LOCUS       NM_001108125            2921 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sestrin 3 (Sesn3), mRNA.
ACCESSION   NM_001108125 XM_001068794 XM_235825
VERSION     NM_001108125.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Taiwo,R.O., Sandouka,S., Saadi,A., Kovac,S. and Shekh-Ahmad,T.
  TITLE     Sestrin 3 promotes oxidative stress primarily in neurons following
            epileptic seizures in rats
  JOURNAL   Neuropharmacology 238, 109670 (2023)
   PUBMED   37482179
  REMARK    GeneRIF: Sestrin 3 promotes oxidative stress primarily in neurons
            following epileptic seizures in rats.
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Xu,D., Shimkus,K.L., Lacko,H.A., Kutzler,L., Jefferson,L.S. and
            Kimball,S.R.
  TITLE     Evidence for a role for Sestrin1 in mediating leucine-induced
            activation of mTORC1 in skeletal muscle
  JOURNAL   Am J Physiol Endocrinol Metab 316 (5), E817-E828 (2019)
   PUBMED   30835510
  REMARK    GeneRIF: In skeletal muscle Sestrin1 expression is higher than
            Sestrin3, whereas Sestrin2 expression is markedly lower. Sestrin1
            has the highest affinity for leucine and Sestrin3 has the lowest
            affinity. Overall, the results presented herein are consistent with
            a model in which leucine-induced activation of mTORC1 in skeletal
            muscle in vivo occurs primarily through release of Sestrin1 from
            GATOR2.
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Huang,L.G., Zou,J. and Lu,Q.C.
  TITLE     Silencing rno-miR-155-5p in rat temporal lobe epilepsy model
            reduces pathophysiological features and cell apoptosis by
            activating Sestrin-3
  JOURNAL   Brain Res 1689, 109-122 (2018)
   PUBMED   29191771
  REMARK    GeneRIF: Results suggest that Sesn3 is a target gene for
            rno-miR-155. Moreover, the rno-miR-155 antagonist may induce the
            expression of Sesn3, and then indirectly decrease the damage of
            oxidative stress to protect the brain from
            epileptogenesis-associated impairments.
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Saxton,R.A., Shen,K., Scaria,S.M.,
            Cantor,J.R. and Sabatini,D.M.
  TITLE     Sestrin2 is a leucine sensor for the mTORC1 pathway
  JOURNAL   Science 351 (6268), 43-48 (2016)
   PUBMED   26449471
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Tao,R., Xiong,X., Liangpunsakul,S. and Dong,X.C.
  TITLE     Sestrin 3 protein enhances hepatic insulin sensitivity by direct
            activation of the mTORC2-Akt signaling
  JOURNAL   Diabetes 64 (4), 1211-1223 (2015)
   PUBMED   25377878
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Chantranupong,L., Wolfson,R.L., Orozco,J.M., Saxton,R.A.,
            Scaria,S.M., Bar-Peled,L., Spooner,E., Isasa,M., Gygi,S.P. and
            Sabatini,D.M.
  TITLE     The Sestrins interact with GATOR2 to negatively regulate the
            amino-acid-sensing pathway upstream of mTORC1
  JOURNAL   Cell Rep 9 (1), 1-8 (2014)
   PUBMED   25263562
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Peng,M., Yin,N. and Li,M.O.
  TITLE     Sestrins function as guanine nucleotide dissociation inhibitors for
            Rag GTPases to control mTORC1 signaling
  JOURNAL   Cell 159 (1), 122-133 (2014)
   PUBMED   25259925
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Lee,J.H., Budanov,A.V., Talukdar,S., Park,E.J., Park,H.L.,
            Park,H.W., Bandyopadhyay,G., Li,N., Aghajan,M., Jang,I.,
            Wolfe,A.M., Perkins,G.A., Ellisman,M.H., Bier,E., Scadeng,M.,
            Foretz,M., Viollet,B., Olefsky,J. and Karin,M.
  TITLE     Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3
  JOURNAL   Cell Metab 16 (3), 311-321 (2012)
   PUBMED   22958918
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473993.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235825.4, XM_001068794.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..2921
                     /gene="Sesn3"
                     /note="sestrin 3"
                     /db_xref="GeneID:315427"
                     /db_xref="RGD:1309470"
     exon            1..227
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1628
                     /gene="Sesn3"
                     /codon_start=1
                     /product="sestrin-3"
                     /protein_id="NP_001101595.1"
                     /db_xref="GeneID:315427"
                     /db_xref="RGD:1309470"
                     /translation="MNRGGSSASASANYLLCTNCRKVLRKDKRIRMSQPLTRGPSAFI
                     PEKEVVQANTADERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGP
                     LPLPDRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLRNLNEINK
                     LLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVYGSGINPERDP
                     GIANGFRLISVSSFCVCDLANDNSIGNASLAGGNFGIVDSLGELEALMERMKRLQEDR
                     EDEETTPEEMSTRFEKEKKESLFVVPGETFHSFPHSDFEDDMIVTADVSRYIEDPGFG
                     YEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMAT
                     HEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKR
                     MYDSYWRQFTHSEKVHVNLLLMEARMQAELLYALRAITRHLT"
     exon            228..293
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            294..491
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..674
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            675..911
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1086
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1205
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1396
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1541
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..2921
                     /gene="Sesn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaacggg ccggtgagcg ccgcggccgc cgtccccgcc gagctcgcgc gggcagccgc
       61 tgcgtcgtcg ctgccgtccg accccctaag aagagaacgt tgaagcagcc cttcgctagc
      121 ggccgcggtg acagcccggc ttcggcgcga tgaaccgcgg tggcagcagc gcgtcggcct
      181 cggccaacta cctgctctgc accaactgcc ggaaagtgct gcggaaggac aaaagaatca
      241 gaatgtctca acccctgaca agaggaccaa gtgcctttat tccagagaag gaagttgtcc
      301 aagcaaacac ggcagatgaa cgaacaaact ttcttgtgga agagtactct acatccggtc
      361 gcctggacaa catcacacag gtgatgagct tgcacacgca gtacctggaa tctttcttac
      421 ggagccagtt ctacatgctg cgcatggatg gcccccttcc cctcccggac aggcactaca
      481 tcgccatcat ggctgcagcc agacaccagt gttcctacct aataaacatg catgtggatg
      541 aatttttaaa gaccggaggg attgctgagt ggctcaatgg cttggaatat gtaccacaaa
      601 gactgagaaa tcttaatgaa attaacaagc tgctggcaca ccggccctgg ctgatcacga
      661 aagagcacat tcagaaactt gtcaaaactg gagaaaataa ttggtccttg cctgagctag
      721 tgcacgctgt ggtcctcttg gctcactatc acgctctggc cagctttgtt tatggtagtg
      781 gcatcaatcc agaaagagac cccggaatcg ccaatgggtt cagactgatc tcagtgagca
      841 gcttctgtgt gtgcgacctg gccaatgaca acagcattgg aaatgcctcc ctggcaggcg
      901 gcaactttgg gattgtggac tctctaggtg agctagaagc cttaatggag aggatgaaaa
      961 ggctccagga agacagggaa gatgaagaga ctactccgga agaaatgagc acacgttttg
     1021 agaaggaaaa gaaagaaagt ctcttcgtgg tccctggaga gactttccac tcgtttcctc
     1081 actcagattt tgaagatgac atgattgtaa cagctgatgt ctctcgatac atcgaagacc
     1141 caggctttgg gtatgaagac ttcgccaggc gaggagaaga acatttgcca acattccgag
     1201 cccaggacta cacctgggaa aatcatgggt tctcgctggt gaacaggctt tactctgaca
     1261 ttgggcatct cctggatgag aagtttcgaa tggtctacaa tctcacctac aacacaatgg
     1321 ccacccatga ggatgttgac actaccacgc tgcgcagagc cctgtttaac tatgttcact
     1381 gtatgtttgg aatcaggtat gatgactatg actatggaga agttaaccag ttactcgagc
     1441 ggagcctgaa ggtttacatc aagacagtga cctgctaccc ggagcgaacc acgaagcgca
     1501 tgtatgacag ctactggcgg cagttcaccc actcagagaa ggtccacgtg aacctgcttc
     1561 tgatggaggc gcggatgcag gccgagctgc tttacgccct gcgggccata actcggcatc
     1621 tgacctgaag cacctgcagg acggtgtcag catgcgtcca ggcctctccc caggactccc
     1681 atcagaactt gtttgtgatt cgccttggca gttactcggt tctctagtgt cgaagtacag
     1741 ctgtcaggct gtggtctttg tttttgattt tatttttgtt ttgttcttgt tgttagggtt
     1801 gttctgggtt tttttttttg ttttgttttg tttttttctg gctgtcatgt gcaatggtgt
     1861 gttttatatt tctcgatgct taacattgct aacgattgca aaagtaaccc tgacgagtac
     1921 tcctttatgt tgttcaagtt ggacttccgg atctgaccat aaatcatgaa ctggtttgtt
     1981 gacgcttcag tactttgaag tacgtatgta tgtgcattgt ttttctttac gtaagaaaac
     2041 aaggaaaagc gcttacactc cgtgtaagca gttgtttttc agatagcagc gttcagccga
     2101 gaatggtgtc tcctccctct ctaaagtccc accgcgtcct gagtctgggg aaaggcaggt
     2161 gctgcggaac cacgcccctc gggcgcagcc tgtgccccgg agagcatcag gctctgcttt
     2221 gctctgttgc agtttatctg actttcttac actgctattg gcaataacgt gaaatgtgat
     2281 accgacacca tccataattt aatgtgaaat taattatgat gaattctata gcatgctact
     2341 gaaatgccaa gttcagctac tttgtcttct aaaacagagg ctgctttccc acatggctgt
     2401 ctgtgtggca gtggactgag gcacagttcc gagggaggcc tgggcagtgg ctctccgtcc
     2461 cctccagtgt ccacagtgca gcccacagct cccgcacttg gtacacacaa gctcacacca
     2521 caacaccgac caaaggtttc tttgctcatt ctcctcttct gagagttaag gatggttaat
     2581 taatagaccc tcatttttcc tgttacactt ctggaaatta tttttacatg atttgctctt
     2641 acaatagctt aagtaatttg ttattcaaag gtaaaaattg tgtttccgtg cattaatgtg
     2701 atggagcaac aagacagcag tgcagtcttg tttagaaatc agctcggctt ccctgccatg
     2761 tcactgcaga agtgtccttt aaacagccat gaagaaatga catttcttta ctgtgctggg
     2821 tgttttcagt ttcacctccc tggggctgaa cagtggtttc accacgccaa agcattcttt
     2881 ccccagaaaa atctgtttgg gcaactaggt taaaacaaaa c
//
