LOCUS       NM_001110793            3400 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus splicing factor 1 (Sf1), transcript variant 1,
            mRNA.
ACCESSION   NM_001110793
VERSION     NM_001110793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3400)
  AUTHORS   Zhou,J.
  TITLE     LncRNA MIAT promotes hypoxia-induced H9C2 cell pyroptosis via
            binding to SF1 to inhibit CGRP transcription
  JOURNAL   Exp Physiol 107 (1), 58-67 (2022)
   PUBMED   34713933
  REMARK    GeneRIF: LncRNA MIAT promotes hypoxia-induced H9C2 cell pyroptosis
            via binding to SF1 to inhibit CGRP transcription.
REFERENCE   2  (bases 1 to 3400)
  AUTHORS   Crisci,A., Raleff,F., Bagdiul,I., Raabe,M., Urlaub,H., Rain,J.C.
            and Kramer,A.
  TITLE     Mammalian splicing factor SF1 interacts with SURP domains of U2
            snRNP-associated proteins
  JOURNAL   Nucleic Acids Res 43 (21), 10456-10473 (2015)
   PUBMED   26420826
REFERENCE   3  (bases 1 to 3400)
  AUTHORS   Ishizuka,A., Hasegawa,Y., Ishida,K., Yanaka,K. and Nakagawa,S.
  TITLE     Formation of nuclear bodies by the lncRNA Gomafu-associating
            proteins Celf3 and SF1
  JOURNAL   Genes Cells 19 (9), 704-721 (2014)
   PUBMED   25145264
REFERENCE   4  (bases 1 to 3400)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3400)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3400)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   7  (bases 1 to 3400)
  AUTHORS   Park,S.Y., Tong,M. and Jameson,J.L.
  TITLE     Distinct roles for steroidogenic factor 1 and desert hedgehog
            pathways in fetal and adult Leydig cell development
  JOURNAL   Endocrinology 148 (8), 3704-3710 (2007)
   PUBMED   17495005
REFERENCE   8  (bases 1 to 3400)
  AUTHORS   Cattaruzza,M., Schafer,K. and Hecker,M.
  TITLE     Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes
            smooth muscle cell proliferation
  JOURNAL   J Biol Chem 277 (8), 6582-6589 (2002)
   PUBMED   11748220
REFERENCE   9  (bases 1 to 3400)
  AUTHORS   Covini,N., Tamburin,M., Consalez,G., Salvati,P. and Benatti,L.
  TITLE     ZFM1/SF1 mRNA in rat and gerbil brain after global ischaemia
  JOURNAL   Eur J Neurosci 11 (3), 781-787 (1999)
   PUBMED   10103072
REFERENCE   10 (bases 1 to 3400)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU671240.1, BC081859.1, CO561066.1 and BQ191177.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-669               BU671240.1         1-669
            670-1750            BC081859.1         583-1663
            1751-2365           CO561066.1         1-615
            2366-2936           BQ191177.1         57-627
            2937-3400           BC081859.1         2212-2675
FEATURES             Location/Qualifiers
     source          1..3400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3400
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /note="splicing factor 1"
                     /db_xref="GeneID:117855"
                     /db_xref="RGD:620645"
     exon            1..418
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2307
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 162"
                     /codon_start=1
                     /product="splicing factor 1 isoform 1"
                     /protein_id="NP_001104263.1"
                     /db_xref="GeneID:117855"
                     /db_xref="RGD:620645"
                     /translation="MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGL
                     TREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTR
                     KKLEEERHTLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPR
                     GNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKA
                     VEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNT
                     TVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSG
                     PATTPLASAPRPAAPASNPPPPSLMSTTQSRPPWMNSGPSENRPYHGMHGGGPGGPGG
                     GPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQY
                     LGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPP
                     PPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGTPQMQGNPTM
                     VPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMP
                     PFGMPPAPPPPPPQN"
     exon            419..547
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            548..623
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            624..776
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            777..866
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1050
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1166
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1274
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1455
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1729
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1789
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1969
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..3376
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgcagta acaagaagtg cgcgctgcga cacctcccag ttcactcggc cccgccgcca
       61 tttcgtcgcc tggcctaacg gttcggccaa tcccgacgcg tattgaaaag aactagtgct
      121 ccgccaatcg gaggccgctg actccgacct cacctcgggc cggcccaatc caggccgcgg
      181 ccccgccgcc cccaacccgc ccccgcggcg tcctctctcc tccctctttg tgcgtctggc
      241 gccgccgccg cccgccgcgt gagaggacgg gctccccgcg ctcttcggga gcgtagtcgg
      301 gtcccctccc cccaacccgc gaaggttcgt gaaggagaag ccgccgcgga ggacgaggaa
      361 ccgctggtgc cggtcccctg gggcgccatg gcgaccggag cgaacgccac gccgctggac
      421 ttcccaagta agaagaggaa gaggagccga tggaaccaag acacaatgga acagaagaca
      481 gtgattccag gcatgcctac ggttatcccc cctggcctga ctcgggaaca agaaagagct
      541 tatatagtgc aactacagat agaagacctg actcgtaaac tgcgcacagg agacctgggc
      601 atccccccta accctgagga caggtcccct tcccctgagc caatctacaa cagcgagggg
      661 aagcggctta atactcgaga attccgtacc cgaaaaaagc ttgaagagga gcggcatacc
      721 ctcattacgg agatggttgc tctcaaccca gactttaaac cacctgcaga ttacaagcct
      781 ccagcaacac gtgtgagcga taaagtaatg atcccccaag acgagtatcc agaaatcaat
      841 tttgtggggc tcctaattgg gcccagaggg aacaccctga agaacattga gaaggaatgc
      901 aacgccaaga tcatgatacg gggaaaggga tcagtaaaag aagggaaagt tgggcgtaaa
      961 gatggtcaga tgttgccagg agaagatgaa cctcttcatg ctctagtcac tgccaataca
     1021 atggagaatg tcaaaaaggc agtggaacag atcagaaaca tcctgaagca gggtattgaa
     1081 accccagagg accagaatga cctaaggaaa atgcagcttc gagagttagc tcgcttgaat
     1141 ggcactctac gggaagatga taacaggatc ttgagaccct ggcagagctc agagacacga
     1201 agcattacca acacgactgt gtgtactaag tgtggagggg ctggtcacat tgcctctgat
     1261 tgcaaatttc agaggcctgg tgaccctcaa tcagctcagg ataaagcacg gatggataaa
     1321 gagtatttgt cccttatggc tgagctaggg gaagctcctg tccctgcatc tgtgggctcc
     1381 acctctggac ctgccaccac acccctggcc agtgcaccaa ggcctgctgc tcctgccagc
     1441 aacccaccac caccgtctct catgtctaca actcagagtc gcccaccctg gatgaattct
     1501 ggtccttcag agaatcggcc ctaccatggc atgcatggag gtggtcctgg tgggcctgga
     1561 ggtggccccc acagtttccc acacccatta cccagcctga caggtgggca tggtggacat
     1621 cccatgcagc acaacccaaa tggaccacca ccaccttgga tgcagccacc accaccaccg
     1681 atgaaccagg gcccccaccc acctgggcac catggccctc ctccaatgga tcagtacctg
     1741 ggaagtacgc ctgtgggctc tggggtctat cgcctgcatc aaggaaaagg tatgatgccg
     1801 ccgccgccta tgggcatgat gccgccgcct ccgccacctc ccagtgggca gcccccgcct
     1861 cctccctctg gtcctcttcc tccatggcag cagcagcagc agcagcctcc accaccccct
     1921 ccgcccagca gcagtatggc ttccagcacc cccttgccat ggcagcaaaa tacgacgact
     1981 accaccacga gcgctggcac agggtccatc ccgccatggc aacagcagca ggcggctgcc
     2041 gcagcttctc caggaacccc tcagatgcaa ggcaacccca ctatggtgcc cctgcccccc
     2101 ggggtccagc cgcctctgcc gcccggggcc cctccccctc cgccgcctcc gccacctggt
     2161 tccgccggca tgatgtatgc cccaccccct cctcctccgc ctcccatgga cccttctaac
     2221 tttgtcacca tgatgggcat gggggtggcg ggcatgccgc ccttcgggat gcctccagct
     2281 cccccaccgc ctccaccaca gaactagact tgtttttttt ttaagaaaat atatattata
     2341 tacatagaga gttggtctcg tttaaacaca cgccgaacct caccatatgg agccagacat
     2401 tgggatgcac gcatgtgatt gtgtgtgcac gcatgtgtgt gtgtgcacgc actgggctgg
     2461 gccaagtgac tggactcgct tgggaaacgg gcaagtggta gtaggggcgc cagcttgggc
     2521 tctcctggcg ccctgtagca tcgagtgtct tctttgtctt ctctcctcac ccaactccct
     2581 ttgcctctcc ccaaaccggg ccgccaggat ccctccccgc agcagcgatg gcccgagcca
     2641 tgagagtgag gactttccgc gcccattggt gacccttcca ggcagacagc ctcaacagcg
     2701 cccctggtgg acaggatggt tcggcaaagc agcctgagtt atttttgtgg acggaatcgg
     2761 aacacgctgg ctccatatcg tgaaattttt attaattttt atctttttcc tttgttattt
     2821 ccttatcttt tcctttcttc agactccgtc caaggagatg ctctccccga tcttctgctg
     2881 cagataggat ccttcccctt gtctccattc ctttcctccc ataggggaga ggggcaaatg
     2941 gtttaggcac aggctttggc tagtaatgtc aggcgtggtg gtggcggcgg ggtcctattg
     3001 ttctaatttg ttgaagggcc tcaaccacac tcaaagaagg gtggtttatc ttcgacatct
     3061 taaagagtct tgataatcct gacattgcta aataggggta atccggcagt gggattcatt
     3121 catatcttcc tgcactcctg ccagcagtac atggcacagc ccaagccacc ctaggccagc
     3181 ctggagtctt ttccatgctc tgatcaccta agctgcctca gaactcattt gcttctctcc
     3241 ttcctggaaa gcttcccttt atgttttatt ttgaccccag atgtccagat gttttgcagt
     3301 gtctggggct tgtgcccctt gttgttcgtt ctgcttcttt gcccctttcc tctacatgga
     3361 gtgattatgt tgacaaaaaa aaaaaaaaaa aaaaaaaaaa
//
