LOCUS       NM_001109558            1977 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Rattus norvegicus SET domain containing 7, histone lysine
            methyltransferase (Setd7), mRNA.
ACCESSION   NM_001109558 XM_001072672
VERSION     NM_001109558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Pan,X., Fan,J., Peng,F., Xiao,L. and Yang,Z.
  TITLE     SET domain containing 7 promotes oxygen-glucose
            deprivation/reoxygenation-induced PC12 cell inflammation and
            oxidative stress by regulating Keap1/Nrf2/ARE and NF-kappaB
            pathways
  JOURNAL   Bioengineered 13 (3), 7253-7261 (2022)
   PUBMED   35259059
  REMARK    GeneRIF: SET domain containing 7 promotes oxygen-glucose
            deprivation/reoxygenation-induced PC12 cell inflammation and
            oxidative stress by regulating Keap1/Nrf2/ARE and NF-kappaB
            pathways.
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Jetton,T.L., Flores-Bringas,P., Leahy,J.L. and Gupta,D.
  TITLE     SetD7 (Set7/9) is a novel target of PPARgamma that promotes the
            adaptive pancreatic beta-cell glycemic response
  JOURNAL   J Biol Chem 297 (5), 101250 (2021)
   PUBMED   34592314
  REMARK    GeneRIF: SetD7 (Set7/9) is a novel target of PPARgamma that
            promotes the adaptive pancreatic beta-cell glycemic response.
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Sharma,N., Sankrityayan,H., Kale,A. and Gaikwad,A.B.
  TITLE     Role of SET7/9 in the progression of ischemic renal injury in
            diabetic and non-diabetic rats
  JOURNAL   Biochem Biophys Res Commun 528 (1), 14-20 (2020)
   PUBMED   32448511
  REMARK    GeneRIF: Role of SET7/9 in the progression of ischemic renal injury
            in diabetic and non-diabetic rats.
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Shen,Y., Ding,Z., Ma,S., Ding,Z., Zhang,Y., Zou,Y., Xu,F., Yang,X.,
            Schafer,M.K.E., Guo,Q. and Huang,C.
  TITLE     SETD7 mediates spinal microgliosis and neuropathic pain in a rat
            model of peripheral nerve injury
  JOURNAL   Brain Behav Immun 82, 382-395 (2019)
   PUBMED   31505256
  REMARK    GeneRIF: SETD7 mediates spinal microgliosis and neuropathic pain in
            a rat model of peripheral nerve injury.
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Dang,Y., Ma,X., Li,Y., Hao,Q., Xie,Y., Zhang,Q., Zhang,F. and Qi,X.
  TITLE     Inhibition of SETD7 protects cardiomyocytes against
            hypoxia/reoxygenation-induced injury through regulating Keap1/Nrf2
            signaling
  JOURNAL   Biomed Pharmacother 106, 842-849 (2018)
   PUBMED   30119254
  REMARK    GeneRIF: SETD7 gene silencing attenuates
            hypoxia/reoxygenation-induced injury of cardiomyocytes via the
            down-regulation of Keap1 and promotion of the Nrf2-mediated
            anti-oxidation signaling pathway.
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Sun,G., Reddy,M.A., Yuan,H., Lanting,L., Kato,M. and Natarajan,R.
  TITLE     Epigenetic histone methylation modulates fibrotic gene expression
  JOURNAL   J Am Soc Nephrol 21 (12), 2069-2080 (2010)
   PUBMED   20930066
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Kruse,J.P. and Gu,W.
  TITLE     Modes of p53 regulation
  JOURNAL   Cell 137 (4), 609-622 (2009)
   PUBMED   19450511
  REMARK    Review article
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Shi,X., Kachirskaia,I., Yamaguchi,H., West,L.E., Wen,H., Wang,E.W.,
            Dutta,S., Appella,E. and Gozani,O.
  TITLE     Modulation of p53 function by SET8-mediated methylation at lysine
            382
  JOURNAL   Mol Cell 27 (4), 636-646 (2007)
   PUBMED   17707234
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Huang,J., Perez-Burgos,L., Placek,B.J., Sengupta,R., Richter,M.,
            Dorsey,J.A., Kubicek,S., Opravil,S., Jenuwein,T. and Berger,S.L.
  TITLE     Repression of p53 activity by Smyd2-mediated methylation
  JOURNAL   Nature 444 (7119), 629-632 (2006)
   PUBMED   17108971
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Couture,J.F., Collazo,E., Hauk,G. and Trievel,R.C.
  TITLE     Structural basis for the methylation site specificity of SET7/9
  JOURNAL   Nat Struct Mol Biol 13 (2), 140-146 (2006)
   PUBMED   16415881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474003.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001072672.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494,
                              SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1977
                     /gene="Setd7"
                     /note="SET domain containing 7, histone lysine
                     methyltransferase"
                     /db_xref="GeneID:689954"
                     /db_xref="RGD:1586346"
     exon            1..136
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1197
                     /gene="Setd7"
                     /EC_number="2.1.1.354"
                     /note="SET domain containing (lysine methyltransferase) 7"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD7"
                     /protein_id="NP_001103028.1"
                     /db_xref="GeneID:689954"
                     /db_xref="RGD:1586346"
                     /translation="MDSDDEVVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGE
                     KNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDG
                     RLIFKGQYKDNIRHGVCWIHYPDGGSLVGEVNEDGEMTGEKIAYVYPDQRTALYGKFI
                     DGEMLEGKLATLMATEEGKPHFELTSGSSVFHFDKSTSSCISSDALLPDPYESERVYV
                     ADSLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVID
                     VPEPYNHVSKYCASLGHKANHSFTPNCVYDMFVHPRFGPIKCIRTLRAVEAEEELTVA
                     YGYDHSPPGKSGPEAPEWYQVELKAFQATQQK"
     exon            137..266
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
     exon            267..468
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
     exon            469..658
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
     exon            659..740
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
     exon            741..858
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1016
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1977
                     /gene="Setd7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagggctta gctcctgcgt tcgctcagcc accgccagca cccggaggga ccggagccgg
       61 acgcacggcc ccgtgctggg tagggtcgca gctgccatgg atagcgacga cgaggtagtg
      121 gaggaagccg tggaagggca cctggacgat gacggattac cacacgggtt ctgcactgtc
      181 acctactcct ccacagacag atttgagggc aacttcgtgc atggagaaaa gaatggacgt
      241 gggaaattct tcttctttga cggcagcacc ctggagggat actatgtgga tgatgccctg
      301 cagggccagg gcgtttacac ctatgaggat ggaggtgttc tgcaaggcac ctatgtggat
      361 ggggagctga atgggccagc ccaggagtac gacaccgacg ggaggctgat cttcaaggga
      421 cagtacaaag acaacattcg acacggagtg tgttggatcc attacccaga tggaggcagt
      481 ctcgtcgggg aagtcaatga agatggggag atgacagggg aaaagatagc ctacgtgtac
      541 cctgatcaga ggactgcgct ctatgggaag ttcattgatg gagagatgct ggaagggaag
      601 ctggccaccc tcatggccac agaagaaggg aagccacact ttgaactgac atcgggaagt
      661 tccgtgttcc actttgataa atcgacttcc tcctgcatct ctagcgatgc cctccttcca
      721 gacccttatg agtccgagag ggtttatgtt gccgactctc tcatctccag tgccggagaa
      781 ggactgtttt ccaaggtagc agtgggaccc aatactgtca tgtcatttta taatggagtc
      841 cgaattacac accaagaggt tgacagcagg gactgggccc taaatgggaa cactctctcc
      901 ctggatgagg aaacagtcat tgatgtgcct gagccctaca accacgtgtc caagtactgt
      961 gcctccttgg gacacaaggc gaatcactcc tttactccaa actgcgtcta tgacatgttt
     1021 gtccatcccc gttttgggcc catcaagtgc atccgcaccc ttcgagctgt ggaggctgag
     1081 gaggagctga ccgttgccta cggctatgac cacagccccc cggggaagag tgggcccgaa
     1141 gcccccgagt ggtatcaggt ggagctgaag gccttccagg ccacccagca aaagtgaaag
     1201 gcttggccct gggttccaga gacctgggat agaaatccgg atctatgcac tacatttatc
     1261 tgacaacggg acaaccaggg actgttcatg ccgtgacttc acatcctctc accctgcgtt
     1321 agcaacgact cctctcgcat actaactagg tttgactgta ttactcatac cagatttaaa
     1381 attagctagc cttgcaacaa agccctactg agagggactg tcgaactgtg ggacaacatg
     1441 atgttctttg atggttgaag tctaaatctg gaccacgttc agagatacca aatgattagg
     1501 ctgaaaaagg gaaatggggt tcttcggtct tttttttttt tttttctctt tctttctttt
     1561 tttttttttt tttttttttt ttggtcgatg ggtttttttt tcccatgatg cttttctcta
     1621 cagccagtgc aaacggtgct cagtcaccct tgcatgttgc caaccgtagg gcaggaagcg
     1681 attacgtctt tatatacatg tagggccact tgccttttaa cctttgatct gtatcttgca
     1741 atagaatggc attgtttttg ttgttactct cctagcttcc caacgttagc tactttacaa
     1801 gaggaagctt ccaaatggat tttgcactcg tagcagcata caggtctttc tggttctttc
     1861 tctgccattt cattcttatg tcctgatata aggtcctggc tcgtagggcc agactgttat
     1921 tatagactta actattctcg catgtcaaca gatatctttg ctttcagatg tgagaag
//
