LOCUS       NM_001107039            1384 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus sarcoglycan, alpha (Sgca), transcript variant 1,
            mRNA.
ACCESSION   NM_001107039 XM_001081302 XM_006247191 XM_220884
VERSION     NM_001107039.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1384)
  AUTHORS   Vermiglio,G., Runci,M., Scibilia,A., Biasini,F. and Cutroneo,G.
  TITLE     Preliminary study on sarcoglycan sub-complex in rat cerebral and
            cerebellar cortex
  JOURNAL   Ital J Anat Embryol 117 (1), 54-64 (2012)
   PUBMED   22894000
  REMARK    GeneRIF: In cerebellar neurons and glial cells alpha-, beta-,
            gamma-, delta-, and epsilon-sarcoglycans are all expressed.
REFERENCE   2  (bases 1 to 1384)
  AUTHORS   Sambasivan,R., Gayraud-Morel,B., Dumas,G., Cimper,C., Paisant,S.,
            Kelly,R.G. and Tajbakhsh,S.
  TITLE     Distinct regulatory cascades govern extraocular and pharyngeal arch
            muscle progenitor cell fates
  JOURNAL   Dev Cell 16 (6), 810-821 (2009)
   PUBMED   19531352
  REMARK    Erratum:[Dev Cell. 2009 Jul;17(1):150. Kelly, Robert [corrected to
            Kelly, Robert G]]
REFERENCE   3  (bases 1 to 1384)
  AUTHORS   Pacak,C.A., Walter,G.A., Gaidosh,G., Bryant,N., Lewis,M.A.,
            Germain,S., Mah,C.S., Campbell,K.P. and Byrne,B.J.
  TITLE     Long-term skeletal muscle protection after gene transfer in a mouse
            model of LGMD-2D
  JOURNAL   Mol Ther 15 (10), 1775-1781 (2007)
   PUBMED   17653106
REFERENCE   4  (bases 1 to 1384)
  AUTHORS   Chen,J., Shi,W., Zhang,Y., Sokol,R., Cai,H., Lun,M., Moore,B.F.,
            Farber,M.J., Stepanchick,J.S., Bonnemann,C.G. and Chan,Y.M.
  TITLE     Identification of functional domains in sarcoglycans essential for
            their interaction and plasma membrane targeting
  JOURNAL   Exp Cell Res 312 (9), 1610-1625 (2006)
   PUBMED   16524571
REFERENCE   5  (bases 1 to 1384)
  AUTHORS   Chockalingam,P.S., Cholera,R., Oak,S.A., Zheng,Y., Jarrett,H.W. and
            Thomason,D.B.
  TITLE     Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling
            are altered in muscle atrophy
  JOURNAL   Am J Physiol Cell Physiol 283 (2), C500-C511 (2002)
   PUBMED   12107060
REFERENCE   6  (bases 1 to 1384)
  AUTHORS   Coral-Vazquez,R., Cohn,R.D., Moore,S.A., Hill,J.A., Weiss,R.M.,
            Davisson,R.L., Straub,V., Barresi,R., Bansal,D., Hrstka,R.F.,
            Williamson,R. and Campbell,K.P.
  TITLE     Disruption of the sarcoglycan-sarcospan complex in vascular smooth
            muscle: a novel mechanism for cardiomyopathy and muscular dystrophy
  JOURNAL   Cell 98 (4), 465-474 (1999)
   PUBMED   10481911
REFERENCE   7  (bases 1 to 1384)
  AUTHORS   Duclos,F., Straub,V., Moore,S.A., Venzke,D.P., Hrstka,R.F.,
            Crosbie,R.H., Durbeej,M., Lebakken,C.S., Ettinger,A.J., van der
            Meulen,J., Holt,K.H., Lim,L.E., Sanes,J.R., Davidson,B.L.,
            Faulkner,J.A., Williamson,R. and Campbell,K.P.
  TITLE     Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice
  JOURNAL   J Cell Biol 142 (6), 1461-1471 (1998)
   PUBMED   9744877
REFERENCE   8  (bases 1 to 1384)
  AUTHORS   Carrie,A., Piccolo,F., Leturcq,F., de Toma,C., Azibi,K.,
            Beldjord,C., Vallat,J.M., Merlini,L., Voit,T., Sewry,C.,
            Urtizberea,J.A., Romero,N., Tome,F.M., Fardeau,M., Sunada,Y.,
            Campbell,K.P., Kaplan,J.C. and Jeanpierre,M.
  TITLE     Mutational diversity and hot spots in the alpha-sarcoglycan gene in
            autosomal recessive muscular dystrophy (LGMD2D)
  JOURNAL   J Med Genet 34 (6), 470-475 (1997)
   PUBMED   9192266
REFERENCE   9  (bases 1 to 1384)
  AUTHORS   Biral,D., Senter,L. and Salviati,G.
  TITLE     Increased expression of dystrophin, beta-dystroglycan and adhalin
            in denervated rat muscles
  JOURNAL   J Muscle Res Cell Motil 17 (5), 523-532 (1996)
   PUBMED   8906620
REFERENCE   10 (bases 1 to 1384)
  AUTHORS   Roberds,S.L., Leturcq,F., Allamand,V., Piccolo,F., Jeanpierre,M.,
            Anderson,R.D., Lim,L.E., Lee,J.C., Tome,F.M., Romero,N.B. et al.
  TITLE     Missense mutations in the adhalin gene linked to autosomal
            recessive muscular dystrophy
  JOURNAL   Cell 78 (4), 625-633 (1994)
   PUBMED   8069911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Jul 21, 2021 this sequence version replaced
            XM_006247191.4, NM_001107039.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215532.1, SRR26360176.291090.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000010.1  80416011-80416075   c
            66-185              JAXUCZ010000010.1  80415110-80415229   c
            186-340             JAXUCZ010000010.1  80414865-80415019   c
            341-413             JAXUCZ010000010.1  80414620-80414692   c
            414-612             JAXUCZ010000010.1  80413894-80414092   c
            613-775             JAXUCZ010000010.1  80413298-80413460   c
            776-984             JAXUCZ010000010.1  80412067-80412275   c
            985-1011            JAXUCZ010000010.1  80411769-80411795   c
            1012-1204           JAXUCZ010000010.1  80405967-80406159   c
            1205-1384           JAXUCZ010000010.1  80405566-80405745   c
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1384
                     /gene="Sgca"
                     /note="sarcoglycan, alpha"
                     /db_xref="GeneID:303468"
                     /db_xref="RGD:1308062"
     exon            1..65
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1192
                     /gene="Sgca"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sarcoglycan, alpha (50kDa dystrophin-associated
                     glycoprotein); alpha-sarcoglycan; sarcoglycan, alpha
                     (dystrophin-associated glycoprotein); adhalin"
                     /codon_start=1
                     /product="alpha-sarcoglycan isoform 1 precursor"
                     /protein_id="NP_001100509.1"
                     /db_xref="GeneID:303468"
                     /db_xref="RGD:1308062"
                     /translation="MVAAATWIPLLAGLLAGLRDSKAQQTTLHPLVGRVFVHPLEHAT
                     FLRLPEHIAVPPTVRLTYHAHLQGHPDLPRWLHYTQRSPYNPGFLYGTPTPEDRGHQV
                     IEVTAYNRDSFDTTRQRLLLLIGDPEGPRLPYQAEFLVRSHDVEEVLPSTPANRFLTA
                     LGGLWEPGELQLLNITSALDRGGRVPLPIEGRKEGVYIKVGSATPFSTCLKMVASPDS
                     YARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPLDEVPTPGDGILEHDPFFC
                     PPTEATGRDFLTDALVTLLVPVLVALLLTLLLVYIMCCRREGRLKRDMATSDIQMFHH
                     CSIHGNTEELRQMAASREVPRPLSTLPMFNVRTGERLPPRVDSAQMPLILDQH"
     exon            66..185
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            186..340
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            341..413
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            414..612
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            613..775
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            776..984
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1011
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1204
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1384
                     /gene="Sgca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcactcacc ggctaggctg gggcaactat ggtagcagcc gcaacttgga ttcctctcct
       61 tgcaggtctc ctggcaggcc tgagggacag caaggcccag cagacaactt tacacccact
      121 tgtgggtcgt gtgtttgtgc atcctttgga acatgctacc ttcctgcgcc ttccagaaca
      181 cattgcggtg ccacccactg tccgactcac ctaccatgct cacctccagg gacatccaga
      241 cctgcccagg tggctgcact acacacaacg cagtccctat aaccctggct tcctctatgg
      301 cactcccact ccggaagatc gtgggcacca agtcattgag gtcacagcct acaatcgtga
      361 cagctttgac accactagac agaggctgct gctgctgatt ggggaccccg aaggtcccag
      421 gttaccatac caagctgaat tcctggtgcg tagccatgat gtggaggagg tcctgccctc
      481 cacacctgcc aaccgcttcc tcaccgcctt ggggggactc tgggagccag gggagctcca
      541 gttgctcaac atcacctctg ccttggaccg aggaggccga gtccctcttc ctattgaggg
      601 ccggaaggaa ggggtttaca ttaaggtggg ctctgccaca cccttttcca cctgcctgaa
      661 gatggtggca tcacctgaca gctatgcccg ttgtgcccag ggacagcctc cactattgtc
      721 ctgctatgac accttggcac ctcacttccg tgtcgactgg tgcaatgtat ctctggtgga
      781 caagtcagtg ccagagcccc tggatgaggt gcctactcct ggcgatggga tcttggagca
      841 cgacccattc ttctgcccgc ccactgaggc cacgggccga gacttcctaa cagatgcctt
      901 ggtgaccctc ttagtgcccg tgctggtggc tctgctgctc accctgttgc tggtttacat
      961 tatgtgctgt cggcgtgaag gacggctgaa gagagacatg gccacctctg acatccagat
     1021 gtttcaccac tgctccatcc acgggaatac ggaagagctt cggcagatgg cagccagccg
     1081 cgaggtgccc cggcctctat ccaccttgcc catgttcaac gtgcgtacag gagagcggtt
     1141 acctccccga gtagacagcg cacagatgcc cctcatcctg gaccagcact gagagccctg
     1201 ccagctccag ttgcaccact cagagctgct gacctgtgaa catagctacg actgattcca
     1261 gctcctagtc cacttggacc tctggctcca aacaggcaga tggatggtag tagggagggg
     1321 cgtgggtgct tggagtcagc acccaagaat aaaaaattac ctgctacact gcttattgct
     1381 ccta
//
