LOCUS       NM_001414937            2587 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus sestrin 1 (Sesn1), mRNA.
ACCESSION   NM_001414937 XM_006256561
VERSION     NM_001414937.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2587)
  AUTHORS   Xu,X., Song,X., Xu,X., Zheng,Y., Xu,L. and Shen,L.
  TITLE     Inhibition of sestrin 1 alleviates polycystic ovary syndrome by
            decreasing autophagy
  JOURNAL   Aging (Albany NY) 13 (8), 11774-11785 (2021)
   PUBMED   33883304
  REMARK    GeneRIF: Inhibition of sestrin 1 alleviates polycystic ovary
            syndrome by decreasing autophagy.
REFERENCE   2  (bases 1 to 2587)
  AUTHORS   Xu,D., Shimkus,K.L., Lacko,H.A., Kutzler,L., Jefferson,L.S. and
            Kimball,S.R.
  TITLE     Evidence for a role for Sestrin1 in mediating leucine-induced
            activation of mTORC1 in skeletal muscle
  JOURNAL   Am J Physiol Endocrinol Metab 316 (5), E817-E828 (2019)
   PUBMED   30835510
  REMARK    GeneRIF: In skeletal muscle Sestrin1 expression is higher than
            Sestrin3, whereas Sestrin2 expression is markedly lower. Sestrin1
            has the highest affinity for leucine and Sestrin3 has the lowest
            affinity. Overall, the results presented herein are consistent with
            a model in which leucine-induced activation of mTORC1 in skeletal
            muscle in vivo occurs primarily through release of Sestrin1 from
            GATOR2.
REFERENCE   3  (bases 1 to 2587)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Saxton,R.A., Shen,K., Scaria,S.M.,
            Cantor,J.R. and Sabatini,D.M.
  TITLE     Sestrin2 is a leucine sensor for the mTORC1 pathway
  JOURNAL   Science 351 (6268), 43-48 (2016)
   PUBMED   26449471
REFERENCE   4  (bases 1 to 2587)
  AUTHORS   Chantranupong,L., Wolfson,R.L., Orozco,J.M., Saxton,R.A.,
            Scaria,S.M., Bar-Peled,L., Spooner,E., Isasa,M., Gygi,S.P. and
            Sabatini,D.M.
  TITLE     The Sestrins interact with GATOR2 to negatively regulate the
            amino-acid-sensing pathway upstream of mTORC1
  JOURNAL   Cell Rep 9 (1), 1-8 (2014)
   PUBMED   25263562
REFERENCE   5  (bases 1 to 2587)
  AUTHORS   Peng,M., Yin,N. and Li,M.O.
  TITLE     Sestrins function as guanine nucleotide dissociation inhibitors for
            Rag GTPases to control mTORC1 signaling
  JOURNAL   Cell 159 (1), 122-133 (2014)
   PUBMED   25259925
REFERENCE   6  (bases 1 to 2587)
  AUTHORS   Lee,J.H., Budanov,A.V., Talukdar,S., Park,E.J., Park,H.L.,
            Park,H.W., Bandyopadhyay,G., Li,N., Aghajan,M., Jang,I.,
            Wolfe,A.M., Perkins,G.A., Ellisman,M.H., Bier,E., Scadeng,M.,
            Foretz,M., Viollet,B., Olefsky,J. and Karin,M.
  TITLE     Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3
  JOURNAL   Cell Metab 16 (3), 311-321 (2012)
   PUBMED   22958918
REFERENCE   7  (bases 1 to 2587)
  AUTHORS   Lee,J.H., Budanov,A.V., Park,E.J., Birse,R., Kim,T.E.,
            Perkins,G.A., Ocorr,K., Ellisman,M.H., Bodmer,R., Bier,E. and
            Karin,M.
  TITLE     Sestrin as a feedback inhibitor of TOR that prevents age-related
            pathologies
  JOURNAL   Science 327 (5970), 1223-1228 (2010)
   PUBMED   20203043
REFERENCE   8  (bases 1 to 2587)
  AUTHORS   Budanov,A.V. and Karin,M.
  TITLE     p53 target genes sestrin1 and sestrin2 connect genotoxic stress and
            mTOR signaling
  JOURNAL   Cell 134 (3), 451-460 (2008)
   PUBMED   18692468
  REMARK    Erratum:[Cell. 2009 Jan 23;136(2):378]
REFERENCE   9  (bases 1 to 2587)
  AUTHORS   Budanov,A.V., Sablina,A.A., Feinstein,E., Koonin,E.V. and
            Chumakov,P.M.
  TITLE     Regeneration of peroxiredoxins by p53-regulated sestrins, homologs
            of bacterial AhpD
  JOURNAL   Science 304 (5670), 596-600 (2004)
   PUBMED   15105503
REFERENCE   10 (bases 1 to 2587)
  AUTHORS   Velasco-Miguel,S., Buckbinder,L., Jean,P., Gelbert,L., Talbott,R.,
            Laidlaw,J., Seizinger,B. and Kley,N.
  TITLE     PA26, a novel target of the p53 tumor suppressor and member of the
            GADD family of DNA damage and growth arrest inducible genes
  JOURNAL   Oncogene 18 (1), 127-137 (1999)
   PUBMED   9926927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 15, 2022 this sequence version replaced XM_006256561.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.61751.1,
                                           SRR26643287.37516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000020.1  46948719-46948875
            158-223             JAXUCZ010000020.1  46956147-46956212
            224-424             JAXUCZ010000020.1  46956934-46957134
            425-607             JAXUCZ010000020.1  46958099-46958281
            608-850             JAXUCZ010000020.1  46960211-46960453
            851-998             JAXUCZ010000020.1  46963516-46963663
            999-1111            JAXUCZ010000020.1  46965746-46965858
            1112-1302           JAXUCZ010000020.1  46966634-46966824
            1303-1447           JAXUCZ010000020.1  46967921-46968065
            1448-2587           JAXUCZ010000020.1  46968871-46970010
FEATURES             Location/Qualifiers
     source          1..2587
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..2587
                     /gene="Sesn1"
                     /note="sestrin 1"
                     /db_xref="GeneID:294518"
                     /db_xref="RGD:1307517"
     exon            1..157
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1534
                     /gene="Sesn1"
                     /EC_number="1.11.1.15"
                     /codon_start=1
                     /product="sestrin-1"
                     /protein_id="NP_001401866.1"
                     /db_xref="GeneID:294518"
                     /db_xref="RGD:1307517"
                     /translation="MRLAAAANEAYAASLAVSELLGCHQCGGGRGQDEELGIRIPRPL
                     GHGPSRFIPEKEMLQVGSEDAQMHTLFADSFAALGRLDNITLVMVFHPQYLESFLKTQ
                     HYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVSDFLHVGGDPKWLNGLENAPQK
                     LQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFG
                     CGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVEETPVPSAGSALVSDSFFEVEAL
                     MEKMKQLQECREEEEASQEEMASRFEMEKRDSMFVFSSDDDEVTPARDVSRHFEDTSY
                     GYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAM
                     HKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKR
                     MYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT"
     exon            158..223
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..424
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..607
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..850
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..998
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1111
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1302
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1447
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..2587
                     /gene="Sesn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtgcagac tgaagctgtg cagcgactga ctgcggccgc agccgtccct ccgacatgcg
       61 cctggccgcc gcggcgaacg aggcgtacgc agcctcgctg gctgtctcgg agctgctggg
      121 ctgccaccag tgcggcggtg gccgcggcca ggacgaggaa cttggaatca gaatccctcg
      181 gccactagga cacggaccaa gcaggttcat cccagagaag gagatgctgc aggtgggcag
      241 cgaggacgca cagatgcaca ctctgtttgc cgactctttc gctgctttgg gtcgtttgga
      301 taacattaca ctagtgatgg tttttcatcc acaatatcta gaaagtttct taaagacaca
      361 acactaccta ctgcagatgg acgggccgtt gcccctccat tatcgccact acattggcat
      421 catggcggca gccaggcatc agtgttccta cctggtgaat ctacacgtca gtgactttct
      481 tcatgttggt ggggacccca agtggctcaa tggtttagag aatgctcctc agaaactgca
      541 gaatttagga gaacttaaca aagtgttagc ccacaggcct tggctaatca ccaaagaaca
      601 catcgagggg ctgctgaagg ctgaggagca cagctggtct cttgcggagc tggtccacgc
      661 tgtggttctg ctcacacact accactctct tgcctccttc acatttggct gtggaattag
      721 tccagagatc cactgtgacg gtggccacac cttcagacct ccttctgtca gtaactactg
      781 catctgcgac attacgaatg gcaaccacag tgtggaggag acgccagtcc cctcagcagg
      841 aagtgccttg gtgagtgact ccttctttga ggtcgaagcc ctcatggaaa agatgaagca
      901 gttacaggag tgccgggagg aggaggaggc cagccaggag gagatggcct cgaggtttga
      961 aatggagaag agagatagca tgtttgtctt ctcttcagat gatgatgaag ttacaccagc
     1021 gagagatgtg tctcggcact ttgaggacac tagttatggc tacaaggatt tctccaggca
     1081 tgggatgcat gttccaacat ttcgtgtcca ggactactgc tgggaggacc atggttattc
     1141 tctggtgaat cgtctttatc cggatgtggg acagttaatc gatgagaaat ttcacattgc
     1201 ttacaacctt acttacaata ccatggcaat gcacaaagat gttgatacct caatgctgcg
     1261 acgggctatc tggaactata tccactgcat gttcggaata cgatacgatg actatgacta
     1321 cggggagatt aaccagctgt tggatcgtag ctttaaagtt tatatcaaaa ctgtcgtgtg
     1381 cactcctgaa aaggtcacca aaagaatgta tgatagcttc tggaggcagt tcaagcactc
     1441 tgagaaggtt catgttaatc tgcttcttat agaagcgagg atgcaagcgg agctcctgta
     1501 tgctctgaga gccattaccc ggtatatgac ctgatgcccc tcctccactg aggatgaccc
     1561 tgcagtgaac agcaaactta gtctccacgg ggatggaacc aagccccagg accaatggta
     1621 gataaaaaga attcagaaat gcgtgtgcca tgattcctgc tattttcctg tgtctgctct
     1681 cactgctgtc agcagtgggc acttggcagc ctcagtgtta gagctgtgaa gaaaggctgt
     1741 ggccacagtg tctgctttgt gacagtgtga ggtgctgtga acttgtttca gtacagcaac
     1801 tagtaattct ccagatcccc tgctccgctg tgacagggtg acggacagga gagtagaggc
     1861 tggacttggg caccaagttc acccgtaggg agccgagcgg attggagctc ggtgctgctg
     1921 tggctgagga caagcgcacg gctgttcctg ccaagcgctg ctgccacctg agcccgcacc
     1981 acaccgtctt cgtgtggttt tcagttgaac tcgtgcgcat ttcttcttgc atctaaaaga
     2041 gcatagaatt attactcagc tcagcgaaga ccgtgttggt ggtgacagtt tgtttctttc
     2101 attacagttt aaaattcagt tgctggagga aattacagtg gcattcttaa gatttcctcc
     2161 aaagagcaat cttaaaataa tagtgtgtta attataagaa aaacaagcta tctttcgaca
     2221 tgctgttttc caacatcctc tcatcctgga gggcagctat cttgtgcggg atttttgttt
     2281 ccagcaccaa caatgtggtt tccagtgttg ctgcaaactg acgcccaggg agtgccgggt
     2341 gcattctgcc ccgtgctcct gctgacctcg tgaccctgac tttgaaggta tacagctcct
     2401 taaagaataa agctggaaaa tgttttattg aagttatcgg atttgtatct tgatttacag
     2461 aaatgctaac cttgagatgc aaacaggttt ggggtaaatg agctaagcgc tttgtactct
     2521 gggacagtaa ctgcttttgg aatctgtcag tattattggt atttttcaat aaagaataat
     2581 ttccaca
//
