LOCUS       NP_001099224             992 aa            linear   ROD 31-MAR-2024
DEFINITION  seizure protein 6 homolog precursor [Rattus norvegicus].
ACCESSION   NP_001099224 XP_001080832 XP_239260
VERSION     NP_001099224.2
DBSOURCE    REFSEQ: accession NM_001105754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 992)
  AUTHORS   Zhang,J., Zhang,J., Wu,Y., Zhou,Y., Shao,Z., Kang,X., Ma,L., Li,M.,
            Liu,L. and Shi,H.
  TITLE     Sez-6 may play an important role in neurite outgrowth through the
            PKCgamma signaling pathways
  JOURNAL   Z Naturforsch C J Biosci 66 (11-12), 614-620 (2011)
   PUBMED   22351987
  REMARK    GeneRIF: results indicate that Sez-6 acts on the neurite outgrowth
            of PC12 cells likely through the PKCgamma signaling pathways
REFERENCE   2  (residues 1 to 992)
  AUTHORS   Gunnersen,J.M., Kuek,A., Phipps,J.A., Hammond,V.E., Puthussery,T.,
            Fletcher,E.L. and Tan,S.S.
  TITLE     Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent
            retina and the consequence of gene deletion
  JOURNAL   PLoS One 4 (8), e6546 (2009)
   PUBMED   19662096
  REMARK    GeneRIF: Retinal morphology, ganglion cell dendritic branching and
            ERG waveforms appeared normal in the Sez-6 knockout mouse
            suggesting that, in spite of widespread expression of Sez-6,
            retinal function in the absence of Sez-6 is not affected
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 992)
  AUTHORS   Gunnersen,J.M., Kim,M.H., Fuller,S.J., De Silva,M., Britto,J.M.,
            Hammond,V.E., Davies,P.J., Petrou,S., Faber,E.S., Sah,P. and
            Tan,S.S.
  TITLE     Sez-6 proteins affect dendritic arborization patterns and
            excitability of cortical pyramidal neurons
  JOURNAL   Neuron 56 (4), 621-639 (2007)
   PUBMED   18031681
REFERENCE   4  (residues 1 to 992)
  AUTHORS   Miyazaki,T., Hashimoto,K., Uda,A., Sakagami,H., Nakamura,Y.,
            Saito,S.Y., Nishi,M., Kume,H., Tohgo,A., Kaneko,I., Kondo,H.,
            Fukunaga,K., Kano,M., Watanabe,M. and Takeshima,H.
  TITLE     Disturbance of cerebellar synaptic maturation in mutant mice
            lacking BSRPs, a novel brain-specific receptor-like protein family
  JOURNAL   FEBS Lett 580 (17), 4057-4064 (2006)
   PUBMED   16814779
REFERENCE   5  (residues 1 to 992)
  AUTHORS   Shimizu-Nishikawa,K., Kajiwara,K., Kimura,M., Katsuki,M. and
            Sugaya,E.
  TITLE     Cloning and expression of SEZ-6, a brain-specific and
            seizure-related cDNA
  JOURNAL   Brain Res Mol Brain Res 28 (2), 201-210 (1995)
   PUBMED   7723619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Sep 2, 2010 this sequence version replaced
            XP_239260.5, XP_001080832.2, NP_001099224.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.62350.1,
                                           SRR26643286.31209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24-q25"
     Protein         1..992
                     /product="seizure protein 6 homolog precursor"
                     /note="seizure related gene 6; seizure protein 6 homolog"
                     /calculated_mol_wt=105550
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1971
     Region          <88..197
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          242..350
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(250,252,254,282,287,320,345,347,349..350)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          355..411
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(365,382)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Region          414..524
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(423,425,427,454,459,494,519,521,523..524)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          530..587
                     /region_name="Sushi"
                     /note="Sushi repeat (SCR repeat); pfam00084"
                     /db_xref="CDD:459664"
     Region          591..700
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(601,603,630,635,668,696,698,700)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          <708..893
                     /region_name="PHA02927"
                     /note="secreted complement-binding protein; Provisional"
                     /db_xref="CDD:222943"
     Region          708..764
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(718,737)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     CDS             1..992
                     /gene="Sez6"
                     /coded_by="NM_001105754.2:18..2996"
                     /db_xref="GeneID:192247"
                     /db_xref="RGD:619780"
ORIGIN      
        1 mrpaallllp sllallahgl sseapitgeg qatgiremdg eltaaptpeq sdrgvhfvtt
       61 aptlkllnhh plleeflqeg legreeaprp alpfqpdspt pftpsplprl tnqdnrpvft
      121 sptpavaaap tqphsrkkpw npeseppely itsplppgps mavptlhped rpsttppsqa
      181 wtptqegpgd mgrpwvpeim skttglgieg tiatstasgd deetttttii ttvttiqppg
      241 pcswnfsgpe gsldspavps vpsdvgldcl yyisvypgyg veikvknisl qegetitveg
      301 lggpdplpla nqsfllrgqv irspthqaav rfqslplpag pgtfhfhyqa yllschfprr
      361 paygdvtvts lhpggsarfh catgyqlkga rfltclnatq pfwdsqepvc iaacggvirn
      421 attgrivspg fpgnysnnlt chwlleapes qrlhlhfekv slaedddrli irngnnveap
      481 pvydsyevey lpiegllssg rhffvefstd ssgaaagmal ryeafqqghc yepfvkygnf
      541 sssapsypvg ttvefscdpg ytleqgsiii ecvdlrdpqw netepacrav csgeitdsag
      601 vvlspnwpep ygrgqdciwg vhveedkrim ldirvlrigs gdvltfydgd dltarvlgqy
      661 sgprghfklf tsmadvtiqf qsdpgtsalg yqqgfvihff evprndtcpe lpeipngwkn
      721 psqpelvhgt vvtyqcypgy qvvgssilmc qwdlswsedl pscqrvtsch dpgdvehsrr
      781 lisslkfpvg atvqyicdqg fvltgsailt chdrqagspk wsdrapkcll eqfkpchgls
      841 apengarspe krlhpagati hfscapgyvl kgqasikcvp ghpshwsdpp picraasldg
      901 fyngrsldva kapatssald aahmaaaifl plvamvllvg gvylyfsrlq gksplqlpgt
      961 hprpynritv esafdnptye tgslsfagde ri
//
