LOCUS       NM_138842               1494 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus surfactant protein B (Sftpb), mRNA.
ACCESSION   NM_138842
VERSION     NM_138842.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1494)
  AUTHORS   Roeder,F., Knudsen,L. and Schmiedl,A.
  TITLE     The expression of the surfactant proteins SP-A and SP-B during
            postnatal alveolarization of the rat lung
  JOURNAL   PLoS One 19 (3), e0297889 (2024)
   PUBMED   38483982
  REMARK    GeneRIF: The expression of the surfactant proteins SP-A and SP-B
            during postnatal alveolarization of the rat lung.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1494)
  AUTHORS   Cao,W., Liu,Q., Wang,T., Zhang,Q., Cheng,F., Tang,Y., Mei,C.,
            Wen,F. and Wang,W.
  TITLE     Recombinant expression of the precursor of rat lung surfactant
            protein B in Escherichia coli and its antibacterial mechanism
  JOURNAL   Protein Expr Purif 179, 105801 (2021)
   PUBMED   33248225
  REMARK    GeneRIF: Recombinant expression of the precursor of rat lung
            surfactant protein B in Escherichia coli and its antibacterial
            mechanism.
REFERENCE   3  (bases 1 to 1494)
  AUTHORS   Wang,K., Huang,Q., Zhao,G., Yang,J., Yang,K. and Huang,Y.
  TITLE     Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175
            affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese
            Han non-small-cell lung cancer patients
  JOURNAL   J Cell Biochem 120 (9), 14804-14812 (2019)
   PUBMED   31016788
REFERENCE   4  (bases 1 to 1494)
  AUTHORS   Zhang,Q.M., Ouyang,W.X., Chai,X.Q. and Deng,F.T.
  TITLE     Expression of Lung Surfactant Proteins SP-B and SP-C and Their
            Regulatory Factors in Fetal Lung of GDM Rats
  JOURNAL   Curr Med Sci 38 (5), 847-852 (2018)
   PUBMED   30341519
  REMARK    GeneRIF: The expression of SP-B and SP-C in GDM group was
            significantly reduced as compared with control group (P<0.05)... It
            was concluded that gestational diabetes mellitus can cause fetal
            lung development and maturation disorders, and FOXA2 in fetal lung
            tissue decreases while nitrocellulose FOXA2 increases
REFERENCE   5  (bases 1 to 1494)
  AUTHORS   Lee,S., Kim,D., Kang,J., Kim,E., Kim,W., Youn,H. and Youn,B.
  TITLE     Surfactant Protein B Suppresses Lung Cancer Progression by
            Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid
            Production
  JOURNAL   Cell Physiol Biochem 42 (4), 1684-1700 (2017)
   PUBMED   28743125
REFERENCE   6  (bases 1 to 1494)
  AUTHORS   Jennings,V.M., Dillehay,D.L., Webb,S.K. and Brown,L.A.
  TITLE     Pulmonary alveolar proteinosis in SCID mice
  JOURNAL   Am J Respir Cell Mol Biol 13 (3), 297-306 (1995)
   PUBMED   7654386
REFERENCE   7  (bases 1 to 1494)
  AUTHORS   Suzuki,Y., Robertson,B., Fujita,Y., Grossmann,G., Kogishi,K. and
            Curstedt,T.
  TITLE     Lung protein leakage in respiratory failure induced by a hybridoma
            making monoclonal antibody to the hydrophobic surfactant-associated
            polypeptide SP-B
  JOURNAL   Int J Exp Pathol 73 (3), 325-333 (1992)
   PUBMED   1622844
REFERENCE   8  (bases 1 to 1494)
  AUTHORS   Floros,J., Gross,I., Nichols,K.V., Veletza,S.V., Dynia,D., Lu,H.W.,
            Wilson,C.M. and Peterec,S.M.
  TITLE     Hormonal effects on the surfactant protein B (SP-B) mRNA in
            cultured fetal rat lung
  JOURNAL   Am J Respir Cell Mol Biol 4 (5), 449-454 (1991)
   PUBMED   1850607
REFERENCE   9  (bases 1 to 1494)
  AUTHORS   Weaver,T.E. and Whitsett,J.A.
  TITLE     Processing of hydrophobic pulmonary surfactant protein B in rat
            type II cells
  JOURNAL   Am J Physiol 257 (2 Pt 1), L100-L108 (1989)
   PUBMED   2475034
REFERENCE   10 (bases 1 to 1494)
  AUTHORS   Emrie,P.A., Shannon,J.M., Mason,R.J. and Fisher,J.H.
  TITLE     cDNA and deduced amino acid sequence for the rat hydrophobic
            pulmonary surfactant-associated protein, SP-B
  JOURNAL   Biochim Biophys Acta 994 (3), 215-221 (1989)
   PUBMED   2920185
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138842.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14778.1, BC072466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000004.1  105917588-105917653
            67-194              JAXUCZ010000004.1  105917949-105918076
            195-266             JAXUCZ010000004.1  105918494-105918565
            267-392             JAXUCZ010000004.1  105918663-105918788
            393-557             JAXUCZ010000004.1  105919260-105919424
            558-647             JAXUCZ010000004.1  105919612-105919701
            648-831             JAXUCZ010000004.1  105921988-105922171
            832-992             JAXUCZ010000004.1  105922826-105922986
            993-1073            JAXUCZ010000004.1  105924708-105924788
            1074-1151           JAXUCZ010000004.1  105925256-105925333
            1152-1494           JAXUCZ010000004.1  105926288-105926630
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..1494
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /note="surfactant protein B"
                     /db_xref="GeneID:192155"
                     /db_xref="RGD:621700"
     exon            1..66
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1136
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /note="pulmonary surfactant-associated protein B;
                     pulmonary surfactant-associated proteolipid SPL(Phe);
                     surfactant associated protein B; surfactant,
                     pulmonary-associated protein B"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein B
                     precursor"
                     /protein_id="NP_620197.2"
                     /db_xref="GeneID:192155"
                     /db_xref="RGD:621700"
                     /translation="MAKLHLQWLLLLPTLCSLGAATESASSPDCAQGPKFWCQSLEQA
                     IQCRALGHCLQEVWGHAGANDLCQECEDIVHLLTKMTKEDAFQDTIRKFLEQECDILP
                     LKLLVPRCRQVLDVYLPLVIDYFQGQIKPKAICSHVGLCPLGQTKPEQKPEMLDAIPN
                     PLLNKLVLPALPGAFLARPGPHTQDLSEQQLPIPLPFCWLCRTLIKRVQAVIPKGVLA
                     VAVSQVCHVVPLVVGGICQCLAERYTVLLLDALLGRVVPQLVCGLVLRCSTADAIGPA
                     LPALEPLIEKWPLQDTECHFCKSVINQAWNTSEQAMPQAMHQACLRFWLDRQKCEQFV
                     ERHMPQLLALVPRSQDAHTSCQALGVCEAPASPLQCFQTPHL"
     exon            67..194
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            195..266
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            267..392
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            393..557
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            558..647
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            648..831
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            832..992
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1073
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1151
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1494
                     /gene="Sftpb"
                     /gene_synonym="Sp-b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccatggc caagttacat ctgcagtggc tactgctcct tcctacactc tgcagcctag
       61 gcgcagctac agagtcggcc tcgtccccgg attgtgcaca aggccctaaa ttctggtgcc
      121 aaagcctgga gcaagcgata cagtgcagag ccctggggca ctgcctacag gaagtctggg
      181 gacatgcagg agctaatgac ctgtgccaag agtgtgagga tattgtccac ctcctcacaa
      241 agatgaccaa ggaagacgct ttccaggaca cgatccggaa gttcctggaa caagaatgtg
      301 atatcctacc cttgaagctg cttgtgcccc ggtgtcgcca agtgcttgat gtctacctgc
      361 ccctggttat cgactacttc cagggccaga ttaaacccaa agccatctgc agtcatgtgg
      421 gcctgtgccc acttgggcag actaagccag agcagaagcc cgagatgctg gatgccattc
      481 caaaccctct gctgaacaag ctggtcctcc ctgcgctgcc aggagccttc ttggcaaggc
      541 ctgggcctca cacacaggac ctctctgagc aacagctccc catccctctg cccttctgct
      601 ggctttgcag gactctgatc aagcgggtcc aagctgtgat tcccaagggt gtgctggccg
      661 tggctgtgtc ccaggtgtgc cacgtggtac ccctggtggt gggtggcatc tgccagtgcc
      721 tggctgagcg ttacacagta cttctactag atgcactgct gggtcgtgtg gtgccccagc
      781 tagtctgtgg cctggtcctc cgatgttcca ctgcagatgc cattggccca gccctccctg
      841 ctctggagcc tctgattgaa aaatggccac tgcaagacac tgagtgccat ttctgcaagt
      901 ctgtgatcaa ccaggcctgg aacaccagtg aacaggctat gccacaggca atgcaccagg
      961 cctgccttcg cttctggcta gacaggcaaa agtgtgagca gtttgtggaa cggcacatgc
     1021 cccagctgct ggccctggtg cctaggagcc aggatgccca cacctcctgc caggcccttg
     1081 gagtatgtga ggccccggcc agccctctgc aatgcttcca aaccccacac ctctgagaac
     1141 ccaggctcca gcaacctgta ccaaaggacc acaagtctca gcctgcaccc ccagccctgt
     1201 gccagcctgt atgtcccagc tctaaccaca gcccaacaac accaccagag tggtttctgg
     1261 ctcctctgat gatgaggtgc agcagaacca tgtcctctag aagccttcag agggggcttc
     1321 aggccttcac ccccaccaga gccaagccca gctccaacag ctcctacagc cccaggactg
     1381 aaaagaaact gtcgtgggtc cacagagagt gggtagaagt ggggctagcc acagcaaccc
     1441 cttgctaaca cttctgtgaa attcgaactt cagatgaata aacactggaa acac
//
