LOCUS       NM_053544               2057 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus secreted frizzled-related protein 4 (Sfrp4),
            mRNA.
ACCESSION   NM_053544
VERSION     NM_053544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2057)
  AUTHORS   Li,N., Zhang,T., He,M. and Mu,Y.
  TITLE     MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury
            via regulation of the SFRP4/Wnt/beta-catenin axis
  JOURNAL   Biomarkers 26 (4), 363-370 (2021)
   PUBMED   33726573
  REMARK    GeneRIF: MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced
            injury via regulation of the SFRP4/Wnt/beta-catenin axis.
REFERENCE   2  (bases 1 to 2057)
  AUTHORS   Kiper,P.O.S., Saito,H., Gori,F., Unger,S., Hesse,E., Yamana,K.,
            Kiviranta,R., Solban,N., Liu,J., Brommage,R., Boduroglu,K.,
            Bonafe,L., Campos-Xavier,B., Dikoglu,E., Eastell,R., Gossiel,F.,
            Harshman,K., Nishimura,G., Girisha,K.M., Stevenson,B.J., Takita,H.,
            Rivolta,C., Superti-Furga,A. and Baron,R.
  TITLE     Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's
            Disease
  JOURNAL   N Engl J Med 374 (26), 2553-2562 (2016)
   PUBMED   27355534
REFERENCE   3  (bases 1 to 2057)
  AUTHORS   Cruciat,C.M. and Niehrs,C.
  TITLE     Secreted and transmembrane wnt inhibitors and activators
  JOURNAL   Cold Spring Harb Perspect Biol 5 (3), a015081 (2013)
   PUBMED   23085770
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2057)
  AUTHORS   Miao,C.G., Huang,C., Huang,Y., Yang,Y.Y., He,X., Zhang,L., Lv,X.W.,
            Jin,Y. and Li,J.
  TITLE     MeCP2 modulates the canonical Wnt pathway activation by targeting
            SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats
  JOURNAL   Cell Signal 25 (3), 598-608 (2013)
   PUBMED   23200852
  REMARK    GeneRIF: Increased SFRP4 down-regulated the key gene beta-catenin,
            the downstream effectors gene ccnd1 and fibronectin expression in
            canonical Wnt pathway at the same time.
REFERENCE   5  (bases 1 to 2057)
  AUTHORS   Granados-Principal,S., Quiles,J.L., Ramirez-Tortosa,C.,
            Camacho-Corencia,P., Sanchez-Rovira,P., Vera-Ramirez,L. and
            Ramirez-Tortosa,M.C.
  TITLE     Hydroxytyrosol inhibits growth and cell proliferation and promotes
            high expression of sfrp4 in rat mammary tumours
  JOURNAL   Mol Nutr Food Res 55 Suppl 1, S117-S126 (2011)
   PUBMED   21120994
  REMARK    GeneRIF: Hydroxytyrosol alters several genes associated with cell
            proliferation, apoptosis and the Wnt signalling pathway, promoting
            a high expression of Sfrp4 in rat mammary tumors.
REFERENCE   6  (bases 1 to 2057)
  AUTHORS   Fujita,M., Ogawa,S., Fukuoka,H., Tsukui,T., Nemoto,N., Tsutsumi,O.,
            Ouchi,Y. and Inoue,S.
  TITLE     Differential expression of secreted frizzled-related protein 4 in
            decidual cells during pregnancy
  JOURNAL   J Mol Endocrinol 28 (3), 213-223 (2002)
   PUBMED   12063187
  REMARK    GeneRIF: Differential expression of secreted frizzled-related
            protein 4 in decidual cells during pregnancy.
REFERENCE   7  (bases 1 to 2057)
  AUTHORS   Wong,S.C., Lo,S.F., Lee,K.C., Yam,J.W., Chan,J.K. and Wendy
            Hsiao,W.L.
  TITLE     Expression of frizzled-related protein and Wnt-signalling molecules
            in invasive human breast tumours
  JOURNAL   J Pathol 196 (2), 145-153 (2002)
   PUBMED   11793365
REFERENCE   8  (bases 1 to 2057)
  AUTHORS   Yam,J.W., Chan,K.W., Wong,V.K. and Hsiao,W.L.
  TITLE     Transcriptional activity of the promoter region of rat
            frizzled-related protein gene
  JOURNAL   Biochem Biophys Res Commun 286 (1), 94-100 (2001)
   PUBMED   11485313
REFERENCE   9  (bases 1 to 2057)
  AUTHORS   Guo,K., Wolf,V., Dharmarajan,A.M., Feng,Z., Bielke,W., Saurer,S.
            and Friis,R.
  TITLE     Apoptosis-associated gene expression in the corpus luteum of the
            rat
  JOURNAL   Biol Reprod 58 (3), 739-746 (1998)
   PUBMED   9510961
REFERENCE   10 (bases 1 to 2057)
  AUTHORS   Wolf,V., Ke,G., Dharmarajan,A.M., Bielke,W., Artuso,L., Saurer,S.
            and Friis,R.
  TITLE     DDC-4, an apoptosis-associated gene, is a secreted frizzled
            relative
  JOURNAL   FEBS Lett 417 (3), 385-389 (1997)
   PUBMED   9409757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Dec 2, 2020 this sequence version replaced NM_053544.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF012891.1, AF140346.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               JAXUCZ010000017.1  50025607-50026298   c
            693-773             JAXUCZ010000017.1  50024320-50024400   c
            774-839             JAXUCZ010000017.1  50024169-50024234   c
            840-1038            JAXUCZ010000017.1  50022054-50022252   c
            1039-1102           JAXUCZ010000017.1  50018952-50019015   c
            1103-2057           JAXUCZ010000017.1  50016050-50017004   c
FEATURES             Location/Qualifiers
     source          1..2057
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..2057
                     /gene="Sfrp4"
                     /note="secreted frizzled-related protein 4"
                     /db_xref="GeneID:89803"
                     /db_xref="RGD:621075"
     exon            1..692
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1294
                     /gene="Sfrp4"
                     /note="FRP; sFRP-4; DDC-4 protein; frizzled related
                     protein"
                     /codon_start=1
                     /product="secreted frizzled-related protein 4 precursor"
                     /protein_id="NP_445996.2"
                     /db_xref="GeneID:89803"
                     /db_xref="RGD:621075"
                     /translation="MLLSILVALCLWLRLALGVRGAPCEAVRIPMCRHMPWNITRMPN
                     HLHHSTQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQ
                     RARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMM
                     VQERSFDADCKHLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVV
                     DVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYERRSRMMLLENCLVEKW
                     RDQLSRRSTQWEERLQEQQRTTQDKKQIASRTSRSNPPKPKGRSPASKPASPKKNIKA
                     RSAPKKSNPKKSTS"
     exon            693..773
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            774..839
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1038
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1102
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..2057
                     /gene="Sfrp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagctgcg gggcgggaga ctggagcttc ctgcgcgggt ctgtgctctg gtgggtgagt
       61 gctgtccctg ccagtgtccg ggcgcccagg gctgatcgac ggccagaacc ccagaactcc
      121 cgttcagtgc ggactggagc tccagcagaa acgctcactt cgctgcccct aggtaaagac
      181 ataaggagat cagagggact tgaagggaag gtccccagtg gggaccgcag cccaggagga
      241 cagtgcgatg ctcctctcca tcctggtagc gttatgcctg tggctgcgcc tggctctggg
      301 agtgcgcgga gcgccctgcg aggctgtgcg catccccatg tgtaggcaca tgccctggaa
      361 catcacccgg atgcccaacc acctgcacca cagcactcag gagaacgcca tcctggccat
      421 cgagcagtac gaggagctgg tagacgtgaa ctgcagctct gtactgcgct tctttctctg
      481 tgccatgtac gcacccatct gtaccctgga gttcctgcac gatcccatca aaccctgcaa
      541 atctgtgtgc cagcgcgcac gcgacgactg cgagcccctc atgaagatgt ataaccacag
      601 ctggccagag agcctggctt gcgatgagct gcctgtctat gaccgtggag tgtgcatctc
      661 tccggaggcg atagtcactg accttccgga agatgtgaag tggatagaca tcacaccaga
      721 tatgatggtt caagaaaggt cctttgatgc tgactgtaaa catctgagcc ctgatcggtg
      781 caagtgcaaa aaggtgaagc caactttggc aacgtacctg agcaaaaact acagctatgt
      841 tattcatgcc aaaataaaag cggtccagag gagtggttgc aatgaggtca caactgtggt
      901 cgatgtaaaa gagatcttca agtcttcatc acctatccct cgaacgcaag tccccctcat
      961 caccaattcc tcctgccagt gtccacacat cctgccccat caagatgtcc taatcatgtg
     1021 ttatgagcgg cgttcaagga tgatgcttct tgaaaattgt ttagttgaga aatggagaga
     1081 tcaactaagc agaaggtcca cacagtggga agagaggctt caggaacagc agagaacaac
     1141 tcaggacaag aagcaaatag ccagccgcac cagtcgcagt aaccccccaa agccaaaggg
     1201 aaggtcacct gcttccaaac ctgccagtcc taagaagaac atcaaagcta gaagtgcacc
     1261 caaaaagtca aacccaaaga aaagtacaag ctaattactt tccaagttga agccaccctt
     1321 acaggataag gtggtactgc ctgggacagc cttccgaagg ccacacacca cttgccttag
     1381 gacccactgt ggttctcttt atagacatgt cttgcagcat ttctcttaat gatagcttca
     1441 gtatttctct ttaaaccaca gatccctgtt atttgtcagt tttcttttat ggaaaggtac
     1501 ctgtgttcag agtggcctgt gagcatactg tgtgaccttc tgctttgaga ttttgaccta
     1561 aaatctacct tataaagttc acatactatg tcaagcaaaa ctttttttga caaaaatatt
     1621 ggatatcctt tgacttctgt taggaagtta gtgatatata aaatgttatt gaaaaaaatg
     1681 tttttgacaa aggcagaaga atgatacata aaagaccttc atgtgtttgt tgtctgcaga
     1741 aagagttttc tgatgaatgt ggttttcaaa aacttgaggt atgggatgag ggaaatgata
     1801 atgtgggttt gtaaaacttt ctcttctgtc tttagttaga aatttctaaa acgaagccaa
     1861 aaatgatgag taaagggact gtcgatgttt atgttcttgc tgtctgattg ccacagcatc
     1921 ctggattctc ctcaacagtg acccatgagc caccccacag acagtatgct tcttttctcc
     1981 tgtatgactt gggtaccaag gagacatctt ggttaatcca tcaagagagc tgggccatcc
     2041 cactccaggg catcgta
//
