LOCUS       NM_001271175            4538 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus SET domain bifurcated histone lysine
            methyltransferase 1 (Setdb1), mRNA.
ACCESSION   NM_001271175 XM_002726023 XM_002729082
VERSION     NM_001271175.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4538)
  AUTHORS   Fukuda,K., Okuda,A., Yusa,K. and Shinkai,Y.
  TITLE     A CRISPR knockout screen identifies SETDB1-target retroelement
            silencing factors in embryonic stem cells
  JOURNAL   Genome Res 28 (6), 846-858 (2018)
   PUBMED   29728365
REFERENCE   2  (bases 1 to 4538)
  AUTHORS   Timms,R.T., Tchasovnikarova,I.A., Antrobus,R., Dougan,G. and
            Lehner,P.J.
  TITLE     ATF7IP-Mediated Stabilization of the Histone Methyltransferase
            SETDB1 Is Essential for Heterochromatin Formation by the HUSH
            Complex
  JOURNAL   Cell Rep 17 (3), 653-659 (2016)
   PUBMED   27732843
REFERENCE   3  (bases 1 to 4538)
  AUTHORS   Valle-Garcia,D., Qadeer,Z.A., McHugh,D.S., Ghiraldini,F.G.,
            Chowdhury,A.H., Hasson,D., Dyer,M.A., Recillas-Targa,F. and
            Bernstein,E.
  TITLE     ATRX binds to atypical chromatin domains at the 3' exons of zinc
            finger genes to preserve H3K9me3 enrichment
  JOURNAL   Epigenetics 11 (6), 398-414 (2016)
   PUBMED   27029610
REFERENCE   4  (bases 1 to 4538)
  AUTHORS   Kostaki,M., Manona,A.D., Stavraka,I., Korkolopoulou,P., Levidou,G.,
            Trigka,E.A., Christofidou,E., Champsas,G., Stratigos,A.J.,
            Katsambas,A., Papadopoulos,O., Piperi,C. and Papavassiliou,A.G.
  TITLE     High-frequency p16(INK) (4A) promoter methylation is associated
            with histone methyltransferase SETDB1 expression in sporadic
            cutaneous melanoma
  JOURNAL   Exp Dermatol 23 (5), 332-338 (2014)
   PUBMED   24673285
REFERENCE   5  (bases 1 to 4538)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4538)
  AUTHORS   Ryu,H., Lee,J., Hagerty,S.W., Soh,B.Y., McAlpin,S.E., Cormier,K.A.,
            Smith,K.M. and Ferrante,R.J.
  TITLE     ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in
            Huntington's disease
  JOURNAL   Proc Natl Acad Sci U S A 103 (50), 19176-19181 (2006)
   PUBMED   17142323
REFERENCE   7  (bases 1 to 4538)
  AUTHORS   Dodge,J.E., Kang,Y.K., Beppu,H., Lei,H. and Li,E.
  TITLE     Histone H3-K9 methyltransferase ESET is essential for early
            development
  JOURNAL   Mol Cell Biol 24 (6), 2478-2486 (2004)
   PUBMED   14993285
REFERENCE   8  (bases 1 to 4538)
  AUTHORS   Wang,H., An,W., Cao,R., Xia,L., Erdjument-Bromage,H., Chatton,B.,
            Tempst,P., Roeder,R.G. and Zhang,Y.
  TITLE     mAM facilitates conversion by ESET of dimethyl to trimethyl lysine
            9 of histone H3 to cause transcriptional repression
  JOURNAL   Mol Cell 12 (2), 475-487 (2003)
   PUBMED   14536086
REFERENCE   9  (bases 1 to 4538)
  AUTHORS   Schultz,D.C., Ayyanathan,K., Negorev,D., Maul,G.G. and
            Rauscher,F.J. 3rd.
  TITLE     SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific
            methyltransferase that contributes to HP1-mediated silencing of
            euchromatic genes by KRAB zinc-finger proteins
  JOURNAL   Genes Dev 16 (8), 919-932 (2002)
   PUBMED   11959841
REFERENCE   10 (bases 1 to 4538)
  AUTHORS   Yang,L., Xia,L., Wu,D.Y., Wang,H., Chansky,H.A., Schubach,W.H.,
            Hickstein,D.D. and Zhang,Y.
  TITLE     Molecular cloning of ESET, a novel histone H3-specific
            methyltransferase that interacts with ERG transcription factor
  JOURNAL   Oncogene 21 (1), 148-152 (2002)
   PUBMED   11791185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Sep 7, 2012 this sequence version replaced
            XM_002729082.2, XM_002726023.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.569524.1,
                                           SRR26360172.370223.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000002.1  185618884-185618982 c
            100-368             JAXUCZ010000002.1  185617775-185618043 c
            369-520             JAXUCZ010000002.1  185616048-185616199 c
            521-555             JAXUCZ010000002.1  185609911-185609945 c
            556-655             JAXUCZ010000002.1  185608194-185608293 c
            656-781             JAXUCZ010000002.1  185607395-185607520 c
            782-983             JAXUCZ010000002.1  185606992-185607193 c
            984-1057            JAXUCZ010000002.1  185606110-185606183 c
            1058-1248           JAXUCZ010000002.1  185603968-185604158 c
            1249-1378           JAXUCZ010000002.1  185603647-185603776 c
            1379-1529           JAXUCZ010000002.1  185602480-185602630 c
            1530-1688           JAXUCZ010000002.1  185602216-185602374 c
            1689-2357           JAXUCZ010000002.1  185600940-185601608 c
            2358-2474           JAXUCZ010000002.1  185599649-185599765 c
            2475-2644           JAXUCZ010000002.1  185592418-185592587 c
            2645-3273           JAXUCZ010000002.1  185591103-185591731 c
            3274-3302           JAXUCZ010000002.1  185590453-185590481 c
            3303-3432           JAXUCZ010000002.1  185590208-185590337 c
            3433-3598           JAXUCZ010000002.1  185589779-185589944 c
            3599-3810           JAXUCZ010000002.1  185588774-185588985 c
            3811-3899           JAXUCZ010000002.1  185588478-185588566 c
            3900-4538           JAXUCZ010000002.1  185587722-185588360 c
FEATURES             Location/Qualifiers
     source          1..4538
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4538
                     /gene="Setdb1"
                     /note="SET domain bifurcated histone lysine
                     methyltransferase 1"
                     /db_xref="GeneID:689883"
                     /db_xref="RGD:1308370"
     exon            1..99
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            100..368
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..4017
                     /gene="Setdb1"
                     /EC_number="2.1.1.354"
                     /note="SET domain, bifurcated 1; histone-lysine
                     N-methyltransferase SETDB1-like"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETDB1"
                     /protein_id="NP_001258104.1"
                     /db_xref="GeneID:689883"
                     /db_xref="RGD:1308370"
                     /translation="MSSLPGCMSLAAAPAAADSAEIAELQQAVVEELGISMEELRQFI
                     DEELEKMDCIQQRKKQLAELETWVLQKESEVAYVDRLFDDASREVTNCESLVKDFYSK
                     LGLQYHDSSSDDEASQPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKS
                     AQDVQKFMDAVNKKSSSQDLHKGTLGQVSGELSKDGDLIVSMRILGKKRTKTWHKGTL
                     IAIQTVGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYKDGNQVWL
                     YAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDSSCRDFIE
                     EYITAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGS
                     TRLEPMFSMKTSSASAMEKKQGGQLRTRPNMGAVRSKGPVVQYTQDLTSTGIQFKPME
                     PLQPIVPPAPLPMLPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPGSVSSGHSSPTS
                     PTLSENVPPGKIGMNQTYRSPSASVTSTPAPAAPSGPPAPPGPLAPPGPPAPPAFHGM
                     LERAPAEPSYRAPMEKLFYLPHVCSYTCLSRIRPMRNEQYRGKNPLLVPLLYDFRRMT
                     ARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLYLEMFCLDPYVLVDRKF
                     QPFKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVG
                     CDCKDGCRDKSKCACHQLTVQATACTPGGQINPSSGYQHKRLEECLPTGVYECNKRCK
                     CDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADK
                     EGLEMGDEYFANLDHIESVENFKEGYESDVPSSSDSSGVDMKDQEDGNSGSEDPEESN
                     DDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKESELSEVTSKDSRAPDRGPPHVPIT
                     PSGSVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSRSSFKTSEGGDGRAGGGR
                     GEAERASTSGLSFKDEGDSKQSKKEDPEDRNKMSVVTEGSQNHGHNPPMKSEGLRRPA
                     SKISMLQSQRVVTSTQSNPDDILTLSSSTESEGESGTSRKPTTGQTSATAVDSDDIQT
                     ISSGSDGDDFEDKKNLSGPTKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPV
                     RKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA
                     SKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL"
     exon            369..520
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..555
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..655
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..781
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..983
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1057
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1248
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1378
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1529
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1688
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..2357
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2474
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2644
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..3273
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3302
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3432
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3598
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3810
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3899
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..4538
                     /gene="Setdb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttttggcga ggcggagccc tggagtaaaa cctggggtcg gtgttgtgag acccggccct
       61 tgcggttggg agccggagct gtggggcggg ctgactgagg gcgaaagcat gtcctccctc
      121 cctgggtgca tgagtttggc tgcagcgcca gctgcggcgg actctgcaga gattgctgag
      181 ctgcagcagg cagtggttga agagctgggt atctctatgg aggaacttcg tcagttcatc
      241 gatgaagaac tggaaaagat ggactgtata cagcagcgca agaagcagct ggcagagctg
      301 gagacgtggg tgctgcagaa ggagtctgag gtggcttatg ttgatcggct gtttgatgat
      361 gcatctaggg aagtgactaa ttgtgagtct ttggtgaagg atttctactc taagctggga
      421 ttacagtatc atgacagtag ctctgacgat gaagcttccc agcctacaga gataatcgag
      481 attcctgatg aagatgatga tgtcctcagt attgattcag gtgatgctgg gagcagaacg
      541 ccaaaagatc agaagcttcg tgaagctatg gctgccttaa gaaaatcagc tcaagatgtc
      601 cagaagttca tggatgctgt gaataagaaa agcagttctc aagatctaca taaaggaacc
      661 ttgggtcagg tgtctggaga actgagcaaa gatggggacc tgatagtcag catgcggatt
      721 ctgggcaaga agaggactaa gacgtggcac aaaggcaccc tcattgccat ccagactgtc
      781 gggctaggaa agaaatacaa agtgaaattt gacaacaaag gaaagagtct gctgtctggg
      841 aaccatattg cctatgatta ccaccctcct gctgacaagc tgtttgtggg cagtcgagtg
      901 gtggccaaat acaaagatgg aaatcaggtc tggctttatg ctggcattgt agctgagacc
      961 cctaacgtca agaacaagct cagattttta attttttttg atgatggcta tgcttcctat
     1021 gtcactcagt ccgagctgta tcccatttgc cgaccattga aaaagacttg ggaggacata
     1081 gaagacagct cctgccgaga cttcatagaa gaatatatca ctgcctatcc aaaccgccca
     1141 atggtacttc tcaagagtgg ccagcttatt aagactgagt gggaaggcac atggtggaag
     1201 tctcgagttg aagaggttga tggcagccta gtcaggatcc tctttctgga tgacaaaaga
     1261 tgtgagtgga tctatcgagg ctctacacgc ctggaaccta tgttcagtat gaagacatcc
     1321 tcagcctctg caatggagaa gaagcaaggg gggcaactca gaacccgtcc taatatgggt
     1381 gctgtgagga gcaaaggtcc tgttgttcag tacactcagg atctaacgag tactggaatc
     1441 cagtttaagc ccatggagcc cctgcagcct atagtcccac ctgccccgct tcccatgctt
     1501 cctctttccc cccaggcagg cgacagtgaa agcttagaaa gccagcttgc tcaatcacgg
     1561 aagcaagtag ccaaaaagag cacatcattc cgaccaggat ctgtgagttc tggccattcc
     1621 tcccctactt cgcccacact cagtgaaaat gtaccccctg ggaaaattgg aatgaaccag
     1681 acatacagat caccttcagc ctctgtaaca tctaccccag cacctgcagc cccttctggg
     1741 cctccagccc ctccagggcc tcttgctcct cctggaccac cggcccctcc agctttccac
     1801 ggcatgttag agcgggcacc agctgagccc tcctatcgtg cccctatgga gaagcttttc
     1861 tatttacctc atgtctgcag ttacacttgt ttgtcccgga ttagacccat gaggaatgaa
     1921 caatatcggg gcaaaaaccc tctactggtc ccactattgt atgacttccg gaggatgaca
     1981 gcacgtcgca gagttaaccg caagatgggc ttccatgtaa tctataagac accctgtggt
     2041 ctctgccttc ggacgatgca ggaaatagag cgctaccttt ttgagactgg ctgtgacttc
     2101 ctgtacctgg agatgttctg tttggatcca tatgtccttg ttgacagaaa gttccagccc
     2161 tttaaacctt tttactatat tttggacatc acctatggca aagaagatgt tcccctgtcc
     2221 tgtgttaatg agattgacac aactccccca ccccaggtgg cctacagcaa ggaacgcatt
     2281 cctggcaagg gtgttttcat taacacaggc cctgaatttc tggttggctg tgactgcaag
     2341 gatgggtgtc gggataaatc caagtgtgcc tgccatcagc tcactgtcca ggccacagcc
     2401 tgtaccccag ggggtcagat caaccctagc tccggctacc agcacaaaag actagaagag
     2461 tgtctgccca caggggttta tgagtgtaac aagcgctgca aatgtgaccc aaacatgtgc
     2521 acaaatcggt tggtgcagca tggactgcag gttcgactac agctgtttaa gacacagaac
     2581 aagggctggg gcatccgctg cttggatgac attgctaaag gctcttttgt ctgcatttat
     2641 gcaggcaaaa tcctgacaga tgactttgca gacaaagaag gcctcgagat gggtgatgag
     2701 tactttgcaa atctggacca cattgaaagt gtggagaact tcaaggaagg atatgagagt
     2761 gacgtcccca gctcctctga cagcagtggg gtggatatga aggaccagga ggatggcaac
     2821 agtggctcag aggaccctga ggagtccaac gacgacagct ccgatgacaa cttctgtaag
     2881 gacgaggact tcagcaccag ttcagtgtgg cgtagctatg caacccggag gcagactcgg
     2941 ggtcagaagg agagtgaact gtctgaggtg acttcaaagg actcccgcgc cccagaccgt
     3001 gggcctcccc acgtccctat cactccctca ggatctgtag ggggttgcaa tccaccttcc
     3061 tccgaagaga cacccaagaa caaggtggcc tcatggttga gctgcaatag tgtcagtgaa
     3121 ggtggatttg ctgactctga cagccgttcc tcctttaaga ctagtgaagg tggagatggc
     3181 cgtgctgggg gaggccgggg agaggctgaa agagcctcta cctcaggatt gagcttcaag
     3241 gatgaaggag acagtaagca atctaaaaaa gaggaccctg aggaccgaaa caagatgtca
     3301 gtagttactg aaggctctca gaatcatgga cacaatcctc ccatgaagtc tgaagggctt
     3361 cgccgaccag ctagtaaaat ttctatgctc cagagccagc gagttgtgac ttctactcag
     3421 tcaaaccctg atgatatcct aacactgtcc agcagcacag aaagtgaggg ggaaagtgga
     3481 accagccgaa agcccactac tggtcagact tcagccacag cagttgacag tgatgacatc
     3541 cagaccatct cttctggctc tgatggcgat gactttgagg acaagaagaa cttgtcggga
     3601 ccaacaaagc gtcaggtggc agtaaaatca acccgaggct ttgctcttaa atcaacccat
     3661 ggtattgcca ttaaatcaac caacatggct tccgtggaca agggggagag tgcaccagtt
     3721 cgtaagaaca cacgccagtt ctatgatggt gaagagtctt gctacatcat tgatgccaaa
     3781 cttgaaggca acctaggccg ctacctcaat cacagttgca gccccaacct gtttgtccag
     3841 aacgtttttg tggataccca tgatcttcgc ttcccttggg tggccttttt tgccagcaag
     3901 agaatccggg ctggaacaga actcacttgg gattacaact atgaagtggg cagtgtggaa
     3961 ggcaaggaac tgctgtgctg ctgtggagcc attgaatgca gagggcggct tctctagagg
     4021 aagactcttc ctcactctga ggatcccttc cccaggaact gggtctttct gactccacgt
     4081 ctctgatctg gcttctcccc agctcctagt agataaaagt gggggtccta gatcaggacg
     4141 ttgccagcgt ggtgctagca ggcactaggg tgggatgacc accctagcat cagcctgagg
     4201 tccttctcat cccgtatgtg ttcatgattc acatgcgccg tgtatctggt ttgtatggtt
     4261 tcttgaaagt cttctaacaa gatgataaaa tagagcttgt ggtttgtctt ctctcctcag
     4321 ccccatcttg accttccagg gagatgtcat ttcccaatgg caactatcat tagtttaccc
     4381 cttgatttta tttgccttgt gtaattttta acagcaacaa aagttccatg accaggaggg
     4441 aagcctaaga aaaataaccc ttctcaagtc ttaatagtct gacacagtca tgttttattt
     4501 aacctttaat atactttaat taaaaaaaat taacagta
//
