LOCUS       NM_001012213            2178 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sideroflexin 1 (Sfxn1), mRNA.
ACCESSION   NM_001012213 XM_344573
VERSION     NM_001012213.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Kory,N., Wyant,G.A., Prakash,G., Uit de Bos,J., Bottanelli,F.,
            Pacold,M.E., Chan,S.H., Lewis,C.A., Wang,T., Keys,H.R., Guo,Y.E.
            and Sabatini,D.M.
  TITLE     SFXN1 is a mitochondrial serine transporter required for one-carbon
            metabolism
  JOURNAL   Science 362 (6416) (2018)
   PUBMED   30442778
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Chen,Y., Liu,Y., Lin,S., Yang,S., Que,H. and Liu,S.
  TITLE     Identification of Novel SCIRR69-Interacting Proteins During ER
            Stress Using SILAC-Immunoprecipitation Quantitative Proteomics
            Approach
  JOURNAL   Neuromolecular Med 19 (1), 81-93 (2017)
   PUBMED   27488499
  REMARK    GeneRIF: SFXN1is a potential SCIRR69-interacting protein in
            endoplasmic reticulum stress.
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Fleming,M.D., Campagna,D.R., Haslett,J.N., Trenor,C.C. 3rd and
            Andrews,N.C.
  TITLE     A mutation in a mitochondrial transmembrane protein is responsible
            for the pleiotropic hematological and skeletal phenotype of
            flexed-tail (f/f) mice
  JOURNAL   Genes Dev 15 (6), 652-657 (2001)
   PUBMED   11274051
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078935.1.
            
            On Feb 11, 2005 this sequence version replaced XM_344573.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078935.1, SRR8487230.63781.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2178
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /note="sideroflexin 1"
                     /db_xref="GeneID:364678"
                     /db_xref="RGD:1308482"
     exon            1..51
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            52..226
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1031
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /note="TCC; tricarboxylate carrier protein; solute carrier
                     family 64 member 1"
                     /codon_start=1
                     /product="sideroflexin-1"
                     /protein_id="NP_001012213.1"
                     /db_xref="GeneID:364678"
                     /db_xref="RGD:1308482"
                     /translation="MSGEVPPNINIKEPRWDQSTFIGRASHFFTVTDPRNILLTNEQL
                     ENARKVVHDYRQGIVPAGLTENELWRAKYAYDSAFHPDTGEKMTLIGRMSAQVPMNMT
                     ITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVA
                     TALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGTRLGES
                     TNAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVTLVGFCL
                     VFATPLCCALFPQKSSMSVTSLEDELQASIQKSHPELRRVYFNKGL"
     exon            227..397
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..496
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..572
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..658
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..786
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..836
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..886
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..934
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..2152
                     /gene="Sfxn1"
                     /gene_synonym="SLC64A1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggcggca cggagcggga ccgagaggcg cgggtggcgg ccggggaggc ggatctggga
       61 caatgtctgg ggaagtgcca cccaacatta acatcaagga gcctcgatgg gaccagagca
      121 cgttcattgg ccgagccagt cacttcttca cggttactga tcccagaaac atccttttaa
      181 cgaacgaaca gctagagaat gcgaggaaag tggtacacga ttacaggcaa ggaatcgttc
      241 ctgctggcct cacggaaaat gagttatgga gagcgaagta cgcgtatgac tcggccttcc
      301 atcccgacac gggtgaaaag atgactctga taggaagaat gtcggctcag gtcccgatga
      361 acatgaccat cacgggctgc atgatgacct tctaccggac cacaccggct gtgcttttct
      421 ggcagtggat aaaccagtcc ttcaatgccg tggtcaacta caccaataga agtggtgacg
      481 ctcccctcac tgtaaatgag ctgggaacgg cttatgtttc tgcaacaacc ggcgccgtgg
      541 cgacagccct tggactcaat gccctaacca agcatgtgtc gccgctgata ggacgttttg
      601 ttcccttcgc tgctgtagct gctgctaact gcattaacat cccgctgatg agacaaaggg
      661 aactcaaggt tggtattcct gtcactgatg agaatggcac acgcttggga gaatcgacca
      721 acgcagcaaa gcaagccatc acgcaggtgg tcatctccag gatcctcatg gcggcccctg
      781 gcatggccat ccctccgttt atcatgaaca ccttggagaa gaaagccttt ttgaagaggt
      841 tcccgtggat gagcgcacca attcaagtca cactggttgg cttttgtttg gtgttcgcca
      901 cccccctgtg ctgtgctctg tttcctcaga agagttccat gtctgtgaca agcttggagg
      961 atgagttgca agccagcatc caaaagagtc atcctgaatt acggcgtgtg tactttaaca
     1021 agggcctgtg aagccaagat caagtgctgg aggcacctcc tgccatctgt gaacctcctg
     1081 aagccaagca gtgaggaaat acgtgtgctg ggcactcccc gctacaaaag cctctgcaaa
     1141 atctgtgtta gagtcaagct gcctgtcagg aacctgacat ttgaatcgtg ttgtaattta
     1201 caaaaaatac ccttctggta gattttaatg atgctgtttt ttccaaagcc cccaccttga
     1261 gctttcaaaa gctctggtgg gcatagcata tatgctccag ttacacactc agcaaacact
     1321 ggttatcaat cattggaaag gttaccagct caactatcac attctgtttc tacttctctc
     1381 ccactggggt ctcagcaatg aattgggaaa acacaaaagg tctaagacaa aatatccaaa
     1441 tttaaatact aaggaaacta tatctccagt ttggcaatgg accagtccaa agtagaacct
     1501 caattaaaaa aattgaggtt cagagcataa acactccata caccttcctg aagtcagcca
     1561 tagaccaggg taggatgcct tccctgccat cctggattct tcaactcttc aatgtgttta
     1621 gtgttcttaa aatattaatt gtacctcaca ggtactttat aatcatgaat ttccatcaaa
     1681 tacttaactg aaatggtcta ttcagtacca gtacaatgtg acattgactg ggtgaccggt
     1741 ttttcagaag tgaaaccata gtccctatat gcctttttcc ccccatcctt gtagaatttc
     1801 tttggctttc aggaagatat acagaaacca cacaaactag tccagcaact gtgcacattg
     1861 tgctgcgttc caccctgttt gaagaccatg aagtcttgtg gcatgtcaac atttctatgg
     1921 tgatttttac atgtgacata ttgggtgtag ctgaggttgc tttggaagtc tgtggctatt
     1981 ccacgtcata gacaagccac ttgttatgct gagtgaaaaa tcattgttaa ttcagatatt
     2041 tgtacgtgga aaaaaacccc acaaaaatag agactatcta gtttctgtag attctttttc
     2101 ccaatgtttc cagattgaat ttcctcataa agaaaatatg gtgtgccttg tgaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaa
//
