LOCUS       NM_017342                782 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus surfactant protein C (Sftpc), mRNA.
ACCESSION   NM_017342
VERSION     NM_017342.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 782)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 782)
  AUTHORS   Zhang,Q.M., Ouyang,W.X., Chai,X.Q. and Deng,F.T.
  TITLE     Expression of Lung Surfactant Proteins SP-B and SP-C and Their
            Regulatory Factors in Fetal Lung of GDM Rats
  JOURNAL   Curr Med Sci 38 (5), 847-852 (2018)
   PUBMED   30341519
  REMARK    GeneRIF: The expression of SP-B and SP-C in GDM group was
            significantly reduced as compared with control group (P<0.05)...It
            was concluded that gestational diabetes mellitus can cause fetal
            lung development and maturation disorders, and FOXA2 in fetal lung
            tissue decreases while nitrocellulose FOXA2 increases
REFERENCE   3  (bases 1 to 782)
  AUTHORS   Heyen,L., Muller,U., Siegemund,S., Schulze,B., Protschka,M.,
            Alber,G. and Piehler,D.
  TITLE     Lung epithelium is the major source of IL-33 and is regulated by
            IL-33-dependent and IL-33-independent mechanisms in pulmonary
            cryptococcosis
  JOURNAL   Pathog Dis 74 (7) (2016)
   PUBMED   27596810
REFERENCE   4  (bases 1 to 782)
  AUTHORS   Hobi,N., Giolai,M., Olmeda,B., Miklavc,P., Felder,E., Walther,P.,
            Dietl,P., Frick,M., Perez-Gil,J. and Haller,T.
  TITLE     A small key unlocks a heavy door: The essential function of the
            small hydrophobic proteins SP-B and SP-C to trigger adsorption of
            pulmonary surfactant lamellar bodies
  JOURNAL   Biochim Biophys Acta 1863 (8), 2124-2134 (2016)
   PUBMED   27155084
  REMARK    GeneRIF: SP-C is present on the surface of exocytosed surfactant
            particles. Antibodies against SP-C stabilize the released particles
            when contacting the air-liquid interface, precluding their
            transformation and the formation of surface films. SP-C acts as an
            essential, preformed molecular key in the initial stages of
            surfactant unpacking and surface film formation.
REFERENCE   5  (bases 1 to 782)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 782)
  AUTHORS   Vorbroker,D.K., Profitt,S.A., Nogee,L.M. and Whitsett,J.A.
  TITLE     Aberrant processing of surfactant protein C in hereditary SP-B
            deficiency
  JOURNAL   Am J Physiol 268 (4 Pt 1), L647-L656 (1995)
   PUBMED   7537464
REFERENCE   7  (bases 1 to 782)
  AUTHORS   Veletza,S.V., Nichols,K.V., Gross,I., Lu,H., Dynia,D.W. and
            Floros,J.
  TITLE     Surfactant protein C: hormonal control of SP-C mRNA levels in vitro
  JOURNAL   Am J Physiol 262 (6 Pt 1), L684-L687 (1992)
   PUBMED   1319687
REFERENCE   8  (bases 1 to 782)
  AUTHORS   Oosterlaken-Dijksterhuis,M.A., van Eijk,M., van Buel,B.L., van
            Golde,L.M. and Haagsman,H.P.
  TITLE     Surfactant protein composition of lamellar bodies isolated from rat
            lung
  JOURNAL   Biochem J 274 (Pt 1) (Pt 1), 115-119 (1991)
   PUBMED   2001226
REFERENCE   9  (bases 1 to 782)
  AUTHORS   Fisher,J.H., Shannon,J.M., Hofmann,T. and Mason,R.J.
  TITLE     Nucleotide and deduced amino acid sequence of the hydrophobic
            surfactant protein SP-C from rat: expression in alveolar type II
            cells and homology with SP-C from other species
  JOURNAL   Biochim Biophys Acta 995 (3), 225-230 (1989)
   PUBMED   2706272
REFERENCE   10 (bases 1 to 782)
  AUTHORS   Schell,H.B. and Abruzzo,T.C.
  TITLE     Measles immunity. Report of countywide school survey
  JOURNAL   N Y State J Med 77 (13), 2095-2096 (1977)
   PUBMED   270627
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X14221.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017342.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14221.1, CF111221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676808 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-782               X14221.1           2-783
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..782
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /note="surfactant protein C"
                     /db_xref="GeneID:50683"
                     /db_xref="RGD:3666"
     exon            1..53
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..596
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /note="pulmonary surfactant-associated protein C;
                     pulmonary surfactant-associated proteolipid SPL(Val);
                     surfactant associated protein C; Surfactant,
                     pulmonary-associated protein C"
                     /codon_start=1
                     /product="surfactant protein C"
                     /protein_id="NP_059038.1"
                     /db_xref="GeneID:50683"
                     /db_xref="RGD:3666"
                     /translation="MDMGSKEVLMESPPDYSTGPRSQFRIPCCPVHLKRLLIVVVVVV
                     LVVVVIVGALLMGLHMSQKHTEMVLEMSIGGAPETQKRLALSEHTDTIATFSIGSTGI
                     VLYDYQRLLTAYKPAPGTYCYIMKMAPESIPSLEALARKFKNFQAKSSTPTSKLGQEE
                     GHSAGSDSDSSGRDLAFLGLAVSTLCGELPLYYI"
     exon            54..212
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            213..338
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            339..449
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            450..606
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            607..782
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      782
                     /gene="Sftpc"
                     /gene_synonym="SP-C"
                     /note="polyA site"
ORIGIN      
        1 gaccttacaa aatggacatg ggtagcaaag aggtactgat ggagagccca ccggattact
       61 cgacaggtcc caggagccag tttcgcattc cctgctgccc cgtgcatctc aaacgccttc
      121 tcatcgtggt tgtggtggta gtccttgtcg tcgtggtgat tgtaggggct ctgctcatgg
      181 gccttcacat gagtcagaaa catactgaga tggtccttga gatgagcatc ggaggagcac
      241 cggaaactca gaaacgcctc gccctgagtg aacacacaga caccatcgct accttctcta
      301 ttggctccac tggcatcgtt ctatatgact accagcggct cctgaccgcc tataagccag
      361 ctccaggaac ctactgctac atcatgaaga tggctccaga gagcatccct agtcttgagg
      421 ctttggctag aaaattcaag aacttccagg ccaagtcctc cacacccacc tctaagttgg
      481 gccaggaaga agggcacagt gctggatccg attctgattc ttctgggcga gacctggctt
      541 tcctgggcct tgctgtgagc accttgtgtg gagagctacc actgtactat atctagcacc
      601 cctcagggtc gagaaaccgc tgcgggacag gaaagaccct ccgcaaaggg tctttggcag
      661 ataagcagga agctgctcct gtccatactc tacagaagag ggtggaaacc tgtggagcaa
      721 aggtgtctcc tacagcctcg gggatcctac tacaaaagaa taaagcagcc ctactgaaaa
      781 ac
//
