LOCUS       XM_039093875            5237 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus SET domain bifurcated histone lysine
            methyltransferase 2 (Setdb2), transcript variant X1, mRNA.
ACCESSION   XM_039093875
VERSION     XM_039093875.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051350.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039093875.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5237
                     /gene="Setdb2"
                     /note="SET domain bifurcated histone lysine
                     methyltransferase 2; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 mRNA, 10 ESTs, 9
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 41 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:100361710"
                     /db_xref="RGD:2319564"
     CDS             605..3631
                     /gene="Setdb2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETDB2
                     isoform X1"
                     /protein_id="XP_038949803.1"
                     /db_xref="GeneID:100361710"
                     /db_xref="RGD:2319564"
                     /translation="MEEKIGDAKTFWMELQDDGKVDFMFEKAQDVLHSLKQKIKDGSA
                     TNGDYVQAMVLVNEATLSNSQTLEKDHTPVTQNEQKNKSNVFPSTSCENPSPEDCIIL
                     STGRKGFLPVNNKTEGSGEKEPPLHASFHHHVCSSACLREAPLSLKGENPLQLPLRCH
                     FQRRHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNTYVQL
                     TRNHPKQNEVVSDVDISNGVESVSISFCNEVDNSKLPQFKYRTTVWPRAYHLNVSSMF
                     SDSCDCSEGCIDIKKCACLQLTAKNAKACPLSPDGECTGYKYKRLQRLIPSGIYECNL
                     FCKCNRQMCQNRVIQHGPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRAT
                     PEKTNIGESESEQQHTVKNSFSKKRKIEVVCSDRQTHCESPKTEGCPPKFSSDLEEPV
                     VEMNNRNISRTQRHSVIRRPKSKTDVFHYNEKNMGFVCSYSAAPEEKNGFKPAQEHLD
                     SKARRAHEDLSSSQVGYSEDKQLTESDVIDTTTSREDTSPAYGCKHAAILNSKNTKKV
                     LEVPVKTSQEEEPAASQSQQVSCGEELASERTKIPSASLVQLSKESLFLLDASKEGNV
                     GRFLNHSCYPNLWVQNVFVETHDRNFPLAAFFTNRYVKARTELTWDYGYEAGTMPEKE
                     ILCQCFCQVTEKMEKRTCVLCPEGHDWSVIYFSPSANIAAHENCLLYSSGLVECEAHD
                     PFNIAKNFDVSSVLEKIWNGSTSKCSFCNNEGAIMGCDETSCAKNYHLLCAKEDRAIL
                     QVGVKRTYKIFCPEHPPQQEETTERANGLSIKKRRGRKKRRSLGPPAQPKTMKCRRSR
                     RHVTGEALGQRDAAVKAPFLKKCLEAGLLTELFEQIQQKMISIHGRFMDETASESDYE
                     GIETLVFGCGLFKDTLIKLEEAIKSKTCEYEERLNQMKQKLEALAHLQQNLHSFQECG
                     DLDPSGSTSGSLLPPEDHQCRCQESPEVQAGSGDSL"
ORIGIN      
        1 ctgtggactg gtgtttcccg ggttgaggtg agggcgcctc aagacttcac gctcaagtgg
       61 gggctgtaca gggcgagcag ggtgccagcc ggcttcaacc cgctgtcctg gtagctgagg
      121 tggccggggg ctctcagccg catctctccc tctgtcttgc ggcgctctct ttcgtggctg
      181 ctggttccga gtaatttggc tataatgggc tgttggcagc ggagcacagt ttaaatctca
      241 ggacactggt ccgttgcaca ggaactattc tttgttgtca ctgcagagtg gttcatgtat
      301 ttatggacca gaccatggga tgaactttta tttttaaaaa gacattgtca gtagtcctga
      361 tccagttttc aagcggcgtt gacgagtatg ctgtacctgt ttttcgtcat tctgaaagtt
      421 tattcaagca cagtttctac ttgaaaattc aaatactaga gaatattagg aagtggccta
      481 atgacatact ctattgaagg actacagatt ccacagagac tgcatttgaa tctcagttac
      541 tctccaatta aagtggtttt gattaaccta attttgaaga attttgtata agcaacacca
      601 aaagatggaa gaaaaaattg gtgatgcaaa gactttctgg atggagctac aagatgatgg
      661 taaagttgac tttatgtttg agaaagcaca agatgtccta cattcactga aacagaagat
      721 aaaagatggg tctgccacaa atggagacta tgtccaagca atggttctgg taaacgaagc
      781 aactctgagt aacagtcaga cactggaaaa agatcataca cctgtgactc agaatgaaca
      841 gaaaaacaaa tcaaatgtgt ttccctctac atcatgtgaa aacccctccc ctgaggactg
      901 tatcattcta tctacaggaa gaaaaggatt cctccctgtg aacaataaaa ctgaaggttc
      961 gggggagaag gagccccctt tgcatgcatc tttccatcac catgtgtgct ccagtgcttg
     1021 cctgagggaa gcgccactgt ccttgaaggg agaaaaccct ctgcagctgc cactcagatg
     1081 tcacttccag agacgacatg caaagacaaa ctctccctct gctgccctcc atgtaaacta
     1141 tagaacgccc tgcggacgga gtctacgaaa catggaggaa gttttccatt acctgcttga
     1201 aacggagtgt aactttttat tcacagacaa cttttctttt aatacttatg ttcagttaac
     1261 tcggaatcac ccaaagcaaa atgaagttgt ttctgatgtg gatattagta atggagtgga
     1321 atcagtgtcg atttctttct gtaatgaggt tgacaatagt aaactcccac agtttaagta
     1381 taggacgaca gtatggcccc gagcatatca tctgaacgtt tccagcatgt tttctgattc
     1441 atgtgactgt tctgagggct gcatagacat aaaaaagtgt gcatgtcttc agttgacagc
     1501 aaagaatgcc aaagcatgtc ccttgtcacc tgacggagaa tgtactggat ataaatataa
     1561 aagactgcag agactcatac cttctggcat ttatgaatgc aacctgttct gcaagtgtaa
     1621 ccgacagatg tgtcaaaacc gcgtcatcca gcatggcccc cgggtgaggc tgcaggtgtt
     1681 caaaagtgag aagaagggct ggggagtgcg ctgcctggat gacattgaca aagggacatt
     1741 tgtgtgcatt tattcaggaa ggttactgag cagagccact cctgagaaaa ctaacattgg
     1801 tgaaagtgaa agtgagcagc agcacaccgt gaaaaattca ttctctaaaa agaggaaaat
     1861 agaagttgta tgttcagatc gtcaaacaca ctgtgaaagt cctaaaactg agggatgtcc
     1921 tcctaagttt agcagtgatc tcgaagagcc cgttgtggaa atgaataata gaaatatttc
     1981 aagaactcag cgtcattcag tcattagaag acctaaatcc aagacagatg tttttcatta
     2041 caatgagaaa aacatgggat tcgtttgctc atattctgct gccccagaag agaagaatgg
     2101 atttaaacca gctcaagaac acctggactc taaagctagg agagctcacg aggacttaag
     2161 ttcaagccaa gttggatatt ctgaagacaa gcagctgact gaatcagatg tgatagatac
     2221 aactaccagt agagaagaca cttccccagc atacgggtgt aagcacgcag ccatattgaa
     2281 tagtaagaac actaaaaaag tgcttgaagt ccccgtaaaa acgtcccaag aggaagagcc
     2341 tgcagcctct caaagccagc aggtctcgtg tggtgaggag ctggcaagtg aaaggacaaa
     2401 gattccatct gcttccctgg tgcagctcag taaggagagt ctgtttctat tggatgcttc
     2461 aaaagaagga aatgtgggcc gtttccttaa tcacagttgc tacccaaatc tctgggtgca
     2521 gaacgtgttt gtagaaaccc atgacaggaa tttcccattg gcggccttct tcaccaacag
     2581 gtatgtgaaa gcaagaacag aactaacatg ggattatggt tatgaagctg ggaccatgcc
     2641 tgaaaaggaa atcctctgcc aatgtttctg tcaggttaca gagaagatgg agaagaggac
     2701 atgtgtcctc tgccctgaag gccacgactg gagtgtgatt tacttttcac catcagcaaa
     2761 tatagctgct catgagaact gtctgctgta ttcatcagga ctggtggagt gtgaggccca
     2821 tgatccattt aatatagcta aaaattttga tgtaagttca gtacttgaga agatctggaa
     2881 cggaagcacg tcgaaatgct cattttgtaa taacgaggga gccatcatgg ggtgtgatga
     2941 aacttcctgt gccaagaatt accacttact ctgtgccaag gaggaccgcg caattctaca
     3001 agttggagtc aaaagaactt acaaaatatt ttgcccagaa catcctccac aacaagaaga
     3061 gaccactgaa cgtgccaatg gcctaagcat caagaagagg agaggaagga agaaacgacg
     3121 ttcattgggc cctcccgcac agccaaaaac gatgaaatgc aggagatcta gaagacatgt
     3181 gacaggagag gctctcggcc agagagatgc agctgtcaaa gctccttttc ttaagaaatg
     3241 cctggaagca ggacttctta ctgaattatt tgaacagata caacaaaaaa tgatttcaat
     3301 tcatggaaga ttcatggatg agactgcttc agagtcagac tatgaaggga tcgagacctt
     3361 agtgtttggc tgtggactat ttaaagacac attaataaaa ttagaagaag caatcaagag
     3421 taaaacttgt gaatatgaag aaaggctgaa ccagatgaag cagaagcttg aggcactcgc
     3481 acacttacaa caaaacctgc actcatttca agaatgtggg gacctggacc cctcaggctc
     3541 tacctcaggg tccttgctac ctcctgagga ccaccagtgc agatgccagg agtctcctga
     3601 agtgcaagca ggctcaggag acagcctgtg acagatccag tcccctccag ctctgacctg
     3661 ctactgctca gccaggctcc atacctgaca ggtgtttctt gtctcctctc tagtcatctc
     3721 acttgtcctg ccttctcctg acagtaacag ctgttcctca ggtcaactgg atcaggcccc
     3781 catgtcctct aaggagcagg aagtcctcct acctacccta cccaccctag tcaggggcag
     3841 ccacaccaca gcctttgctc atccttttgt ggaatcttag agctttcttc ttgcttctgc
     3901 tactcctgca gtaggtctgt gtcatcatgg tctcctctca gtattagtga cttcatcaga
     3961 atggagcaga gcctcactcc tgtgcatagc tcgctggtac cctgggtttc tgctcactac
     4021 caccttccca acattgagca cacttaataa atgcttgaca aaacactgtg aagaatcaac
     4081 agtttcttta atacagttcc cagcagccct cagcggtaag aagacacagt gcactattct
     4141 gtcttaccaa ttctgtgggt ctccatcagt ctttttagaa gtgtctttgt gggcacagtc
     4201 attacaaggg caagcttcat cttcaagacc gagtctggca tttcaactgg gctctttgaa
     4261 taagagcacc aggggaatag ggaatgtgga gaacggaggc tttccccacc tgacaatatg
     4321 catcagatct gtgtgcaaca ctgcccctgg cccttgattc ctttcacatt cacatttcta
     4381 atttcctccc atgatcctct gggttacagt aaagcacctg tcagaatgaa gttgagctgt
     4441 gtcctaacat tgggtctagt ttgtaatgag tgctcacgcc tacgtgtgta ggaatcactc
     4501 ctgtacaaga ctgtggtgac caaggccagt ctaagccact tctttgcaga tcagctggaa
     4561 tgactgcagt gtgagcgccg gtctgaacca gctgggacac ttatgttcgg ccttcctctg
     4621 ctgctttatt caactggaat ttgttcatct cagtaaatta tgtggcacag aaagcactgt
     4681 ttggtgttta taaagtaggc gtatattggg caaactgata aaataaacct gctgttatta
     4741 ctgaaaaatc atcaaatact cacagccctc actttaataa cagaaagcag acagctgaac
     4801 tgacctttcc cagttgctct ctgacctcca caaggatggc acattgacac ctccatgtgc
     4861 aaaggtcatg tttaagaagt cacagatccc attacatcac tgctgttagc ccaacctcta
     4921 ctttctctgt agagccagtc tgtctcacaa ggacagtggc tttttccatc agatgcttca
     4981 actgtccact tgtaacagaa ataagatctt ttggtggtga gttagtggag aaatagctga
     5041 cacattcaga atggtaactt acttttattc taacattgat aatgtaaaaa tcatgataca
     5101 atgcaagtaa caatttaaca taacttttgt ttgttctttc tccatgtaaa tgcttttaaa
     5161 atatataggt cggaggcata aaatacaacc aaaattatta ttcatccaca aacttcttca
     5221 ccttgcaaaa aaaaaaa
//
