LOCUS       NM_001025048            1569 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SET domain and mariner transposase fusion gene
            (Setmar), mRNA.
ACCESSION   NM_001025048 XM_575631
VERSION     NM_001025048.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Kim,H.S., Chen,Q., Kim,S.K., Nickoloff,J.A., Hromas,R.,
            Georgiadis,M.M. and Lee,S.H.
  TITLE     The DDN catalytic motif is required for Metnase functions in
            non-homologous end joining (NHEJ) repair and replication restart
  JOURNAL   J Biol Chem 289 (15), 10930-10938 (2014)
   PUBMED   24573677
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Hromas,R., Williamson,E.A., Fnu,S., Lee,Y.J., Park,S.J., Beck,B.D.,
            You,J.S., Leitao,A., Nickoloff,J.A. and Lee,S.H.
  TITLE     Chk1 phosphorylation of Metnase enhances DNA repair but inhibits
            replication fork restart
  JOURNAL   Oncogene 31 (38), 4245-4254 (2012)
   PUBMED   22231448
  REMARK    Erratum:[Oncogene. 2014 Jan 23;33(4):536. Laitao, A [corrected to
            Leitao, A]]
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Beck,B.D., Lee,S.S., Williamson,E., Hromas,R.A. and Lee,S.H.
  TITLE     Biochemical characterization of metnase's endonuclease activity and
            its role in NHEJ repair
  JOURNAL   Biochemistry 50 (20), 4360-4370 (2011)
   PUBMED   21491884
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Fnu,S., Williamson,E.A., De Haro,L.P., Brenneman,M., Wray,J.,
            Shaheen,M., Radhakrishnan,K., Lee,S.H., Nickoloff,J.A. and
            Hromas,R.
  TITLE     Methylation of histone H3 lysine 36 enhances DNA repair by
            nonhomologous end-joining
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 540-545 (2011)
   PUBMED   21187428
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   De Haro,L.P., Wray,J., Williamson,E.A., Durant,S.T., Corwin,L.,
            Gentry,A.C., Osheroff,N., Lee,S.H., Hromas,R. and Nickoloff,J.A.
  TITLE     Metnase promotes restart and repair of stalled and collapsed
            replication forks
  JOURNAL   Nucleic Acids Res 38 (17), 5681-5691 (2010)
   PUBMED   20457750
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   Wray,J., Williamson,E.A., Chester,S., Farrington,J., Sterk,R.,
            Weinstock,D.M., Jasin,M., Lee,S.H., Nickoloff,J.A. and Hromas,R.
  TITLE     The transposase domain protein Metnase/SETMAR suppresses
            chromosomal translocations
  JOURNAL   Cancer Genet Cytogenet 200 (2), 184-190 (2010)
   PUBMED   20620605
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Wray,J., Williamson,E.A., Royce,M., Shaheen,M., Beck,B.D.,
            Lee,S.H., Nickoloff,J.A. and Hromas,R.
  TITLE     Metnase mediates resistance to topoisomerase II inhibitors in
            breast cancer cells
  JOURNAL   PLoS One 4 (4), e5323 (2009)
   PUBMED   19390626
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Williamson,E.A., Rasila,K.K., Corwin,L.K., Wray,J., Beck,B.D.,
            Severns,V., Mobarak,C., Lee,S.H., Nickoloff,J.A. and Hromas,R.
  TITLE     The SET and transposase domain protein Metnase enhances chromosome
            decatenation: regulation by automethylation
  JOURNAL   Nucleic Acids Res 36 (18), 5822-5831 (2008)
   PUBMED   18790802
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Beck,B.D., Park,S.J., Lee,Y.J., Roman,Y., Hromas,R.A. and Lee,S.H.
  TITLE     Human Pso4 is a metnase (SETMAR)-binding partner that regulates
            metnase function in DNA repair
  JOURNAL   J Biol Chem 283 (14), 9023-9030 (2008)
   PUBMED   18263876
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Lee,S.H., Oshige,M., Durant,S.T., Rasila,K.K., Williamson,E.A.,
            Ramsey,H., Kwan,L., Nickoloff,J.A. and Hromas,R.
  TITLE     The SET domain protein Metnase mediates foreign DNA integration and
            links integration to nonhomologous end-joining repair
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 18075-18080 (2005)
   PUBMED   16332963
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088181.1.
            
            On Jun 25, 2005 this sequence version replaced XM_575631.1.
            
            Summary: This gene encodes a histone-lysine N-methyltransferase
            that may be involved in the methylation of histone H3. In
            anthropoid primates this gene is a fusion gene of a SET
            histone-lysine N-methyltransferase and a mariner (MAR) family
            transposase. In all other species this gene contains only the SET
            domain. [provided by RefSeq, Feb 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088181.1, CO561012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132267
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..1569
                     /gene="Setmar"
                     /note="SET domain and mariner transposase fusion gene"
                     /db_xref="GeneID:500281"
                     /db_xref="RGD:1565882"
     exon            1..177
                     /gene="Setmar"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..966
                     /gene="Setmar"
                     /EC_number="2.1.1.357"
                     /note="SET domain and mariner transposase fusion
                     gene-containing protein homolog; SET domain without
                     mariner transposase fusion; SET domain and mariner
                     transposase fusion protein homolog"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETMAR"
                     /protein_id="NP_001020219.1"
                     /db_xref="GeneID:500281"
                     /db_xref="RGD:1565882"
                     /translation="MSAEAVKKLSFEIAPSEEESEATIEQQDVACGLENLPVSLWPLG
                     AGPRPKPFQYTPDHVAGPGVDMDPTQITFPGCACIKTPCVPGTCSCLRHESNYNDNLC
                     LRDVGSEAKYAKPVFECNVLCQCGEHCRNRVVQSGLQFLLQVFQTEKKGWGLRTLEYI
                     PKGRFVCEYAGEVLGFSEVQRRIHLQTAHDPNYIIALREHTYNGQVMETFVDPTYIGN
                     IGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQISSKDK
                     ERIDCGQPRKPCYCGAQSCATFLPYDSSLYGPLENPGTS"
     exon            178..1545
                     /gene="Setmar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgaggtga gaccataaat gtctgcggaa gctgtgaaaa agctttcttt cgagatagca
       61 ccatctgagg aggaatctga ggccacgata gaacaacaag atgtagcgtg cggcctggag
      121 aacttgcccg tgagcctgtg gcccttgggg gcggggccca ggcctaaacc tttccagtat
      181 actcctgatc atgtagctgg gcctggagta gacatggacc ccacacaaat aaccttccct
      241 ggttgtgctt gcatcaaaac tccatgtgtc cctggtactt gctcctgtct tcgtcatgag
      301 agtaactaca atgacaattt atgccttagg gatgtgggat cagaagcaaa gtacgccaag
      361 ccagtctttg aatgcaatgt tctgtgccag tgtggcgagc actgcagaaa cagggtggtc
      421 cagagtggtc tccagttcct tctccaggta ttccagacag aaaaaaaagg ctggggactt
      481 cggaccttgg aatatatacc caagggaaga ttcgtctgtg agtatgctgg ggaggtatta
      541 ggattctctg aagtacaaag aagaattcac ctacaaacag cacatgaccc aaattacatc
      601 atcgccctca gggagcacac atacaatggc caggtcatgg aaacatttgt cgaccctacc
      661 tacataggaa atattgggag attcctcaat cattcttgtg aaccaaatct gttgatgatt
      721 cctgtccgaa ttgactcaat ggtgcccaag ctcgcacttt ttgcagccaa agatattttg
      781 ccaggagaag aactctctta cgactattca ggaagattcc ttaatcaaat aagcagtaaa
      841 gacaaagaaa ggatagactg tggacaacca aggaagcctt gttactgcgg tgcccaatca
      901 tgtgccactt tcctgcccta tgacagttca ctatatggcc ccttagaaaa tccaggcacc
      961 agttaggaaa ggaggtccta cctgcctgcc cctttgtgga cagaaatcag agggagccaa
     1021 gcaagcaacc tacactcaag ggaaggctac cttgtagtct gcatcttgct catccctgta
     1081 agacaagggg ttgtgcagac ctgtctctgc cagggtccct atgttcaact cagcaatatg
     1141 gcccacactg aagaatgtcc aacaatacac tttctcccag aacacttgta tttgtagcta
     1201 aatgtgggta tgttgaaact atcaggatgc atgcgatgga tgactccttg ggtatcgtcc
     1261 ttgtgtttct tcttcaaaac cagaaaccat acttgatggc tagacttggg gacagccatc
     1321 ctaaagccag gacgaccctg gcaaaggatc attcagagct aatcatcaaa gtatctggca
     1381 ctggagaaaa tcctgctagt cctgagctga tgcctctgca cttgtaggtg gggagcctac
     1441 aatgttaagc cactgttgcc tcacatttga gcaaacctta ttcaaccgga ccttagcctc
     1501 gcttttcggc tagttttgcc agcaataaaa ctgtcttcta tctgaaaaaa aaaaaaaaaa
     1561 aaaaaaaaa
//
