LOCUS       NM_001106326            3218 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus splicing factor 3b, subunit 2 (Sf3b2), mRNA.
ACCESSION   NM_001106326 XM_001073034 XM_215182
VERSION     NM_001106326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3218)
  AUTHORS   Zhang X, Yan C, Zhan X, Li L, Lei J and Shi Y.
  TITLE     Structure of the human activated spliceosome in three
            conformational states
  JOURNAL   Cell Res 28 (3), 307-322 (2018)
   PUBMED   29360106
REFERENCE   2  (bases 1 to 3218)
  AUTHORS   Cretu C, Schmitzova J, Ponce-Salvatierra A, Dybkov O, De Laurentiis
            EI, Sharma K, Will CL, Urlaub H, Luhrmann R and Pena V.
  TITLE     Molecular Architecture of SF3b and Structural Consequences of Its
            Cancer-Related Mutations
  JOURNAL   Mol Cell 64 (2), 307-319 (2016)
   PUBMED   27720643
REFERENCE   3  (bases 1 to 3218)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3218)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3218)
  AUTHORS   Chen YI, Moore RE, Ge HY, Young MK, Lee TD and Stevens SW.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   6  (bases 1 to 3218)
  AUTHORS   Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S,
            Tuschl T and Luhrmann R.
  TITLE     The human 18S U11/U12 snRNP contains a set of novel proteins not
            found in the U2-dependent spliceosome
  JOURNAL   RNA 10 (6), 929-941 (2004)
   PUBMED   15146077
REFERENCE   7  (bases 1 to 3218)
  AUTHORS   Tran HT, Ulke A, Morrice N, Johannes CJ and Moorhead GB.
  TITLE     Proteomic characterization of protein phosphatase complexes of the
            mammalian nucleus
  JOURNAL   Mol Cell Proteomics 3 (3), 257-265 (2004)
   PUBMED   14724321
REFERENCE   8  (bases 1 to 3218)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 3218)
  AUTHORS   Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P,
            Sleeman J, Lamond A and Mann M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215182.4, XM_001073034.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3218
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3218
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /note="splicing factor 3b, subunit 2"
                     /db_xref="GeneID:293671"
                     /db_xref="RGD:1307159"
     exon            1..187
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2691
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /codon_start=1
                     /product="splicing factor 3B subunit 2"
                     /protein_id="NP_001099796.2"
                     /db_xref="GeneID:293671"
                     /db_xref="RGD:1307159"
                     /translation="MAAEHPEPPKGELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQ
                     GSREELVERLQTYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLSGIPMPPPPLGLPPL
                     QPPPPPPPPPPGLGLGFPMAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQ
                     EERAKQAAVLMEQERQQEIAKMGTAVPRPPQDMGQLGVRTPLGPRVAAPVGPVVPTPT
                     VLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEE
                     EEMETDTRSSLGQSASETEEDTVSTSKKEKNRKRRNRKKKKKPQRVRAASSESSGDRE
                     KDSARSRGSDSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEK
                     LDKMENSAVPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQ
                     LVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELP
                     DFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPK
                     LTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGP
                     PPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTE
                     EEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAG
                     METPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRK
                     GPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQ
                     KKRKAQPQDSRGGSKKYKEFKF"
     exon            188..234
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            235..312
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            313..552
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            553..670
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            671..780
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            781..877
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            878..969
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1185
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1323
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1404
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1632
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1782
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1872
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1980
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2088
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2231
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2333
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2619
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..3218
                     /gene="Sf3b2"
                     /gene_synonym="SAP145"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccggcggc tgacctgagc ttccgtgtta gtcgcgcgcc ttcttgtggc taagatggcg
       61 gcggagcatc ctgaacctcc caaaggagaa ttgcagttgc caccgcctcc ccctccaggc
      121 cactatgggg cctgggctgc ccaggagctt caggccaaat tggcagagat aggagcgccg
      181 atccagggga gtcgcgagga gctagtagag cggctgcaga cctacacccg ccagactggc
      241 attgtgctga atcgaccagt tttgagagga gaggatgggg acaaagctgc tcctcctccg
      301 atgtcagcac agctctctgg gattcctatg ccgccgccac ctttgggact cccccctcta
      361 cagcctcctc caccacctcc accacctcca ccaggccttg gccttggctt tcctatggct
      421 cacccaccaa atctggggcc cccaccacct cttcgagtgg gtgagcctgt ggcactgtca
      481 gaagaagagc ggctgaagct ggcccagcag caggcagctt tactgatgca gcaagaggaa
      541 cgcgccaaac aggcagccgt attaatggag caggaacggc agcaggaaat tgccaagatg
      601 ggcactgcag tccctaggcc tcctcaggat atggggcagc tgggggtccg tactcctctg
      661 gggcctcgag tagctgctcc agtaggccct gtggttccca cacctactgt tttgcccatg
      721 ggggcacctg ttcctcgccc tcggggtccc ccgccacccc ctggagatga gaacagagag
      781 atggatgatc cttctgtggg ccccaagatc ccccaggctt tggaaaagat tctgcagctg
      841 aaggagagcc gtcaggaaga gatgaactcc cagcaggagg aagaagaaat ggagacagac
      901 actcgctcat ctctgggaca gtcagcatca gagactgagg aggacactgt gtctacatcc
      961 aaaaaagaga aaaaccggaa gcgtcggaac cgaaagaaga agaaaaagcc acagcgggtg
     1021 cgggcagcct cgtcagagag ctccggggac cgagagaaag actcagctcg gtcccgaggc
     1081 tctgactctc ctgctgctga tgtggagatt gagtatgtga ctgaagagcc tgaaatctac
     1141 gagcccaact tcatcttctt caagaggatt tttgaggctt tcaagctaac tgatgatgtg
     1201 aaaaaggaaa aggaaaagga gccagagaag cttgacaaga tggagaactc tgcagtcccc
     1261 aagaagaagg gctttgagga ggagcacaaa gacagtgacg atgacagcag tgacgacgaa
     1321 caggagaaga agccggaagc ccctaagctg tccaagaaga agctgcgccg gatgaaccgc
     1381 ttcaccgtgg cagagctgaa gcagctggtg gcccgacctg atgttgttga gatgcatgac
     1441 gtgacagcac aggaccctaa gcttttggtt cacctcaagg ccacccggaa ctctgtccct
     1501 gtgccacgcc actggtgttt taagcgcaag taccttcaag gcaaacgagg cattgagaaa
     1561 cccccctttg agctgccaga cttcatcaaa cgcacaggca ttcaggagat gcgagaggcc
     1621 ctgcaggaga aggaagaaca gaagaccatg aagtcaaaaa tgagagagaa ggttcggccg
     1681 aagatgggga agattgacat tgactaccag aagttacacg atgccttctt caagtggcag
     1741 accaagccga agctcaccat ccatggggac ctttattacg aggggaagga gtttgagaca
     1801 cggctgaagg agaagaagcc tggagatttg tctgatgagc taaggatttc tttagggatg
     1861 ccagtaggac ctaatgccca caaagttcct cctccgtggc tgattgccat gcagcgatac
     1921 gggccaccgc catcctaccc aaacctgaaa atccctggac tgaactcacc tatccctgag
     1981 agctgttcct ttggatacca tgctggtggc tggggcaaac ccccagtaga tgagactggg
     2041 aagccacttt atggggacgt gtttggaacc aatgctgctg agtttcagac caaaactgaa
     2101 gaagaagaaa ttgaccggac tccatggggg gagctggagc catcggatga agaatcctca
     2161 gaagaggagg aagaggagga aagcgatgaa gacaagccag atgagactgg ctttatcaca
     2221 cctgcggaca gtggcctcat cactcctgga gggttctcct ccgtgccagc tggaatggag
     2281 acccctgaac tcattgagct gagaaagaag aagattgaag aggcgatgga tgggagcgag
     2341 acacctcagt tgttcactgt attgccagag aagaggacag ccactgttgg tggggccatg
     2401 atgggatcta cccacattta tgacatgtcc acggttatga gccggaaggg cccggcccct
     2461 gagttgcaag gtgtggaagt agcactggct cccgaggagt tggagttgga ccccatggcc
     2521 atgacccaga agtatgagga gcatgtccgg gagcagcagg cccaagtcga gaaagaagac
     2581 ttcagtgaca tggtggcgga gcatgctgcc aaacagaagc aaaagaaacg gaaagctcag
     2641 ccccaggaca gtcgtggggg cagcaagaaa tacaaggagt tcaaatttta ggtccttctc
     2701 acatacctgg ccttccttta ggccctttgt atgtctgggc tttctatgtg ggttcctgaa
     2761 gctagttctg tactccctag gcttgtcact tcctgttctt attttagact tgttttgtaa
     2821 ataaagctgt ttcccaagga ggaatgaata caggcactct tgaacctctc tcttttttag
     2881 cttctgcaaa agaatatact tcttgcctat aatcagactg ccccacagaa ctatgggact
     2941 gtagttgctg aaatgactgt gtggataatt cactatctcc tacccttcct gtgtatgaag
     3001 gctctgagga aagtaccttt aggtctgggc tgaccttact gctttgtccg tggggaataa
     3061 aaatagccag cttagcaccc tggctaggct gggaagtaac taactgtagg ctggggaagt
     3121 aggccaggtc aggcctgcct tattgacctt gtggcagaaa ggcctatttc ttactattgg
     3181 agaacatctg tatctaaata aaatctaaat tgttccag
//
