LOCUS       NM_001107591            1989 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus secreted frizzled-related protein 5 (Sfrp5),
            mRNA.
ACCESSION   NM_001107591 XM_001055342 XM_219887
VERSION     NM_001107591.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Deng D, Han X, Diao Z and Liu W.
  TITLE     Secreted Frizzled-Related Protein 5 Ameliorates Vascular
            Calcification in a Rat Model of Chronic Kidney Disease through the
            Wnt/beta-Catenin Pathway
  JOURNAL   Kidney Blood Press Res 46 (6), 758-767 (2021)
   PUBMED   34469882
  REMARK    GeneRIF: Secreted Frizzled-Related Protein 5 Ameliorates Vascular
            Calcification in a Rat Model of Chronic Kidney Disease through the
            Wnt/beta-Catenin Pathway.
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Oh YJ, Kim H, Kim AJ, Ro H, Chang JH, Lee HH, Chung W, Jun HS and
            Jung JY.
  TITLE     Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular
            Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in
            Chronic Kidney Disease
  JOURNAL   Int J Mol Sci 21 (10), 3539 (2020)
   PUBMED   32429518
  REMARK    GeneRIF: Reduction of Secreted Frizzled-Related Protein 5 Drives
            Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK
            Signaling in Chronic Kidney Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Li Y, Tian M, Yang M, Yang G, Chen J, Wang H, Liu D, Wang H, Deng
            W, Zhu Z, Zheng H and Li L.
  TITLE     Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride
            secretion
  JOURNAL   Metabolism 103, 154029 (2020)
   PUBMED   31770545
  REMARK    GeneRIF: Central Sfrp5 signaling activates a previously
            unappreciated InsR-Akt-PI3k-KATP channel pathway in the
            hypothalamus and brain-hepatic vagus neurocircuitry to decrease
            hepatic glucose production and VLDL-triglyceride secretion.
REFERENCE   4  (bases 1 to 1989)
  AUTHORS   Carstensen-Kirberg M, Rohrig K, Niersmann C, Ouwens DM, Belgardt
            BF, Roden M and Herder C.
  TITLE     Sfrp5 increases glucose-stimulated insulin secretion in the rat
            pancreatic beta cell line INS-1E
  JOURNAL   PLoS One 14 (3), e0213650 (2019)
   PUBMED   30921355
  REMARK    GeneRIF: Sfrp5 reduces markers of cell proliferation, but increases
            in parallel dose-dependently glucose-stimulated insulin secretion
            in INS-1E cells
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1989)
  AUTHORS   Teliewubai J, Ji H, Lu Y, Bai B, Yu S, Chi C, Xu Y and Zhang Y.
  TITLE     SFRP5 serves a beneficial role in arterial aging by inhibiting the
            proliferation, migration and inflammation of smooth muscle cells
  JOURNAL   Mol Med Rep 18 (5), 4682-4690 (2018)
   PUBMED   30221661
  REMARK    GeneRIF: the present results suggested that SFRP5 may inhibit SMC
            proliferation, migration and inflammation by suppressing the
            Wnt/bcatenin and p38/mitogenactivated protein kinase signaling
            pathways.
REFERENCE   6  (bases 1 to 1989)
  AUTHORS   Su HY, Lai HC, Lin YW, Liu CY, Chen CK, Chou YC, Lin SP, Lin WC,
            Lee HY and Yu MH.
  TITLE     Epigenetic silencing of SFRP5 is related to malignant phenotype and
            chemoresistance of ovarian cancer through Wnt signaling pathway
  JOURNAL   Int J Cancer 127 (3), 555-567 (2010)
   PUBMED   19957335
REFERENCE   7  (bases 1 to 1989)
  AUTHORS   Matsuyama M, Aizawa S and Shimono A.
  TITLE     Sfrp controls apicobasal polarity and oriented cell division in
            developing gut epithelium
  JOURNAL   PLoS Genet 5 (3), e1000427 (2009)
   PUBMED   19300477
REFERENCE   8  (bases 1 to 1989)
  AUTHORS   Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA and Zorn AM.
  TITLE     Sfrp5 coordinates foregut specification and morphogenesis by
            antagonizing both canonical and noncanonical Wnt11 signaling
  JOURNAL   Genes Dev 22 (21), 3050-3063 (2008)
   PUBMED   18981481
REFERENCE   9  (bases 1 to 1989)
  AUTHORS   Satoh W, Matsuyama M, Takemura H, Aizawa S and Shimono A.
  TITLE     Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the
            planar cell polarity pathways during early trunk formation in mouse
  JOURNAL   Genesis 46 (2), 92-103 (2008)
   PUBMED   18257070
REFERENCE   10 (bases 1 to 1989)
  AUTHORS   Cox S, Smith L, Bogani D, Cheeseman M, Siggers P and Greenfield A.
  TITLE     Sexually dimorphic expression of secreted frizzled-related (SFRP)
            genes in the developing mouse Mullerian duct
  JOURNAL   Mol Reprod Dev 73 (8), 1008-1016 (2006)
   PUBMED   16700072
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055342.1, XM_219887.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1989
                     /gene="Sfrp5"
                     /note="secreted frizzled-related protein 5"
                     /db_xref="GeneID:309377"
                     /db_xref="RGD:1310369"
     exon            1..761
                     /gene="Sfrp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1186
                     /gene="Sfrp5"
                     /note="secreted frizzled-related sequence protein 5"
                     /codon_start=1
                     /product="secreted frizzled-related protein 5 precursor"
                     /protein_id="NP_001101061.1"
                     /db_xref="GeneID:309377"
                     /db_xref="RGD:1310369"
                     /translation="MRVAGGARTAALALLLGALHGAPARGQEYDYYGWQTEPLHGRSY
                     SKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQ
                     VFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCI
                     AVQFGHLPATAPPVTKICAQCEIEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLI
                     GAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDNLTGSFLVMGRKVEGQLLLT
                     AVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH"
     exon            762..839
                     /gene="Sfrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1989
                     /gene="Sfrp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggggtg ggagttgagg gggaccagcg gctgcagatt ggctagggaa cggcgaagcc
       61 tgggctggag ccccgtggtg ggaggcgcct ggatcactcc ggcagcggag cggagcagag
      121 gttgcctcct acttggacga ccagagcagc ggacggctgc agggagcatc ccagcccggg
      181 cgcacgcggg gcagcggggc gccgagcacc gagccgtcgg ggcgggcggc aatatccagc
      241 catgcgggtg gccgggggtg cgcggaccgc cgcgctggcg ctgctgctcg gggcgctgca
      301 tggggcgccg gcgcgcggcc aggaatacga ctactatggt tggcaaactg agcccctgca
      361 cggccgctcc tactccaagc caccgcagtg cctcgacatc cccgccgatc tgcccctctg
      421 ccacacagtg ggctacaagc gcatgcggct gccgaacctc ctggagcacg aaagcctggc
      481 ggaggtgaag cagcaggcaa gcagctggct gccgctgctg gccaagcgtt gccactcgga
      541 cacccaggtc ttcctctgct cgctcttcgc tcctgtctgc ctggaccgac ccatctaccc
      601 gtgccgctcg ctgtgcgaag ccgtgcgcgc cggctgcgcg ccgctcatgg aggcctatgg
      661 cttcccttgg cctgagatgc tgcactgcca caagtttcct ctggacaacg acctctgcat
      721 cgcggtgcag tttgggcacc tgcctgccac cgcgcctcca gtgaccaaga tctgtgccca
      781 gtgtgagatc gagcacagtg ctgacggcct catggagcag atgtgctcca gcgacttcgt
      841 ggtcaagatg cgcattaagg agatcaagat agacaatggg gaccgcaagt tgattggagc
      901 ccagaagaag aagaagctgc tcaaggcagg ccccttaaag cgcaaggaca ccaagaagct
      961 ggttctgcac atgaagaacg gggccagctg cccctgcccg cagttagaca acctgacagg
     1021 gagcttcctg gtcatgggcc gcaaagtgga gggacagctg ctgctcacag ccgtctaccg
     1081 ctgggacaag aagaataagg agatgaagtt tgcagtcaaa ttcatgttct cctacccctg
     1141 ttccctctac tacccctttt tctatggggc agctgaaccc cactgaaggg ctttccttct
     1201 ttccccaacc atccagctgt gccttgcctc gccctcagtc cctgcccact tggcctcacc
     1261 ctcactccca ggctgaccca tcccctggca aggatggctt cgtgcagcta ctgcttgcct
     1321 aacttctagc atggagccac cctccttgac tgaagggaat cctggagcct gtccggggag
     1381 gccccttctc ccaggagaag gactttctct tctggggtaa gccctaatgt ctgagaaaac
     1441 aggcagagga ggaaaatgtg agggacggat acagggcctc tggcggatgg atacagggcc
     1501 tcccagagcc tggggagggg ctttccagaa agaattgtgg gtgtcatggc taagcaggat
     1561 ccgtacttaa gagatcagct ttcctccccc atgacccttt gtgtgtcatc acagttctcc
     1621 aaagagcaag agccaaggcc tccatgtcct ccagtcacac ccactcctca tctggagccc
     1681 tgccgggact ggagtgcagg ctcagcagct tctacattca ctgctaccta cacaggtttg
     1741 cttcctggct gggcctcctc cgtccctgta tcccaacaat gataaattat tgctactgct
     1801 gtgcggccac tggttctaga caacaggttt ggtccttgat ttttttttaa agtttttttt
     1861 tttctttttt tcggagctgg ggaccgaacc cagggccttg cggttgctag gcaagcgctc
     1921 taccactgag ctaaatcccc aaccccaaaa gtttttaatt aaataaaaca acgtttgctt
     1981 tggagcagt
//
