LOCUS       NM_001395600            1340 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus sarcoglycan, alpha (Sgca), transcript variant 2,
            mRNA.
ACCESSION   NM_001395600 XM_006247192
VERSION     NM_001395600.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Vermiglio,G., Runci,M., Scibilia,A., Biasini,F. and Cutroneo,G.
  TITLE     Preliminary study on sarcoglycan sub-complex in rat cerebral and
            cerebellar cortex
  JOURNAL   Ital J Anat Embryol 117 (1), 54-64 (2012)
   PUBMED   22894000
  REMARK    GeneRIF: In cerebellar neurons and glial cells alpha-, beta-,
            gamma-, delta-, and epsilon-sarcoglycans are all expressed.
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Sambasivan,R., Gayraud-Morel,B., Dumas,G., Cimper,C., Paisant,S.,
            Kelly,R.G. and Tajbakhsh,S.
  TITLE     Distinct regulatory cascades govern extraocular and pharyngeal arch
            muscle progenitor cell fates
  JOURNAL   Dev Cell 16 (6), 810-821 (2009)
   PUBMED   19531352
  REMARK    Erratum:[Dev Cell. 2009 Jul;17(1):150. Kelly, Robert [corrected to
            Kelly, Robert G]]
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Pacak,C.A., Walter,G.A., Gaidosh,G., Bryant,N., Lewis,M.A.,
            Germain,S., Mah,C.S., Campbell,K.P. and Byrne,B.J.
  TITLE     Long-term skeletal muscle protection after gene transfer in a mouse
            model of LGMD-2D
  JOURNAL   Mol Ther 15 (10), 1775-1781 (2007)
   PUBMED   17653106
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Chen,J., Shi,W., Zhang,Y., Sokol,R., Cai,H., Lun,M., Moore,B.F.,
            Farber,M.J., Stepanchick,J.S., Bonnemann,C.G. and Chan,Y.M.
  TITLE     Identification of functional domains in sarcoglycans essential for
            their interaction and plasma membrane targeting
  JOURNAL   Exp Cell Res 312 (9), 1610-1625 (2006)
   PUBMED   16524571
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Chockalingam,P.S., Cholera,R., Oak,S.A., Zheng,Y., Jarrett,H.W. and
            Thomason,D.B.
  TITLE     Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling
            are altered in muscle atrophy
  JOURNAL   Am J Physiol Cell Physiol 283 (2), C500-C511 (2002)
   PUBMED   12107060
REFERENCE   6  (bases 1 to 1340)
  AUTHORS   Coral-Vazquez,R., Cohn,R.D., Moore,S.A., Hill,J.A., Weiss,R.M.,
            Davisson,R.L., Straub,V., Barresi,R., Bansal,D., Hrstka,R.F.,
            Williamson,R. and Campbell,K.P.
  TITLE     Disruption of the sarcoglycan-sarcospan complex in vascular smooth
            muscle: a novel mechanism for cardiomyopathy and muscular dystrophy
  JOURNAL   Cell 98 (4), 465-474 (1999)
   PUBMED   10481911
REFERENCE   7  (bases 1 to 1340)
  AUTHORS   Duclos,F., Straub,V., Moore,S.A., Venzke,D.P., Hrstka,R.F.,
            Crosbie,R.H., Durbeej,M., Lebakken,C.S., Ettinger,A.J., van der
            Meulen,J., Holt,K.H., Lim,L.E., Sanes,J.R., Davidson,B.L.,
            Faulkner,J.A., Williamson,R. and Campbell,K.P.
  TITLE     Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice
  JOURNAL   J Cell Biol 142 (6), 1461-1471 (1998)
   PUBMED   9744877
REFERENCE   8  (bases 1 to 1340)
  AUTHORS   Carrie,A., Piccolo,F., Leturcq,F., de Toma,C., Azibi,K.,
            Beldjord,C., Vallat,J.M., Merlini,L., Voit,T., Sewry,C.,
            Urtizberea,J.A., Romero,N., Tome,F.M., Fardeau,M., Sunada,Y.,
            Campbell,K.P., Kaplan,J.C. and Jeanpierre,M.
  TITLE     Mutational diversity and hot spots in the alpha-sarcoglycan gene in
            autosomal recessive muscular dystrophy (LGMD2D)
  JOURNAL   J Med Genet 34 (6), 470-475 (1997)
   PUBMED   9192266
REFERENCE   9  (bases 1 to 1340)
  AUTHORS   Biral,D., Senter,L. and Salviati,G.
  TITLE     Increased expression of dystrophin, beta-dystroglycan and adhalin
            in denervated rat muscles
  JOURNAL   J Muscle Res Cell Motil 17 (5), 523-532 (1996)
   PUBMED   8906620
REFERENCE   10 (bases 1 to 1340)
  AUTHORS   Roberds,S.L., Leturcq,F., Allamand,V., Piccolo,F., Jeanpierre,M.,
            Anderson,R.D., Lim,L.E., Lee,J.C., Tome,F.M., Romero,N.B. et al.
  TITLE     Missense mutations in the adhalin gene linked to autosomal
            recessive muscular dystrophy
  JOURNAL   Cell 78 (4), 625-633 (1994)
   PUBMED   8069911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 21, 2021 this sequence version replaced XM_006247192.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.44396.1,
                                           SRR26643288.42747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000010.1  80416011-80416075   c
            66-185              JAXUCZ010000010.1  80415110-80415229   c
            186-296             JAXUCZ010000010.1  80414865-80414975   c
            297-369             JAXUCZ010000010.1  80414620-80414692   c
            370-568             JAXUCZ010000010.1  80413894-80414092   c
            569-731             JAXUCZ010000010.1  80413298-80413460   c
            732-940             JAXUCZ010000010.1  80412067-80412275   c
            941-967             JAXUCZ010000010.1  80411769-80411795   c
            968-1160            JAXUCZ010000010.1  80405967-80406159   c
            1161-1340           JAXUCZ010000010.1  80405566-80405745   c
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1340
                     /gene="Sgca"
                     /note="sarcoglycan, alpha"
                     /db_xref="GeneID:303468"
                     /db_xref="RGD:1308062"
     exon            1..65
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            66..185
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1148
                     /gene="Sgca"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sarcoglycan, alpha (50kDa dystrophin-associated
                     glycoprotein); alpha-sarcoglycan; sarcoglycan, alpha
                     (dystrophin-associated glycoprotein); adhalin"
                     /codon_start=1
                     /product="alpha-sarcoglycan isoform 2"
                     /protein_id="NP_001382529.1"
                     /db_xref="GeneID:303468"
                     /db_xref="RGD:1308062"
                     /translation="MLPSCAFQNTLGHPDLPRWLHYTQRSPYNPGFLYGTPTPEDRGH
                     QVIEVTAYNRDSFDTTRQRLLLLIGDPEGPRLPYQAEFLVRSHDVEEVLPSTPANRFL
                     TALGGLWEPGELQLLNITSALDRGGRVPLPIEGRKEGVYIKVGSATPFSTCLKMVASP
                     DSYARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPLDEVPTPGDGILEHDPF
                     FCPPTEATGRDFLTDALVTLLVPVLVALLLTLLLVYIMCCRREGRLKRDMATSDIQMF
                     HHCSIHGNTEELRQMAASREVPRPLSTLPMFNVRTGERLPPRVDSAQMPLILDQH"
     exon            186..296
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            297..369
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            370..568
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            569..731
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            732..940
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            941..967
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1160
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1340
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcactcacc ggctaggctg gggcaactat ggtagcagcc gcaacttgga ttcctctcct
       61 tgcaggtctc ctggcaggcc tgagggacag caaggcccag cagacaactt tacacccact
      121 tgtgggtcgt gtgtttgtgc atcctttgga acatgctacc ttcctgcgcc ttccagaaca
      181 cattgggaca tccagacctg cccaggtggc tgcactacac acaacgcagt ccctataacc
      241 ctggcttcct ctatggcact cccactccgg aagatcgtgg gcaccaagtc attgaggtca
      301 cagcctacaa tcgtgacagc tttgacacca ctagacagag gctgctgctg ctgattgggg
      361 accccgaagg tcccaggtta ccataccaag ctgaattcct ggtgcgtagc catgatgtgg
      421 aggaggtcct gccctccaca cctgccaacc gcttcctcac cgccttgggg ggactctggg
      481 agccagggga gctccagttg ctcaacatca cctctgcctt ggaccgagga ggccgagtcc
      541 ctcttcctat tgagggccgg aaggaagggg tttacattaa ggtgggctct gccacaccct
      601 tttccacctg cctgaagatg gtggcatcac ctgacagcta tgcccgttgt gcccagggac
      661 agcctccact attgtcctgc tatgacacct tggcacctca cttccgtgtc gactggtgca
      721 atgtatctct ggtggacaag tcagtgccag agcccctgga tgaggtgcct actcctggcg
      781 atgggatctt ggagcacgac ccattcttct gcccgcccac tgaggccacg ggccgagact
      841 tcctaacaga tgccttggtg accctcttag tgcccgtgct ggtggctctg ctgctcaccc
      901 tgttgctggt ttacattatg tgctgtcggc gtgaaggacg gctgaagaga gacatggcca
      961 cctctgacat ccagatgttt caccactgct ccatccacgg gaatacggaa gagcttcggc
     1021 agatggcagc cagccgcgag gtgccccggc ctctatccac cttgcccatg ttcaacgtgc
     1081 gtacaggaga gcggttacct ccccgagtag acagcgcaca gatgcccctc atcctggacc
     1141 agcactgaga gccctgccag ctccagttgc accactcaga gctgctgacc tgtgaacata
     1201 gctacgactg attccagctc ctagtccact tggacctctg gctccaaaca ggcagatgga
     1261 tggtagtagg gaggggcgtg ggtgcttgga gtcagcaccc aagaataaaa aattacctgc
     1321 tacactgctt attgctccta
//
