LOCUS       NM_001011951            1565 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus splicing factor 3B subunit 4 (Sf3b4), mRNA.
ACCESSION   NM_001011951 XM_238245
VERSION     NM_001011951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Li,Y., Diao,Y., Wang,Z., Wang,S., Peng,J. and Kong,B.
  TITLE     The splicing factor SF3B4 drives proliferation and invasion in
            cervical cancer by regulating SPAG5
  JOURNAL   Cell Death Discov 8 (1), 326 (2022)
   PUBMED   35853859
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1565)
  AUTHORS   Liu,Z., Li,W., Pang,Y., Zhou,Z., Liu,S., Cheng,K., Qin,Q., Jia,Y.
            and Liu,S.
  TITLE     SF3B4 is regulated by microRNA-133b and promotes cell proliferation
            and metastasis in hepatocellular carcinoma
  JOURNAL   EBioMedicine 38, 57-68 (2018)
   PUBMED   30391496
REFERENCE   3  (bases 1 to 1565)
  AUTHORS   Shen,Q., Eun,J.W., Lee,K., Kim,H.S., Yang,H.D., Kim,S.Y., Lee,E.K.,
            Kim,T., Kang,K., Kim,S., Min,D.H., Oh,S.N., Lee,Y.J., Moon,H.,
            Ro,S.W., Park,W.S., Lee,J.Y. and Nam,S.W.
  TITLE     Barrier to autointegration factor 1, procollagen-lysine,
            2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as
            early-stage cancer decision markers and drivers of hepatocellular
            carcinoma
  JOURNAL   Hepatology 67 (4), 1360-1377 (2018)
   PUBMED   29059470
  REMARK    Erratum:[Hepatology. 2018 Jul;68(1):391. doi: 10.1002/hep.30114..
            PMID: 29975814]
REFERENCE   4  (bases 1 to 1565)
  AUTHORS   Zhang,X., Yan,C., Zhan,X., Li,L., Lei,J. and Shi,Y.
  TITLE     Structure of the human activated spliceosome in three
            conformational states
  JOURNAL   Cell Res 28 (3), 307-322 (2018)
   PUBMED   29360106
REFERENCE   5  (bases 1 to 1565)
  AUTHORS   Teng,T., Tsai,J.H., Puyang,X., Seiler,M., Peng,S., Prajapati,S.,
            Aird,D., Buonamici,S., Caleb,B., Chan,B., Corson,L., Feala,J.,
            Fekkes,P., Gerard,B., Karr,C., Korpal,M., Liu,X., T Lowe,J.,
            Mizui,Y., Palacino,J., Park,E., Smith,P.G., Subramanian,V.,
            Wu,Z.J., Zou,J., Yu,L., Chicas,A., Warmuth,M., Larsen,N. and Zhu,P.
  TITLE     Splicing modulators act at the branch point adenosine binding
            pocket defined by the PHF5A-SF3b complex
  JOURNAL   Nat Commun 8, 15522 (2017)
   PUBMED   28541300
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1565)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1565)
  AUTHORS   Bernier,F.P., Caluseriu,O., Ng,S., Schwartzentruber,J.,
            Buckingham,K.J., Innes,A.M., Jabs,E.W., Innis,J.W., Schuette,J.L.,
            Gorski,J.L., Byers,P.H., Andelfinger,G., Siu,V., Lauzon,J.,
            Fernandez,B.A., McMillin,M., Scott,R.H., Racher,H., Majewski,J.,
            Nickerson,D.A., Shendure,J., Bamshad,M.J. and Parboosingh,J.S.
  CONSRTM   FORGE Canada Consortium
  TITLE     Haploinsufficiency of SF3B4, a component of the pre-mRNA
            spliceosomal complex, causes Nager syndrome
  JOURNAL   Am J Hum Genet 90 (5), 925-933 (2012)
   PUBMED   22541558
REFERENCE   8  (bases 1 to 1565)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   9  (bases 1 to 1565)
  AUTHORS   Will,C.L., Schneider,C., Hossbach,M., Urlaub,H., Rauhut,R.,
            Elbashir,S., Tuschl,T. and Luhrmann,R.
  TITLE     The human 18S U11/U12 snRNP contains a set of novel proteins not
            found in the U2-dependent spliceosome
  JOURNAL   RNA 10 (6), 929-941 (2004)
   PUBMED   15146077
REFERENCE   10 (bases 1 to 1565)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078997.1.
            
            On Feb 11, 2005 this sequence version replaced XM_238245.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078997.1, SRR8487231.138883.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1565
                     /gene="Sf3b4"
                     /note="splicing factor 3B subunit 4"
                     /db_xref="GeneID:295270"
                     /db_xref="RGD:1309667"
     exon            1..271
                     /gene="Sf3b4"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1512
                     /gene="Sf3b4"
                     /codon_start=1
                     /product="splicing factor 3B subunit 4"
                     /protein_id="NP_001011951.1"
                     /db_xref="GeneID:295270"
                     /db_xref="RGD:1309667"
                     /translation="MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHM
                     PKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANI
                     FIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIE
                     AMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPP
                     SAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAGGHGPP
                     AAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPP
                     PRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPP
                     PYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ"
     exon            272..400
                     /gene="Sf3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            401..943
                     /gene="Sf3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1150
                     /gene="Sf3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1324
                     /gene="Sf3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1533
                     /gene="Sf3b4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaactgta tcaagaccgg ctgattcact tctgttccac cccgattgct gcggcagctc
       61 cagagcacct ttcccttctg tccgacacga atctgactcc taagatggcc gcgatcgctt
      121 ccggctcctc ccttgtcgcc ggccccgccc aatgtgagcc ttggcccgga agtggaagta
      181 gaaactgagg tcaggggggc ggtgctgctg cttagagacg gcgggagccc tttcgccatg
      241 gctgccggac cgatctccga acggaatcag gatgccacgg tgtacgtggg aggtctagac
      301 gagaaagtga gcgagccact gctatgggag ctctttctcc aggcagggcc agtggtcaac
      361 acccacatgc caaaggatag agtcactggc cagcaccaag gctatggctt tgttgaattc
      421 ttgagtgagg aagatgctga ctatgccatt aagattatga acatgatcaa actctatggg
      481 aagccaatac gggtgaacaa agcctcggct cacaacaaaa acctggatgt aggagccaac
      541 attttcattg gaaatctgga cccagaaatt gatgagaagt tgctttacga tacttttagc
      601 gcctttggag tcatcttaca gacccccaag attatgcggg accctgacac aggcaactcc
      661 aagggttacg ccttcattaa ttttgcttca tttgatgctt cagatgcagc aattgaggcc
      721 atgaatgggc agtacctgtg taaccgccct atcactgtgt cttatgcctt caagaaggac
      781 tctaagggtg aacgacatgg ctcagcagct gaacgacttc tggcagccca gaacccgctg
      841 tctcaggctg accgccctca tcagctgttt gccgatgcac cccctccacc ctctgccccc
      901 aatcctgtgg tttcatccct gggttctggg cttcctccac caggaatgcc acctcctggt
      961 tcgttcccac ctccagtgcc acctcctggg gcccttcctc ctgggatacc cccagcaatg
     1021 cccccaccac ctatgccacc tggggctgga ggacatggtc ccccagcagc aggaactcca
     1081 ggggctggac atcctggtca tggacattca catcctcatc cattcccacc aggtgggatg
     1141 ccccatccag ggatgtccca gatgcagctg gcccaccatg gcccccatgg cctaggacac
     1201 ccccatgctg ggcctccagg ctctggaggg cagccaccac cccgaccacc ccctggaatg
     1261 cctcatcctg gaccacctcc gatgggcatg cctccccgag ggcctccttt tggatctccc
     1321 atgggtcacc caggtcccat gcctccacac ggtatgcgtg ggcctcctcc attgatgccc
     1381 cctcatggat acaccggtcc tccgagaccc cctccctatg gctaccagcg gggacccctc
     1441 cctccaccca gacccactcc acggccccca gttcctcctc gtggtccact tcggggccca
     1501 cttcctcagt aaatggtcat cctttgtctc cttaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaa
//
