LOCUS       NM_001006993            1523 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus sarcoglycan, gamma (Sgcg), mRNA.
ACCESSION   NM_001006993 XM_224257
VERSION     NM_001006993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1523)
  AUTHORS   Chen M, Zhang X, Fang Q, Wang T, Li T and Qiao H.
  TITLE     Three single nucleotide polymorphisms associated with type 2
            diabetes mellitus in a Chinese population
  JOURNAL   Exp Ther Med 13 (1), 121-126 (2017)
   PUBMED   28123479
REFERENCE   2  (bases 1 to 1523)
  AUTHORS   Al-Zaidy SA, Malik V, Kneile K, Rosales XQ, Gomez AM, Lewis S,
            Hashimoto S, Gastier-Foster J, Kang P, Darras B, Kunkel L, Carlo J,
            Sahenk Z, Moore SA, Pyatt R and Mendell JR.
  TITLE     A slowly progressive form of limb-girdle muscular dystrophy type 2C
            associated with founder mutation in the SGCG gene in Puerto Rican
            Hispanics
  JOURNAL   Mol Genet Genomic Med 3 (2), 92-98 (2015)
   PUBMED   25802879
REFERENCE   3  (bases 1 to 1523)
  AUTHORS   Vermiglio G, Runci M, Scibilia A, Biasini F and Cutroneo G.
  TITLE     Preliminary study on sarcoglycan sub-complex in rat cerebral and
            cerebellar cortex
  JOURNAL   Ital J Anat Embryol 117 (1), 54-64 (2012)
   PUBMED   22894000
  REMARK    GeneRIF: In cerebellar cortex sections, labelling for alpha-,
            beta-, gamma-, delta-, and epsilon-sarcoglycans is found.
REFERENCE   4  (bases 1 to 1523)
  AUTHORS   Heydemann A, Demonbreun A, Hadhazy M, Earley JU and McNally EM.
  TITLE     Nuclear sequestration of delta-sarcoglycan disrupts the nuclear
            localization of lamin A/C and emerin in cardiomyocytes
  JOURNAL   Hum Mol Genet 16 (4), 355-363 (2007)
   PUBMED   17164264
REFERENCE   5  (bases 1 to 1523)
  AUTHORS   Chen J, Shi W, Zhang Y, Sokol R, Cai H, Lun M, Moore BF, Farber MJ,
            Stepanchick JS, Bonnemann CG and Chan YM.
  TITLE     Identification of functional domains in sarcoglycans essential for
            their interaction and plasma membrane targeting
  JOURNAL   Exp Cell Res 312 (9), 1610-1625 (2006)
   PUBMED   16524571
REFERENCE   6  (bases 1 to 1523)
  AUTHORS   Vermeer S, Verrips A, Willemsen MA, ter Laak HJ, Ginjaar IB and
            Hamel BC.
  TITLE     Novel mutations in three patients with LGMD2C with phenotypic
            differences
  JOURNAL   Pediatr Neurol 30 (4), 291-294 (2004)
   PUBMED   15087111
REFERENCE   7  (bases 1 to 1523)
  AUTHORS   Wheeler MT, Zarnegar S and McNally EM.
  TITLE     Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is
            reduced in muscular dystrophy
  JOURNAL   Hum Mol Genet 11 (18), 2147-2154 (2002)
   PUBMED   12189167
REFERENCE   8  (bases 1 to 1523)
  AUTHORS   Durbeej M, Cohn RD, Hrstka RF, Moore SA, Allamand V, Davidson BL,
            Williamson RA and Campbell KP.
  TITLE     Disruption of the beta-sarcoglycan gene reveals pathogenetic
            complexity of limb-girdle muscular dystrophy type 2E
  JOURNAL   Mol Cell 5 (1), 141-151 (2000)
   PUBMED   10678176
REFERENCE   9  (bases 1 to 1523)
  AUTHORS   Coral-Vazquez R, Cohn RD, Moore SA, Hill JA, Weiss RM, Davisson RL,
            Straub V, Barresi R, Bansal D, Hrstka RF, Williamson R and Campbell
            KP.
  TITLE     Disruption of the sarcoglycan-sarcospan complex in vascular smooth
            muscle: a novel mechanism for cardiomyopathy and muscular dystrophy
  JOURNAL   Cell 98 (4), 465-474 (1999)
   PUBMED   10481911
REFERENCE   10 (bases 1 to 1523)
  AUTHORS   Hack AA, Ly CT, Jiang F, Clendenin CJ, Sigrist KS, Wollmann RL and
            McNally EM.
  TITLE     Gamma-sarcoglycan deficiency leads to muscle membrane defects and
            apoptosis independent of dystrophin
  JOURNAL   J Cell Biol 142 (5), 1279-1287 (1998)
   PUBMED   9732288
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083748.1.
            
            On Nov 22, 2004 this sequence version replaced XM_224257.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083748.1, SRR8487230.29503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1523
                     /gene="Sgcg"
                     /note="sarcoglycan, gamma"
                     /db_xref="GeneID:305941"
                     /db_xref="RGD:1359577"
     exon            1..87
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
     exon            88..285
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..969
                     /gene="Sgcg"
                     /note="sarcoglycan, gamma (dystrophin-associated
                     glycoprotein)"
                     /codon_start=1
                     /product="gamma-sarcoglycan"
                     /protein_id="NP_001006994.1"
                     /db_xref="GeneID:305941"
                     /db_xref="RGD:1359577"
                     /translation="MVREQYTTVTEGTHIERPENQHVYKIGIYGWRKRCLYLFVLILL
                     TILVVNLALTIWILRVMWFSPIGMGHLHVTADGLRLEGESEFLFPLYAKEIRSRVDSS
                     LLLQSTQNVTVNARNSEGEVTGRVKVGAQMVEVQSQHLQISSEDGKPLFTAEEQGVVV
                     GTGRLRVTGPEGALFEHSVETPLVRAEHPFQDLRLESPTRSLSMDAPRGVHIEARAGK
                     MEALSQMDIVLQSSDGVLVLDAETVGLAKLKQGTQGPPGSSNGVYEICACPDGKLYLS
                     MAGEATTCEEHSHICL"
     exon            286..387
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
     exon            388..475
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
     exon            476..595
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
     exon            596..671
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
     exon            672..795
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1499
                     /gene="Sgcg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaatggga gtttaaatct ctccacctcc acagagctca ggccctcatc gggatcattt
       61 catcagtgtg gtttctgagt ggctgagagg atggtgcgag aacagtacac cacggtcaca
      121 gaggggactc acatagagcg gcctgagaac cagcatgtct acaagatcgg catttatgga
      181 tggaggaagc gctgtctgta cctatttgtt cttatcctcc tcaccatcct cgtcgtgaat
      241 ctcgctctca ccatctggat tctgagagtg atgtggtttt ctccaatagg aatgggtcac
      301 ctgcatgtta cggcagatgg acttcggctg gaaggggagt cagagttttt atttccgctg
      361 tacgccaaag aaatacgctc cagagtggac tcatctctgc ttctgcagtc aactcagaac
      421 gtgacagtca atgctcgcaa ctcagaaggg gaggtcacag gcagggtgaa agtgggtgcc
      481 cagatggtag aagtccagag ccagcactta cagatcagtt ctgaagatgg caagccgctg
      541 ttcaccgccg aggagcaggg cgtcgtggtc ggcaccggca gactgcgggt tacagggcca
      601 gaaggagctc tttttgaaca ctcagtggag acaccccttg tcagagctga gcacccattt
      661 caagacctta ggttggaatc cccaactcgg agtctcagca tggatgcccc aaggggcgtt
      721 cacattgaag ctcgtgctgg aaaaatggag gccctttctc agatggacat cgtcttgcag
      781 agtagtgatg gagtgctggt gctcgatgct gaaactgtgg gtttggccaa gttgaagcag
      841 gggacacagg gtccccctgg cagctcaaat ggagtctatg agatctgtgc atgtcctgat
      901 gggaagctgt acctgtctat ggctggcgag gccaccactt gcgaggaaca cagccacatc
      961 tgtctctgac cactccctct tctgcagagc acctacggtg tcccggagag accacagctg
     1021 tgtcccacag ctggattgga gctggactca ctgccaaaac acttagaagc gcgcagggga
     1081 gcgtgcccac gggactgttg ggccgaagtc tacctggttt tagaacgatc caaagaaatg
     1141 gcaggaatgc attcactgta ttcctctttc tagccctgct ccagatctct cacaatgaac
     1201 tgctacccgc aaacaattta tagtactcaa tggcagacat ctgtctcctc ccaaacgaac
     1261 ggttggctgg aggactctaa catgccccaa ctgtgcacac ctcctccttt agattaaacc
     1321 tcaagggctc ccttcagctg agtgcaatgt gtctgattca ccaagagatc tccagggttt
     1381 gcagggagtt taaggtcaat gtgattttca atatggagct aaggagagaa atgacacaaa
     1441 tttagtcatg ccttctatat acacacacct atgagcaata aaaatgacac ttttccagaa
     1501 aaaaaaaaaa aaaaaaaaaa aaa
//
