LOCUS       NM_001109358            2723 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Rattus norvegicus sestrin 2 (Sesn2), mRNA.
ACCESSION   NM_001109358 XM_001065176 XM_001065235 XM_001065290 XM_578496
VERSION     NM_001109358.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2723)
  AUTHORS   Yang,X. and Wu,X.
  TITLE     The impact of sestrin2 on reactive oxygen species in diabetic
            retinopathy
  JOURNAL   Cell Biochem Funct 42 (4), e4024 (2024)
   PUBMED   38666564
  REMARK    GeneRIF: The impact of sestrin2 on reactive oxygen species in
            diabetic retinopathy.
REFERENCE   2  (bases 1 to 2723)
  AUTHORS   Li,Y., Wu,J., Yu,S., Zhu,J., Zhou,Y., Wang,P., Li,L. and Zhao,Y.
  TITLE     Sestrin2 promotes angiogenesis to alleviate brain injury by
            activating Nrf2 through regulating the interaction between p62 and
            Keap1 following photothrombotic stroke in rats
  JOURNAL   Brain Res 1745, 146948 (2020)
   PUBMED   32526292
  REMARK    GeneRIF: Sestrin2 promotes angiogenesis to alleviate brain injury
            by activating Nrf2 through regulating the interaction between p62
            and Keap1 following photothrombotic stroke in rats.
REFERENCE   3  (bases 1 to 2723)
  AUTHORS   Fan,Y., Xing,Y., Xiong,L. and Wang,J.
  TITLE     Sestrin2 overexpression alleviates hydrogen peroxide-induced
            apoptosis and oxidative stress in retinal ganglion cells by
            enhancing Nrf2 activation via Keap1 downregulation
  JOURNAL   Chem Biol Interact 324, 109086 (2020)
   PUBMED   32275923
  REMARK    GeneRIF: Sestrin 2 overexpression alleviates hydrogen
            peroxide-induced apoptosis and oxidative stress in rat retinal
            ganglion cells by downregulating Keap1 and reinforcing activation
            of Nrf2/antioxidant response element signaling.
REFERENCE   4  (bases 1 to 2723)
  AUTHORS   Wang,P., Wang,L., Lu,J., Hu,Y., Wang,Q., Li,Z., Cai,S., Liang,L.,
            Guo,K., Xie,J., Wang,J., Lan,R., Shen,J. and Liu,P.
  TITLE     SESN2 protects against doxorubicin-induced cardiomyopathy via
            rescuing mitophagy and improving mitochondrial function
  JOURNAL   J Mol Cell Cardiol 133, 125-137 (2019)
   PUBMED   31199952
  REMARK    GeneRIF: SESN2 protected against Dox-induced cardiotoxicity through
            improving mitochondria function and mitophagy. These results
            established SESN2 as a key player in mitochondrial function and
            provided a potential therapeutic approach to Dox-induced
            cardiomyopathy.
REFERENCE   5  (bases 1 to 2723)
  AUTHORS   Wang,P., Zhao,Y., Li,Y., Wu,J., Yu,S., Zhu,J., Li,L. and Zhao,Y.
  TITLE     Sestrin2 overexpression attenuates focal cerebral ischemic injury
            in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis
  JOURNAL   Neuroscience 410, 140-149 (2019)
   PUBMED   31085280
  REMARK    GeneRIF: Sestrin2 overexpression activates the Nrf2/HO-1 pathway,
            leading to enhanced angiogenesis following cerebral ischemia.
REFERENCE   6  (bases 1 to 2723)
  AUTHORS   Lee,J.H., Budanov,A.V., Park,E.J., Birse,R., Kim,T.E.,
            Perkins,G.A., Ocorr,K., Ellisman,M.H., Bodmer,R., Bier,E. and
            Karin,M.
  TITLE     Sestrin as a feedback inhibitor of TOR that prevents age-related
            pathologies
  JOURNAL   Science 327 (5970), 1223-1228 (2010)
   PUBMED   20203043
REFERENCE   7  (bases 1 to 2723)
  AUTHORS   Soriano,F.X., Papadia,S., Bell,K.F. and Hardingham,G.E.
  TITLE     Role of histone acetylation in the activity-dependent regulation of
            sulfiredoxin and sestrin 2
  JOURNAL   Epigenetics 4 (3), 152-158 (2009)
   PUBMED   19430206
  REMARK    GeneRIF: the importance of histone acetylation in the regulation of
            Srxn1 and Sesn2, to understand more about how these genes are
            regulated by synaptic activity was investigated.
REFERENCE   8  (bases 1 to 2723)
  AUTHORS   Woo,H.A., Bae,S.H., Park,S. and Rhee,S.G.
  TITLE     Sestrin 2 is not a reductase for cysteine sulfinic acid of
            peroxiredoxins
  JOURNAL   Antioxid Redox Signal 11 (4), 739-745 (2009)
   PUBMED   19113821
REFERENCE   9  (bases 1 to 2723)
  AUTHORS   Budanov,A.V. and Karin,M.
  TITLE     p53 target genes sestrin1 and sestrin2 connect genotoxic stress and
            mTOR signaling
  JOURNAL   Cell 134 (3), 451-460 (2008)
   PUBMED   18692468
  REMARK    Erratum:[Cell. 2009 Jan 23;136(2):378]
REFERENCE   10 (bases 1 to 2723)
  AUTHORS   Budanov,A.V., Sablina,A.A., Feinstein,E., Koonin,E.V. and
            Chumakov,P.M.
  TITLE     Regeneration of peroxiredoxins by p53-regulated sestrins, homologs
            of bacterial AhpD
  JOURNAL   Science 304 (5670), 596-600 (2004)
   PUBMED   15105503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166423.1.
            
            On Apr 29, 2008 this sequence version replaced NM_001109358.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166423.1, SRR8487227.303325.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2723
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /note="sestrin 2"
                     /db_xref="GeneID:502988"
                     /db_xref="RGD:1566319"
     exon            1..390
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1743
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /EC_number="1.11.1.15"
                     /codon_start=1
                     /product="sestrin-2"
                     /protein_id="NP_001102828.1"
                     /db_xref="GeneID:502988"
                     /db_xref="RGD:1566319"
                     /translation="MIVADSECHGEIKGYLPFTRGGVAGPGTREEHREGQARRGPRGP
                     SAFIPVEEILREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYLSSFWRLHYLLLH
                     TDGPLASSWRHYIAIMAAARHQCSYLVGSHMTEFLQTGGDPEWLLGLHRAPEKLRKLS
                     EINKLLAHRPWLITKEHIQALLKTGEHSWSLAELIQALVLLTHCHCLASFVFGCGILP
                     EGDAEGSPASQAPSPPSEQGGPPSRDPLNNSGGFEAARDIEALMERMRQLQESLLRDE
                     GASQEEMENRFELEKTESLLVTPSADILEPSPHPDILCFVEDPTFGYEDFTRRGTQAP
                     PTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQVAYSLTYNTIAMHSGVDTSMLRRA
                     VWNYIHCVFGIRYDDYDYGEVNQLLERNLKIYIKTVACYPEKTTRRMYNLFWRHFRHS
                     EKVHVNLLLLEARMQAALLYALRAITRYMT"
     exon            391..456
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            457..654
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            655..837
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1050
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1201
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1320
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1511
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1656
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..2710
                     /gene="Sesn2"
                     /gene_synonym="RGD1566319"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgaggag cgccggcttc gcgagcagcg ctggccactg cggacttccg aggcactccg
       61 ggccgtgaaa acctctgcgc cgcggccaat ctcaggcctc caaggccggc cacagttctc
      121 caagctgggc tggaaggagt gtccagcgcg gtatcgccag ttctcctcgt tcggagagat
      181 accccgggga tctcgagctt ccccggcgac ccctagtccg ggcctccttt gcgcgcccgc
      241 ctcagacccc cacgggtgcc cggggcgctg acgagccgcg gccgggtcct ggcgcacacc
      301 atgatcgtag ccgactccga gtgccatggg gagatcaagg gctacctgcc gttcaccagg
      361 ggcggtgtgg ccggccccgg gacccgagag gagcatcggg agggccaggc gcggcgaggc
      421 cctcgaggac ccagcgcctt catcccagtg gaggagatcc ttcgggaagg agctgagagc
      481 ctggagcagc acctggggct cgaggctctg atgtcttcag ggcgggtgga caacctggcg
      541 gtggtgatgg gcctacaccc cgactacctt agcagcttct ggcgcctcca ctacctgctg
      601 ctgcacacgg atgggcccct ggccagctcc tggcgccact acattgccat catggctgct
      661 gcccgccacc agtgttctta cctggtgggt tcccacatga ccgagttcct gcagaccggc
      721 ggtgaccccg agtggctgct gggcctccat cgcgcccctg aaaagctccg caagctcagc
      781 gagatcaaca aattactggc acatcggcca tggcttatca ccaaggagca tattcaggcc
      841 ttgctgaaga ctggagagca cagctggtcc ctggctgagc tcatccaagc gctggtcctg
      901 ctcacccact gccactgtct ggcctccttt gtgtttggct gtgggatact tcctgaggga
      961 gacgctgagg gcagccctgc ctcacaggca ccttcgccac ccagtgagca aggcggcccc
     1021 ccaagcagag acccattgaa caactcgggg ggctttgaag ccgcccgtga catagaagct
     1081 ctgatggaac gcatgaggca gcttcaggag agcctcctgc gggatgaggg ggcttcccag
     1141 gaggaaatgg agaaccgttt tgagctggag aagacggaaa gcctgctggt gaccccctca
     1201 gcggatattc tggagccctc tccacaccca gacatcctat gctttgtaga ggaccccacg
     1261 tttggatatg aagacttcac tcgtcgaggg actcaggccc ccccaacctt tcgtgcccag
     1321 gattatacct gggaagacca tggctactcg ctgatccagc ggctctaccc cgagggaggg
     1381 cagctgctgg atgagaagtt tcaggtagcc tacagcctca cctataacac catcgccatg
     1441 cacagtggcg tagacacctc catgctccgc agagccgtct ggaactacat ccactgcgtc
     1501 tttggtatca gatatgatga ctatgattat ggagaggtaa accagctcct ggaaaggaac
     1561 ctcaagatct atatcaagac ggttgcctgc tacccggaga agacgacccg cagaatgtac
     1621 aacctctttt ggaggcactt ccgccactca gagaaggttc acgtgaactt gctgctcctc
     1681 gaagcccgca tgcaagcagc tttgctctat gccctccgcg ccatcacccg ctacatgacc
     1741 tgattacctg gcacacagga atggcacctg gaacagctga ccctgggcca ctgtcctccg
     1801 tgcaaggact tctgtgtctg gagacagatc caggaccctt tccgtctcat gtccatccac
     1861 caaatgccag ggatgagcat gcgtatggcc atgcacagcc cccgaggcaa gccacacctt
     1921 ccttttcctc actggactga acaggatcgt tgcactgact ttgggggtct tggctctgtc
     1981 cctagagctg gaagattagg aaaacccaaa ggctccgccc ccttttcttt ccttgctcct
     2041 taaagcagag gaagtctaca gagctaaagt ccggcttacg agccagcagg ctggacccca
     2101 ggcacaaatg ctgccttcct ggactgggaa gcccctggct gcccatgtgg gaaaaaagca
     2161 gggactaaca ctccagaaag cttgccttcc ctagttcctc attcacaagt gtcatcacac
     2221 acacacacac acacacacac acacacacac ccacccgcct tccacccatc aatgtgaaag
     2281 ttggactcac agctggcctg tgtgcccagt tccccctaag cctgttctgt cgggcagcct
     2341 gttccttggt tacctgaata ttggttcagt ccttttgtct cctttcccct tacacccttt
     2401 tctcccatgc ctggtggtgt ggggcctggg agagcggcca aacacatcca aagaacacac
     2461 tgtctctgga gagttggagc ccacggtggt ctctctgctg tctgaagagt aaggaatggg
     2521 tgctgacgaa ctctgcattt gggtcttgag gctgaggtct ggtctcttga ggacctcacc
     2581 atggaaccag agtcaaagcc taggagggag ttgacactgt tcttctaggt tgtattgcca
     2641 cacagaggct ggcgtcccat tctcctcatc ccttgggttc tgcctagagt gcttgccaaa
     2701 aaaaaaaaaa aaaaaaaaaa aaa
//
