LOCUS       NM_001276712            4170 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus secreted frizzled-related protein 1 (Sfrp1),
            mRNA.
ACCESSION   NM_001276712 XM_001072532 XM_224987
VERSION     NM_001276712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Zhu,H., Liu,X., Ouyang,W., Hao,Y., Ding,Z., Tan,K., Tang,J.,
            Zhao,J., Ding,X., Teng,Z., Deng,X., Wu,W. and Ding,Z.
  TITLE     Sfrp1 as a Pivotal Paracrine Factor in the Trained Pericardial Stem
            Cells that Foster Reparative Activity
  JOURNAL   Stem Cells Transl Med 13 (2), 137-150 (2024)
   PUBMED   37936560
  REMARK    GeneRIF: Sfrp1 as a Pivotal Paracrine Factor in the Trained
            Pericardial Stem Cells that Foster Reparative Activity.
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   Gu,Y., Ding,Y., Zhang,X., Li,Y. and Shang,Z.
  TITLE     Secreted frizzled-related protein 3 alleviated cardiac remodeling
            induced by angiotensin II via inhibiting oxidative stress and
            apoptosis in mice
  JOURNAL   Eur J Pharmacol 934, 175303 (2022)
   PUBMED   36174667
  REMARK    GeneRIF: Secreted frizzled-related protein 3 alleviated cardiac
            remodeling induced by angiotensin II via inhibiting oxidative
            stress and apoptosis in mice.
REFERENCE   3  (bases 1 to 4170)
  AUTHORS   Ipposhi,K., Tomokiyo,A., Ono,T., Yamashita,K., Alhasan,M.A.,
            Hasegawa,D., Hamano,S., Yoshida,S., Sugii,H., Itoyama,T., Ogawa,M.
            and Maeda,H.
  TITLE     Secreted Frizzled-Related Protein 1 Promotes Odontoblastic
            Differentiation and Reparative Dentin Formation in Dental Pulp
            Cells
  JOURNAL   Cells 10 (9), 2491 (2021)
   PUBMED   34572140
  REMARK    GeneRIF: Secreted Frizzled-Related Protein 1 Promotes Odontoblastic
            Differentiation and Reparative Dentin Formation in Dental Pulp
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4170)
  AUTHORS   Hu,Y.H., Liu,J., Lu,J., Wang,P.X., Chen,J.X., Guo,Y., Han,F.H.,
            Wang,J.J., Li,W. and Liu,P.Q.
  TITLE     sFRP1 protects H9c2 cardiac myoblasts from doxorubicin-induced
            apoptosis by inhibiting the Wnt/PCP-JNK pathway
  JOURNAL   Acta Pharmacol Sin 41 (9), 1150-1157 (2020)
   PUBMED   32238888
  REMARK    GeneRIF: sFRP1 protects H9c2 cardiac myoblasts from
            doxorubicin-induced apoptosis by inhibiting the Wnt/PCP-JNK
            pathway.
REFERENCE   5  (bases 1 to 4170)
  AUTHORS   Liu,H.P., Hao,D.J., Wang,X.D., Hu,H.M., Li,Y.B. and Dong,X.H.
  TITLE     MiR-30a-3p promotes ovariectomy-induced osteoporosis in rats via
            targeting SFRP1
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (22), 9754-9760 (2019)
   PUBMED   31799642
  REMARK    GeneRIF: MiR-30a-3p promotes ovariectomy-induced osteoporosis in
            rats via targeting SFRP1.
REFERENCE   6  (bases 1 to 4170)
  AUTHORS   Bafico,A., Gazit,A., Pramila,T., Finch,P.W., Yaniv,A. and
            Aaronson,S.A.
  TITLE     Interaction of frizzled related protein (FRP) with Wnt ligands and
            the frizzled receptor suggests alternative mechanisms for FRP
            inhibition of Wnt signaling
  JOURNAL   J Biol Chem 274 (23), 16180-16187 (1999)
   PUBMED   10347172
REFERENCE   7  (bases 1 to 4170)
  AUTHORS   Zhou,Z., Wang,J., Han,X., Zhou,J. and Linder,S.
  TITLE     Up-regulation of human secreted frizzled homolog in apoptosis and
            its down-regulation in breast tumors
  JOURNAL   Int J Cancer 78 (1), 95-99 (1998)
   PUBMED   9724099
REFERENCE   8  (bases 1 to 4170)
  AUTHORS   Melkonyan,H.S., Chang,W.C., Shapiro,J.P., Mahadevappa,M.,
            Fitzpatrick,P.A., Kiefer,M.C., Tomei,L.D. and Umansky,S.R.
  TITLE     SARPs: a family of secreted apoptosis-related proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13636-13641 (1997)
   PUBMED   9391078
REFERENCE   9  (bases 1 to 4170)
  AUTHORS   Finch,P.W., He,X., Kelley,M.J., Uren,A., Schaudies,R.P.,
            Popescu,N.C., Rudikoff,S., Aaronson,S.A., Varmus,H.E. and
            Rubin,J.S.
  TITLE     Purification and molecular cloning of a secreted, Frizzled-related
            antagonist of Wnt action
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6770-6775 (1997)
   PUBMED   9192640
REFERENCE   10 (bases 1 to 4170)
  AUTHORS   Leung,A.K. and Robson,W.L.
  TITLE     Urinary tract infection in infancy and childhood
  JOURNAL   Adv Pediatr 38, 257-285 (1991)
   PUBMED   1927703
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Feb 26, 2021 this sequence version replaced NM_001276712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.51027.1,
                                           SRR26643295.53018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-819               JAXUCZ010000016.1  75315918-75316736   c
            820-897             JAXUCZ010000016.1  75311290-75311367   c
            898-4170            JAXUCZ010000016.1  75278325-75281597   c
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..4170
                     /gene="Sfrp1"
                     /gene_synonym="sFRP-1"
                     /note="secreted frizzled-related protein 1"
                     /db_xref="GeneID:84402"
                     /db_xref="RGD:621074"
     exon            1..819
                     /gene="Sfrp1"
                     /gene_synonym="sFRP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1220
                     /gene="Sfrp1"
                     /gene_synonym="sFRP-1"
                     /codon_start=1
                     /product="secreted frizzled-related protein 1 precursor"
                     /protein_id="NP_001263641.2"
                     /db_xref="GeneID:84402"
                     /db_xref="RGD:621074"
                     /translation="MGVGRNARGRGGAASGVLLALAAALLAAGSASEYDYVSFQSDIG
                     SYQSGRFYTKPPQCVDIPVDLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLN
                     KNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKF
                     PEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKK
                     ENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDNLSHNFLIMGRKVK
                     SQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK"
     exon            820..897
                     /gene="Sfrp1"
                     /gene_synonym="sFRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..4170
                     /gene="Sfrp1"
                     /gene_synonym="sFRP-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagcgcc gcaagtaggt gcagcagccc gcagctcgcc gcgcctctgc gagccgggac
       61 ggcactcggc cccgcgcgct ccccgcctcg cgccagcccc gccgccggga cctgcggcag
      121 ccgaagaccc catcgatcag agactcgggg agcagcgcgc ggccccgagc cggacggggc
      181 cgggcactgc gcctttgtcc ccggaggctc cgggaagttt gcagcgggac gcgcgcgtga
      241 aagcagcgtg ggcagccccg acgtcgccga gcagcatggg cgtcgggcgc aacgcgcggg
      301 gtcgcggcgg ggccgcctcc ggcgtgctgc tggcgttggc cgccgcgctg ctggccgcgg
      361 gttcggccag cgagtacgac tacgtgagct tccagtcgga tatcggctcc tatcagagcg
      421 ggcgcttcta caccaagccc ccgcagtgcg tggacatccc ggtggacctg cggctgtgcc
      481 acaacgtggg ctacaagaag atggtgctgc ccaacctgct ggagcacgag accatggcag
      541 aggtgaagca gcaggccagc agctgggtgc cgctgctcaa caagaactgc cacatgggca
      601 cccaggtctt cctctgctcg ctcttcgcgc ccgtctgtct ggaccggcct atctacccgt
      661 gtcgctggct ctgcgaggct gttcgcgact cgtgcgagcc ggtcatgcag ttcttcggct
      721 tctactggcc cgagatgctc aaatgtgaca agttccccga gggcgacgtc tgcatcgcca
      781 tgaccccgcc caatgccacc gaagcctcga agccccaagg tacaacagtg tgtcctccgt
      841 gtgacaacga gttgaaatcg gaggccatca tcgaacatct ctgtgcaagc gagtttgcgc
      901 tgagaatgaa aatcaaagaa gtaaaaaagg aaaacggtga caagaagatt gtccccaaga
      961 agaagaaacc cttgaagctg gggcccatca agaagaagga gctgaagcgg ctcgtgcttt
     1021 tcctaaagaa tggcgccgac tgtccctgcc accagctgga caacctcagc cacaacttcc
     1081 tcatcatggg gcgcaaggtg aagagccagt acttgctcac agccattcac aagtgggaca
     1141 agaaaaacaa ggagttcaaa aacttcatga agaaaatgaa aaaccacgag tgtcccacct
     1201 tccagtctgt ttttaagtga cgctggggtg gactggggag ggagcgtggc ttggggtgag
     1261 ggtgggggcg tgtgaatgac cctggctctt ggggttcaca tgttgctctc tcccattaca
     1321 gttgtggctt ttgcatcgca cctggctctg ttcctacagc gatccctctc ccttccctcc
     1381 acagccaatc cagctaaggc cctttagatt aggaaggctt ttttttttta agggctgcag
     1441 cagggccagc aggcacaagg agagtcagaa tcctttcact gagcctcagg cacaaaacag
     1501 aaaatgtttg ccagtttggg gaaaaaaaaa aaaggattgt aaagaagtgc aggaggacag
     1561 tcattcagct tgaagttgtt ctgaacagca ttcccaattc cttgtggagt ctaaagcctt
     1621 tacaacccct ctctttctgc cttagataga aacaagacca ttgtcacctt caacacacac
     1681 acacacacac acacacacac acacacacac acacacacac acacacacac aaggggctgg
     1741 aaactgtagg tctcaaatgg acatttcatc gggataccag gatggcaggg atctgctttt
     1801 gtatgaggag gaacgtgagc atgaagagaa tgaggcgttt cagactgaga agccaatggt
     1861 tactagtttt caaaaataat agtgaaagaa aagaacaaat gtagacggtc aagcaggtca
     1921 cgagtcaggg tgactgggga atcctgtgtg gaagggcctc acattgtaat cccgtctgtc
     1981 acatttcgaa agaacagaga cataaacagt gataaaaccc cacacatctt ccgaggcttg
     2041 gataaaactc cacactgagc atttcaaaga taaccaagac taacatcgcg gattgcccaa
     2101 ggcgccctct taataagcac actgcgcata tgctgtggaa ggcaagtctg tctgcgcatg
     2161 tgctgtggag gagatgggcg tggcatcatg gctgtgccta gctgccatgt cagtggaagg
     2221 agacaagtgt ccacaatgct gcccggactc tgcttttctg caaggagagc cctttttctt
     2281 aaacacgatt gcctataatt ccaacaaaat tggaattgct gcctgcctga gccctccacc
     2341 tttatttttg tatgcctcca ctcacgttct tttgaggcta agccctaccc gaggagatgg
     2401 tttcaaaggc accatcggca gtttccccaa gtgcccaaag gtatttctta aagttggtat
     2461 gcttaataag tgatgtaaat attccagttc tctttggtag ccttactcct gttgtccgag
     2521 tagttcttct tcttcttttt ttttaaagct aatttcttcc accaaagtct gattattcac
     2581 tccccaccac atctcaaggg ccacagtggc tgtccctttg gcttactcaa tccagaggca
     2641 gcattggttg tgaagagtca tgtgatctag tggccttgga ttggcacaga agcagaaaac
     2701 ttctggttac ttctgaaaga ctccggcctg aaaattacca tgccaaccta gttaccgatc
     2761 taagtggggt agtgagctaa ttaactttat gtctagtaat tctattatcc taacactttt
     2821 aagaattcta ccaaccttaa tcataacggt attaagaatc ttaaatgatt tgccgataat
     2881 tgtatatgat ttaattagta atttgaaata gtctaccttt tcattgtcca actgaaagac
     2941 aaattttcat gagtgtagat ttgggcctcc agccactagt cagtgcctag tgagggtctg
     3001 ttcattttgg caaagttcac catgtggcag ggccctctcc aagtggcaga ggaccaccta
     3061 tattaatttt tctgaggatg gtagcagttt cacagaacaa aagtgacagc ctgtgctggg
     3121 cagattagga atcctcaggt aggaggcaac attctcagaa aggattcaca atcaactgat
     3181 cacgtgaact ccagcgactg tcctcccact ccagaatccc cggctttaga gttccattgt
     3241 ggacctgtga ggattttaga cacgcacaca gaccagtttt gtctctacta catcagcagt
     3301 tctagacaaa aagggaggct aagggcccaa agctgcgtga tcagcagcct ttgtccatta
     3361 caacaaaagg tataacaaac caatgtgcag actcgttggc tttgcccctg gtttccaatg
     3421 gtggaggtcc atgtgtgctc tgaccagcgt tgccagtgaa aagaagagct ttaaaatagc
     3481 cattctggag agtcaggaaa agccaacccc ccccaccccc ccaaccaaac ttttggaaac
     3541 taccagtagt tatcttggaa aataggctcg gaggcacgaa ttgtaaagat attctacttt
     3601 aaaaacattc tgtagcaata ctcaaaactc gtggttggtg ggttagcact gtgttctccc
     3661 tggggcagag tccaggcttc ctgtgaatgt gtaaattaca gaactctcgg ttcccaaagc
     3721 tagaacctgt ttttcttgtt agccttcgtg taaccagatg ctctgttgta ccttcatagc
     3781 tggaagtgtt tcaagatgag cttcagaagc aaacctgaag cttcatcttc acaatggcat
     3841 gctgactgct ctgacctggc actgcgggtc ctaagcacat atgtggaatc cctgttggcc
     3901 ctagtccccg cgcccctgcc ccccttgccc cgtgaggact ccactttata gcctaaacct
     3961 tttatacaaa agctttggat actgtgaaga tgttttacat tccatttcgt tcgtgttgtt
     4021 tttttttttt aactacattt gaccagatgt tttgatgtta tcacttatgt taatagtaat
     4081 tcccagatgt gttttgttct cattgctttc cctgccgtgt attcactaaa atcactcgat
     4141 caataacagt gtgagttgtg attggcccaa
//
