LOCUS       NM_001191068            3711 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus sarcoglycan, beta (Sgcb), mRNA.
ACCESSION   NM_001191068 XM_001056227
VERSION     NM_001191068.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3711)
  AUTHORS   Pozsgai,E.R., Griffin,D.A., Heller,K.N., Mendell,J.R. and
            Rodino-Klapac,L.R.
  TITLE     Systemic AAV-Mediated beta-Sarcoglycan Delivery Targeting Cardiac
            and Skeletal Muscle Ameliorates Histological and Functional
            Deficits in LGMD2E Mice
  JOURNAL   Mol Ther 25 (4), 855-869 (2017)
   PUBMED   28284983
REFERENCE   2  (bases 1 to 3711)
  AUTHORS   Vermiglio,G., Runci,M., Scibilia,A., Biasini,F. and Cutroneo,G.
  TITLE     Preliminary study on sarcoglycan sub-complex in rat cerebral and
            cerebellar cortex
  JOURNAL   Ital J Anat Embryol 117 (1), 54-64 (2012)
   PUBMED   22894000
  REMARK    GeneRIF: In cerebellar neurons and glial cells alpha-, beta-,
            gamma-, delta-, and epsilon-sarcoglycans are all expressed.
REFERENCE   3  (bases 1 to 3711)
  AUTHORS   Sharma,P., Tran,T., Stelmack,G.L., McNeill,K., Gosens,R.,
            Mutawe,M.M., Unruh,H., Gerthoffer,W.T. and Halayko,A.J.
  TITLE     Expression of the dystrophin-glycoprotein complex is a marker for
            human airway smooth muscle phenotype maturation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 294 (1), L57-L68 (2008)
   PUBMED   17993586
REFERENCE   4  (bases 1 to 3711)
  AUTHORS   Heydemann,A., Demonbreun,A., Hadhazy,M., Earley,J.U. and
            McNally,E.M.
  TITLE     Nuclear sequestration of delta-sarcoglycan disrupts the nuclear
            localization of lamin A/C and emerin in cardiomyocytes
  JOURNAL   Hum Mol Genet 16 (4), 355-363 (2007)
   PUBMED   17164264
REFERENCE   5  (bases 1 to 3711)
  AUTHORS   Chen,J., Shi,W., Zhang,Y., Sokol,R., Cai,H., Lun,M., Moore,B.F.,
            Farber,M.J., Stepanchick,J.S., Bonnemann,C.G. and Chan,Y.M.
  TITLE     Identification of functional domains in sarcoglycans essential for
            their interaction and plasma membrane targeting
  JOURNAL   Exp Cell Res 312 (9), 1610-1625 (2006)
   PUBMED   16524571
REFERENCE   6  (bases 1 to 3711)
  AUTHORS   Durbeej,M., Cohn,R.D., Hrstka,R.F., Moore,S.A., Allamand,V.,
            Davidson,B.L., Williamson,R.A. and Campbell,K.P.
  TITLE     Disruption of the beta-sarcoglycan gene reveals pathogenetic
            complexity of limb-girdle muscular dystrophy type 2E
  JOURNAL   Mol Cell 5 (1), 141-151 (2000)
   PUBMED   10678176
REFERENCE   7  (bases 1 to 3711)
  AUTHORS   Coral-Vazquez,R., Cohn,R.D., Moore,S.A., Hill,J.A., Weiss,R.M.,
            Davisson,R.L., Straub,V., Barresi,R., Bansal,D., Hrstka,R.F.,
            Williamson,R. and Campbell,K.P.
  TITLE     Disruption of the sarcoglycan-sarcospan complex in vascular smooth
            muscle: a novel mechanism for cardiomyopathy and muscular dystrophy
  JOURNAL   Cell 98 (4), 465-474 (1999)
   PUBMED   10481911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001056227.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1079303.1,
                                           SRR26360194.2384364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000014.1  34917663-34917717
            56-265              JAXUCZ010000014.1  34920959-34921168
            266-451             JAXUCZ010000014.1  34924925-34925110
            452-643             JAXUCZ010000014.1  34925812-34926003
            644-775             JAXUCZ010000014.1  34926280-34926411
            776-3711            JAXUCZ010000014.1  34929726-34932661
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..3711
                     /gene="Sgcb"
                     /note="sarcoglycan, beta"
                     /db_xref="GeneID:680229"
                     /db_xref="RGD:1594202"
     exon            1..55
                     /gene="Sgcb"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..979
                     /gene="Sgcb"
                     /note="sarcoglycan, beta (dystrophin-associated
                     glycoprotein)"
                     /codon_start=1
                     /product="beta-sarcoglycan"
                     /protein_id="NP_001177997.1"
                     /db_xref="GeneID:680229"
                     /db_xref="RGD:1594202"
                     /translation="MAAAAAAAAATEQQGSNGPVKKSMREKAVERRNVNKEHNSNFKA
                     GYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLLITLVIWAVIRIGPNGCDSL
                     EFHESGLLRFKQVSDMGIIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVEKN
                     KTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDL
                     NIKVDGRAIVRGNEGVFIMGKTIEFHMRGDVELKAENSIILNGTVMVSPTRLPSSSGG
                     DQSGSGDWVRYKLCMCADGTLFKVQVTSHNMGCQVSDNPCGNTH"
     exon            56..265
                     /gene="Sgcb"
                     /inference="alignment:Splign:2.1.0"
     exon            266..451
                     /gene="Sgcb"
                     /inference="alignment:Splign:2.1.0"
     exon            452..643
                     /gene="Sgcb"
                     /inference="alignment:Splign:2.1.0"
     exon            644..775
                     /gene="Sgcb"
                     /inference="alignment:Splign:2.1.0"
     exon            776..3711
                     /gene="Sgcb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcggcgg gccaagatgg cggcagcggc agcagcggcg gcggcgaccg agcagcaagg
       61 ttccaacggg ccagtgaaga agtccatgcg ggagaaggca gtggaacgaa ggaacgtcaa
      121 caaagagcat aacagcaact tcaaagctgg gtacattccc atcgatgaag accggctgca
      181 taaaaccggg ctgagaggga gaaagggcaa cctagccatc tgtgtgattg tcctcctgtt
      241 tatcctggct gtcatcaacc tgcttattac acttgtcatc tgggccgtga ttcgcattgg
      301 gccaaatggc tgtgacagct tggagtttca tgagagcggt ctgctgcgat tcaagcaagt
      361 gtccgacatg ggtatcatcc atccgcttta taagagcaca gtgggaggaa ggcggaatga
      421 aaacctggtc atcactggca acaaccagcc gattgttttt cagcaaggga caaccaagct
      481 gagtgttgaa aagaacaaaa cctccatcac cagcgacatt ggaatgcaat tttttgaccc
      541 aaggacacaa aatatcttat tcagcacaga ctatgagact catgagtttc acctgccaag
      601 cggagtgaaa agtttgaacg ttcagaaagc gtcaactgaa aggatcacca gcaacgctac
      661 cagtgacttg aacatcaaag tcgatgggcg tgcaattgtg cgaggcaatg aaggcgtgtt
      721 catcatgggc aaaaccattg aatttcacat gcgaggggat gtggaactaa aggctgaaaa
      781 cagcatcatc ctcaatggca ctgtgatggt cagcccaacg cgtctgccca gctcctccgg
      841 cggagaccag tcaggcagtg gtgactgggt gcggtacaag ctctgcatgt gtgcagacgg
      901 cacactcttc aaagtacaag taacaagcca caacatgggc tgccaggtct ctgacaaccc
      961 ttgtggaaac acgcattaga aggagcatcc gcagggctca gcatgttcag atctaactcg
     1021 accctcccct tttgaagaat gcatgtgagc catgtttcta cagtttgcgt aacttgtaat
     1081 tattttaact gggaaacacc actgtatcta ttatgtgctc tccatattta aggggttttg
     1141 agtgcctaaa ttctaataca atttagtaag ttgcactgat attcaaagga cagttctcta
     1201 aaataattat gagaaattaa taaaatcaaa attaatcttt gaaatgtttt taacattcta
     1261 ctatctctta tcctaaagga caaagggctg aagcagttaa gactcgccat agtaagccct
     1321 tggtcatttc tcgtggggag agatccacta gagatgtttg gagggcacag ggacactgtt
     1381 tgtgctctgt ctttggcttt taaaggggaa ggcacagata ttttaatgca ttaacccaaa
     1441 gccacatttt cacaaacaag ttattaaaga gctttccata tataagtttg taaaaagcta
     1501 tgtttcctta gttttgcact aaagaaaata ctgtcagcta tgtttacttg gaataatgat
     1561 acatgtaagc ttttatagtg tgtggacatt agacacaagc acggttctca ctcctgtgac
     1621 agaagctgtc atccccaggc ctcctcttgc cgagcactgt cctgggcact gtacgctgga
     1681 tctctctgtt ccagctgcac ctctctaagc aagtgcttcg ctcccagctc tactcatcag
     1741 gaaactgaag gtcagggagg ttcagaaaat tgacccatac tgtatggtaa aagatggact
     1801 cagggttaga agtcaagtac agttccaacc caggggaacc tattccaagt gtgtttctgc
     1861 cttttttaca actacactga attttcaact atttaaaact ctcaaaggat gggaaaagcc
     1921 aaatcctaat ttacctaaca ggtaaaaatc tagctcgtgt gctactctct agttaaaata
     1981 acagtgctag caaaacatga ccaatcactg tcagatttta aactatcttg agccagttct
     2041 aagctgtcat tcaataaacc ggtctccttg gtctgcttgt catgtgagag cacctgaatg
     2101 agtgatagag aagccaacac acttttccct aagccctggg gaagctcagt ggaaagggag
     2161 gaagctaggc cccagtaggc acagctgtcc tgatgttatt cctccagtgt cccatacggc
     2221 atcacccttt agaagtacac tgtgcctaga aattaatata catgagaata aagggtgcta
     2281 attctggaga taaagcaggt cattttagct aggtataaaa cttttatctc tgctcctcat
     2341 ctcagtctca ttttaattac ttacagcccc caagccagtt gattcttagc atagtttata
     2401 cttgatttga aaagaatttc ttgatattat taagacacat gggatggggg atgaagaaac
     2461 atagctctaa agtacagtag ggaggtatcc tgggcctagc tacagagatg agtgttgtag
     2521 tctgtcatgg ccacttagaa ctgtgtggat aagaaatcaa tatataaaac aatttgtatt
     2581 caatattgtc acaattctgt caaatggaaa aactaaatac cttatagatt gtgaactcag
     2641 gctaaggtaa gagttgactt gagacctgac actaagtgca gattttagat gtaaagaaag
     2701 agagcaattt atacctctgg atatattcaa gtattgttta ataactaaat aacgctcaga
     2761 aaaatcatgc ttggaattct cctttccatg ctcagtgtat ttttaaattg tacatttgtt
     2821 acatgttcta tttaaatttg ttttgagaat ttctttaaat aaatattttt actaaatcca
     2881 cagaacacta tattacaaag tattatttac taaatgcaat tcattttttt aaaaagtgta
     2941 tttttacatg tctgtgagaa acacttgtgt tttgatacat ctccattgag cactttgtag
     3001 tttgagaata tcctgatgct ttgtaaaact cgtgcttact aagtatggta ttttagacca
     3061 cactgtggta aacccactga ctgacacact gacttggaag ctctgcccaa gccaagcttg
     3121 gcgtacaggg aagccgcact gttaaatcgg gccaccaggg ggcatattcc ctctcatgtg
     3181 ttcatctgtt ttgaatgtac cacactgaga ggacttactg caggcctctg gaaggtagat
     3241 gcaggaggaa cccagggagg aaaacaaaca cacatttaaa gtaaggacag tattctagag
     3301 atgaatatca atgcaaagag atagaaaaaa ataaaagtaa gattcgttct ggattgtcca
     3361 gtggagggag ggcatccaca acacaaagca agagctacct gccaacgtca gcagtctttt
     3421 aatcgcttta ttggcaatct ttttgcattg tgacagaagc aaaataaact ttgtgtgcta
     3481 gttttgatga tgaaaggtag aatttctacc tggttttgat gagtgttttt ataaaggggt
     3541 tataattact gtgttaaact taatgaagag gagaccattg aagtgctggt cattataatc
     3601 tttcgaatga catcaagagg gacaaagttt acaagttatg ccatacaaaa aatataccta
     3661 tgtatttctg attgatgacc tctgtttaca ataaaacgct gagaacttgg c
//
