cacatcatgg
      781 cagaacgcaa cgtgctactg aagaacgtgc ggcacccctt ccttgtgggc ctgcgctact
      841 ccttccagac cccagagaag ctctactttg tgcttgacta tgtcaacggg ggagagcttt
      901 tcttccatct ccagcgggaa cacaggttcc tggagccccg ggcccggttc tacacggcag
      961 aggtggcaag cgccatcggt tatcttcact ctctcaacat catctacaga gacctgaagc
     1021 cagaaaacat tctcttggac tgccagggtc acgtggtact gacagatttc ggcctttgca
     1081 aggaatgtgt agagcccgag gagaccacat ccaccttctg cggcacccct gagtacttgg
     1141 ctccagaagt ccttcgtaaa gagccttacg atcgagcagt cgactggtgg tgcttagggg
     1201 ccgttctcta cgagatgctg cacggcctgc cccccttctt caacacagat gtggcccaga
     1261 tgtatgagaa cattttgcat cagccgctac agatccctgg aggccggaca gtggctgcct
     1321 gtgacctcct gcagggtctt ctccacaagg accagaggca gcggctgggc tccaaggaag
     1381 actttctcga cataaagaac cacatgttct tcagtcccat aaattgggat gatctgtacc
     1441 acaagaggct gactccaccc ttcaacccaa acgtggaggg acccgctgac ttgaaacact
     1501 ttgacccaga gttcacccag gaggctgtgt ccaagtccat tggctgcacc cctgacacca
     1561 tgtccagcag ttctggggcc tcaagtgcat tcctcggatt ctcctatgca caggatgatg
     1621 atgacatctt ggactcttga gagccaagtg cttggaaagc caccaagccc agctgggacc
     1681 tgcaggaact accttctgct gcactaagac acgacgagtc ccgaagaagt cagatgcagt
     1741 agctcaggga agaggggagc attttccatc ccataaaaga acggtgaagg gttcaggctg
     1801 gctgactagg ctcccgagta cccagccgtc tgcggttgag acttgccctt cttgagaaat
     1861 gacttctgtg cttggttttt catttttggt tttgtttgtt gttgctgagg ctgtgacaaa
     1921 gtatgcaaga aaagtaatgt aaagaatatc tatttgggct cacagtttca gaaggttcag
     1981 cccatagttg gctgatccat tgctgtggtc tttagccgaa gttgagtcat cttgctggaa
     2041 ggagtgactt accctatgcc tagcaggaaa cagaaactga gtctgggttg ggaataagat
     2101 accttctgat aagatatttc tgagtgaccc actcccttcc agtggggcca atgtcctagt
     2161 tatcacctct ccgtgctata aaattacaaa tctgtgaatg gactaacttg ctgaggaagc
     2221 ctgagcccct ccctcattgc atagtgatcc aatcagttac gaaaggcctt atcagctgaa
     2281 caccacaacc ttcagaaaac acttcagatc agaagcacga tggctttgaa tattgggtta
     2341 cgagaccaca aagtggcctg ctggtcactt ttgtgttcta agcaagagaa aaggaggaac
     2401 gggacagaag tgggttgccc ggaagcccgg tctggtggct tcctttagtg tgtcataaat
     2461 tctccagctc tactggaata gagcctgggc acaagctacc tctcttagta agagggttcg
     2521 aatgctgagg gagaggggag aatgtggcgg aggcgaccgg cactctggga gaggacctct
     2581 tggtagctgg atttttattt ctgtgtataa attgatgaaa tgtagtgagc ctgtcatgtg
     2641 ttgccttcgg tttcacattg ctctgtgggt ggtgtctttg tttgaggtgg cattaaacac
     2701 actggata
//
