LOCUS       NM_001270645            1635 bp    mRNA    linear   ROD 23-MAR-2024
DEFINITION  Rattus norvegicus surfactant protein A1 (Sftpa1), transcript
            variant 1, mRNA.
ACCESSION   NM_001270645
VERSION     NM_001270645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Roeder,F., Knudsen,L. and Schmiedl,A.
  TITLE     The expression of the surfactant proteins SP-A and SP-B during
            postnatal alveolarization of the rat lung
  JOURNAL   PLoS One 19 (3), e0297889 (2024)
   PUBMED   38483982
  REMARK    GeneRIF: The expression of the surfactant proteins SP-A and SP-B
            during postnatal alveolarization of the rat lung.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Wang,Q., Wang,Q., Zhao,Z., Fan,J., Qin,L., Alexander,D.B.,
            Tsuda,H., Zhao,D. and Xu,J.
  TITLE     Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common
            Pathway Associated With Phagocytosis of Nanomaterials and Cytokine
            Production
  JOURNAL   Front Immunol 12, 758941 (2021)
   PUBMED   34777371
  REMARK    GeneRIF: Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a
            Common Pathway Associated With Phagocytosis of Nanomaterials and
            Cytokine Production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Ran,R., Cai,D., King,S.D., Que,X., Bath,J.M. and Chen,S.Y.
  TITLE     Surfactant Protein A, a Novel Regulator for Smooth Muscle
            Phenotypic Modulation and Vascular Remodeling-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (2), 808-814 (2021)
   PUBMED   33267655
  REMARK    GeneRIF: Surfactant Protein A, a Novel Regulator for Smooth Muscle
            Phenotypic Modulation and Vascular Remodeling-Brief Report.
REFERENCE   4  (bases 1 to 1635)
  AUTHORS   Yu,G.H., Kim,H.B., Ko,S.H., Kim,Y.W., Lim,Y.S., Park,S.W., Cho,C.G.
            and Park,J.H.
  TITLE     Expression of surfactant Protein-A in the Haemophilus
            influenzae-induced otitis media in a rat model
  JOURNAL   Int J Pediatr Otorhinolaryngol 112, 61-66 (2018)
   PUBMED   30055742
  REMARK    GeneRIF: SP-A expression was up-regulated in the middle ear
            effusion of non-typeable Haemophilus influenza otitis media.
REFERENCE   5  (bases 1 to 1635)
  AUTHORS   Rynkiewicz,M.J., Wu,H., Cafarella,T.R., Nikolaidis,N.M., Head,J.F.,
            Seaton,B.A. and McCormack,F.X.
  TITLE     Differential Ligand Binding Specificities of the Pulmonary
            Collectins Are Determined by the Conformational Freedom of a
            Surface Loop
  JOURNAL   Biochemistry 56 (31), 4095-4105 (2017)
   PUBMED   28719181
  REMARK    GeneRIF: SPA binds dipalmitoyl-phosphatidylcholine, the major
            surfactant lipid component, but not phosphatidylinositol; SPD
            exhibits the opposite preference. Data suggest flexibility in a key
            surface loop supports distinctive lipid binding of SPA; quadruple
            mutant SPA (E171D/P175E/R197N/K203D) that introduces SPD-like
            loop-stabilizing Ca2+ binding site in carbohydrate recognition
            domain exhibits ligand-binding preferences of SPD.
REFERENCE   6  (bases 1 to 1635)
  AUTHORS   Toki,N., Sueishi,K., Minamitani,M., Maeda,H., Nakano,H. and
            Suzuki,Y.
  TITLE     Immunohistochemical distribution of surfactant apoproteins in
            hypoplastic lungs of nonimmunologic hydrops fetalis
  JOURNAL   Hum Pathol 26 (11), 1252-1259 (1995)
   PUBMED   7590701
REFERENCE   7  (bases 1 to 1635)
  AUTHORS   Smith,C.I., Rosenberg,E., Reisher,S.R., Li,F., Kefalides,P.,
            Fisher,A.B. and Feinstein,S.I.
  TITLE     Sequence of rat surfactant protein A gene and functional mapping of
            its upstream region
  JOURNAL   Am J Physiol 269 (5 Pt 1), L603-L612 (1995)
   PUBMED   7491978
REFERENCE   8  (bases 1 to 1635)
  AUTHORS   Schellhase,D.E. and Shannon,J.M.
  TITLE     Effects of maternal dexamethasone on expression of SP-A, SP-B, and
            SP-C in the fetal rat lung
  JOURNAL   Am J Respir Cell Mol Biol 4 (4), 304-312 (1991)
   PUBMED   2015097
REFERENCE   9  (bases 1 to 1635)
  AUTHORS   Fisher,J.H., Emrie,P.A., Shannon,J., Sano,K., Hattler,B. and
            Mason,R.J.
  TITLE     Rat pulmonary surfactant protein A is expressed as two differently
            sized mRNA species which arise from differential polyadenylation of
            one transcript
  JOURNAL   Biochim Biophys Acta 950 (3), 338-345 (1988)
   PUBMED   2901856
REFERENCE   10 (bases 1 to 1635)
  AUTHORS   Sano,K., Fisher,J., Mason,R.J., Kuroki,Y., Schilling,J., Benson,B.
            and Voelker,D.
  TITLE     Isolation and sequence of a cDNA clone for the rat pulmonary
            surfactant-associated protein (PSP-A)
  JOURNAL   Biochem Biophys Res Commun 144 (1), 367-374 (1987)
   PUBMED   3579914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085353.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085353.1, CK478637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680426
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1635              BC085353.1         1-1635
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1635
                     /gene="Sftpa1"
                     /gene_synonym="PSAP; PSP-A; Sftp1; Sftpa; Sftpl; SP-A"
                     /note="surfactant protein A1"
                     /db_xref="GeneID:24773"
                     /db_xref="RGD:3665"
     exon            1..37
                     /gene="Sftpa1"
                     /gene_synonym="PSAP; PSP-A; Sftp1; Sftpa; Sftpl; SP-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..808
                     /gene="Sftpa1"
                     /gene_synonym="PSAP; PSP-A; Sftp1; Sftpa; Sftpl; SP-A"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pulmonary surfactant-associated protein A;
                     Surfactant-associated protein 1 (pulmonary surfactant
                     protein, SP-A); surfactant, pulmonary-associated protein
                     A1; pulmonary surfactant-associated protein A-like"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein A
                     isoform 1 precursor"
                     /protein_id="NP_001257574.1"
                     /db_xref="GeneID:24773"
                     /db_xref="RGD:3665"
                     /translation="MWQKPLGIVAMSLCSLAFTLFLTVVAGIKCNVTDVCAGSPGIPG
                     APGNHGLPGRDGRDGVKGDPGPPGPMGPPGGMPGLPGRDGLPGAPGAPGERGDKGEPG
                     ERGLPGFPAYLDEELQTELYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDT
                     IKEMCTRAGGNIAVPRTPEENEAIASIAKKYNNYVYLGMIEDQTPGDFHYLDGASVNY
                     TNWYPGEPRGQGKEKCVEMYTDGTWNDRGCLQYRLAVCEF"
     exon            38..233
                     /gene="Sftpa1"
                     /gene_synonym="PSAP; PSP-A; Sftp1; Sftpa; Sftpl; SP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            234..353
                     /gene="Sftpa1"
                     /gene_synonym="PSAP; PSP-A; Sftp1; Sftpa; Sftpl; SP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            354..431
                     /gene="Sftpa1"
                     /gene_synonym="PSAP; PSP-A; Sftp1; Sftpa; Sftpl; SP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            432..1614
                     /gene="Sftpa1"
                     /gene_synonym="PSAP; PSP-A; Sftp1; Sftpa; Sftpl; SP-A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagatatc cacacagcct gcaggctctg tatgtggcag aagccactgg ggatagtagc
       61 catgtcactg tgttctttgg ccttcaccct cttcttgact gttgtcgctg gtatcaagtg
      121 caatgtgaca gacgtttgtg ctggaagccc tgggatccct ggagctcctg gaaaccatgg
      181 tctgcctggc agagacggga gagacggtgt caaaggagac cctggacctc caggtcccat
      241 gggccctcct ggaggaatgc caggtcttcc tggacgcgat gggctgcccg gagcccctgg
      301 tgcacctgga gaacgtggag acaagggaga gcctggagaa aggggcctgc caggatttcc
      361 agcttacctg gatgaggagc tccagactga actctatgag atcaaacatc agattctgca
      421 aacaatggga gtcctcagct tgcaaggatc catgctgtca gtgggggata aagtcttttc
      481 caccaatggg cagtcagtca actttgatac cattaaagag atgtgtacca gagcaggagg
      541 caacattgct gtcccgagga ctcctgagga gaacgaggcc attgcaagta ttgcgaagaa
      601 gtacaacaac tatgtctact tgggcatgat tgaagaccag actcctggag acttccacta
      661 cctggatggg gcttctgtga actacaccaa ctggtaccca ggagaaccca ggggtcaggg
      721 caaagaaaag tgtgtagaaa tgtatacaga tgggacatgg aatgataggg gctgcctgca
      781 gtaccggctg gctgtttgtg aattttgatc aagcaattag acgaaaagat gaaccctcac
      841 actgcctcta tcctgatgat tcatctggtc tgtaaaaccc tgcaactacc tttcaagcaa
      901 atttacttgt ggccttcaga attagaagca tcttttgtca ccccgctccc acatagttcc
      961 caaacacttc tccatattca ttagcaatcc tgagtgtttc cctagagtcc catctgagcg
     1021 ttcattcaag gtagccattg taaaccttgg ccttgaccat gagatggata gatacttcct
     1081 ttttcctcac tttatccagt cttcatttat aaatggtggc catgaagacc cagcatggaa
     1141 ggaccctcta aactaagtgc tgccctctga cctttccacc cttctgtagc tcggtgtccc
     1201 aggatttaga agtccaggtt aaacataggg gatttctggg aaagcctagt atgtgggtgc
     1261 aggccacatt cagtgccatc tgtatccatg gctttcaagg caaacattgt ctctaagaag
     1321 ccagagaacc aggtaggacc aggtagtact gggggaacat aaactcactg gttggcatgt
     1381 atggctccct ccttgggtct ggaggtgcca tcttgacctc ttgaactaac agcagccacc
     1441 ctgggttttg agagaacgac tttcccagcc cagaccccaa ctcaagtaat ttcctgctaa
     1501 cagacacagc ctcagttcac tttacatcac tgaggcattc atgatacgaa ctgcaatctg
     1561 ttttctcctc tcgtgagttc aatcagctat tccattaaag tcaactgcat tccaaaaaaa
     1621 aaaaaaaaaa aaaaa
//
