LOCUS       NM_019232               2467 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus serum/glucocorticoid regulated kinase 1 (Sgk1),
            transcript variant 3, mRNA.
ACCESSION   NM_019232
VERSION     NM_019232.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Li,Y.H., Sun,C.C., Chen,P.M. and Chen,H.H.
  TITLE     SGK1 Target Genes Involved in Heart and Blood Vessel Functions in
            PC12 Cells
  JOURNAL   Cells 12 (12), 1641 (2023)
   PUBMED   37371111
  REMARK    GeneRIF: SGK1 Target Genes Involved in Heart and Blood Vessel
            Functions in PC12 Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2467)
  AUTHORS   Zou,Z., Zhao,T., Zeng,Z. and An,Y.
  TITLE     Serum and glucocorticoid inducible kinase 1 modulates mitochondrial
            dysfunction and oxidative stress in doxorubicin-induced
            cardiomyocytes by regulating Hippo pathway via Neural precursor
            cell-expressed developmentally down-regulated 4 type 2
  JOURNAL   Hum Exp Toxicol 42, 9603271231158039 (2023)
   PUBMED   36781297
  REMARK    GeneRIF: Serum and glucocorticoid inducible kinase 1 modulates
            mitochondrial dysfunction and oxidative stress in
            doxorubicin-induced cardiomyocytes by regulating Hippo pathway via
            Neural precursor cell-expressed developmentally down-regulated 4
            type 2.
REFERENCE   3  (bases 1 to 2467)
  AUTHORS   Wang,F. and Han,L.
  TITLE     Upregulation of serum and glucocorticoid-regulated kinase 1 (SGK1)
            ameliorates doxorubicin-induced cardiotoxic injury, apoptosis,
            inflammation and oxidative stress by suppressing glucose regulated
            protein 78 (GRP78)-mediated endoplasmic reticulum stress
  JOURNAL   Bioengineered 13 (1), 844-855 (2022)
   PUBMED   34898378
  REMARK    GeneRIF: Upregulation of serum and glucocorticoid-regulated kinase
            1 (SGK1) ameliorates doxorubicin-induced cardiotoxic injury,
            apoptosis, inflammation and oxidative stress by suppressing glucose
            regulated protein 78 (GRP78)-mediated endoplasmic reticulum stress.
REFERENCE   4  (bases 1 to 2467)
  AUTHORS   Liu,B.W., Zhang,J., Hong,Y.S., Li,N.B., Liu,Y., Zhang,M., Wu,W.Y.,
            Zheng,H., Lampert,A. and Zhang,X.W.
  TITLE     NGF-Induced Nav1.7 Upregulation Contributes to Chronic
            Post-surgical Pain by Activating SGK1-Dependent Nedd4-2
            Phosphorylation
  JOURNAL   Mol Neurobiol 58 (3), 964-982 (2021)
   PUBMED   33063281
  REMARK    GeneRIF: NGF-Induced Nav1.7 Upregulation Contributes to Chronic
            Post-surgical Pain by Activating SGK1-Dependent Nedd4-2
            Phosphorylation.
REFERENCE   5  (bases 1 to 2467)
  AUTHORS   Lee,R.H., Grames,M.S., Wu,C.Y., Lien,C.F., Couto E Silva,A.,
            Possoit,H.E., Clemons,G.A., Citadin,C.T., Neumann,J.T., Pastore,D.,
            Lauro,D., Della-Morte,D. and Lin,H.W.
  TITLE     Upregulation of serum and glucocorticoid-regulated kinase 1
            exacerbates brain injury and neurological deficits after cardiac
            arrest
  JOURNAL   Am J Physiol Heart Circ Physiol 319 (5), H1044-H1050 (2020)
   PUBMED   32946263
  REMARK    GeneRIF: Upregulation of serum and glucocorticoid-regulated kinase
            1 exacerbates brain injury and neurological deficits after cardiac
            arrest.
REFERENCE   6  (bases 1 to 2467)
  AUTHORS   Maiyar,A.C., Phu,P.T., Huang,A.J. and Firestone,G.L.
  TITLE     Repression of glucocorticoid receptor transactivation and DNA
            binding of a glucocorticoid response element within the
            serum/glucocorticoid-inducible protein kinase (sgk) gene promoter
            by the p53 tumor suppressor protein
  JOURNAL   Mol Endocrinol 11 (3), 312-329 (1997)
   PUBMED   9058378
REFERENCE   7  (bases 1 to 2467)
  AUTHORS   Maiyar,A.C., Huang,A.J., Phu,P.T., Cha,H.H. and Firestone,G.L.
  TITLE     p53 stimulates promoter activity of the sgk.
            serum/glucocorticoid-inducible serine/threonine protein kinase gene
            in rodent mammary epithelial cells
  JOURNAL   J Biol Chem 271 (21), 12414-12422 (1996)
   PUBMED   8647846
REFERENCE   8  (bases 1 to 2467)
  AUTHORS   Richards,J.S., Fitzpatrick,S.L., Clemens,J.W., Morris,J.K.,
            Alliston,T. and Sirois,J.
  TITLE     Ovarian cell differentiation: a cascade of multiple hormones,
            cellular signals, and regulated genes
  JOURNAL   Recent Prog Horm Res 50, 223-254 (1995)
   PUBMED   7740159
  REMARK    Review article
REFERENCE   9  (bases 1 to 2467)
  AUTHORS   Imaizumi,K., Tsuda,M., Wanaka,A., Tohyama,M. and Takagi,T.
  TITLE     Differential expression of sgk mRNA, a member of the Ser/Thr
            protein kinase gene family, in rat brain after CNS injury
  JOURNAL   Brain Res Mol Brain Res 26 (1-2), 189-196 (1994)
   PUBMED   7854047
REFERENCE   10 (bases 1 to 2467)
  AUTHORS   Webster,M.K., Goya,L., Ge,Y., Maiyar,A.C. and Firestone,G.L.
  TITLE     Characterization of sgk, a novel member of the serine/threonine
            protein kinase gene family which is transcriptionally induced by
            glucocorticoids and serum
  JOURNAL   Mol Cell Biol 13 (4), 2031-2040 (1993)
   PUBMED   8455596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM068981.1, FM123924.1 and BC078843.1.
            
            On Aug 4, 2010 this sequence version replaced NM_019232.2.
            
            Transcript Variant: This variant (3) represents use of an alternate
            promoter, 5' UTR, and 5' coding region, compared to variant 1. The
            resulting isoform (3) has a shorter and distinct N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078843.1, L01624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 FM068981.1         8-14
            8-46                FM123924.1         1-39
            47-2467             BC078843.1         1-2421
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2467
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /note="serum/glucocorticoid regulated kinase 1"
                     /db_xref="GeneID:29517"
                     /db_xref="RGD:3668"
     exon            1..136
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1356
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     serine/threonine-protein kinase Sgk1; serine/threonine
                     protein kinase SGK"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Sgk1 isoform 3"
                     /protein_id="NP_062105.2"
                     /db_xref="GeneID:29517"
                     /db_xref="RGD:3668"
                     /translation="MTVKTEAARSTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKLAN
                     NSYACKHPEVQSYLKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLK
                     VIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV
                     GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNI
                     VYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDR
                     TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQK
                     DRTKRLGAKDDFMEIKSHIFFSLINWDDLINKKITPPFNPNVSGPSDLRHFDPEFTEE
                     PVPSSIGRSPDSILVTASVKEAAEAFLGFSYAPPMDSFL"
     exon            137..212
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            213..288
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            289..393
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            394..477
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            478..609
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            610..722
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            723..846
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            847..942
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1098
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1188
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..2439
                     /gene="Sgk1"
                     /gene_synonym="Sgk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggctaagcc ggtctcactg ctcctttagt ctctttggac actttccaaa tatcggggcg
       61 atgaccgtca aaaccgaggc tgctcgaagt accctcacct actccagaat gaggggaatg
      121 gtagcaatcc tcatcgcttt catgaaacag agaaggatgg gcctgaacga ttttattcag
      181 aagcttgcca acaactccta tgcatgcaaa caccctgaag ttcaatccta tttgaaaatc
      241 tcccaacctc aggagcccga acttatgaac gccaacccct cacctcctcc aagtccctct
      301 caacaaatca acctgggtcc atcctcaaat ccccacgcca aaccctctga cttccacttc
      361 ttgaaagtga tcggaaaagg cagttttgga aaggttcttc tagcaaggca caaggcagaa
      421 gaagcattct atgccgtcaa agttttgcag aagaaagcca tcttgaagaa gaaggaggag
      481 aagcatatta tgtcagagcg caatgttctg ttgaagaatg tgaagcaccc tttcctggtg
      541 ggccttcact tctctttcca gactgctgac aaactctact tcgtcctaga ctacattaat
      601 ggcggagagc tgttctacca tctccagagg gagcgctgct tcctggaacc ccgtgctcgc
      661 ttctacgcag ctgaaatagc cagtgccttg ggttatctgc actccctaaa catcgtttat
      721 cgagacttaa aaccagagaa tattctccta gactcacagg gacacatcgt cctcactgac
      781 tttgggctct gcaaggagaa catcgagcac aatgggacaa cgtccacctt ctgtggcacg
      841 cctgagtatc tcgctcctga ggttctccat aagcagccgt acgaccggac agtggactgg
      901 tggtgcctcg gggctgtctt gtatgagatg ctctatggcc tgcctccgtt ctacagccgg
      961 aacacagccg agatgtatga caatattctg aacaagcctc tccagctgaa accaaatatc
     1021 accaactcag caaggcacct gctggagggc ctcctgcaga aggaccggac caagaggctg
     1081 ggtgccaagg atgactttat ggagattaag agtcatattt tcttctcttt gattaactgg
     1141 gatgatctca ttaataagaa gatcacgccc ccatttaacc caaatgtgag cgggcccagt
     1201 gaccttcggc actttgatcc cgagtttact gaggagccgg tccccagctc catcgggcga
     1261 tcccctgaca gcatccttgt cacagccagt gtgaaagaag ccgcggaagc cttccttggc
     1321 ttctcctatg cccctcctat ggactccttc ctctgaaagc tcccaggatg gttccgaagg
     1381 atttcctcag cgtttttcta aagtgtttta gttagccttt ggtggagtta ccagctgaca
     1441 gaacatctta gaagagaaat ttgcacacca ggaagcttgg cagtcccgcc tgccgggcgc
     1501 tgcacgcggc ttgacgcgga agctttccgg aagctttccg aagagcacat cctcctctca
     1561 gtgagctagt gaggtcttca tttcttttct tccttccaac gtggtgctag ctctaaagga
     1621 gcttgagagt gccgcctgag acgcaccttg gtctcagtga gaaggaagat gcaggtctaa
     1681 gagggatctc cgcaggtctg agctgtgatc aagaatattc tgcaatgtgc cttttctgag
     1741 attgtgttag ctccaaagct tttcctatcg cagagtgtcc agtttttgtt tgtttttttt
     1801 tttttgtttt gttttttgtt tcgttttttt tcccaaccct tgcgtatttc ccatgtgtgc
     1861 agttagtgtg agtgctatgc ctgatcacag acagttttgt tgtaagcatc aatgtgacac
     1921 ttgcaggaca ctacaatgtg ggacattgtt tgtttcttcc acatttggaa gataaattta
     1981 tgcgcagact gttttttttt tgtaagatat aataactaaa acctattgaa acggtcttgc
     2041 agtgacgagc atccagatgc ttgagggaag cattgctgct acaaatattt ctatttttag
     2101 aaagggtttt tatggaccaa tgccccagtt gtcagtcaga gccgttggtg tttcattgtt
     2161 taaaatgtca cctgcaaaat gggcattatt tatggttccc cccaaccttt gttcattttc
     2221 ttttgcattc ctgattattg tgtgtaaaga aagtctgtac attgggttat aacactagat
     2281 atttaaactt acaggcttat ttgtaaacca tcattttaat gtcctgtaat taacatggtt
     2341 ataacatgta cactcccccc tactcaccac acaacttttt ttgtgtgcgg tgaaaccaat
     2401 tttggtttgc aataaaatct tgaaaactat ttgcacaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaa
//
