LOCUS       NM_001134409            1351 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serpin family I member 2 (Serpini2), mRNA.
ACCESSION   NM_001134409 XM_342263
VERSION     NM_001134409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1351)
  AUTHORS   Hill,R.M., Coates,L.C., Parmar,P.K., Mezey,E., Pearson,J.F. and
            Birch,N.P.
  TITLE     Expression and functional characterization of the serine protease
            inhibitor neuroserpin in endocrine cells
  JOURNAL   Ann N Y Acad Sci 971, 406-415 (2002)
   PUBMED   12438159
  REMARK    GeneRIF: neuroserpin may play a role in cell communication, cell
            adhesion, and/or cell migration
REFERENCE   2  (bases 1 to 1351)
  AUTHORS   Laes,J.F., Ravoet,M., Quan,X., Van Vooren,P., Szpirer,J. and
            Szpirer,C.
  TITLE     Improved radiation hybrid map of rat chromosome 2: colocalization
            of the genes encoding corticotropin-releasing hormone and
            IL6-receptor with quantitative trait loci regulating the
            inflammatory response
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 130-133 (2001)
   PUBMED   11306811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001134409.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X99773.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN06680412 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               JAXUCZ010000002.1  162342619-162342875 c
            258-488             JAXUCZ010000002.1  162335642-162335872 c
            489-683             JAXUCZ010000002.1  162334153-162334347 c
            684-876             JAXUCZ010000002.1  162333882-162334074 c
            877-974             JAXUCZ010000002.1  162328555-162328652 c
            975-1061            JAXUCZ010000002.1  162326490-162326576 c
            1062-1151           JAXUCZ010000002.1  162323884-162323973 c
            1152-1351           JAXUCZ010000002.1  162313325-162313524 c
FEATURES             Location/Qualifiers
     source          1..1351
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..1351
                     /gene="Serpini2"
                     /note="serpin family I member 2"
                     /db_xref="GeneID:171149"
                     /db_xref="RGD:619897"
     exon            1..257
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1228
                     /gene="Serpini2"
                     /note="neuroserpin; serpin I2; serine (or cysteine)
                     peptidase inhibitor, clade I, member 2; serpin peptidase
                     inhibitor, clade I, member 2; serpin peptidase inhibitor,
                     clade I (pancpin), member 2"
                     /codon_start=1
                     /product="serpin I2 precursor"
                     /protein_id="NP_001127881.1"
                     /db_xref="GeneID:171149"
                     /db_xref="RGD:619897"
                     /translation="MKKTILWSFLLFLSGSQTSRTMDQKNAEFAVDLYKAISLSNKNN
                     VIFSPLGTTVLLGMVQLGAKGKAQQQIMQTLRMQKTSTGEEFSVLKSLFSAISKKKQE
                     FTFNLASALYLQEGFIVKESYLHSNKEFFQSATKLVDFLDAKTSAQAISTWVESKTDG
                     KIKNMFSEEDFGPLTRLVLVNAIYFKGDWKQKFRKEDTEMTDFSKKDGSTVKIPMMKA
                     LLRAKYGYFSESSMTYQVLELPYKADEFSLVILLPTEDVNIEEVEKQVTARHVQKWFS
                     ELHEEEVEVSLPRFKIEQKLDFKEALFSLNVTEIFSGGCDLSGITDSSELYVSRAMQK
                     VFFEINEDGSEAAASTGINIPAIMSLTQTQFLANHPFLFIMKHIQTESILFMGKVTDP
                     DIHTVKGRDLDSL"
     exon            258..488
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..683
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..876
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..974
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1061
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1151
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1351
                     /gene="Serpini2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagtcaag atgaaaaaga caatattgtg gagtttccta ctatttcttt ctggaagtca
       61 aacttcaaga actatggatc aaaagaatgc tgaatttgca gtggatcttt ataaagctat
      121 ttctttatcc aacaagaaca atgttatatt ttcacctctt ggaaccactg tgcttcttgg
      181 gatggtccag ttaggtgcga aaggaaaagc acagcagcag atcatgcaaa ctttaagaat
      241 gcagaaaact tcaacaggag aggaattctc tgtgctgaag tcactttttt cagccatctc
      301 gaagaagaaa caggaattta catttaatct tgccagtgcc ctctaccttc aagaaggatt
      361 cattgtgaag gaatcgtatc tccatagcaa caaggagttt tttcagagtg ctacaaaact
      421 ggtggatttt ctagatgcaa agacttctgc acaggcaata agcacctggg tagaaagcaa
      481 aacagatgga aaaattaaaa atatgttctc agaagaagac tttggcccct tgactcgtct
      541 ggtcttggta aacgccattt attttaaggg ggattggaaa cagaaattca gaaaagaaga
      601 cacagaaatg acagatttta gtaagaaaga tggctcaaca gtcaagattc caatgatgaa
      661 ggctctgttg agagcaaaat atggttattt ttccgagtca tccatgacat atcaagtttt
      721 ggaattgcct tacaaggctg atgagtttag tttagtcatc cttcttccca cagaagatgt
      781 gaacatagaa gaagtggaaa aacaagttac tgctcgtcat gtccagaaat ggttctctga
      841 gctgcatgaa gaggaagtgg aagtcagcct ccctcgattt aaaatagaac aaaaattaga
      901 cttcaaagaa gcattatttt ctttaaacgt aactgagata tttagtggtg gctgtgacct
      961 ttctggaata acagactcat ctgaactcta tgtctccaga gccatgcaga aagttttctt
     1021 tgagataaat gaagacggaa gtgaagctgc agcatccaca ggcataaaca tccctgcaat
     1081 catgagtttg actcaaactc aatttctagc aaatcatcca tttctgttta ttatgaagca
     1141 catccaaaca gaatcaattt tgtttatggg aaaggtgaca gatccggaca tccatacagt
     1201 gaaaggaaga gatttagatt cactgtgaat aaaaatgatg gtcttggaac acaagacaga
     1261 ccttggaaaa tgattgatgg atgagatatc atcattttga aaattttcta acatttctga
     1321 ttaaaattgt acctataaaa taaataacga a
//
