LOCUS       NM_001106614            7113 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SET domain containing 5 (Setd5), mRNA.
ACCESSION   NM_001106614 XM_001076318 XM_001076340 XM_001076365 XM_001076382
            XM_001076404 XM_001076430 XM_238368
VERSION     NM_001106614.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7113)
  AUTHORS   Yang,Z., Zhang,C., Liu,X., Che,N., Feng,Y. and Xuan,Y.
  TITLE     SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and
            Fuels Tumor Growth
  JOURNAL   Am J Pathol 192 (4), 712-721 (2022)
   PUBMED   35063407
REFERENCE   2  (bases 1 to 7113)
  AUTHORS   Cheung,M.Y., Roberts,C., Scambler,P. and Stathopoulou,A.
  TITLE     Setd5 is required in cardiopharyngeal mesoderm for heart
            development and its haploinsufficiency is associated with outflow
            tract defects in mouse
  JOURNAL   Genesis 59 (7-8), e23421 (2021)
   PUBMED   34050709
REFERENCE   3  (bases 1 to 7113)
  AUTHORS   Piao,L., Li,H., Feng,Y., Yang,Z., Kim,S. and Xuan,Y.
  TITLE     SET domain-containing 5 is a potential prognostic biomarker that
            promotes esophageal squamous cell carcinoma stemness
  JOURNAL   Exp Cell Res 389 (1), 111861 (2020)
   PUBMED   31981592
REFERENCE   4  (bases 1 to 7113)
  AUTHORS   Sessa,A., Fagnocchi,L., Mastrototaro,G., Massimino,L., Zaghi,M.,
            Indrigo,M., Cattaneo,S., Martini,D., Gabellini,C., Pucci,C.,
            Fasciani,A., Belli,R., Taverna,S., Andreazzoli,M., Zippo,A. and
            Broccoli,V.
  TITLE     SETD5 Regulates Chromatin Methylation State and Preserves Global
            Transcriptional Fidelity during Brain Development and Neuronal
            Wiring
  JOURNAL   Neuron 104 (2), 271-289 (2019)
   PUBMED   31515109
REFERENCE   5  (bases 1 to 7113)
  AUTHORS   Moore,S.M., Seidman,J.S., Ellegood,J., Gao,R., Savchenko,A.,
            Troutman,T.D., Abe,Y., Stender,J., Lee,D., Wang,S., Voytek,B.,
            Lerch,J.P., Suh,H., Glass,C.K. and Muotri,A.R.
  TITLE     Setd5 haploinsufficiency alters neuronal network connectivity and
            leads to autistic-like behaviors in mice
  JOURNAL   Transl Psychiatry 9 (1), 24 (2019)
   PUBMED   30655503
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7113)
  AUTHORS   Zhang,Y., Yan,L., Yao,W., Chen,K., Xu,H. and Ye,Z.
  TITLE     Integrated Analysis of Genetic Abnormalities of the Histone Lysine
            Methyltransferases in Prostate Cancer
  JOURNAL   Med Sci Monit 25, 193-239 (2019)
   PUBMED   30616239
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7113)
  AUTHORS   Deliu,E., Arecco,N., Morandell,J., Dotter,C.P., Contreras,X.,
            Girardot,C., Kasper,E.L., Kozlova,A., Kishi,K., Chiaradia,I.,
            Noh,K.M. and Novarino,G.
  TITLE     Haploinsufficiency of the intellectual disability gene SETD5
            disturbs developmental gene expression and cognition
  JOURNAL   Nat Neurosci 21 (12), 1717-1727 (2018)
   PUBMED   30455454
REFERENCE   8  (bases 1 to 7113)
  AUTHORS   Osipovich,A.B., Gangula,R., Vianna,P.G. and Magnuson,M.A.
  TITLE     Setd5 is essential for mammalian development and the
            co-transcriptional regulation of histone acetylation
  JOURNAL   Development 143 (24), 4595-4607 (2016)
   PUBMED   27864380
REFERENCE   9  (bases 1 to 7113)
  AUTHORS   Pinheiro,I., Margueron,R., Shukeir,N., Eisold,M., Fritzsch,C.,
            Richter,F.M., Mittler,G., Genoud,C., Goyama,S., Kurokawa,M.,
            Son,J., Reinberg,D., Lachner,M. and Jenuwein,T.
  TITLE     Prdm3 and Prdm16 are H3K9me1 methyltransferases required for
            mammalian heterochromatin integrity
  JOURNAL   Cell 150 (5), 948-960 (2012)
   PUBMED   22939622
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001106614.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               JAXUCZ010000004.1  147773028-147773307
            281-467             JAXUCZ010000004.1  147804862-147805048
            468-692             JAXUCZ010000004.1  147805846-147806070
            693-885             JAXUCZ010000004.1  147809379-147809571
            886-991             JAXUCZ010000004.1  147809840-147809945
            992-1143            JAXUCZ010000004.1  147810329-147810480
            1144-1202           JAXUCZ010000004.1  147810818-147810876
            1203-1381           JAXUCZ010000004.1  147811184-147811362
            1382-1624           JAXUCZ010000004.1  147814418-147814660
            1625-1773           JAXUCZ010000004.1  147815119-147815267
            1774-1891           JAXUCZ010000004.1  147815596-147815713
            1892-2001           JAXUCZ010000004.1  147816378-147816487
            2002-2248           JAXUCZ010000004.1  147816979-147817225
            2249-2332           JAXUCZ010000004.1  147817839-147817922
            2333-2590           JAXUCZ010000004.1  147818990-147819247
            2591-2911           JAXUCZ010000004.1  147820523-147820843
            2912-3154           JAXUCZ010000004.1  147821246-147821488
            3155-3284           JAXUCZ010000004.1  147827638-147827767
            3285-3532           JAXUCZ010000004.1  147837692-147837939
            3533-4003           JAXUCZ010000004.1  147841564-147842034
            4004-4302           JAXUCZ010000004.1  147845511-147845809
            4303-4436           JAXUCZ010000004.1  147846981-147847114
            4437-4525           JAXUCZ010000004.1  147847528-147847616
            4526-7113           JAXUCZ010000004.1  147848080-147850667
FEATURES             Location/Qualifiers
     source          1..7113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..7113
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /note="SET domain containing 5"
                     /db_xref="GeneID:297514"
                     /db_xref="RGD:1310433"
     exon            1..280
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            281..467
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            468..692
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            693..885
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     CDS             794..5134
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /note="SET domain-containing protein 5"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD5"
                     /protein_id="NP_001100084.1"
                     /db_xref="GeneID:297514"
                     /db_xref="RGD:1310433"
                     /translation="MEVLRDPIKKNSSESKPAQSGFSRGNSPLCCPESVEASPAVNEK
                     SLYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPC
                     GLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTAT
                     QHTPTSITLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIR
                     LWTDQYEEAFTNQYSADVQNALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGSQM
                     QLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLF
                     YSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEV
                     TIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNAAELPLPPPSFPTIGAETRRRKAR
                     RKELEMEQQNEVPEENHDPQPQEVPEKVTVSSEHEEVDNPEEKPEEEKEEATDDQENS
                     AHSRRTREDRKVEAIMHAFETLEKRKKRRDQPVEQSNSDVEITTSSSEIGVGEETKTA
                     APESEVNNPVTNIAIPSIPQSTGVNTRRSSHAGDVAAEKPVPKPPPAKPSRPRPKSRI
                     SRYRTSSAQRLKRQKQANAQQAELAQAALEEGGSNNSVTLPEAGNIDSSGESRPLTGS
                     DPTVVSVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATT
                     LNMLPGLIHSPLICTTPKHYIRFGSPFMPERRRRPLLPDGTFSSCKKRWIKQALEEGM
                     TQTSSVPQETRTQHLYQSNENSNSSSICKDNADLLSPLKKWKSRYLMEQNITKLLRPL
                     SPVTPPPPSSGSKSPQLTTPGQTHPGEEECRNGYSLMFSPITSLTTASRSNTPLQFEL
                     CHRKDLDLTKVGYPDSSTHSCGDRPSLLNCSHPDLTSHPSVAPTSEAGFPSRSGDGPQ
                     TLLRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGF
                     SSRYEHGFMKDLSRGSMSPGGERTCEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSG
                     GGSDSSQSKSKSSGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFSPSHSSTSHLEA
                     VSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPT
                     WESNITEKESDPADGEGPEPLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQS
                     SSPFRGHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSYPSPAHPVSTDSLAPFTG
                     TPGYYSSQPHSGNSTGSNLPRRSCSSSAASPTPQGPSDSPTSDSVSQSSTGTLSSTSF
                     PQNSRSSLPSDLRTISLPSAGQSAAYQASRVSAVSSSQHYPHRGSGGVHQYRLQPLQG
                     SGVKTQTGLS"
     exon            886..991
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1143
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1202
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1381
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1624
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1773
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1891
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2001
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2248
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2332
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2590
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2911
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3154
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3284
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3532
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..4003
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4302
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4436
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4525
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..7113
                     /gene="Setd5"
                     /gene_synonym="RGD1310433"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcggcc gccgcccgcc tgcgctcaga gactcacgca gccctagtcc cgccagtccg
       61 ccaacacagt agtgccggcc cccctccgcc cctggccctc cccctccccg ccttgggctc
      121 gctccgcctt ttctgccccc cacccccacc tcacgggtac gggccattcc cggccaggaa
      181 acgccgtggc gccgcgttgg gcctaactcg agtctcgctg cctcccggga gtgccgtgcg
      241 ccgcagcccg ggcccaggcc ccggcagcgc ctgggtcaag gattcctcat gtccgtaaca
      301 tgttggctga ggctctgcag ttcaccccca ctctttgagt ggtcagtctc cattaattgg
      361 accccgtgat tcctaccctc tgctgtcttg gacgtcatga gcattgcaat ccctctggga
      421 gtcaccacac cagatacatc gtactcagat atggctgctg gatcagaaaa ggaagtggaa
      481 gccccctacc tttcaagacg aagtggcact acaccaggat gtgaaagtcc agcgaaagag
      541 acccaagggg cctagggggc agcacacccc cagaagccaa gtctattcca ggcagtacca
      601 gggattaggg tctgggctgg aaaaatcctg gtgttttgaa tatgttcagg tccagttcag
      661 actcttgatc ccacagccac ttcttgagtg agggtatcct gtcttggtag tgaatggaag
      721 agggcctggt ccctggggca gtgcagaagg cactttcatc atctcactca ctgcaaatgt
      781 catgtgaggt ttcatggaag tattaagaga tccaattaag aagaatagtt ctgagtctaa
      841 accagcccag agtggcttct ctaggggaaa ctccccgctc tgctgccctg aatctgtgga
      901 ggctagtcca gcagttaatg agaagagcct gtactccact cataattatg ggaccactca
      961 gaggcatggg tgtcgaggac tgccttatgc tacgatcatc cctcgttctg acctgaatgg
     1021 cctgccgtcg cccgtagagg aacgctgtgg agacagcccg aactctgaag gagagactgt
     1081 tcctacctgg tgtccttgtg gtctttctca ggatggcttc cttctcaact gtgacaagtg
     1141 caggggaatg agcaggggga aggttattag acttcatcgg cggaagcagg acaacatatc
     1201 aggtggggat agcagtgcaa cagaaagctg ggatgaggag ctttctcctt ccactgtgtt
     1261 gtacacagca acacagcaca cacctacaag catcacctta actgttagaa gaaccaaacc
     1321 caagaagcgg aaaaagagtc cagaaaaggg tcgtgcagca ccaaagacga agaagatcaa
     1381 gaattctccc tctgaagcac agaatttaga tgaaaatacc actgagggct gggaaaatcg
     1441 gataagacta tggactgatc aatatgaaga agctttcact aatcagtaca gtgcggatgt
     1501 acagaatgcc cttgaacaac atctccattc aaacaaggaa tttgtgggca aacctgctat
     1561 tttagacact attaataaaa ctgaactggc ctgtaataat acagtaattg gttcccaaat
     1621 gcagttacag ctgggaagag tcacccgtgt tcaaaagcac cggaaaatcc tgagggctgc
     1681 aagagatttg gctttggaca ctcttataat agaatatcgt gggaaagtca tgttacgaca
     1741 acaatttgag gtcaatgggc atttcttcaa aaaaccatat ccctttgtgc tcttctactc
     1801 aaaattcaat ggtgtagaga tgtgtgtcga tgctcgtact ttcggtaatg atgctcggtt
     1861 catcagaaga tcttgtacac caaatgcaga ggtgagacac atgattgcag atgggatgat
     1921 tcacctgtgt atctatgctg tatctgctat caccaaggat gctgaagtca ccattgcatt
     1981 tgattatgaa tatagtaatt gtaattacaa agtggactgt gcttgtcaca agggaaaccg
     2041 gaattgcccc atacagaaaa gaaatcccaa tgctgcagaa ttgccactcc cacctcctag
     2101 ctttcccacc attggagcag agaccagacg tagaaaagca cggcggaaag agctggagat
     2161 ggagcagcaa aatgaggttc cagaagagaa tcatgaccca caaccacaag aagttccaga
     2221 aaaagtaact gtatccagtg agcatgagga agttgacaat ccagaagaaa aaccggaaga
     2281 agaaaaagaa gaggccacag acgaccagga gaactcagct catagcagaa ggactcggga
     2341 agataggaag gttgaagcca tcatgcatgc ttttgaaact ttagagaaga gaaagaaacg
     2401 gcgggatcag cctgtagagc agagcaactc agacgtagag attactacta gcagttcaga
     2461 gataggagtt ggagaagaga caaaaactgc agcccccgag tcagaagtta acaaccctgt
     2521 tacaaacatt gccatcccaa gcatcccaca gagcactggt gtgaatactc ggcggtcttc
     2581 ccatgctggg gatgtagcgg cagaaaagcc agtccccaaa ccacctccag ctaagccttc
     2641 tagaccccga ccgaagagta gaatttctcg gtaccggacc agttcagccc aaagactaaa
     2701 acgtcagaag caggccaacg cacaacaggc agagctcgca caagctgcct tggaagaagg
     2761 aggaagtaac aactcagtaa ctcttcctga agctggaaat atagacagtt caggagagag
     2821 cagaccgtta acagggtctg acccaactgt ggtatcagtt actggatccc atgtcaatcg
     2881 tgctgcatct aaatacccca aaaccaaaaa gtatctagtt acagaatggt taaatgacaa
     2941 ggcagagaag caagaatgcc ctgtcgagtg tcctttgcgt atcaccactg acccaactgt
     3001 attggcaaca accctgaaca tgctaccggg tcttattcat tccccattaa tttgtacgac
     3061 ccccaaacac tacattcgct ttggctcacc ctttatgcct gagaggcgtc gaaggcccct
     3121 tctgcctgat ggcacattca gctcctgtaa gaagcgctgg ataaagcaag ctttggaaga
     3181 agggatgact cagacatcat ctgtgcccca agagactaga acacagcacc tataccaaag
     3241 taatgagaat agtaattctt ctagtatctg taaagataat gcagacttat tgagcccatt
     3301 aaagaaatgg aagtctcgct atctgatgga gcagaatatc accaagttgc ttcggcctct
     3361 gtctccagtt acaccacccc cacccagctc aggctcaaag agtccccagc tgaccacacc
     3421 tggccagact cacccaggag aagaggagtg tcgaaatgga tacagcctca tgttctcacc
     3481 aatcacatct cttactactg ctagtcgttc caacactcct ctgcagtttg agctttgtca
     3541 ccgaaaagac ctagatttga caaaagtggg atacccagac tccagcactc acagctgcgg
     3601 tgataggcct tccctgctca actgcagtca tcctgacctg acttctcatc cctccgttgc
     3661 tcccacctcc gaggctggct tcccaagcag gagtggagat ggtcctcaga ccttgctgag
     3721 aaactcagac caggcgttta ggacagagtt caatttgatg tacgcctact cccctttgaa
     3781 tgctatgcct cgagcagatg gactatatag agggtctccc ttggtggggg acaggaagcc
     3841 tttacattta gatggaggat attgttcccc tgcagaaggc ttttctagca gatatgaaca
     3901 tggctttatg aaagacctct ctcggggatc catgtcacct ggtggtgaaa ggacctgtga
     3961 aggagtccca tctgctcctc agaacccacc acaaaggaaa aaggtgtcct tgctagagta
     4021 ccgcaaaagg aaacaagaag ctaaggagaa ttctggtggg ggaagtgact cttcacagag
     4081 caaaagcaag tcttcaggag ctgggcaagg cagcagtaat tctgtttctg acactggtgc
     4141 ccatggtgtg cagggatcct cagcccgaac cccctcatcc cctcacaaaa agttttcccc
     4201 atctcattcc tctacatcac atttggaggc ggtaagccca tcagattcca ggggcacttc
     4261 ttcctctcac tgcagacctc aagaaaacat cagcagtaga tggatggttc ctacatcagt
     4321 tgaacgactc cgagaaggag gtagcatccc taaggttctt cgaagcagtg tgagagttgc
     4381 ccaaaaggga gagccatctc ccacgtggga gagcaacatc acagagaaag agtcagaccc
     4441 tgcagatgga gaaggcccag agccattaag ctcagcactc tctaaaggag caactgttta
     4501 cagcccatcc agatatagct accagctcct gcagtgtgac agtccgagga cagaatcaca
     4561 aagcctcctt cagcagagtt cgtccccctt tagaggacat cccacccaat ctccaggata
     4621 cagttatcga actactgcac tgagacctgg aaaccctccc tctcatggtt cttcggaatc
     4681 atccctctct tccacgtcct accccagccc tgcccaccct gtgtctacag actcgttggc
     4741 cccatttacg gggactccag ggtattacag cagccagccg cattctggaa acagcactgg
     4801 cagcaatctt ccaaggagga gctgttcttc gagtgctgct agccctaccc cacagggccc
     4861 ctcagactca ccgacctcag actcggtttc tcagtccagc acaggaactc tgagttccac
     4921 ctcctttcct cagaactcta ggtcgtcatt gccatcagac ttacggacta tcagtctgcc
     4981 cagtgctggg cagtcagctg cctaccaggc ctccagggta tctgcggttt ccagttcaca
     5041 gcactaccca catcgtggga gtgggggtgt acaccagtac cgactccagc cattgcaagg
     5101 gtcaggagtc aagactcaga caggactttc ctagggcttc tggatatggg caaactgaac
     5161 ttaatgggcc catagctgct tccttccagc tgcctctgga atcaaggccg agcatattgc
     5221 tggggaagag gggtacaagg tgccagagga atgggtctgg tcagcaagaa atgagacttg
     5281 tggtcatgac tggcctctgg ccttggagaa agatgtaaat cttgtctgaa gcagagacta
     5341 tgaagaagtt tctccctgct gttaagggta cattgttaac aagcagatgg tgtttcggtt
     5401 agtaacgacg gttctaagtg caatgacttg tgttgaagcc tatgtctccc atccttgcct
     5461 gtagcctgta gtcacttgtg cagtaaggac atctttttca ataaaaaaaa ataataattt
     5521 ttttttcttt tcaaaagaaa aaagtgggaa gagccaatct taaagcccca agccatccga
     5581 gtagtgttag ggttttatgc acttaagaaa aaaaaaggta ggtatgtaaa tgtccactgt
     5641 gagacaacca ttcctaaagc agatgcatgg tcaaggtgtg tccacctgga gtgtgcccta
     5701 cctttgtctt atagccacca ggaaatgggc agggtgagga atgctgggtg cctactctga
     5761 ctgaggcttg cctggctctc tgagaggagg agctcctggg tatttgggag cagatttggg
     5821 atggactggg ctccagctgt taccatccac tcctcctttc caagttgttt cacagcttag
     5881 tgattaccct gtgaagtaag tagagaagtg aggcaggcca ctttaggaag catccagtgg
     5941 tctgggtaat ctttggattt tagttttcct attcccagtt aatcaggagt tgctgtccta
     6001 agagcaggat ggcctccatg actgaaaagc atgcactcat gactgcaggg taagaatggg
     6061 acagataggg ttgcggagtg gcaccgacag ggctgtgatt gtgtgtgggg cctgccccac
     6121 gtttctatgg gggatgctta tatgacagtg ggcaggtgag agagttaaca agtcacccat
     6181 acccctaaca ctgttctgta tgagagacaa agagcagact ggcttctccc catcagtgca
     6241 ttgtgcctgt tgtacacccc tggaggagcc ctgaagccag cccaggtggg gtacacaatc
     6301 tttttaaatt ccatatggtt gccagcttat ttctttcact tgtttactgt aatacctggc
     6361 gtgtttttat ttatctaatt ttgtattcag ctataaccat ggtagggtag tgagtgtatg
     6421 acagtgtgat ccctggtgct gcagtggacc gtacttcttt tggacaagat atactgtgag
     6481 tctccctcct tacctctaat tgttttcttt cccattccct agactctttc atctccttct
     6541 ttctgccctg acctacaact atcatatgca cagtcttctc tctttgtgtg tgactgttac
     6601 aaaatttcac ttttcaaaat tgaaatcagg tgtttgctca aatgagggga gaattttttt
     6661 tgttttggtt ttatttgttt ttatttgttt ttaatgctga accttcagca tagtactttt
     6721 ttgttgtttt ccctacaaac ccatcagtct gggagagcat tgggagtgga aatcatgttg
     6781 cctgggatgc cggtttcttt gtatattata taaaacgtat gtaaatgtct ctccatttgg
     6841 gctggggttt gcattctccc attggctaaa agccgaaggg agaggccagc gggcaggcgg
     6901 ccctcaccct gcctggcacg tgcagagacc ccagccactc tgtgtgggca gggtgctgtc
     6961 aagaccagac ctctgggggg gagggtgggg ggaggggggc tcttggaagg gaaggagcac
     7021 cgcttcttcc tcaagtggag tgtttacacc ttgctgtaac atttgaactt tcacaagaga
     7081 tgtaataatt ttgataataa aattcttaac cat
//
