LOCUS       NM_001401163            8384 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SET domain containing 2, histone lysine
            methyltransferase (Setd2), mRNA.
ACCESSION   NM_001401163 XM_039081609
VERSION     NM_001401163.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8384)
  AUTHORS   Wang,D., Guan,H., Wang,Y., Song,G. and Xia,Y.
  TITLE     N6-methyladenosine modification in trophoblasts promotes circSETD2
            expression, inhibits miR-181a-5p, and elevates MCL1 transcription
            to reduce apoptosis of trophoblasts
  JOURNAL   Environ Toxicol 38 (2), 422-435 (2023)
   PUBMED   36260529
  REMARK    GeneRIF: N6-methyladenosine modification in trophoblasts promotes
            circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1
            transcription to reduce apoptosis of trophoblasts.
REFERENCE   2  (bases 1 to 8384)
  AUTHORS   Foggetti,G., Li,C., Cai,H., Hellyer,J.A., Lin,W.Y., Ayeni,D.,
            Hastings,K., Choi,J., Wurtz,A., Andrejka,L., Maghini,D.G.,
            Rashleigh,N., Levy,S., Homer,R., Gettinger,S.N., Diehn,M.,
            Wakelee,H.A., Petrov,D.A., Winslow,M.M. and Politi,K.
  TITLE     Genetic Determinants of EGFR-Driven Lung Cancer Growth and
            Therapeutic Response In Vivo
  JOURNAL   Cancer Discov 11 (7), 1736-1753 (2021)
   PUBMED   33707235
REFERENCE   3  (bases 1 to 8384)
  AUTHORS   Hata,A., Nakajima,T., Matsusaka,K., Fukuyo,M., Nakayama,M.,
            Morimoto,J., Ito,Y., Yamamoto,T., Sakairi,Y., Rahmutulla,B.,
            Ota,S., Wada,H., Suzuki,H., Iwata,T., Matsubara,H., Ohara,O.,
            Yoshino,I. and Kaneda,A.
  TITLE     Genetic alterations in squamous cell lung cancer associated with
            idiopathic pulmonary fibrosis
  JOURNAL   Int J Cancer 148 (12), 3008-3018 (2021)
   PUBMED   33533494
REFERENCE   4  (bases 1 to 8384)
  AUTHORS   Yu,M., Yu,M., Zhu,L.J., Yuan,X.Y. and Zhang,X.
  TITLE     [Expression and clinical significance of SETD2 in maligant pleural
            mesothelioma]
  JOURNAL   Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 39 (2), 91-98 (2021)
   PUBMED   33691361
REFERENCE   5  (bases 1 to 8384)
  AUTHORS   Zhou,Y., Zheng,X., Xu,B., Deng,H., Chen,L. and Jiang,J.
  TITLE     Histone methyltransferase SETD2 inhibits tumor growth via
            suppressing CXCL1-mediated activation of cell cycle in lung
            adenocarcinoma
  JOURNAL   Aging (Albany NY) 12 (24), 25189-25206 (2020)
   PUBMED   33223508
REFERENCE   6  (bases 1 to 8384)
  AUTHORS   Wilson,B.G. and Roberts,C.W.
  TITLE     SWI/SNF nucleosome remodellers and cancer
  JOURNAL   Nat Rev Cancer 11 (7), 481-492 (2011)
   PUBMED   21654818
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8384)
  AUTHORS   Hu,M., Sun,X.J., Zhang,Y.L., Kuang,Y., Hu,C.Q., Wu,W.L., Shen,S.H.,
            Du,T.T., Li,H., He,F., Xiao,H.S., Wang,Z.G., Liu,T.X., Lu,H.,
            Huang,Q.H., Chen,S.J. and Chen,Z.
  TITLE     Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for
            embryonic vascular remodeling
  JOURNAL   Proc Natl Acad Sci U S A 107 (7), 2956-2961 (2010)
   PUBMED   20133625
REFERENCE   8  (bases 1 to 8384)
  AUTHORS   Yoh,S.M., Lucas,J.S. and Jones,K.A.
  TITLE     The Iws1:Spt6:CTD complex controls cotranscriptional mRNA
            biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation
  JOURNAL   Genes Dev 22 (24), 3422-3434 (2008)
   PUBMED   19141475
REFERENCE   9  (bases 1 to 8384)
  AUTHORS   Edmunds,J.W., Mahadevan,L.C. and Clayton,A.L.
  TITLE     Dynamic histone H3 methylation during gene induction: HYPB/Setd2
            mediates all H3K36 trimethylation
  JOURNAL   EMBO J 27 (2), 406-420 (2008)
   PUBMED   18157086
REFERENCE   10 (bases 1 to 8384)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 3, 2022 this sequence version replaced XM_039081609.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.37489.1,
                                           SRR26643284.11842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000008.1  119390207-119390417
            212-227             JAXUCZ010000008.1  119407261-119407276
            228-4510            JAXUCZ010000008.1  119409581-119413863
            4511-4642           JAXUCZ010000008.1  119415047-119415178
            4643-4771           JAXUCZ010000008.1  119418003-119418131
            4772-4895           JAXUCZ010000008.1  119422252-119422375
            4896-4973           JAXUCZ010000008.1  119423764-119423841
            4974-5071           JAXUCZ010000008.1  119425172-119425269
            5072-5198           JAXUCZ010000008.1  119427704-119427830
            5199-5333           JAXUCZ010000008.1  119429488-119429622
            5334-5453           JAXUCZ010000008.1  119430600-119430719
            5454-6116           JAXUCZ010000008.1  119432148-119432810
            6117-6165           JAXUCZ010000008.1  119448082-119448130
            6166-6346           JAXUCZ010000008.1  119450137-119450317
            6347-7016           JAXUCZ010000008.1  119451395-119452064
            7017-7151           JAXUCZ010000008.1  119455843-119455977
            7152-7291           JAXUCZ010000008.1  119459020-119459159
            7292-7403           JAXUCZ010000008.1  119460718-119460829
            7404-7484           JAXUCZ010000008.1  119472739-119472819
            7485-7586           JAXUCZ010000008.1  119474661-119474762
            7587-8384           JAXUCZ010000008.1  119475066-119475863
FEATURES             Location/Qualifiers
     source          1..8384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..8384
                     /gene="Setd2"
                     /note="SET domain containing 2, histone lysine
                     methyltransferase"
                     /db_xref="GeneID:316013"
                     /db_xref="RGD:1305576"
     exon            1..211
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..7748
                     /gene="Setd2"
                     /EC_number="2.1.1.354"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD2"
                     /protein_id="NP_001388092.1"
                     /db_xref="GeneID:316013"
                     /db_xref="RGD:1305576"
                     /translation="MKQLPSQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGP
                     IFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFFTALSNEKQSDSPH
                     SPATPQVDSNPKAKMEAGDTFPATEESSPPKSRVELGRIHFKKHLLHVTSRPQLATTT
                     TVASLLPPTTQLPVAIAESTVDSPPSSPPPPPPPPQVSSPSPPAPISEPVALPHPPVT
                     ALMTSTPGPLPVDAAVRAQKEPPMKSVPESLELDMKQDIVSNSLEEHTNQTLKEQADN
                     ALQKEDSHIGKEEEVSDGSKISLSSKKASSKKKSSQFEGTFLGSESDEDSVRTSSSQR
                     SHDLKSSTSIEKERDFKKSSAPSKSEDLGKSSRSKTERDDKYFSYSKLERDTRYVSTR
                     CRSERDRRRSRSRSRSDRVSRTSLSYSRSERSHYYDSERRYHRSSPYRERTRYSRPYT
                     DNRARESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSKFDRDCKTETSYLEMERRGKY
                     SSKLERESKRTSEHEAIKRCCSPPNELGFRRGSSYSKHDNNSTSRYKSALSKSISKSD
                     KFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKIPEREKTGSPSPSNQLNDSP
                     TFKKLDESPILKPEFIGHDSHESIKELELPKMKNDQLRNFCSIELNVNGSPETETDVA
                     TFRTSKPDAISMTSDDSVTGSEVSPLIKGCVLSSNGFQSVGRCRERDADDACRQHNKS
                     KSPFRETEPLLSPHHDKVMSLPVKTIDYSKTLIKEPVDKRHSCCKTKDSDRYCSPNES
                     SEAENREISSNCFVNVHLDSKTVVCDNRELTDQHSEFTCDGYKQSIGSTSSASLNHFD
                     DLYESVGSSGISSLQSLPSGIRCEENTSPALDTVQSKKGIDFLKYVGKETDVVSALPD
                     SGKAFSSWENRHNMLSGQSLQESQEEGSSTLHERRGRSEVSLDEEEQRGHTHISDDSE
                     VVFPYDLNLTMEDSDGVTYTLKCDSSGNAPEIVSTVHGDYSASSASSSDESDSEDTES
                     DDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDGLESRRHAYEE
                     KFESMASKGCSQTEKFFLHKGTERNPETSYSQFSRKIDNHLPEIAHSQSDGVDSTSHT
                     DVKSDSVGHLNSEDAIRAKMSRPQELPVYCDDFEDLPNTSRQQMIFSNRPDSSRLGKA
                     ELSFSSSCDISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQSA
                     EHYGGTHDYWQGNGYWDPRSAGRPPGTGVVYDRIQGQVPDSLTDDREEEENWDQRSGS
                     HFSSPSNKFFFHQKDKGSVQAPEISSNSIKDSLVINERKDFSKNFEKNDIKERGPPKK
                     RRQELESDSESDGELQARKKVRVEIEQGQSSVPQHSELVGPSCAMDDFRDPQRWKEFA
                     KLGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEVACGEDCLN
                     RLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYC
                     GEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQ
                     KWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
                     IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTC
                     LKLIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTK
                     NMLEESKVLPIIQRWSQTKTAVPQLSEGDGYSSENTSRAHTPLNTPDPSAKPSTEVDT
                     DTPKKLIFRRLKIISENSMDSAVSDVTSELECKDGKEDLDQLETVTVEEDEELQSQQL
                     LPSQLCESKVESESTIDVSKLPISEPEADTETEPKDSNGTKLEETIAEETPSQDEEEG
                     VSDVESERSQEPPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKESTVTERGRDT
                     AAFRDQTAPKTPNRSREREPDKQSQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDTPT
                     SKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPFDSLGYNASH
                     HPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTESLAA
                     PPSVPVVPHGAASVEVSSSQYAAQSESVVHQDSSVPGMPVQTPGPVQGQNYSVWDSNQ
                     QSVSVQPQYSPAQSQATIYYQGQTCSTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQ
                     IFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPPEMVVTNNLLDLPPPSPPKPKTIVLPP
                     NWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKT
                     SKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLA
                     RKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE"
     exon            212..227
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..4510
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4642
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4643..4771
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4772..4895
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..4973
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4974..5071
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..5198
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5199..5333
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5334..5453
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5454..6116
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            6117..6165
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            6166..6346
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            6347..7016
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            7017..7151
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            7152..7291
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            7292..7403
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            7404..7484
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            7485..7586
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
     exon            7587..8384
                     /gene="Setd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgagcca gccagccagc gacgcgggcc gcccctgccg ccgccgcgat cggacctgcg
       61 gcctcctccc ctccggtccc ctcccccgca tcggcctgcc gcggggaggg ggctagcgtc
      121 gccgcctcca gctgctcctc atgaagcagc tgccgtcgca gccgccaccg aagatggggg
      181 atttctacga tcccgagcac ccgacccctg aagaagaaga aaatgaggca aagattgaaa
      241 atgtgcagaa aacaggcttc atcaaaggac caatattcaa aggtgttgct tcaagtcgat
      301 ttttgcccaa aggcacgaag acaaaagtta atttggagga acaaggacgg cagaaggttt
      361 cattcagctt cagtcttaca aagaaaactt tacagaatag atttttcact gcacttagca
      421 atgaaaagca aagtgactct ccacactccc cagctacccc tcaagtagac tcaaacccta
      481 aagctaaaat ggaagctgga gatacttttc ctgctacaga agaatcttcg ccaccaaaat
      541 caagagtgga attgggcaga attcatttta agaaacatct gcttcatgtg acatccaggc
      601 cacagctggc tacaactaca acagtagcat ctctgcttcc tcccacaaca cagttaccag
      661 tagccatagc agaatcaact gtagattcac caccttcatc tccacctccc cctccgcccc
      721 ctccccaagt ctcatcaccc tcaccaccag caccaatatc agagccagtg gccttgccgc
      781 atcccccagt aacagcacta atgacatcaa caccgggacc tttaccagta gatgcagcag
      841 ttagagctca gaaagagcca ccaatgaaaa gtgtaccaga atctttagag ttggatatga
      901 agcaagatat tgtatctaac agtttggaag aacacacaaa tcaaactttg aaggaacaag
      961 cagataatgc cctgcaaaaa gaagattccc atattgggaa ggaagaagag gtttcagatg
     1021 gctctaagat aagcctcagt tctaaaaaag caagttctaa gaagaaatct tcacaatttg
     1081 aaggtacatt tcttggttca gaatctgatg aagattctgt acggacttcc tccagtcaaa
     1141 gatcacatga tttaaaatct tcaacaagca ttgagaaaga aagagatttt aagaagagct
     1201 cagcaccttc aaaaagtgag gatttgggaa aatcatcaag atctaaaaca gagagagatg
     1261 ataaatactt tagctactca aaacttgaaa gagacactcg gtatgtatct actcgatgta
     1321 ggtctgaaag agatcgaagg cgaagccgat ctcgttctag atctgacaga gtctctagaa
     1381 ctagtttgtc ttattctcgg tcagaaagat ctcattatta tgattctgaa cgccgttacc
     1441 ataggagttc cccttatcgt gagaggacac gctattctcg gccatataca gataacaggg
     1501 cacgggagag ctcagactct gaagacgagt ataagaagac atatccaagg cgtacctcag
     1561 cccactccta cagagaccta aggacatcat catcttactc taaatttgat cgggactgta
     1621 aaactgagac ctcttactta gaaatggaga gaagaggaaa gtattcttca aaactagaaa
     1681 gagaatccaa acggacttca gagcatgaag ccataaaaag atgttgttct cccccaaatg
     1741 aattgggatt ccgacgggga tcatcatatt ccaagcatga taacaacagt acttcccgtt
     1801 ataaatctgc cctttcaaaa tctatatcta agtctgataa atttaaaaat tctttctgtt
     1861 gtacagaatt aaatgaggaa aacaaacaat ctcattcttt tagtttgcag acgccttgtt
     1921 caaaaggtag tgaattaaga acaattaata aaattcctga aagagaaaag actgggtctc
     1981 catctccatc aaatcaatta aatgattcac ctacttttaa aaagctagat gaatctccta
     2041 ttcttaagcc tgaatttata ggacatgata gccatgagag tattaaagaa ttggagttac
     2101 caaaaatgaa aaatgatcaa ttgagaaatt tttgttccat tgaattaaat gtaaacggat
     2161 ctccagagac agaaactgat gtggcaacat ttcgaacttc taaaccagat gctatctcaa
     2221 tgacttctga tgatagtgtg actggatcag aggtatcccc tttgatcaag ggttgcgtgc
     2281 tttcatcaaa tggatttcag agtgttggta gatgcagaga aagggatgca gatgatgctt
     2341 gtaggcagca taataaatca aaaagtccat ttagggaaac ggaacctttg ttgtcaccac
     2401 accatgataa agtcatgtct ttgccagtta agactataga ttattccaaa acgttaatta
     2461 aagagccagt tgataagaga cattcttgct gcaaaaccaa agattcagat agatactgtt
     2521 ctccaaatga aagctctgaa gctgaaaata gggagatttc ttcaaattgc tttgtgaatg
     2581 tgcatttgga ttccaaaaca gttgtctgtg ataataggga gctgacagac cagcactcag
     2641 aatttacgtg tgacggatat aagcagagca ttggtagcac tagctcggcc tctcttaacc
     2701 attttgatga cttgtatgag tctgtaggga gttcaggtat ttcatctctc cagagtcttc
     2761 catcaggaat aagatgtgaa gagaacacgt ctccagctct agacacagtg cagagtaaaa
     2821 aaggtataga ttttttaaag tatgtaggga aagagacaga tgttgttagt gcccttcccg
     2881 attcaggaaa agcattttct tcttgggaaa acaggcataa tatgttgtct gggcagtctt
     2941 tgcaagagtc tcaagaagaa gggagttcca cattgcatga gagaagagga agatcagaag
     3001 tctccttaga tgaggaagaa caaaggggtc atacacatat ttctgatgat tcggaagttg
     3061 tatttcctta tgatttgaac ttaaccatgg aagacagtga tggtgtaact tacaccttaa
     3121 aatgtgacag cagtggtaat gctcccgaga ttgtatcaac tgtccatgga gattactctg
     3181 cgtcttctgc aagttcaagc gatgagagtg attcagaaga tacagagtct gatgacagca
     3241 gtattccgag aaaccgtctc cagtctgttg tggttgtgcc aaagaattct actttgccca
     3301 tggaagagac aagtccctgc tcttctcgga gcagtcagag ctacagacat tattccgacc
     3361 actgggagga tgggttagag tcgaggagac atgcgtatga ggaaaagttt gagagtatgg
     3421 caagtaaagg ctgttcccaa actgaaaagt tctttcttca taaaggaaca gagaggaatc
     3481 cagaaacatc ttattcacaa ttcagcagga agatagataa tcacctgcct gaaattgctc
     3541 attctcagag tgatggggtt gatagtacaa gtcatacaga cgtgaagtct gactctgtag
     3601 gtcacctgaa ttcagaagac gcaataagag ccaaaatgtc caggccacaa gagctcccag
     3661 tctattgtga tgactttgaa gacctcccaa atacgtctcg gcagcagatg attttctcca
     3721 atcggccaga tagtagtaga ctaggaaaag ccgagctgag tttttcttcc tcttgtgaca
     3781 tttcccgaat ggatggcttg cactcatcag aagagctcag aaacctaggg tgggactttt
     3841 cccaacaaga aaggcccacc accacatacc agcagcctga cagcagctat ggaacttgtg
     3901 gtacacacaa gtatcaacag agtgccgagc attacggtgg gacccatgat tactggcaag
     3961 gcaatggcta ttgggatcca aggtcagcag gtagacctcc aggaactggg gttgtttatg
     4021 atcgaatcca agggcaagta ccagattctc taacagatga tcgtgaagaa gaggaaaatt
     4081 gggatcaacg aagtggatca catttttcaa gcccatccaa taaatttttc ttccatcaga
     4141 aggacaaggg atcagtgcaa gcaccagaaa taagcagcaa ttcaattaaa gactctttag
     4201 ttataaacga aaggaaagat ttttcaaaaa acttcgaaaa aaatgatata aaagagcgag
     4261 gacctcctaa aaaacgaagg caagaattgg agagtgattc tgaaagtgat ggtgagctac
     4321 aggctagaaa gaaagttaga gtggagatag aacagggaca gtcgtctgtg ccccagcact
     4381 cagagctggt ggggccttcg tgtgctatgg atgacttcag ggacccgcag cggtggaaag
     4441 agtttgccaa gctggggaag atgccttgtt actttgatct gattgaagaa aatgtttatt
     4501 taacagaaag gaagaagaac aaatcccatc gggatattaa gcggatgcag tgtgagtgca
     4561 cacctctttc taaagatgaa cgagctcaag gtgaagttgc ctgtggagag gattgcctta
     4621 atcgtctcct catgattgaa tgttcctctc gatgtccaaa tggagattat tgttcgaaca
     4681 gacggtttca gagaaaacag cacgcagatg tagaagtcat acttacagaa aagaaaggct
     4741 ggggcttaag ggccgccaag gatcttcctt cgaacacctt tgtcctggaa tactgcggag
     4801 aggtacttga tcataaagag tttaaagctc gggtgaagga atatgcgcgg aacaaaaaca
     4861 tccactacta tttcatggcc ctgaagaatg atgagataat agatgccact cagaaaggga
     4921 actgctctcg ttttatgaat catagctgtg aaccaaactg tgaaacccaa aaatggactg
     4981 tgaatggaca gctgagggtt ggatttttta ccaccaaatt agttccttca ggctcagaat
     5041 taacgtttga ttaccagttc caacgatatg gcaaggaggc tcagaagtgt ttctgtggat
     5101 cagcgaactg tcggggttac ttgggaggag aaaacagagt cagtatcaga gctgcagggg
     5161 ggaagatgaa aaaggaacgc tctcgaaaga aggattcagt ggatggagaa cttgaagcac
     5221 tgatggaaaa tggtgaaggc ctctctgata agaaccaagt tcttagttta tcccggctca
     5281 tggttagaat cgaaactttg gaacagaagc ttacctgtct caagcttatt cagaacacac
     5341 actcacagtc ctgtctcaag tcatttctgg aacggcatgg gttgtcactg ttgtggatct
     5401 ggatggcaga gctcggcgat ggccgggaaa gtaaccagaa gcttcaggaa gagattataa
     5461 agactttgga gcatttgccc attcctacta aaaatatgtt ggaagaaagc aaagtacttc
     5521 caattattca acgctggtct cagactaaga ctgctgttcc tcagttaagt gaaggagacg
     5581 ggtattctag tgagaataca tcacgtgctc acacaccgct taatacaccg gacccttctg
     5641 ccaagccgag cacagaggtg gatacagata ctcccaagaa actcatattt cgcagactaa
     5701 agattataag tgaaaatagc atggacagtg cagtctcaga cgtcaccagt gagctagaat
     5761 gcaaggatgg caaagaggac ctggatcagt tagagactgt cactgtggag gaagatgaag
     5821 aactgcagtc ccaacagctc ctgccatcac aactctgcga gtccaaagtt gagagtgaaa
     5881 gcaccatcga cgtcagtaaa ttacccatat ctgaaccgga ggctgacact gagaccgagc
     5941 ccaaagacag caatggcaca aaactagaag aaactattgc cgaggaaaca ccatcccaag
     6001 atgaggaaga gggtgtgtct gatgttgaga gtgagagaag ccaggaacca ccagataaaa
     6061 cagtggatat aagtgatttg gctaccaagc tactagacag ttggaaagat ctaaaggagg
     6121 tatatcgaat tccaaagaaa agtcaaaccg aaaaggagag cacagtaact gaacgaggga
     6181 gggacactgc tgccttcaga gatcaaacag ctccaaagac ccctaacagg tcgagagaga
     6241 gagagccaga caagcagtct caaaataaag agaaaaggaa acgccggggc tcgctgtcac
     6301 caccttcttc tgcgtatgaa cggggaacaa aaaggccaga tgacaggtat gatacaccaa
     6361 cttctaaaaa gaaagtacga attaaagacc gaaacaaact ttctacagag gagcgcagga
     6421 agttgtttga acaagaggta gcacaaaggg aggctcagaa gcaacagcaa cagatgcaga
     6481 acttggggat gacatcacca ctaccctttg actctctggg ttataatgcc tctcatcacc
     6541 cctttgctgg gtacccacca ggttatccca tgcaagccta tgtggatccc agcaacccta
     6601 atgctggaaa ggtgcttctg cctacaccta gcatggaccc tgtgtgctcc cctgcgcctt
     6661 atgatcacgc tcagcccttg gtaggacatt ctacagagtc tcttgctgcc cctccgtctg
     6721 tgccagtggt accacacggg gcagcctccg tggaagtttc tagttcacag tatgcagctc
     6781 agagtgaaag tgtggtgcat caagactcca gtgtccctgg aatgccagta caaactccag
     6841 gcccagtcca aggacagaat tacagtgtct gggattcaaa ccaacagtct gtcagtgtac
     6901 agccccagta ttctcctgcc caatctcaag caaccatata ttaccaagga cagacatgtt
     6961 caactgtcta cggtgtgacc tctccttatt cacagacaac tcctccaatt gtgcagagtt
     7021 atgcccagcc aagtcttcag tatatccagg gacagcagat tttcacagct cacccacaag
     7081 gagtggtggt acagccagct gcagccgtga ctacaatagt tgcaccaggg cagcctcagc
     7141 ccttacagcc acctgaaatg gttgtaacaa ataatctact ggatctgcca ccgccctccc
     7201 ctccaaaacc aaaaacgatt gttttacctc ccaactggaa gacagcccga gatcctgaag
     7261 ggaagatcta ttactaccac gtaatcacga gacagactca gtgggatcct cctacctggg
     7321 aaagcccagg agatgatgcc agccttgagc atgaagctga gatggacctg ggaaccccaa
     7381 cctatgatga aaaccccatg aagacatcaa aaaagcccaa gacagcagaa gcagacacct
     7441 ccagtgagct ggcaaagaaa agcaaagaag tattcagaaa agagatgtct cagttcattg
     7501 tccagtgcct gaatccttac cggaaacctg actgcaaggt ggggaggatc acgacgactg
     7561 aagatttcaa gcacctcgcg cgaaagctga ctcatggagt catgaacaag gagctgaagt
     7621 actgtaagaa ccctgaggac ctggagtgca acgagaatgt gaaacacaaa accaaggagt
     7681 acatcaagaa gtacatgcag aagtttgggg ctgtttacaa acctaaagag gacactgaac
     7741 tagagtgaca tcaggccaga gtggagtctg agcagaaagg atgagtcctg tggcttctgc
     7801 cctaccccac ggccagggct gtgctgctgg tgtggtgacc cagcatccaa gcagttcaga
     7861 ctcgcaggtg tcactgtaag ctgcagagtg agctctagct acaaacgccc ctagttgtga
     7921 gctgctggtg taacacttac aggccatcag aggcagtagc ctagggaaga ccttggccac
     7981 acttgacccc attctcaaat ctgggtctcc cccttggcgg tgctgtcagc gcacagaccc
     8041 atgcgcaccc tcccccaaga tcctttaccc tgacaatatg tattatattt taatgtatat
     8101 gtgaacatat tgaaaataat ttgtttgttt tcctggtttt gttcagtgtt tgtttgctgt
     8161 tagctatgtg ctagaatcat ggaaagactt tgtcaggatg gtataaattc tcctgcaagg
     8221 tgtaatttgt tatcatgtaa atattccaaa gcaggctgcc tcatggtttt ggccagcctt
     8281 gtgctatgtt gataagattg atttactgct taagatcact ttactttatc caatttttac
     8341 tgaacttttt atgtaaaaaa taaaatcaat taaagaactt ggaa
//
