LOCUS       NM_001100700            2001 bp    mRNA    linear   ROD 09-JAN-2024
DEFINITION  Rattus norvegicus secreted frizzled-related protein 2 (Sfrp2),
            mRNA.
ACCESSION   NM_001100700 XM_001065174 XM_227314
VERSION     NM_001100700.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2001)
  AUTHORS   Zheng H, Li W, Huang G, Zhu H, Wen W, Liu X, Sun L, Ma T, Huang X,
            Hu Y and Huang Y.
  TITLE     Secreted frizzled-related protein 2 ameliorates diabetic
            cardiomyopathy by activating mitophagy
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166989 (2024)
   PUBMED   38101654
  REMARK    GeneRIF: Secreted frizzled-related protein 2 ameliorates diabetic
            cardiomyopathy by activating mitophagy.
REFERENCE   2  (bases 1 to 2001)
  AUTHORS   Lin M, Liu X, Zheng H, Huang X, Wu Y, Huang A, Zhu H, Hu Y, Mai W
            and Huang Y.
  TITLE     IGF-1 enhances BMSC viability, migration, and anti-apoptosis in
            myocardial infarction via secreted frizzled-related protein 2
            pathway
  JOURNAL   Stem Cell Res Ther 11 (1), 22 (2020)
   PUBMED   31918758
  REMARK    GeneRIF: IGF-1 enhances BMSC viability, migration, and
            anti-apoptosis in myocardial infarction via secreted
            frizzled-related protein 2 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2001)
  AUTHORS   Wang JC, Li YQ, Feng DY, Zhou X, Yan FQ, Li Y, Gao L and Li LH.
  TITLE     Loss of Sfrp2 contributes to the neurological disorders related
            with morphine withdrawal via Wnt/beta-catenin signaling
  JOURNAL   Behav Brain Res 359, 609-618 (2019)
   PUBMED   30291843
  REMARK    GeneRIF: Wnt signaling was activated in the nucleus accumbens of
            rats suffering from morphine withdrawal and that Sfrp2 attenuated
            the overexpression of Wnt signaling. Similarly, the withdrawal-like
            symptoms of morphine dependent rats were abrogated by intracerebral
            Sfrp2 injection. Damage on proximal spine density caused by
            morphine treatment was restored by intracerebral Sfrp2 injection.
REFERENCE   4  (bases 1 to 2001)
  AUTHORS   Akpulat U, Onbasilar I and Kocaefe YC.
  TITLE     Tenotomy immobilization as a model to investigate skeletal muscle
            fibrosis (with emphasis on Secreted frizzled-related protein 2)
  JOURNAL   Physiol Genomics 48 (6), 397-408 (2016)
   PUBMED   27113532
  REMARK    GeneRIF: Sfrp2 shows itself to be a therapeutic target for the
            prevention of irreversible fibrosis.
REFERENCE   5  (bases 1 to 2001)
  AUTHORS   Xavier CP, Melikova M, Chuman Y, Uren A, Baljinnyam B and Rubin JS.
  TITLE     Secreted Frizzled-related protein potentiation versus inhibition of
            Wnt3a/beta-catenin signaling
  JOURNAL   Cell Signal 26 (1), 94-101 (2014)
   PUBMED   24080158
REFERENCE   6  (bases 1 to 2001)
  AUTHORS   Roth W, Wild-Bode C, Platten M, Grimmel C, Melkonyan HS, Dichgans J
            and Weller M.
  TITLE     Secreted Frizzled-related proteins inhibit motility and promote
            growth of human malignant glioma cells
  JOURNAL   Oncogene 19 (37), 4210-4220 (2000)
   PUBMED   10980594
REFERENCE   7  (bases 1 to 2001)
  AUTHORS   Lee CS, Buttitta LA, May NR, Kispert A and Fan CM.
  TITLE     SHH-N upregulates Sfrp2 to mediate its competitive interaction with
            WNT1 and WNT4 in the somitic mesoderm
  JOURNAL   Development 127 (1), 109-118 (2000)
   PUBMED   10654605
REFERENCE   8  (bases 1 to 2001)
  AUTHORS   Leimeister C, Bach A, Woolf AS and Gessler M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
REFERENCE   9  (bases 1 to 2001)
  AUTHORS   Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA,
            Kiefer MC, Tomei LD and Umansky SR.
  TITLE     SARPs: a family of secreted apoptosis-related proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13636-13641 (1997)
   PUBMED   9391078
REFERENCE   10 (bases 1 to 2001)
  AUTHORS   Roy K, Mitsugi K and Sirotnak FM.
  TITLE     Additional organizational features of the murine folylpolyglutamate
            synthetase gene. Two remotely situated exons encoding an alternate
            5' end and proximal open reading frame under the control of a
            second promoter
  JOURNAL   J Biol Chem 272 (9), 5587-5593 (1997)
   PUBMED   9038166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161900.1.
            
            On or before May 31, 2008 this sequence version replaced
            XM_227314.4, XM_001065174.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161900.1, CB715407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2001
                     /gene="Sfrp2"
                     /note="secreted frizzled-related protein 2"
                     /db_xref="GeneID:310552"
                     /db_xref="RGD:735163"
     exon            1..711
                     /gene="Sfrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1097
                     /gene="Sfrp2"
                     /codon_start=1
                     /product="secreted frizzled-related protein 2 precursor"
                     /protein_id="NP_001094170.1"
                     /db_xref="GeneID:310552"
                     /db_xref="RGD:735163"
                     /translation="MLRGPASLLLLVLASHCCLGSARGLFLFGQPDFSYKRSNCKPIP
                     ANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPV
                     CLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDH
                     LLPPTEEAPKVCEACKTKNEDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKS
                     KTIYKLNGVSDRDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKRW
                     QKGQREFKRISRSIRKLQC"
     exon            712..792
                     /gene="Sfrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1977
                     /gene="Sfrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccccggg tcggagcccc ccggagctgc gcgcgggctt gcagtgcctt gcccgcgccg
       61 acctcctggc tcccggcttc gcgcgctcgc gccaccgact gtccagagcc cacgagcaga
      121 gcgagcgagt ccgggacgag ctcgggctcc gatcgccact cgcttcccca gctcggctcc
      181 ctcagccccc cgggggtcgc tagtccacga tgctgcgggg ccctgcctcg ctgcttctgc
      241 tagtcctcgc ctcgcactgc tgcctgggct cggcgcgtgg gctcttcctc ttcggccagc
      301 ccgacttctc ctacaagcgc agcaactgca agcccatccc cgccaacctg cagctgtgcc
      361 acggcatcga gtaccagaac atgcggctgc ccaacctgct gggccacgag accatgaagg
      421 aggtgctgga gcaagcgggc gcctggattc cgctggtcat gaagcagtgc cacccggaca
      481 ccaagaagtt cctgtgctcg ctcttcgccc ctgtctgtct cgacgaccta gacgagacca
      541 tccagccgtg tcactcgctc tgcgtgcagg tgaaggaccg ttgtgccccg gtcatgtccg
      601 ccttcggctt cccctggcca gacatgctgg agtgcgaccg cttcccgcag gacaacgatc
      661 tctgcatccc ccttgctagc agcgaccacc tcctgccgcc cacagaggaa gctcccaagg
      721 tgtgtgaagc ctgcaaaact aagaacgagg atgacaacga cataatggaa actctttgta
      781 aaaatgactt cgcactgaaa atcaaagtga aggagataac ctacatcaac agagacacca
      841 aaatcatcct ggagacaaag agcaagacca tttacaagct gaacggggtg tccgataggg
      901 acctgaagaa atcagtgctg tggctcaaag acagcctgca gtgcacctgt gaggagatga
      961 acgacatcaa cgctccctat ctggtcatgg gacagaaaca gggtggagag ctggtgatca
     1021 cctccgtgaa acggtggcag aagggccaga gagagttcaa gcgcatctcc cgcagcatcc
     1081 gcaagctgca atgctagttt cctagtggag tggcttctcg ccgaccaggc cctgggctcc
     1141 gtggaccact tccactctgc gacctcattt ccggtttccc aagtactgtc gggagagcta
     1201 cagtctcagc ttggagcagc ttgccctgcc ttttgcatgt gtgtatccta acgtgtcctg
     1261 agttataagg ccctaggagg ccccgggaac agatagctat tttcacataa agcgaaaagt
     1321 ccatccagat cttgtagaaa tattcacaac taataaaatc atgactgttt tttatgaagt
     1381 tttaaaacag ctcattttaa gggtagtttt gaatagctgt agtactgtga cccgaggggc
     1441 attttctctc tttggtcagt ctgttggttt atactgtgcc cttaggttgc catgtcaggc
     1501 aaattgtttc tttttttttc ccctctgtgg tctaagcgtg tgggtcccag acttggtggt
     1561 tgagataaag ctggctgtta tctcaaaggc tccctctgtt ccagcctgag actcggcgtc
     1621 taaatcttca aaggttttca ttgctcattt tacaccctca ttaactccga ccgttgcatg
     1681 catcccagcc cagctacaga acttcatttt ataagcacac attaaccatt cctcattgca
     1741 tgatgccttc aaataaaggg caacgtgaat acagtttata aatcaacgag tattttaagc
     1801 cttgtttaaa acatcttttt actccatttt ttttcttttt ttttttcttc aaactaaatc
     1861 attgtagcta acctgtaata tacgtagtag ttgacctgga aaagttgtaa aaatattgct
     1921 ttaaccgaca ctgtaaatat ttcagataaa cattatattc tttgtatata aactttaaaa
     1981 aaaaaaaaaa aaaaaaaaaa a
//
