LOCUS       NM_001105754            3975 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus seizure related 6 homolog (Sez6), mRNA.
ACCESSION   NM_001105754 XM_001080832 XM_239260
VERSION     NM_001105754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3975)
  AUTHORS   Zhang,J., Zhang,J., Wu,Y., Zhou,Y., Shao,Z., Kang,X., Ma,L., Li,M.,
            Liu,L. and Shi,H.
  TITLE     Sez-6 may play an important role in neurite outgrowth through the
            PKCgamma signaling pathways
  JOURNAL   Z Naturforsch C J Biosci 66 (11-12), 614-620 (2011)
   PUBMED   22351987
  REMARK    GeneRIF: results indicate that Sez-6 acts on the neurite outgrowth
            of PC12 cells likely through the PKCgamma signaling pathways
REFERENCE   2  (bases 1 to 3975)
  AUTHORS   Gunnersen,J.M., Kuek,A., Phipps,J.A., Hammond,V.E., Puthussery,T.,
            Fletcher,E.L. and Tan,S.S.
  TITLE     Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent
            retina and the consequence of gene deletion
  JOURNAL   PLoS One 4 (8), e6546 (2009)
   PUBMED   19662096
  REMARK    GeneRIF: Retinal morphology, ganglion cell dendritic branching and
            ERG waveforms appeared normal in the Sez-6 knockout mouse
            suggesting that, in spite of widespread expression of Sez-6,
            retinal function in the absence of Sez-6 is not affected
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3975)
  AUTHORS   Gunnersen,J.M., Kim,M.H., Fuller,S.J., De Silva,M., Britto,J.M.,
            Hammond,V.E., Davies,P.J., Petrou,S., Faber,E.S., Sah,P. and
            Tan,S.S.
  TITLE     Sez-6 proteins affect dendritic arborization patterns and
            excitability of cortical pyramidal neurons
  JOURNAL   Neuron 56 (4), 621-639 (2007)
   PUBMED   18031681
REFERENCE   4  (bases 1 to 3975)
  AUTHORS   Miyazaki,T., Hashimoto,K., Uda,A., Sakagami,H., Nakamura,Y.,
            Saito,S.Y., Nishi,M., Kume,H., Tohgo,A., Kaneko,I., Kondo,H.,
            Fukunaga,K., Kano,M., Watanabe,M. and Takeshima,H.
  TITLE     Disturbance of cerebellar synaptic maturation in mutant mice
            lacking BSRPs, a novel brain-specific receptor-like protein family
  JOURNAL   FEBS Lett 580 (17), 4057-4064 (2006)
   PUBMED   16814779
REFERENCE   5  (bases 1 to 3975)
  AUTHORS   Shimizu-Nishikawa,K., Kajiwara,K., Kimura,M., Katsuki,M. and
            Sugaya,E.
  TITLE     Cloning and expression of SEZ-6, a brain-specific and
            seizure-related cDNA
  JOURNAL   Brain Res Mol Brain Res 28 (2), 201-210 (1995)
   PUBMED   7723619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Sep 2, 2010 this sequence version replaced
            XM_239260.5, XM_001080832.2, NM_001105754.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.62350.1,
                                           SRR26643286.31209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JAXUCZ010000010.1  63317126-63317197
            73-735              JAXUCZ010000010.1  63339996-63340658
            736-869             JAXUCZ010000010.1  63341254-63341387
            870-1065            JAXUCZ010000010.1  63349764-63349959
            1066-1251           JAXUCZ010000010.1  63355889-63356074
            1252-1420           JAXUCZ010000010.1  63360445-63360613
            1421-1587           JAXUCZ010000010.1  63360690-63360856
            1588-1782           JAXUCZ010000010.1  63361604-63361798
            1783-1921           JAXUCZ010000010.1  63362020-63362158
            1922-2118           JAXUCZ010000010.1  63362269-63362465
            2119-2313           JAXUCZ010000010.1  63363069-63363263
            2314-2505           JAXUCZ010000010.1  63364282-63364473
            2506-2703           JAXUCZ010000010.1  63364555-63364752
            2704-2742           JAXUCZ010000010.1  63364971-63365009
            2743-2860           JAXUCZ010000010.1  63365249-63365366
            2861-2963           JAXUCZ010000010.1  63365453-63365555
            2964-3975           JAXUCZ010000010.1  63365712-63366723
FEATURES             Location/Qualifiers
     source          1..3975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24-q25"
     gene            1..3975
                     /gene="Sez6"
                     /note="seizure related 6 homolog"
                     /db_xref="GeneID:192247"
                     /db_xref="RGD:619780"
     exon            1..72
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2996
                     /gene="Sez6"
                     /note="seizure related gene 6; seizure protein 6 homolog"
                     /codon_start=1
                     /product="seizure protein 6 homolog precursor"
                     /protein_id="NP_001099224.2"
                     /db_xref="GeneID:192247"
                     /db_xref="RGD:619780"
                     /translation="MRPAALLLLPSLLALLAHGLSSEAPITGEGQATGIREMDGELTA
                     APTPEQSDRGVHFVTTAPTLKLLNHHPLLEEFLQEGLEGREEAPRPALPFQPDSPTPF
                     TPSPLPRLTNQDNRPVFTSPTPAVAAAPTQPHSRKKPWNPESEPPELYITSPLPPGPS
                     MAVPTLHPEDRPSTTPPSQAWTPTQEGPGDMGRPWVPEIMSKTTGLGIEGTIATSTAS
                     GDDEETTTTTIITTVTTIQPPGPCSWNFSGPEGSLDSPAVPSVPSDVGLDCLYYISVY
                     PGYGVEIKVKNISLQEGETITVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAAVRFQS
                     LPLPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARF
                     LTCLNATQPFWDSQEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPES
                     QRLHLHFEKVSLAEDDDRLIIRNGNNVEAPPVYDSYEVEYLPIEGLLSSGRHFFVEFS
                     TDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSAPSYPVGTTVEFSCDPGYTLEQG
                     SIIIECVDLRDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVE
                     EDKRIMLDIRVLRIGSGDVLTFYDGDDLTARVLGQYSGPRGHFKLFTSMADVTIQFQS
                     DPGTSALGYQQGFVIHFFEVPRNDTCPELPEIPNGWKNPSQPELVHGTVVTYQCYPGY
                     QVVGSSILMCQWDLSWSEDLPSCQRVTSCHDPGDVEHSRRLISSLKFPVGATVQYICD
                     QGFVLTGSAILTCHDRQAGSPKWSDRAPKCLLEQFKPCHGLSAPENGARSPEKRLHPA
                     GATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNGRSLDVAKAPA
                     TSSALDAAHMAAAIFLPLVAMVLLVGGVYLYFSRLQGKSPLQLPGTHPRPYNRITVES
                     AFDNPTYETGSLSFAGDERI"
     exon            73..735
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            736..869
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1065
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1251
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1420
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1587
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1782
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1921
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2118
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2313
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2505
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2703
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2742
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2860
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2963
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3975
                     /gene="Sez6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcaag cagcaccatg cgcccagcag ccctgctgct cctgccctcg ctgctggcgc
       61 tcctggctca cggactctcc tcagaggctc caatcacggg ggaaggtcaa gccacgggca
      121 tcagggagat ggatggggag ctgaccgcag cccctacacc tgagcagtca gaccgaggcg
      181 tccacttcgt caccacagcc cctaccctca agctactcaa ccaccaccca cttctggagg
      241 aatttcttca agaggggcta gaagggagag aggaagctcc gaggccggca ctgcccttcc
      301 agccagactc acctacaccc tttactccaa gcccccttcc ccgcctcacc aaccaggaca
      361 accgccctgt ctttaccagt ccgacgccag ctgtagctgc ggcacccacg cagccccact
      421 ccagaaagaa accctggaac ccagagtcag agcccccgga gctttacatc acatctcccc
      481 tccctccagg gccgagtatg gcagtgccca cactgcaccc agaggacaga cccagcacta
      541 caccccccag ccaagcatgg actccaaccc aggagggtcc tggagacatg ggcagacctt
      601 gggttccaga gatcatgtct aagaccacag ggcttggtat cgaggggacc attgccacct
      661 ccacagcttc aggggatgac gaagagacca ccaccaccac catcattacc accgtcacca
      721 caattcagcc accaggcccc tgtagctgga atttctcagg cccggagggc tctctggatt
      781 cccctgcggt ccccagcgtc ccctctgatg ttggcctgga ctgtctctac tacatctctg
      841 tctaccctgg atatggagtc gagatcaagg tgaagaacat cagccttcag gaaggagaga
      901 ccataaccgt ggagggcctg ggggggcctg acccactgcc cttggctaac cagtctttcc
      961 tgctgagggg ccaggtcatc cgcagcccca cccaccaggc agccgtgagg ttccaaagcc
     1021 ttccacttcc cgctggacct ggtactttcc atttccacta ccaagcctat ctcctgagct
     1081 gccactttcc tcggcgtcca gcttatggag atgtgactgt caccagcctc cacccaggag
     1141 gcagcgcccg cttccactgt gccactggct accagctaaa gggtgccagg ttcctcacct
     1201 gtctcaatgc cacccagccc ttttgggatt cccaagagcc tgtctgcatt gctgcttgtg
     1261 gaggagtgat tcggaatgcc accactggcc gcattgtctc tcctggcttt cccgggaact
     1321 acagcaacaa cctcacctgc cactggctgc tagaagcccc cgagagccag cggctgcacc
     1381 tgcactttga aaaggtctcc ctggcagaag atgacgacag gctcatcatc cgtaacggga
     1441 ataacgtgga ggccccgcca gtgtatgact cctatgaggt ggagtacctg cccattgagg
     1501 gcctgctcag ttctggcaga cacttcttcg tggagttcag tactgacagc agcggggcag
     1561 ccgcaggcat ggcactgcgc tatgaggcct tccagcaagg acattgctat gagccctttg
     1621 tcaaatacgg taacttcagc agcagcgcac cgtcctaccc tgtgggtacg actgtggagt
     1681 tcagctgtga ccctggctac accctggagc agggttccat catcatcgaa tgcgtcgacc
     1741 tccgtgaccc ccagtggaat gagacagaac cagcctgccg agccgtgtgc agcggggaga
     1801 tcacagactc tgcaggcgtg gtgctctctc caaactggcc ggagccttat ggccgagggc
     1861 aggactgcat ctggggtgtg catgtggagg aggacaagcg catcatgctg gacatccgag
     1921 tgctgcgcat aggctctggg gatgtactga ccttctacga tggggatgac ctgacagccc
     1981 gggtcctggg ccaatactca gggccccgtg gccacttcaa gctctttacc tccatggctg
     2041 atgtcaccat tcagttccag tcagaccctg ggacgtcggc gctgggttac cagcaaggat
     2101 ttgtcatcca cttctttgag gtgccccgca atgacacatg tccagagctt cccgagatcc
     2161 ccaacggctg gaagaaccca tcacagcctg agctggtgca tggcacggtg gtcacctatc
     2221 agtgctaccc cggttaccag gtggtgggat ccagtattct catgtgccag tgggacctga
     2281 gctggagtga ggacctgccc tcatgccaga gagtgacatc ctgccatgac ccaggggatg
     2341 tggagcacag ccgacgcctc atatccagcc tcaagtttcc tgtgggagca actgtgcagt
     2401 atatctgtga ccagggtttt gtgctcacgg gtagcgccat ccttacttgc catgatcgtc
     2461 aagcgggcag tcccaagtgg agtgacaggg cccccaagtg tctcttggaa cagttcaaac
     2521 catgtcatgg cctcagtgcc cctgagaatg gtgcccgcag ccctgagaag aggctccacc
     2581 cagcaggggc caccattcac ttctcctgtg cccctggtta tgtgctgaag ggccaggcca
     2641 gcatcaaatg cgtgcctgga cacccctcac attggagtga tcctccaccc atctgtaggg
     2701 ctgcttctct ggatgggttc tacaacggcc gtagcctgga tgttgccaag gcacctgcca
     2761 cctccagtgc cctggatgct gcccacatgg cagctgccat ctttctacca ttggtggcca
     2821 tggtgttgct ggtgggagga gtgtacctct atttctccag actccaggga aaaagtcctc
     2881 tgcagcttcc cggaactcat cctcgcccct ataaccgtat cacggtagag tcagcatttg
     2941 acaatccaac ttatgagacc ggatctcttt cctttgcagg agacgagaga atatgaagtt
     3001 tccatctagg tgggagcagc ctggggatgc acatgcagtc ctgcatcaca agccggcggc
     3061 agggctccca gctctctgct gtccctcacc tcctgtacat accgcctggg aagagacacc
     3121 accgacccct tccccgcctg caatgcccac agtgacctct tttcttggca ccactgccca
     3181 cttagggccc ttctttggat ttggcggtgc gtgcctcagg tagaactggc gcacattacc
     3241 agaagccaac attctgcttc tcttttgccc tggacctcca gccctggaag ttgcaggcag
     3301 agaaggggca cgtcttacac atagccacca tccagccctg gcatgcaagg actccagaag
     3361 agctgacttg acagcagggt gcccctcaca gggccagcac cagaggtaga ggtcgaaatt
     3421 gttctcaact atgacctctt ggaagtcctg gcataccaac accagcccct cagggaggtt
     3481 tttagttcct ctctaaaggc ttagaatagg acaggtaagc cttctgccct gtcctgggga
     3541 ggtgatgact ttaaggcatt ctaaaaggtt cagggactct atcccaagct caggttgggc
     3601 ctcactggat acccatgctc cacaccaaag caggacaccc tatggctccc tggcatccct
     3661 ctaccctgag gagggaaagc ccttccttga aattatctgg ctgttacaaa tgtccctttt
     3721 cccacctatc cctcgtctaa gccacttatg atgttccccc ttcctgccac tatgttatgg
     3781 caggtacatt ctggagacga gcagatgtcc aaggacccag gaatgtggca cagaacagaa
     3841 gtaaaaaatc cccaggagga atctcagtct ggaccgaagg tcactttgta catatgatgt
     3901 attatatggg gtctgggctc cagccagaga acaatctttt atttctgttg tttccttatt
     3961 aaaatggtgt tttgg
//
