LOCUS       NM_001134514            2772 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SEC14 and spectrin domain containing 1 (Sestd1),
            mRNA.
ACCESSION   NM_001134514 XM_001066119 XM_230024
VERSION     NM_001134514.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Lee CC, Huang CC and Hsu KS.
  TITLE     The phospholipid-binding protein SESTD1 negatively regulates
            dendritic spine density by interfering with Rac1-Trio8 signaling
            pathway
  JOURNAL   Sci Rep 5, 13250 (2015)
   PUBMED   26272757
  REMARK    GeneRIF: These results suggest that SESTD1 may act as a negative
            regulator of the Rac1-Trio8 signaling pathway to reduce dendritic
            spine density and lower excitatory synaptic transmission in
            hippocampal neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Miehe S, Bieberstein A, Arnould I, Ihdene O, Rutten H and Strubing
            C.
  TITLE     The phospholipid-binding protein SESTD1 is a novel regulator of the
            transient receptor potential channels TRPC4 and TRPC5
  JOURNAL   J Biol Chem 285 (16), 12426-12434 (2010)
   PUBMED   20164195
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC169110.1.
            
            On Dec 24, 2009 this sequence version replaced NM_001134514.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169110.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2772              BC169110.1         1-2772
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2772
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /note="SEC14 and spectrin domain containing 1"
                     /db_xref="GeneID:295678"
                     /db_xref="RGD:1562244"
     exon            1..61
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            62..131
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2167
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /note="SEC14 and spectrin domains 1"
                     /codon_start=1
                     /product="SEC14 domain and spectrin repeat-containing
                     protein 1"
                     /protein_id="NP_001127986.2"
                     /db_xref="GeneID:295678"
                     /db_xref="RGD:1562244"
                     /translation="MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELS
                     VTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDE
                     FWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKR
                     LVFEKFTKESTSLLDELALINNGSDKGNEQEKERSVDLNFLPSVDPETVLQTGHELLS
                     ELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEE
                     IQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELN
                     QQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQ
                     QLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQAS
                     WAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQ
                     AVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLC
                     QSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEA
                     MNDEEQFEEIEAIGKSLLDRLTIPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLK
                     RQQLRHPEMVTTES"
     exon            132..240
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            241..331
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            332..445
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            446..559
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            560..657
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            658..713
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            714..925
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1048
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1243
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1358
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1518
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1600
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1723
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1915
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2037
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2747
                     /gene="Sestd1"
                     /gene_synonym="RGD1562244"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtctctgtg gaaggtgcag agtcctttga gtgtgcccag gagttatcgt gggacccttt
       61 gaggcaagga cgtgaaatgg aggcctcggt gatattgccc atcctgaaga agaagctggc
      121 cttcctttca ggaggaaagg acagacgcag tggactcatc ttgacaattc cattatgcct
      181 tgaacagaca aatatggatg agctgagtgt cactctggac tatctactca gcattccaag
      241 tgagaaatgt aaggccagag gattcactgt gatcgtggac ggcaggaagt ctcaatggaa
      301 cgtggtgaag acagtggtcc taatgctgca gaacgttgtt ccagctgagg tatcccttgt
      361 ttgtgtagtg aagccagatg aattctggga taagaaagta acacattttt gtttttggaa
      421 agaaaaggat agacttggct ttgaggttat tttagtgtct gccaataagc tgactcgata
      481 catagagccc tgccagttga cagaagactt tggtgggagt ctcacctacg atcacatgga
      541 ctggctaaat aagaggctgg tctttgagaa gtttacaaag gagtctacat cattgctaga
      601 tgaactcgct ctgattaaca atggaagtga caaggggaat gagcaggaga aggaaaggtc
      661 cgtggattta aactttcttc catctgttga tcctgagaca gttcttcaga cagggcatga
      721 gttgttatct gaattacagc agcgtcgatt taatggctct gatggagggg tctcctggtc
      781 tcctatggat gacgaactgc tcgcacagcc acaggttatg aagttgttag actcactccg
      841 ggagcagtat acgcgctacc aggaggtctg caggcagcgc agtaagcgca cacagttaga
      901 ggagatccag cagaaggtga tgcaggttgt gaactggctt gaagggcctg ggtctgagca
      961 actgagagca cagtggggca ttggtgactc catcagggca tcccaggccc tgcaacagaa
     1021 gcatgaggag atcgagagcc agcacagtga gtggtttgca gtgtacgtgg agctcaacca
     1081 acagatcgca gcgctcctga atgccggaga tgaggaagac cttgtggagt tgaagtccct
     1141 gcagcagcag ctcagcgacg tctgctaccg gcaggccagc cagctagaat ttaggcagaa
     1201 cctcctgcag gcagctttgg agtttcatgg tgtggcccaa gatttgtctc agcagttgga
     1261 cggcttatta gggatgttgt gcgtagacgt agcaccagct gatggagcat cgattcagca
     1321 aactttaaaa ctgcttgaag agaagctgaa aagtgttgat gtgggattgc aaggcttacg
     1381 agaaaaaggt caaggtctcc tggatcagat ctccaatcag gcttcctggg cctatggaaa
     1441 ggatgtaaca attgagaata aagaaaacgt ggaccacata caaggagtga tggaagatat
     1501 gcaacttagg aaacaaagat gtgaggacat ggtagacgtg cggaggctga agatgcttca
     1561 gatggtgcag ttgtttaaat gcgaagagga tgcttcacag gcagtagaat ggctaagtga
     1621 acttctggat gccctgttga agacccatat cagattgggt gatgatgctc aggaaacaaa
     1681 ggttttactg gaaaaacaca gaaaatttgt ggatgttgca cagagcactt acgactatgg
     1741 cagacagctg ctgcaggcca cagttgtgct gtgccagtct ctgcgctgta cttcccgatc
     1801 ctcaggggac acgcttcctc gactgaacag agtgtggaag cagttcacgg tagcctctga
     1861 agagagagtg cacaggttgg aaatggctat tgccttccac tcgaatgctg aaaagatttt
     1921 gcaagattgc ccagaagagc ctgaagcaat gaacgatgag gagcagtttg aggaaattga
     1981 agcaattgga aaatcacttc tggatagact cactatcccc gtcgtttacc cggatggaac
     2041 tgaacaatat tttggaagtc caagtgacat ggcttctact gcagagcaca tcagagacag
     2101 aatgaaactg gtcagtctca aaaggcagca gctgagacat cctgaaatgg tgaccacgga
     2161 gagctaatgc cccagctccc acagatctgc aggtcatgtg cccacacatc tttgctgttg
     2221 gtatactacg gagttagcca cagctcatta agatgcattt cacagcagga taagcctcct
     2281 ttcttcccac aacacgtctc tctctaaatg ctaacatttc tcgactacca aggcataatc
     2341 acataacatg ctttgagact gtagactcct ggtatcgtaa aagaaggagc tgtaaccacg
     2401 cactgagtct ttgttttcac gctgttcctg atctgtcagt ttgtagacga cagcccatac
     2461 taagctttga atggtgctaa tcagagttta ggaattcgct acaaaccatg gctgcccttc
     2521 ctccccaggt gatgtagata tttagactat agttagactg ttagtgaata gtggtatcct
     2581 caaaacttta ctttgtaatt cttcaaaatt gattattttt attgtctata tgaagaaaac
     2641 ccttcagatc tttgatatat catattcatt gaaagacatt ttcctgttgt attcataatg
     2701 tattaaaagt tgtttgtgct taataaaaat cttctttaaa catcttaaaa aaaaaaaaaa
     2761 aaaaaaaaaa aa
//
