LOCUS       NM_001025698            1789 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus splicing factor 3a, subunit 3 (Sf3a3), mRNA.
ACCESSION   NM_001025698 XM_233500
VERSION     NM_001025698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Zhang,X., Yan,C., Zhan,X., Li,L., Lei,J. and Shi,Y.
  TITLE     Structure of the human activated spliceosome in three
            conformational states
  JOURNAL   Cell Res 28 (3), 307-322 (2018)
   PUBMED   29360106
REFERENCE   2  (bases 1 to 1789)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1789)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1789)
  AUTHORS   Chen,Y.I., Moore,R.E., Ge,H.Y., Young,M.K., Lee,T.D. and
            Stevens,S.W.
  TITLE     Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes
            expands the catalog of participating factors
  JOURNAL   Nucleic Acids Res 35 (12), 3928-3944 (2007)
   PUBMED   17537823
REFERENCE   5  (bases 1 to 1789)
  AUTHORS   Tanackovic,G. and Kramer,A.
  TITLE     Human splicing factor SF3a, but not SF1, is essential for pre-mRNA
            splicing in vivo
  JOURNAL   Mol Biol Cell 16 (3), 1366-1377 (2005)
   PUBMED   15647371
REFERENCE   6  (bases 1 to 1789)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 1789)
  AUTHORS   Nesic,D. and Kramer,A.
  TITLE     Domains in human splicing factors SF3a60 and SF3a66 required for
            binding to SF3a120, assembly of the 17S U2 snRNP, and
            prespliceosome formation
  JOURNAL   Mol Cell Biol 21 (19), 6406-6417 (2001)
   PUBMED   11533230
REFERENCE   8  (bases 1 to 1789)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   9  (bases 1 to 1789)
  AUTHORS   Chiara,M.D., Champion-Arnaud,P., Buvoli,M., Nadal-Ginard,B. and
            Reed,R.
  TITLE     Specific protein-protein interactions between the essential
            mammalian spliceosome-associated proteins SAP 61 and SAP 114
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6403-6407 (1994)
   PUBMED   8022796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099183.1.
            
            On Jul 22, 2005 this sequence version replaced XM_233500.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1789
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /note="splicing factor 3a, subunit 3"
                     /db_xref="GeneID:313583"
                     /db_xref="RGD:1308726"
     exon            1..159
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1569
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /codon_start=1
                     /product="splicing factor 3A subunit 3"
                     /protein_id="NP_001020869.1"
                     /db_xref="GeneID:313583"
                     /db_xref="RGD:1308726"
                     /translation="METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTR
                     AMQDRYMEVSGNLRDLYDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEI
                     CVPMSVEFEELLKARENPSEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDY
                     ITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQTDFE
                     KKWDNGTFPGWPKETSSALTHAGAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGG
                     TLEERAQRLFSTKGKSLESLDTSLFAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEIL
                     GEQRQLTHENVQRKQARTGEEREEEEEEQISESESEDEENEIIYNPKNLPLGWDGKPI
                     PYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVT
                     QIEDAVSLWAKLKLQKASERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL"
     exon            160..207
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            208..260
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            261..366
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            367..439
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            440..531
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            532..614
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            615..753
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            754..822
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            823..890
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            891..998
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1068
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1233
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1344
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1435
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1491
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1748
                     /gene="Sf3a3"
                     /gene_synonym="LRRGT00093"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcaggc agtgtttccg gcagtgttag cggtctgaat tgaagtaccg cggccaagag
       61 aaaatggaga caattttaga gcagcaacgg cgctatcatg aggagaaaga acggcttatg
      121 gatgttatgg ccaaagaaat gctcactaag aagtccacgc tccgggacca gatcaattcc
      181 gatcaccgca ctagggccat gcaagataga tacatggagg tcagtgggaa cctgagggat
      241 ttgtatgatg ataaggatgg attacgaaag gaggagctca atgctatttc aggacccaat
      301 gagtttgctg aattctataa cagactgaag cagataaagg aatttcatcg gaagcaccca
      361 aatgagatct gtgtgccaat gtcggtggaa ttcgaggagc tcctgaaagc tcgagagaat
      421 ccaagtgaag aggcacaaaa cttggtggag tttacagatg aagagggata tggtcgctac
      481 cttgatctcc atgactgcta cctcaagtac attaacctga aggcatctga gaagctggat
      541 tacatcacat acctgtccat cttcgatcag ttatttgaca ttccgaaaga aagaaagaat
      601 gcagagtata aaagatacct ggagatgctg ctggagtacc tacaggatta cacagataga
      661 gtgaagcccc ttcaggatca gaacgagctc tttgggaaga ttcagaccga ctttgagaag
      721 aagtgggata atggcacctt ccctggatgg ccgaaagaga caagcagtgc cctgactcac
      781 gcgggagccc atcttgatct ctccgcattc tcctcctggg aggagttggc atccctgggt
      841 ctggacagat tgaaatctgc actgttggct ttaggcctga agtgtggtgg gaccctagaa
      901 gaacgagctc agagactctt cagcaccaaa ggaaagtcct tggagtcgct cgacacctct
      961 ctgtttgcca aaaatcccaa gtcaaagggc acaaagagag acactgagag gaacaaagac
     1021 attgctttcc tggaagccca gatctatgaa tatgtggaga ttcttgggga acagcgacag
     1081 ctcactcatg aaaatgtaca gcgcaagcaa gccaggacag gtgaggagcg ggaggaggag
     1141 gaagaagagc agatcagcga gagcgaaagt gaggacgaag agaatgaaat catttacaac
     1201 cccaaaaacc tgcctctggg ctgggacggc aaacccatcc cctactggct gtacaagctc
     1261 cacggcctga acatcaacta caactgtgag atctgcggga actacactta ccgagggccg
     1321 aaggccttcc agcggcactt cgctgaatgg cgtcatgctc atggcatgag gtgtttgggc
     1381 atcccaaaca ctgcccactt tgcaaatgtg acacagattg aagatgctgt ctccttgtgg
     1441 gccaagctga aactgcagaa ggcttcagaa cgatggcagc ctgacaccga ggaagaatat
     1501 gaagactcca gtggaaatgt tgtgaacaag aagacatacg aggatctgaa aagacaagga
     1561 ctgctctagt ggttggccat gcctgggctt ccgtgagaag cctgagaaaa tttttcccaa
     1621 ccaaatgttc ttaaagactt tttgctatgt agtatctacc ttgtaggaag aagacatgct
     1681 gacagattgc agaattgaga tgtgttttat ctttgtttta tattaaaaag atttgtggga
     1741 aaataaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
