LOCUS       NM_012878               1251 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus surfactant protein D (Sftpd), mRNA.
ACCESSION   NM_012878 XM_346495
VERSION     NM_012878.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Jiang,H., Zhang,Y., Hu,G., Shang,X., Ming,J., Deng,M., Li,Y.,
            Ma,Y., Liu,S. and Zhou,Y.
  TITLE     Innate/Inflammatory Bioregulation of Surfactant Protein D
            Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4
            Signaling
  JOURNAL   Front Immunol 13, 913901 (2022)
   PUBMED   35865531
  REMARK    GeneRIF: Innate/Inflammatory Bioregulation of Surfactant Protein D
            Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4
            Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1251)
  AUTHORS   Wang,Q., Wang,Q., Zhao,Z., Fan,J., Qin,L., Alexander,D.B.,
            Tsuda,H., Zhao,D. and Xu,J.
  TITLE     Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common
            Pathway Associated With Phagocytosis of Nanomaterials and Cytokine
            Production
  JOURNAL   Front Immunol 12, 758941 (2021)
   PUBMED   34777371
  REMARK    GeneRIF: Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a
            Common Pathway Associated With Phagocytosis of Nanomaterials and
            Cytokine Production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1251)
  AUTHORS   Hanna,D.A., Khalaf,M.M. and Abo-Saif,A.A.
  TITLE     Polydatin protects against ovalbumin-induced bronchial asthma in
            rats; involvement of urocortin and surfactant-D expression
  JOURNAL   Immunopharmacol Immunotoxicol 41 (3), 403-412 (2019)
   PUBMED   30422021
  REMARK    GeneRIF: Polydatin significantly reduced the inflammatory mediators
            and restored the normal values of oxidative and nitrosative stress
            biomarkers. It also significantly reduced the expression of
            surfactant-D and UCN as compared to asthma control
REFERENCE   4  (bases 1 to 1251)
  AUTHORS   Rynkiewicz,M.J., Wu,H., Cafarella,T.R., Nikolaidis,N.M., Head,J.F.,
            Seaton,B.A. and McCormack,F.X.
  TITLE     Differential Ligand Binding Specificities of the Pulmonary
            Collectins Are Determined by the Conformational Freedom of a
            Surface Loop
  JOURNAL   Biochemistry 56 (31), 4095-4105 (2017)
   PUBMED   28719181
  REMARK    GeneRIF: SPA binds dipalmitoyl-phosphatidylcholine, the major
            surfactant lipid component, but not phosphatidylinositol; SPD
            exhibits the opposite preference. Data suggest flexibility in a key
            surface loop supports distinctive lipid binding of SPA; quadruple
            mutant SPA (E171D/P175E/R197N/K203D) that introduces SPD-like
            loop-stabilizing Ca2+ binding site in carbohydrate recognition
            domain exhibits ligand-binding preferences of SPD.
REFERENCE   5  (bases 1 to 1251)
  AUTHORS   Hashimoto,J., Takahashi,M., Saito,A., Murata,M., Kurimura,Y.,
            Nishitani,C., Takamiya,R., Uehara,Y., Hasegawa,Y., Hiyama,Y.,
            Sawada,N., Takahashi,S., Masumori,N., Kuroki,Y. and Ariki,S.
  TITLE     Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic
            Escherichia coli To Protect the Bladder from Infection
  JOURNAL   J Immunol 198 (7), 2898-2905 (2017)
   PUBMED   28228557
REFERENCE   6  (bases 1 to 1251)
  AUTHORS   Taneva,S., Voelker,D.R. and Keough,K.M.
  TITLE     Adsorption of pulmonary surfactant protein D to phospholipid
            monolayers at the air-water interface
  JOURNAL   Biochemistry 36 (26), 8173-8179 (1997)
   PUBMED   9201966
REFERENCE   7  (bases 1 to 1251)
  AUTHORS   Deterding,R.R., Shimizu,H., Fisher,J.H. and Shannon,J.M.
  TITLE     Regulation of surfactant protein D expression by glucocorticoids in
            vitro and in vivo
  JOURNAL   Am J Respir Cell Mol Biol 10 (1), 30-37 (1994)
   PUBMED   8292379
REFERENCE   8  (bases 1 to 1251)
  AUTHORS   Lacaze-Masmonteil,T., Fraslon,C., Bourbon,J., Raymondjean,M. and
            Kahn,A.
  TITLE     Characterization of the rat pulmonary surfactant protein A promoter
  JOURNAL   Eur J Biochem 206 (3), 613-623 (1992)
   PUBMED   1606951
REFERENCE   9  (bases 1 to 1251)
  AUTHORS   Shimizu,H., Fisher,J.H., Papst,P., Benson,B., Lau,K., Mason,R.J.
            and Voelker,D.R.
  TITLE     Primary structure of rat pulmonary surfactant protein D. cDNA and
            deduced amino acid sequence
  JOURNAL   J Biol Chem 267 (3), 1853-1857 (1992)
   PUBMED   1370483
REFERENCE   10 (bases 1 to 1251)
  AUTHORS   Persson,A., Chang,D., Rust,K., Moxley,M., Longmore,W. and Crouch,E.
  TITLE     Purification and biochemical characterization of CP4 (SP-D), a
            collagenous surfactant-associated protein
  JOURNAL   Biochemistry 28 (15), 6361-6367 (1989)
   PUBMED   2675969
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012878.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81231.1, BC070507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                JAXUCZ010000016.1  17093033-17093047   c
            16-214              JAXUCZ010000016.1  17090886-17091084   c
            215-331             JAXUCZ010000016.1  17085733-17085849   c
            332-448             JAXUCZ010000016.1  17085376-17085492   c
            449-565             JAXUCZ010000016.1  17084934-17085050   c
            566-682             JAXUCZ010000016.1  17084418-17084534   c
            683-766             JAXUCZ010000016.1  17082908-17082991   c
            767-1251            JAXUCZ010000016.1  17080575-17081059   c
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1251
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /note="surfactant protein D"
                     /db_xref="GeneID:25350"
                     /db_xref="RGD:3667"
     exon            1..15
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
     exon            16..214
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1143
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /note="pulmonary surfactant-associated protein D;
                     pulmonary surfactant protein D; CP4; PSP-D; lung
                     surfactant protein D; surfactant, pulmonary-associated
                     protein D; surfactant associated protein D"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein D
                     precursor"
                     /protein_id="NP_037010.1"
                     /db_xref="GeneID:25350"
                     /db_xref="RGD:3667"
                     /translation="MLHFLSMLVLLVQPLGDLGAEMKTLSQRSITNTCTLVLCSPTEN
                     GLPGRDGRDGREGPRGEKGDPGLPGPMGLSGLPGPRGPVGPKGENGSAGEPGPKGERG
                     LVGPPGSPGISGPAGKEGPSGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGAKGP
                     AGPKGERGAPGEQGAPGNAGAAGPAGPAGPQGAPGSRGPPGLKGDRGAPGDRGIKGES
                     GLPDSAALRQQMEALNGKLQRLEAAFSRYKKAALFPDGQSVGDKIFRAANSEEPFEDA
                     KEMCRQAGGQLASPRSATENAAVQQLVTAHSKAAFLSMTDVGTEGKFTYPTGEALVYS
                     NWAPGEPNNNGGAENCVEIFTNGQWNDKACGEQRLVICEF"
     exon            215..331
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
     exon            332..448
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
     exon            449..565
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
     exon            566..682
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
     exon            683..766
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1251
                     /gene="Sftpd"
                     /gene_synonym="SP-D; SPD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accaggaagc aatctgccat gctgcacttt ctctccatgc ttgtcctgct tgtacagccc
       61 ctgggcgatc tgggagcaga aatgaagacc ctctcgcaga gatcaataac caacacatgc
      121 accctagtct tgtgtagtcc aacagagaat ggcctgcctg gtcgtgatgg acgggatggc
      181 agagagggtc cacggggcga gaagggtgat ccaggtttgc caggacctat gggactctca
      241 gggttgcctg gccctagagg tccagttggg cccaaaggag agaatggctc tgctggagaa
      301 cctggaccaa agggagaacg tggactagtt ggacctccag gatctccagg tatttctggt
      361 ccggctggaa aagaaggccc ctctgggaag cagggaaaca taggacccca aggcaaacca
      421 ggtcctaaag gagaggctgg gccgaaagga gaagtaggtg ctcccggcat gcaaggatct
      481 gcaggggcaa aaggccctgc tggccccaaa ggagaaagag gtgcccctgg tgagcaagga
      541 gcccctggga atgctggggc agcaggacct gccggacctg cgggtccaca gggagctcca
      601 ggttccaggg ggcctccagg actcaagggg gacagaggtg ctcctggaga cagaggaatc
      661 aaaggcgaaa gtggacttcc agacagtgct gctctgaggc agcagatgga ggctttgaat
      721 ggaaaacttc agcgtctaga ggctgccttt tctcgctata agaaagccgc gctcttccct
      781 gatggccaaa gtgttggaga caaaatcttc agggcggcaa actcggaaga gccttttgag
      841 gatgccaagg agatgtgcag gcaggccgga gggcagctgg cctccccacg ttctgctact
      901 gagaatgctg cagtacagca gctcgtcaca gcccacagca aagctgcttt cctgagtatg
      961 acagatgtgg gcacggaggg caagttcact taccccacag gagaggccct ggtctattct
     1021 aactgggctc caggggagcc caacaacaat ggaggggcag agaactgtgt ggagatcttc
     1081 accaatgggc agtggaatga caaggcttgt ggagagcagc gcctggttat ctgtgagttc
     1141 tgagccccta gaggtagaag acagaacaat actgggccag gagcttagcc agtgtggtat
     1201 agctcagacc tctatgctgc caccatccga ataaaaggtg tatagcctgg g
//
