LOCUS       NM_001002023            1657 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus sarcoglycan, epsilon (Sgce), mRNA.
ACCESSION   NM_001002023
VERSION     NM_001002023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1657)
  AUTHORS   Hou,J.Y., Wang,Y.G., Ma,S.J., Yang,B.Y. and Li,Q.P.
  TITLE     Identification of a prognostic 5-Gene expression signature for
            gastric cancer
  JOURNAL   J Cancer Res Clin Oncol 143 (4), 619-629 (2017)
   PUBMED   28035468
REFERENCE   2  (bases 1 to 1657)
  AUTHORS   Vermiglio,G., Runci,M., Scibilia,A., Biasini,F. and Cutroneo,G.
  TITLE     Preliminary study on sarcoglycan sub-complex in rat cerebral and
            cerebellar cortex
  JOURNAL   Ital J Anat Embryol 117 (1), 54-64 (2012)
   PUBMED   22894000
  REMARK    GeneRIF: In cerebellar neurons and glial cells alpha-, beta-,
            gamma-, delta-, and epsilon-sarcoglycans are all expressed.
REFERENCE   3  (bases 1 to 1657)
  AUTHORS   Sharma,P., Tran,T., Stelmack,G.L., McNeill,K., Gosens,R.,
            Mutawe,M.M., Unruh,H., Gerthoffer,W.T. and Halayko,A.J.
  TITLE     Expression of the dystrophin-glycoprotein complex is a marker for
            human airway smooth muscle phenotype maturation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 294 (1), L57-L68 (2008)
   PUBMED   17993586
REFERENCE   4  (bases 1 to 1657)
  AUTHORS   Esapa,C.T., Waite,A., Locke,M., Benson,M.A., Kraus,M.,
            McIlhinney,R.A., Sillitoe,R.V., Beesley,P.W. and Blake,D.J.
  TITLE     SGCE missense mutations that cause myoclonus-dystonia syndrome
            impair epsilon-sarcoglycan trafficking to the plasma membrane:
            modulation by ubiquitination and torsinA
  JOURNAL   Hum Mol Genet 16 (3), 327-342 (2007)
   PUBMED   17200151
REFERENCE   5  (bases 1 to 1657)
  AUTHORS   Xiao,J. and LeDoux,M.S.
  TITLE     Cloning, developmental regulation and neural localization of rat
            epsilon-sarcoglycan
  JOURNAL   Brain Res Mol Brain Res 119 (2), 132-143 (2003)
   PUBMED   14625080
REFERENCE   6  (bases 1 to 1657)
  AUTHORS   Coral-Vazquez,R., Cohn,R.D., Moore,S.A., Hill,J.A., Weiss,R.M.,
            Davisson,R.L., Straub,V., Barresi,R., Bansal,D., Hrstka,R.F.,
            Williamson,R. and Campbell,K.P.
  TITLE     Disruption of the sarcoglycan-sarcospan complex in vascular smooth
            muscle: a novel mechanism for cardiomyopathy and muscular dystrophy
  JOURNAL   Cell 98 (4), 465-474 (1999)
   PUBMED   10481911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089947.1.
            
            On Feb 20, 2005 this sequence version replaced NM_001002023.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089947.1, AY164274.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132267,
                                           SAMD00132277 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1657
                     /gene="Sgce"
                     /note="sarcoglycan, epsilon"
                     /db_xref="GeneID:432360"
                     /db_xref="RGD:1303201"
     exon            1..151
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1356
                     /gene="Sgce"
                     /note="epsilon-SG"
                     /codon_start=1
                     /product="epsilon-sarcoglycan"
                     /protein_id="NP_001002023.1"
                     /db_xref="GeneID:432360"
                     /db_xref="RGD:1303201"
                     /translation="MLLFWWWELGDPCAWTGKGRGTLKMSPATTGTFLLTVYTLFSKV
                     HSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEVSNDPITFNTNLMGYPDRPGWLR
                     YIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEEFPLPY
                     QAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPIKDM
                     KEGVYVMVGADVAFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLV
                     DKTKQVSTYQEVVRGEGILPDGGEYKPPSDSLKSRDYYTDFLVTLAVPSAVALVLFLI
                     LAYIMCCRREGVEKRNMQTPDIQLVHHSSIQKSTKELRDMSKNREIAWPLSTLPVFHP
                     VTGEIIPPMHTDNYDSTNMPLMQTQPNLPHQTQIPQQQTTGKWYP"
     exon            152..274
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            275..432
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            433..505
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            506..704
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            705..867
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1079
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1106
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1295
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1339
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1629
                     /gene="Sgce"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggggag gatcgaggac ggacggctta ggcaggccaa gaatgctatt attctggtgg
       61 tgggagctgg gagacccttg tgcttggacg ggaaagggtc gggggacact caagatgagc
      121 cccgcgacca ctggcacatt cttactgaca gtgtacactc ttttctccaa ggtgcactct
      181 gaccggaacg tctacccatc tgcgggtgtc ctctttgtcc atgtgctgga gagagagtat
      241 tttaaggggg aatttccacc ttatccaaag cctggtgagg ttagtaatga tcccataaca
      301 tttaacacaa atttaatggg ctatccagac agacctggat ggcttcggta catccaaaga
      361 acaccataca gcgatggagt cctgtatggg tctccaacag ccgaaaacgt ggggaaacca
      421 actatcattg agataactgc ctacaacaga cgtacctttg agactgcaag gcataatttg
      481 ataatcaata taatgtcagc agaagaattc ccgttgccat atcaagcaga attcttcatc
      541 aaaaatatga atgtggaaga aatgttggcc agtgaggttc ttggagactt tctcggggct
      601 gtaaagaatg tgtggcagcc ggaacgcctc aatgctatca acatcacatc ggccctagac
      661 aggggcggta gggtgccact tcctattaaa gacatgaagg agggtgttta tgtcatggtt
      721 ggtgccgacg ttgcattttc ttcttgttta cgagaagttg aaaatccaca gaatcagtta
      781 aggtgcagtc aagaaatgga acctgtgata acatgcgata aaaagttccg aactcagttt
      841 tacattgact ggtgcaagat ttcattggtt gataaaacaa agcaagtgtc cacctatcag
      901 gaagtggttc gtggcgaggg cattttgccc gatggtgggg agtacaagcc cccttcggat
      961 tctttgaaaa gccgagacta ttacacggat ttcctcgtta ccctggctgt gccctcggca
     1021 gtagcactag ttcttttcct aatactcgct tatatcatgt gctgccgacg ggaaggagtg
     1081 gaaaagagaa acatgcaaac cccagatatc caacttgtcc atcacagctc tattcagaaa
     1141 tctaccaagg agcttcgaga catgtccaaa aacagagaga ttgcatggcc cctgtcaaca
     1201 ctccccgtgt ttcacccagt gactggggag atcatacctc ccatgcacac ggacaactac
     1261 gacagtacca acatgccctt gatgcagaca cagccgaact tgccacacca gactcagatc
     1321 ccccaacagc agactacagg taaatggtat ccctgaagaa agaaagctga cggaagccat
     1381 gagtttataa tcagcagcac agcaatcacg tctccccccc ctttcacctc caatcgtgca
     1441 tgagctttcc tgacatcatt gtgcatgtca actatattac atccatacca aatactatca
     1501 cctagctctc tcatttacta atgtattttt tttgtactta aagcattttt gaaaatttat
     1561 aagacatcaa tgactttata tttgttacaa taaaaagtga actttaaaat aaatattaat
     1621 gaagcctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
