LOCUS       NM_001025271            2510 bp    mRNA    linear   ROD 12-DEC-2023
DEFINITION  Rattus norvegicus splicing factor proline and glutamine rich
            (Sfpq), mRNA.
ACCESSION   NM_001025271 XM_342920
VERSION     NM_001025271.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Jiao W, Li W, Li T, Feng T, Wu C and Zhao D.
  TITLE     Induced pluripotent stem cell-derived extracellular vesicles
            overexpressing SFPQ protect retinal Muller cells against
            hypoxia-induced injury
  JOURNAL   Cell Biol Toxicol 39 (6), 2647-2663 (2023)
   PUBMED   36790503
  REMARK    GeneRIF: Induced pluripotent stem cell-derived extracellular
            vesicles overexpressing SFPQ protect retinal Muller cells against
            hypoxia-induced injury.
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D,
            Dubois E, Schwartz O, Bennasser Y and Benkirane M.
  TITLE     HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex
            that Regulates DNA-Mediated Innate Immune Response
  JOURNAL   Mol Cell 67 (3), 387-399 (2017)
   PUBMED   28712728
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Lee M, Sadowska A, Bekere I, Ho D, Gully BS, Lu Y, Iyer KS,
            Trewhella J, Fox AH and Bond CS.
  TITLE     The structure of human SFPQ reveals a coiled-coil mediated polymer
            essential for functional aggregation in gene regulation
  JOURNAL   Nucleic Acids Res 43 (7), 3826-3840 (2015)
   PUBMED   25765647
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Sury MD, McShane E, Hernandez-Miranda LR, Birchmeier C and Selbach
            M.
  TITLE     Quantitative proteomics reveals dynamic interaction of c-Jun
            N-terminal kinase (JNK) with RNA transport granule proteins
            splicing factor proline- and glutamine-rich (Sfpq) and non-POU
            domain-containing octamer-binding protein (Nono) during neuronal
            differentiation
  JOURNAL   Mol Cell Proteomics 14 (1), 50-65 (2015)
   PUBMED   25326457
  REMARK    GeneRIF: Quantitative proteomics reveals dynamic interaction of JNK
            with RNA transport granule proteins Sfpq and Nono during neuronal
            differentiation
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Zanivan S, Maione F, Hein MY, Hernandez-Fernaud JR, Ostasiewicz P,
            Giraudo E and Mann M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Zhong N, Kim CY, Rizzu P, Geula C, Porter DR, Pothos EN, Squitieri
            F, Heutink P and Xu J.
  TITLE     DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase
            by inhibiting the sumoylation of pyrimidine tract-binding
            protein-associated splicing factor
  JOURNAL   J Biol Chem 281 (30), 20940-20948 (2006)
   PUBMED   16731528
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi
            SP, Geula C and Yankner BA.
  TITLE     The Parkinson's disease-associated DJ-1 protein is a
            transcriptional co-activator that protects against neuronal
            apoptosis
  JOURNAL   Hum Mol Genet 14 (9), 1231-1241 (2005)
   PUBMED   15790595
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Ju BG, Solum D, Song EJ, Lee KJ, Rose DW, Glass CK and Rosenfeld
            MG.
  TITLE     Activating the PARP-1 sensor component of the groucho/ TLE1
            corepressor complex mediates a CaMKinase IIdelta-dependent
            neurogenic gene activation pathway
  JOURNAL   Cell 119 (6), 815-829 (2004)
   PUBMED   15607978
  REMARK    Erratum:[Cell. 2006 Dec 16;127(6):1283]
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Kanai Y, Dohmae N and Hirokawa N.
  TITLE     Kinesin transports RNA: isolation and characterization of an
            RNA-transporting granule
  JOURNAL   Neuron 43 (4), 513-525 (2004)
   PUBMED   15312650
REFERENCE   10 (bases 1 to 2510)
  AUTHORS   Too CK, Knee R, Pinette AL, Li AW and Murphy PR.
  TITLE     Prolactin induces expression of FGF-2 and a novel FGF-responsive
            NonO/p54nrb-related mRNA in rat lymphoma cells
  JOURNAL   Mol Cell Endocrinol 137 (2), 187-195 (1998)
   PUBMED   9605521
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098731.1.
            
            On Jul 14, 2005 this sequence version replaced XM_342920.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2510
                     /gene="Sfpq"
                     /note="splicing factor proline and glutamine rich"
                     /db_xref="GeneID:252855"
                     /db_xref="RGD:727923"
     exon            1..877
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2173
                     /gene="Sfpq"
                     /note="NonO/p54nrb homolog; splicing factor
                     proline/glutamine-rich; splicing factor proline/glutamine
                     rich (polypyrimidine tract binding protein associated)"
                     /codon_start=1
                     /product="splicing factor, proline- and glutamine-rich"
                     /protein_id="NP_001020442.1"
                     /db_xref="GeneID:252855"
                     /db_xref="RGD:727923"
                     /translation="MSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNR
                     GPMGPGPGGPKPPLPPPPPHQQQQQPPPQQPPPQQPPPHQQPPPHQPPHQQPPPPPQE
                     SKPVVPQGPGSAPGVSTAPPPAVSAPPANPPTTGAPPGPGPTPTPPPAVPSTAPGPPP
                     PSTPSSGVSTTPPQTGGPPPPPAGGAGPGPKQGPGPGGPKGGKMPGGPKPGGGPGMGA
                     PGGHPKPPHRGGGEPRGGRQHHAPYHQQHHQGPPPGGPGPRTEEKISDSEGFKANLSL
                     LRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESR
                     ALAEIAKAELDDTPMRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERA
                     VVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVIVEPLEQLDDEDG
                     LPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAK
                     DKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELHSQEMQKRKEMQLRQEEERRRR
                     EEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGTMNMGDPYGSGGQKFP
                     PLGGGGGIGYEANPGVPPATMSGSMMGSDMRTERFGQGGAGPVGGQGPRGMGPGTPAG
                     YGRGREEYEGPNKKPRF"
     exon            878..1066
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1368
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1464
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1661
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1746
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1864
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1913
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2035
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2481
                     /gene="Sfpq"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctaagcaag gtggcaacca cgttccctga gcgacttctc cgcttctgcc tcgaccgccc
       61 cttgactaca gatatgtctc gggatcggtt ccggagccgc ggtggtggtg gtggaggctt
      121 tcatcggcgt ggaggaggcg gtggccgcgg cggcctccac gacttccgct ctccgccgcc
      181 tggcatgggc ctcaaccaga atcgcggccc catgggcccc ggccctggcg gcccgaagcc
      241 accgctcccg cctccacctc cgcaccagca gcagcagcaa cctccgccgc agcagccccc
      301 gccgcagcag cctccaccgc accagcagcc gccgccacac cagccgcccc atcaacagcc
      361 cccgcctccg ccgcaggaat ccaagcccgt cgtcccgcaa ggccccggct cggcgcccgg
      421 agtgagcact gcgccgcctc cggcggtctc ggccccgccc gccaaccccc ctaccaccgg
      481 cgccccgccg ggcccgggtc ctaccccgac tccgccgccc gcagtcccct ctactgcccc
      541 cggaccgcct cccccttcca cgccgagcag cggagtctca acaacgcctc cacagaccgg
      601 tggccctccg ccaccgcccg ccgggggcgc cggtccaggg cctaagcaag gcccaggccc
      661 tggcggtccc aaaggcggca agatgccggg tgggcctaag cctggcggtg gtccgggcat
      721 gggcgctcct ggtggccacc cgaagccacc tcaccgaggt ggcggggagc cccgtggggg
      781 ccggcagcac cacgcgccct accaccagca gcaccatcag ggcccccctc ccggcggccc
      841 gggacctcgc acagaggaaa agatatccga ctcggaggga tttaaagcca acttgtctct
      901 cttgcggagg cctggagaaa aaacttacac acagcgctgt cggttgtttg tggggaacct
      961 acctgctgat atcacagagg atgaattcaa aagactgttt gctaaatacg gagaaccggg
     1021 agaagttttt atcaacaagg gcaaagggtt cgggttcatt aaacttgagt caagagcctt
     1081 ggctgaaatt gccaaagctg aacttgatga tacccccatg agaggtagac agctacgggt
     1141 tcggtttgcc acacatgctg cagccctgtc tgttcggaat ctttctcctt atgtatccaa
     1201 tgaacttttg gaagaggcct ttagccagtt tggtcctatt gaaagggctg ttgtaattgt
     1261 ggatgatcgt ggaagatcca cggggaaagg cattgttgaa tttgcttcga agccagcagc
     1321 aagaaaagca tttgaaagat gcagtgaagg tgttttccta ctgacaacga ctcctcgccc
     1381 agtcattgtg gaaccacttg agcagttaga tgatgaagat ggtcttcctg aaaaactggc
     1441 ccagaagaat ccaatgtatc aaaaggagag agaaacgcct cctcgttttg ctcagcatgg
     1501 cacatttgag tatgaatatt ctcaacgatg gaagtctttg gatgaaatgg aaaaacagca
     1561 aagggaacaa gttgaaaaaa acatgaagga tgcaaaagac aagttggaaa gtgaaatgga
     1621 agatgcctac catgaacacc aagcaaatct tttgcgccaa gatctgatga gacgccagga
     1681 agaattaagg cgcatggagg aacttcacag tcaagaaatg cagaaacgta aagaaatgca
     1741 gttgaggcaa gaggaggaac ggcgtagaag agaggaagag atgatgattc gccaacgtga
     1801 gatggaagaa caaatgagac gccaacgaga agaaagctac agcaggatgg gctacatgga
     1861 tccaagagaa agagacatga gaatgggtgg tggtggaaca atgaacatgg gagatcccta
     1921 tggttcagga ggccagaaat ttccaccgct aggtggtggt ggtggcatag gttatgaagc
     1981 taatcctgga gttccaccag caaccatgag tggttccatg atgggaagcg acatgcgtac
     2041 tgagcgcttt gggcagggag gtgcgggtcc tgtgggtgga cagggtccta gaggaatggg
     2101 gcctggaacg ccagcaggat atggtagagg gagagaagag tatgaagggc caaataaaaa
     2161 accccgattt tagatactta ggctttcatt ccagtttggt tttgtcttct tgtttagata
     2221 ccacttaaat tcttggcatt ttagtaagaa agctaccttt ttatggatgt tagcagttta
     2281 ttgacctgat atttgtaaat ggcctgtttg ggcaggtaaa attatgtaac gcagtgttcg
     2341 aaacaggaga aaaatttttt catttacttt ttttttaact gtataatgtt tctcaagtta
     2401 atggcagtgt accttgtgcc actgaatttc caaagtgtac catttttttt ttactgtgct
     2461 tcaaataaat agaaaaaaat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
