LOCUS       NM_001106187            4524 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus splicing factor 3b, subunit 3 (Sf3b3), mRNA.
ACCESSION   NM_001106187 XM_001077410 XM_214697
VERSION     NM_001106187.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4524)
  AUTHORS   Zhang X, Yan C, Zhan X, Li L, Lei J and Shi Y.
  TITLE     Structure of the human activated spliceosome in three
            conformational states
  JOURNAL   Cell Res 28 (3), 307-322 (2018)
   PUBMED   29360106
REFERENCE   2  (bases 1 to 4524)
  AUTHORS   Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will
            CL, Urlaub H, Kastner B, Luhrmann R and Stark H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   3  (bases 1 to 4524)
  AUTHORS   Teng T, Tsai JH, Puyang X, Seiler M, Peng S, Prajapati S, Aird D,
            Buonamici S, Caleb B, Chan B, Corson L, Feala J, Fekkes P, Gerard
            B, Karr C, Korpal M, Liu X, T Lowe J, Mizui Y, Palacino J, Park E,
            Smith PG, Subramanian V, Wu ZJ, Zou J, Yu L, Chicas A, Warmuth M,
            Larsen N and Zhu P.
  TITLE     Splicing modulators act at the branch point adenosine binding
            pocket defined by the PHF5A-SF3b complex
  JOURNAL   Nat Commun 8, 15522 (2017)
   PUBMED   28541300
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4524)
  AUTHORS   Cretu C, Schmitzova J, Ponce-Salvatierra A, Dybkov O, De Laurentiis
            EI, Sharma K, Will CL, Urlaub H, Luhrmann R and Pena V.
  TITLE     Molecular Architecture of SF3b and Structural Consequences of Its
            Cancer-Related Mutations
  JOURNAL   Mol Cell 64 (2), 307-319 (2016)
   PUBMED   27720643
REFERENCE   5  (bases 1 to 4524)
  AUTHORS   Cordero-Espinoza L and Hagen T.
  TITLE     Regulation of Cullin-RING ubiquitin ligase 1 by
            Spliceosome-associated protein 130 (SAP130)
  JOURNAL   Biol Open 2 (8), 838-844 (2013)
   PUBMED   23951410
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4524)
  AUTHORS   Chen YI, Moore RE, Ge HY, Young MK, Lee TD and Stevens SW.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   7  (bases 1 to 4524)
  AUTHORS   Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S,
            Tuschl T and Luhrmann R.
  TITLE     The human 18S U11/U12 snRNP contains a set of novel proteins not
            found in the U2-dependent spliceosome
  JOURNAL   RNA 10 (6), 929-941 (2004)
   PUBMED   15146077
REFERENCE   8  (bases 1 to 4524)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 4524)
  AUTHORS   Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK,
            Chait BT and Roeder RG.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB706187.1, CB767922.1, FM083013.1, CA512836.1, BC168883.1 and
            CA505966.1.
            
            On or before May 30, 2010 this sequence version replaced
            XM_214697.6, XM_001077410.3, NM_001106187.1.
            
            Sequence Note: This RefSeq record was assembled using transcripts
            from multiple strains because no single transcript was available
            for the full length of the gene.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               CB706187.1         5-330
            327-589             CB767922.1         154-416
            590-753             FM083013.1         36-199
            754-1095            CA512836.1         174-515
            1096-4228           BC168883.1         1-3133
            4229-4524           CA505966.1         1-296               c
FEATURES             Location/Qualifiers
     source          1..4524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4524
                     /gene="Sf3b3"
                     /note="splicing factor 3b, subunit 3"
                     /db_xref="GeneID:292019"
                     /db_xref="RGD:1311636"
     exon            1..103
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            104..240
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..3824
                     /gene="Sf3b3"
                     /codon_start=1
                     /product="splicing factor 3B subunit 3"
                     /protein_id="NP_001099657.2"
                     /db_xref="GeneID:292019"
                     /db_xref="RGD:1311636"
                     /translation="MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPD
                     PNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKI
                     HQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEA
                     HKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLN
                     HVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRN
                     DLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVP
                     VAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPL
                     KNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVS
                     ELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSC
                     SLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYF
                     EMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDC
                     LQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPV
                     TGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLE
                     FASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLI
                     IIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPK
                     AGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLI
                     LSPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDL
                     GKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYP
                     RWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQK
                     AEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEM
                     HLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEV
                     SKKLEDIRTRYAF"
     exon            241..567
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..740
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..882
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            883..995
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1133
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1237
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1403
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1499
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1572
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1724
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1880
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2036
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2180
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2303
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2458
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2633
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2839
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2996
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3122
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3335
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3434
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3578
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3683
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..4508
                     /gene="Sf3b3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaggctaa tggcggacgc cggcgggttg gcagtggtgg tggcttaggc cttgaaggga
       61 ttcagcatcc gtcgggtatc gaagccatcc ttcttgcagc aggcctgctt tgacttggaa
      121 ctgttgccat aaccaagacg tgactgagtg tcacagcttt gcttgtcatc atgtttctgt
      181 acaacttgac cttacagcgg gccactggca tcagctttgc catccatggc aacttctctg
      241 gaaccaaaca acaggaaatt gtcgtttccc gtgggaagat tttggagtta cttcgcccag
      301 atcctaacac tggcaaagtg catacccttc tcactgttga agtttttggt gttatccggt
      361 cacttatggc atttaggcta acaggtggca ccaaagacta cattgtagtt ggcagtgact
      421 caggccgaat tgttatcttg gaataccagc catcaaagaa tatgtttgag aaaattcacc
      481 aagaaacttt cggcaaaagt ggatgtcgcc gtattgttcc tggccagttc ttagccgtgg
      541 atcccaaagg aagagctgtt atgattagtg cgattgagaa gcagaaattg gtgtatatct
      601 tgaacagaga cgctgcagcc cgacttacca tttcatctcc cctggaggcc cacaaagcaa
      661 acactctagt gtaccatgtg gttggagtag atgtgggatt tgaaaatcct atgtttgctt
      721 gtctggaaat ggattatgag gaagcagaca atgatccaac aggggaagca gcagccaata
      781 cccagcagac acttactttc tatgaattgg accttggttt aaatcacgtg gttcggaaat
      841 acagtgaacc gttggaggaa catggcaact tccttattac agttcctgga gggtcagatg
      901 gtccaagtgg agtgctgatc tgctctgaga attatatcac ctacaagaac tttggtgacc
      961 agccagacat ccgatgtcca attcccagga gacggaatga cctggatgac cctgaaagag
     1021 gaatgatttt tgtttgctct gccacccata agaccaagtc catgttcttc tttttggccc
     1081 aaacggagca gggagatatc tttaagatca ctttggagac agatgaagat atggtaactg
     1141 agatccgcct caagtatttt gatactgttc ctgttgctgc tgctatgtgt gtgcttaaaa
     1201 caggcttcct ttttgtggca tcagaatttg gaaatcatta cttgtatcaa attgcccatc
     1261 ttggagatga tgatgaagag cctgagtttt catctgccat gcctttagaa gaaggagaca
     1321 cattcttctt tcagccgaga ccactcaaaa atctcgtgct ggtggatgaa ctggacagcc
     1381 tctctcctat tctcttttgc cagatagctg atttggccaa tgaagacact ccacagctgt
     1441 atgtagcctg tggtagggga ccccggtcgt ctctgagagt cttaagacat ggacttgagg
     1501 tgtcggaaat ggctgtttct gagctccctg gtaaccccaa tgctgtctgg actgtccgtc
     1561 ggcacattga agatgagttt gatgcctaca tcattgtgtc tttcgtgaat gccacgctgg
     1621 tgctgtccat cggagagact gtggaagaag tgacagactc cgggttcttg ggtaccactc
     1681 caaccttgtc ctgttcctta ttgggagatg acgcgttggt gcaggtgtat ccagatggca
     1741 ttcgacacat ccgagcagac aagagagtca atgagtggaa gactcctggc aagaagacaa
     1801 ttgtgaagtg tgcagtgaac cagcgacaag tggtgatcgc cttgactggg ggagagctgg
     1861 tctatttcga gatggatcct tcaggacagt tgaatgagta cacggagcgg aaagaaatgt
     1921 cagcagatgt ggtgtgcatg agtctggcca acgtaccccc tggagaacag cggtctcggt
     1981 tcctggctgt ggggctggtg gacaacactg tcagaatcat ctcccttgac ccatcagact
     2041 gtttgcagcc tctgagtatg caggctctcc cagcccagcc tgagtctctg tgtattgtgg
     2101 aaatgggtgg gaccgagaaa caagatgagc tgggtgagag gggctctatc ggcttcctgt
     2161 acctgaacat tggactccag aacggtgtgc tgctgaggac tgtcctagac cctgttactg
     2221 gggacctgtc tgacacccgc actaggtatc tggggtcccg tcctgtgaag ctctttcggg
     2281 ttcggatgca aggccaggag gctgttctgg ctatgtctag tcgctcatgg ctgagctact
     2341 cttaccagtc tcgattccat ctcacccctc tgtcttatga gaccctggaa tttgcatcgg
     2401 gctttgcctc tgaacagtgt cctgaaggca tcgttgccat ctccaccaac actttgagga
     2461 ttttggcact agagaagctt ggcgctgtct tcaatcaagt ggcctttcct ttgcagtaca
     2521 cacccaggaa gtttgtcatc caccctgaga gtaacaacct tatcatcata gagacggatc
     2581 acaatgccta cactgaggct acaaaagctc agagaaagca gcagatggct gaggaaatgg
     2641 tagaagcagc aggggaggat gaacgggagc tggctgcaga gatggcagcc gcgttcctca
     2701 atgaaaacct cccagaatcc attttcggag ctcccaaggc tggcaatggg cagtgggcct
     2761 ctgtgattcg ggtaatgaac cctatccagg ggaatacact agaccttgtc cagctggagc
     2821 agaatgaggc agcctttagt gtggcagtgt gtaggttctc caacactggt gaagactggt
     2881 atgtgctggt tggtgttgct aaggacttga tcctgagccc tcggtctgtg gcagggggct
     2941 ttgtgtatac atacaagctt gtgaacaatg gggaaaagtt ggagtttttg cacaagactc
     3001 cagtggaaga agtccctgct gccattgccc cattccaggg gagggtactg attggtgtgg
     3061 ggaaactttt acgagtctat gacctgggga agaagaagtt acttcgaaag tgtgagaata
     3121 agcatattgc caactacata tcagggatcc agacaattgg tcacagggta atcgtgtctg
     3181 atgtccagga aagtttcatc tgggttcgct acaagcgtaa tgagaaccag ctcattatct
     3241 ttgctgatga cacctatccc agatgggtca ccactgccag ccttctcgac tatgatactg
     3301 tggctggggc agacaagttt ggcaacattt gtgtggtgag gctcccacct aacaccaacg
     3361 atgaggtgga tgaagatccc actggaaaca aagccctgtg ggaccggggc ttgctcaatg
     3421 gggcttcaca gaaggcagag gtcatcatga actaccacgt tggggagaca gtgctgtcgt
     3481 tgcagaagac cacactgatc cctggaggct cagaatcact tgtctatacc actttatctg
     3541 gaggaattgg catccttgtc cctttcacgt ctcatgagga ccacgacttt ttccagcatg
     3601 ttgagatgca cctgcggtct gagcatcctc ctctctgtgg acgggaccac ctcagctttc
     3661 gttcttatta tttccctgtt aagaatgtga ttgatggaga cctttgtgag cagttcaact
     3721 ccatggagcc caacaagcag aaaaatgtct ctgaagagct ggaccgaacc ccacctgaag
     3781 tgtccaagaa gcttgaggat attcggaccc gctatgcttt ctgaatccat cgttgtcggg
     3841 gggctcgcca gagagcccct cttgtttcca tcactggtgt ctggctcttg ccacacagca
     3901 ggagaaagtg gtgtagcgtt taagactgca gctgaacgcc tggtcccctc agttggcact
     3961 ggggtctgct ccttcacata gtgtgtggcc ctgcgcttcg gcgtggaact ccgtattcct
     4021 tattcccaaa gccgcccctg catgtgtgat ttctggctct tgtctacttt tgtacacatt
     4081 cttaattctc attttgtttt cctgtaaata cagttttgta caatgttgct ttgtaaggcg
     4141 gagggagaca ggctaaggtg ttgcagtgtg gctcagccct gccctctgaa ccctcctgga
     4201 tatataaaac tagtttttaa ggtgtccagc atgcctgtag ttttttgttg tttcttagtt
     4261 ctttcctggg gatgagaatt ctggagagag gcttgagccc agattagaac aataattgga
     4321 tcttttactt cttggttctt tacatcatgg ctctagtggt ttcttagcat gtcttggttc
     4381 tttgctgtgg aggtagaaca tgagctcacc ccactactca tggatgttga aggggctgct
     4441 tccctccccc tcaggttttt accactgtga aatcttagaa tattaaattt ggcacaattc
     4501 ccagttaaaa aaaaaaaaaa aaaa
//
