LOCUS       NM_001346470            2773 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SET domain containing 3, actin N3(tau)-histidine
            methyltransferase (Setd3), mRNA.
ACCESSION   NM_001346470 XM_216781
VERSION     NM_001346470.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2773)
  AUTHORS   Xu,X., Cui,Y., Li,C., Wang,Y., Cheng,J., Chen,S., Sun,J., Ren,J.,
            Yao,X., Gao,J., Huang,X., Wan,Q. and Wang,Q.
  TITLE     SETD3 Downregulation Mediates PTEN Upregulation-Induced Ischemic
            Neuronal Death Through Suppression of Actin Polymerization and
            Mitochondrial Function
  JOURNAL   Mol Neurobiol 58 (10), 4906-4920 (2021)
   PUBMED   34218417
  REMARK    GeneRIF: SETD3 Downregulation Mediates PTEN Upregulation-Induced
            Ischemic Neuronal Death Through Suppression of Actin Polymerization
            and Mitochondrial Function.
REFERENCE   2  (bases 1 to 2773)
  AUTHORS   Guo,Q., Liao,S., Kwiatkowski,S., Tomaka,W., Yu,H., Wu,G., Tu,X.,
            Min,J., Drozak,J. and Xu,C.
  TITLE     Structural insights into SETD3-mediated histidine methylation on
            beta-actin
  JOURNAL   Elife 8, e43676 (2019)
   PUBMED   30785395
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2773)
  AUTHORS   Wilkinson,A.W., Diep,J., Dai,S., Liu,S., Ooi,Y.S., Song,D.,
            Li,T.M., Horton,J.R., Zhang,X., Liu,C., Trivedi,D.V., Ruppel,K.M.,
            Vilches-Moure,J.G., Casey,K.M., Mak,J., Cowan,T., Elias,J.E.,
            Nagamine,C.M., Spudich,J.A., Cheng,X., Carette,J.E. and Gozani,O.
  TITLE     SETD3 is an actin histidine methyltransferase that prevents primary
            dystocia
  JOURNAL   Nature 565 (7739), 372-376 (2019)
   PUBMED   30626964
REFERENCE   4  (bases 1 to 2773)
  AUTHORS   Kwiatkowski,S., Seliga,A.K., Vertommen,D., Terreri,M., Ishikawa,T.,
            Grabowska,I., Tiebe,M., Teleman,A.A., Jagielski,A.K.,
            Veiga-da-Cunha,M. and Drozak,J.
  TITLE     SETD3 protein is the actin-specific histidine N-methyltransferase
  JOURNAL   Elife 7, e37921 (2018)
   PUBMED   30526847
  REMARK    GeneRIF: SETD3 protein is the actin-specific histidine
            N-methyltransferase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2773)
  AUTHORS   Jiang,X., Li,T., Sun,J., Liu,J. and Wu,H.
  TITLE     SETD3 negatively regulates VEGF expression during hypoxic pulmonary
            hypertension in rats
  JOURNAL   Hypertens Res 41 (9), 691-698 (2018)
   PUBMED   29950684
  REMARK    GeneRIF: The functional interplay between SETD3 and FoxM1 on
            chromatin may negatively regulate VEGF expression under hypoxic
            pulmonary hypertension (HPH); through the VEGF
            receptor-extracellular signal-regulated kinase-hypoxia-induced
            factor-1 signal pathway.
REFERENCE   6  (bases 1 to 2773)
  AUTHORS   Eom,G.H., Kim,K.B., Kim,J.H., Kim,J.Y., Kim,J.R., Kee,H.J.,
            Kim,D.W., Choe,N., Park,H.J., Son,H.J., Choi,S.Y., Kook,H. and
            Seo,S.B.
  TITLE     Histone methyltransferase SETD3 regulates muscle differentiation
  JOURNAL   J Biol Chem 286 (40), 34733-34742 (2011)
   PUBMED   21832073
  REMARK    GeneRIF: SETD3 is a H3K4/K36 methyltransferase and plays an
            important role in the transcriptional regulation of muscle cell
            differentiation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 14, 2016 this sequence version replaced XM_216781.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.656732.1,
                                           SRR26360172.2275098.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               JAXUCZ010000006.1  132854264-132854421 c
            159-268             JAXUCZ010000006.1  132840122-132840231 c
            269-361             JAXUCZ010000006.1  132838429-132838521 c
            362-510             JAXUCZ010000006.1  132835574-132835722 c
            511-583             JAXUCZ010000006.1  132833729-132833801 c
            584-840             JAXUCZ010000006.1  132833206-132833462 c
            841-899             JAXUCZ010000006.1  132799916-132799974 c
            900-1014            JAXUCZ010000006.1  132799096-132799210 c
            1015-1089           JAXUCZ010000006.1  132794174-132794248 c
            1090-1256           JAXUCZ010000006.1  132793034-132793200 c
            1257-1342           JAXUCZ010000006.1  132792138-132792223 c
            1343-1503           JAXUCZ010000006.1  132789474-132789634 c
            1504-2773           JAXUCZ010000006.1  132787478-132788747 c
FEATURES             Location/Qualifiers
     source          1..2773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2773
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /note="SET domain containing 3, actin N3(tau)-histidine
                     methyltransferase"
                     /db_xref="GeneID:299295"
                     /db_xref="RGD:1309550"
     exon            1..158
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            159..268
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1956
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /EC_number="2.1.1.85"
                     /note="SET domain-containing protein 3; histone-lysine
                     N-methyltransferase setd3; histone-lysine
                     N-methyltransferase setd3-like; protein-L-histidine
                     N-tele-methyltransferase; SET domain containing 3, actin
                     histidine methyltransferase"
                     /codon_start=1
                     /product="actin-histidine N-methyltransferase"
                     /protein_id="NP_001333399.1"
                     /db_xref="GeneID:299295"
                     /db_xref="RGD:1309550"
                     /translation="MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPG
                     KEWEEYTQIRALVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFK
                     EEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSILGPLYSQDRILQAMGNIALAFH
                     LLCERASPNSFWQPYIQTLPSEYDTPLYFEEEEVRCLQSTQAIHDVFSQYKNTARQYA
                     YFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDM
                     CNHTNGLITTGYNLEDDRCECVALQDFQAGDQIYIFYGTRSNAEFVIHSGFFFDNNSH
                     DRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTE
                     EELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKT
                     VLKNPDLSVRATMAIKLRLGEKEILEKAVKSAAMNREYYRKHMEERAPLPRYEESDLG
                     LLEGGVGDSRLPLVLRKLEEEAGVQESLSLTETVSKVKAAENGLVNGESLIPNGTRSE
                     NESLSPEESENTTGDTEESSGSMDAVKERL"
     exon            269..361
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            362..510
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            511..583
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            584..840
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            841..899
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1014
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1089
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1256
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1342
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1503
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..2773
                     /gene="Setd3"
                     /gene_synonym="RGD1309550"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggcggcgg ggctgtctct ggctgccgtc ccgcccctcc cgtccggccg ccgccgccgc
       61 cgccgccgcc accgccgccg cctgggggtt ggttgaggcg gacggtgggg tcccggccgg
      121 agtgtggcgc cgccgctgcg cgtaggcaaa gcgggcagtc agaaaatggg taagaagagt
      181 cgagtgaaaa ctcagaaatc aggtactgga gccacagcca ccgtgtcacc gaaggaaatc
      241 ttgaacctga caagtgagct gttgcagaaa tgtagcagtc ctgcacccgg cccaggaaaa
      301 gaatgggaag agtacacaca gatccgggct ctggttgaga aaatacgaaa gaagcaaaaa
      361 ggtctgtctg ttacttttga tgggaaaaga gaagattact tccctgatct aatgaaatgg
      421 gcctctgaaa acggggcttc tgtcgagggt tttgaaatgg ttaacttcaa agaagagggc
      481 tttggtttga gagcaacaag agacatcaag gcagaagaat tatttttatg ggttccacga
      541 aagttactaa tgactgttga atctgctaag aattcaatat tggggcccct gtattcccaa
      601 gaccgaattc tccaagctat gggaaacatt gcactggcct ttcatctgct gtgtgagcga
      661 gccagcccca actctttctg gcagccatac attcagaccc tccccagtga gtatgacacc
      721 cctctctact tcgaagaaga ggaagtgcgc tgtcttcagt cgacacaagc catccatgat
      781 gtcttcagcc agtataaaaa cacagcacgc cagtacgcct atttctataa agtcatccag
      841 acccatcctc atgccaacaa actgcccttg aaggattctt tcacttacga ggactacagg
      901 tgggccgtct cgtcagttat gacacggcaa aaccaaattc ctacagagga tggttcccgg
      961 gtgaccttgg ctctgattcc tttatgggac atgtgcaatc ataccaacgg cctgatcaca
     1021 actggctata acctggaaga tgaccgctgt gagtgcgtgg ctctgcagga ctttcaggct
     1081 ggagatcaga tttacatttt ttacggcact cggtcaaatg cagagtttgt gatccacagt
     1141 ggttttttct ttgacaataa ctcacacgac agagtgaaaa taaagcttgg agtgagtaaa
     1201 agtgacaggc tctacgctat gaaggctgag gtcttggctc gggctggcat cccaacatcc
     1261 agtgtttttg cattgcattt tactgagcca cccatctctg cccagcttct agcttttctc
     1321 cgagtattct gcatgactga agaggagctg aaagagcact tgctagggga cagcgccatt
     1381 gacaggatct tcactctggg gaactcggag tttcctgtca gctgggacaa tgaggtcaaa
     1441 ctttggacat ttctggaaga tagagcctca cttcttttaa aaacatataa aacgacaatt
     1501 gaggaagata agactgtctt gaaaaaccct gacctctctg tccgtgccac gatggccatc
     1561 aaattgcgct tgggtgagaa ggagattttg gaaaaagcag tgaagagtgc agccatgaac
     1621 cgagagtact accgcaaaca catggaggag agggcgccac tgcccagata cgaggagagt
     1681 gacctggggc tgttggaggg tggtgtgggg gactcgaggc tccctctggt cctgagaaag
     1741 ctggaggagg aggcaggtgt acaggagtct ctgagtctca cagagactgt cagcaaagtc
     1801 aaggctgccg aaaatgggct cgtcaatggg gaaagcttga tccctaatgg gaccaggtct
     1861 gaaaatgaaa gcttaagccc agaagagagt gaaaacacga caggagacac ggaagagtct
     1921 tcaggaagca tggatgcggt gaaggagcga ctctgagatg ctcacggatc cagttgagca
     1981 gaagttgcag acagcccacc acatcaccgt gttccttgtt aacatttttc ttttcgcaga
     2041 gaggaaaata tgttttgctg ctttatataa agtgattttt aagttattat aaagatctag
     2101 cttccctttt tgattaagat tgccatcttg cttctgggcg gaataaagta gtgaagagca
     2161 gcagagggga ggaggcgccc ttgagagact gcagaccagc tgtgggcagc gctgctctcc
     2221 tcgctccaca gtgagtgctg gcgctgctcc tgccgaggga gtgaggttgg actctgggtg
     2281 tcgagtggat ggtggagggt gaggcacagt gaaaagaaag ctgggtgagg tggttacaaa
     2341 caagagtctg ggcaaatctt ttattttttt ccttaacaag aatatcccca gtaccaaaag
     2401 aaaaggtaag gtggcaacct gatttttaat ggcttaaaat gttgatgatg atcctaatta
     2461 tataaacaca cacatatatc tagtaatttc taaggatttg tttacttttt gtgttctgtt
     2521 ttgctgtatt aaaaacttgt cctttacctt aaatcaaagt aggcctcgcg tcctcctggg
     2581 ttttcacgct ggctttgttt cagagaggtg cactgactcc agtgatggca gtggagtgcc
     2641 gtagacactg cagccgtggc tcacgcacgg tgtcgggata ggcggccccc tggctttctg
     2701 gtttcacaac aagctagaga ttttcaaagc tacccttttg agtaaaaccc cttattaaaa
     2761 gaaaaaaaca tga
//
