LOCUS       NM_053779               2916 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus serpin family I member 1 (Serpini1), mRNA.
ACCESSION   NM_053779
VERSION     NM_053779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2916)
  AUTHORS   Wang,L., Zhang,Y., Asakawa,T., Li,W., Han,S., Li,Q., Xiao,B.,
            Namba,H., Lu,C. and Dong,Q.
  TITLE     Neuroprotective effect of neuroserpin in oxygen-glucose
            deprivation- and reoxygenation-treated rat astrocytes in vitro
  JOURNAL   PLoS One 10 (4), e0123932 (2015)
   PUBMED   25874935
  REMARK    GeneRIF: neuroserpin has a role in oxygen-glucose deprivation- and
            reoxygenation-treated rat astrocytes
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2916)
  AUTHORS   Lee,T.W., Yang,A.S., Brittain,T. and Birch,N.P.
  TITLE     An analysis approach to identify specific functional sites in
            orthologous proteins using sequence and structural information:
            application to neuroserpin reveals regions that differentially
            regulate inhibitory activity
  JOURNAL   Proteins 83 (1), 135-152 (2015)
   PUBMED   25363759
  REMARK    GeneRIF: The majority of the mutant neuroserpin proteins were found
            to fold correctly and could still form inhibitory complexes with
            tissue plasminogen activator (tPA).
REFERENCE   3  (bases 1 to 2916)
  AUTHORS   Tsang,V.W., Young,D., During,M.J. and Birch,N.P.
  TITLE     AAV-mediated overexpression of neuroserpin in the hippocampus
            decreases PSD-95 expression but does not affect
            hippocampal-dependent learning and memory
  JOURNAL   PLoS One 9 (3), e91050 (2014)
   PUBMED   24608243
  REMARK    GeneRIF: Rats overexpressing neuroserpin also showed a significant
            decrease in the levels of postsynaptic density protein 95, a major
            postsynaptic scaffolding protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2916)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2916)
  AUTHORS   Roet,K.C., Franssen,E.H., de Bree,F.M., Essing,A.H., Zijlstra,S.J.,
            Fagoe,N.D., Eggink,H.M., Eggers,R., Smit,A.B., van Kesteren,R.E.
            and Verhaagen,J.
  TITLE     A multilevel screening strategy defines a molecular fingerprint of
            proregenerative olfactory ensheathing cells and identifies SCARB2,
            a protein that improves regenerative sprouting of injured sensory
            spinal axons
  JOURNAL   J Neurosci 33 (27), 11116-11135 (2013)
   PUBMED   23825416
REFERENCE   6  (bases 1 to 2916)
  AUTHORS   Kinghorn,K.J., Crowther,D.C., Sharp,L.K., Nerelius,C., Davis,R.L.,
            Chang,H.T., Green,C., Gubb,D.C., Johansson,J. and Lomas,D.A.
  TITLE     Neuroserpin binds Abeta and is a neuroprotective component of
            amyloid plaques in Alzheimer disease
  JOURNAL   J Biol Chem 281 (39), 29268-29277 (2006)
   PUBMED   16849336
  REMARK    GeneRIF: neuroserpin interacts with Abeta(1-42) to form off-pathway
            non-toxic oligomers and so protects neurons in Alzheimer disease
REFERENCE   7  (bases 1 to 2916)
  AUTHORS   Hill,R.M., Coates,L.C., Parmar,P.K., Mezey,E., Pearson,J.F. and
            Birch,N.P.
  TITLE     Expression and functional characterization of the serine protease
            inhibitor neuroserpin in endocrine cells
  JOURNAL   Ann N Y Acad Sci 971, 406-415 (2002)
   PUBMED   12438159
  REMARK    GeneRIF: neuroserpin may play a role in cell communication, cell
            adhesion, and/or cell migration
REFERENCE   8  (bases 1 to 2916)
  AUTHORS   Fell,B., Smith,A.M., Hill,R.M., Parmar,P.K., Coates,L.C., Mezey,E.
            and Birch,N.P.
  TITLE     Characterisation of two serine protease inhibitors expressed in the
            pituitary gland
  JOURNAL   Arch Physiol Biochem 110 (1-2), 26-33 (2002)
   PUBMED   11935397
  REMARK    GeneRIF: novel intracellular serpin from the rat pituitary gland;
            data suggest raPIT5a may regulate apoptosis in the pituitary by
            inhibition of granzyme B or GLP IIIa, or members of the caspase
            enzyme family.
REFERENCE   9  (bases 1 to 2916)
  AUTHORS   Hill,R.M., Parmar,P.K., Coates,L.C., Mezey,E., Pearson,J.F. and
            Birch,N.P.
  TITLE     Neuroserpin is expressed in the pituitary and adrenal glands and
            induces the extension of neurite-like processes in AtT-20 cells
  JOURNAL   Biochem J 345 Pt 3 (Pt 3), 595-601 (2000)
   PUBMED   10642518
REFERENCE   10 (bases 1 to 2916)
  AUTHORS   Osterwalder,T., Cinelli,P., Baici,A., Pennella,A., Krueger,S.R.,
            Schrimpf,S.P., Meins,M. and Sonderegger,P.
  TITLE     The axonally secreted serine proteinase inhibitor, neuroserpin,
            inhibits plasminogen activators and plasmin but not thrombin
  JOURNAL   J Biol Chem 273 (4), 2312-2321 (1998)
   PUBMED   9442076
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053779.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF193014.1, AF193015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000002.1  162645362-162645454
            94-361              JAXUCZ010000002.1  162695356-162695623
            362-592             JAXUCZ010000002.1  162699168-162699398
            593-787             JAXUCZ010000002.1  162701184-162701378
            788-992             JAXUCZ010000002.1  162704342-162704546
            993-1090            JAXUCZ010000002.1  162710019-162710116
            1091-1177           JAXUCZ010000002.1  162727459-162727545
            1178-1267           JAXUCZ010000002.1  162729794-162729883
            1268-2916           JAXUCZ010000002.1  162730084-162731732
FEATURES             Location/Qualifiers
     source          1..2916
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..2916
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /note="serpin family I member 1"
                     /db_xref="GeneID:116459"
                     /db_xref="RGD:619896"
     exon            1..93
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     exon            94..361
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1344
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /note="neuroserpin; serine (or cysteine) proteinase
                     inhibitor clade member 1; serpin I1; protease inhibitor
                     17; peptidase inhibitor 12; serine protease inhibitor 17;
                     serine (or cysteine) proteinase inhibitor, clade I
                     (neuroserpin), member 1; serine (or cysteine) peptidase
                     inhibitor, clade I, member 1; serpin peptidase inhibitor,
                     clade I, member 1; serpin peptidase inhibitor, clade I
                     (neuroserpin), member 1"
                     /codon_start=1
                     /product="neuroserpin precursor"
                     /protein_id="NP_446231.1"
                     /db_xref="GeneID:116459"
                     /db_xref="RGD:619896"
                     /translation="MAYLGLLSLVALQSLVTGAAFPDETIAEWSVNVYNHLRATGEDE
                     NILFSPLSIALAMGVMELGAQGSTLKEIRHSMGYESLKSGEEFSFLRDFSSMVSAEEG
                     QYVMKIANSLFVQNGFHINEEFLQMMKMYFNAEVNHVDFSENVAVANYINKWVENYTN
                     SLLKDLVSPGDFDAVTHLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMY
                     QQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLLKPQLI
                     EEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLS
                     KAVHKSFIEVNEEGSEAAVASGMIAISRMAVLFPQVIVDHPFLFLIKNRKTGTILFMG
                     RVMHPETMNTSGHDFEEL"
     exon            362..592
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     exon            593..787
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     exon            788..992
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1090
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1177
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1267
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..2916
                     /gene="Serpini1"
                     /gene_synonym="PI-12; raPIT5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagaggca agagcaggat cccgagcgaa cacatcctgc ccagcatcct ctccagcatc
       61 ccaagccaag ccgaggttgc aggtgtgagg gagacttgaa accattccat catggcttac
      121 cttggactgc tctctttagt ggccttgcaa agtttggtga caggggcagc tttcccagat
      181 gaaaccatag ccgagtggtc agtgaatgtg tataaccatc ttcgagccac tggggaagat
      241 gaaaacatcc tcttctctcc actaagcatt gcccttgcta tgggggtgat ggagctcggg
      301 gctcaaggat ctactctgaa agaaatccgc cattcaatgg gatacgagag cctgaaaagt
      361 ggtgaagaat tttctttcct gagggatttt tctagcatgg tctctgctga agaaggccaa
      421 tatgtgatga aaattgccaa ttcactcttt gtgcaaaacg gatttcatat caatgaggaa
      481 ttcttgcaaa tgatgaaaat gtactttaat gcagaagtca atcatgtgga cttcagtgaa
      541 aatgtggcgg tggccaacta catcaataag tgggtggaga attatacaaa cagtctattg
      601 aaagatctgg tgtccccggg ggattttgac gctgtcaccc atctggccct tatcaatgct
      661 gtatatttca aagggaactg gaagtctcag tttagacctg aaaataccag aactttctcc
      721 ttcacaaaag atgatgaaag tgaagtacag attccaatga tgtatcaaca aggagaattt
      781 tattacgggg aatttagtga tggatccaat gaggctggtg gcatctacca agtccttgag
      841 ataccttatg agggagacga gatcagcatg atgctggtac tgtccagaca ggaagtccca
      901 ctggccacac tggagcctct gctcaaacca cagctgatcg aagaatgggc aaactccgtg
      961 aagaaacaaa aggtggaagt ctacttgccc aggttcaccg tggaacagga aattgattta
     1021 aaagacatct tgaaagccct tggggtcact gaaattttca tcaaagatgc aaatttgact
     1081 gccatgtcag ataagaaaga actgttcctc tccaaagctg ttcacaagtc cttcattgag
     1141 gttaatgaag aagggtcaga agcagctgtg gcctcaggaa tgattgcaat tagcaggatg
     1201 gctgtgctgt tccctcaggt tattgtcgac catccatttt tatttctcat caagaacagg
     1261 aaaactggta caatcttatt catgggacga gtcatgcacc ctgaaacaat gaacacaagt
     1321 ggccatgact ttgaggaact ttaaatgatg acgtttgagt acaaaggcag cagtagcaaa
     1381 gcacattatg tcttcaagtg gtatatattt aggatttttg ttttaaagta ttacttaagg
     1441 aaatatttaa aatagttctg gatagtagta aatccacgtg acctataagt tagcctgtcc
     1501 aaaaaaaaaa atgttatcag tgtaatgact gtggtcccat tgttgcattg tgtctggtgt
     1561 gctgttgttt aaaataaaag tacatattga aaatgtgaac aacttttttc attttagagc
     1621 tagttgtagt ctatacaaca ctgtatctga gatttgaaaa ctatgccatt tctttaggaa
     1681 ttataataaa gtaatcctac aaggcaaaaa tgtagaaacc attgtttctg agttttctca
     1741 tcatcttgca gaatcaacac caaagtgagc gacatacatg tatataataa gcaatactgt
     1801 gaagggaagg caaacaggcc acagaaattg agattgtcat ttactgtagg gctccatgac
     1861 aaagatttat gaaaaaaaag tgggatacgt aaggcccaca gactttactg actttgtgta
     1921 tactgtagta ttatactttt aaattattaa agtatacatc ttttatttat ttttaaaagt
     1981 ttactgtgac tcagaattaa taacaagctc agatatctca ttagctatgc tagatggcat
     2041 caagagcccc catagaggaa tttccttgta ccattgaagt ttcagtgaag tttttgatgt
     2101 tcgcacaaag acgaaatcac acagtggcac attctctaga ctatacccaa gaaagtcacc
     2161 aagtgggaca gtcatgaacc agcaaaatag atgtgattac tttataaaaa agaatcactg
     2221 gtaagtgcat catatggagt caatgcttct taaactcaca cctcgtcacc tactacaaat
     2281 taggttctta cccaagatat ctaaagcata gtagggacta catttcagac atcagaatga
     2341 tgccacaggg atttggccat gagttggtgt ttgtcacttg ggttgtaaaa gtttacttga
     2401 agtcagcagc acattttcac agacagagat tagagagaat cagggcgaag gcaggaggta
     2461 attaatctgc actaataata caatgccctt gtcaagcatt ggtgtgattc caaagtattt
     2521 ctagtacata ctatagatat gtaagattct tctgtatatt acaacacttg aaatacagct
     2581 gttaaaacat ggagacattt atataggtaa tacccatgaa aggatttatg aatatcccag
     2641 gatacggtac ttaatgctga aatcttttac agcttatatt ttcagaggac tcgtagttta
     2701 ttcataaatc ttcacattat tatagaatag tgctcttgtt ttcatttata atttatggag
     2761 ctgggatgcc tgatgttaat tcagagttta cattctgtgc taagaccagt ctttatctct
     2821 gtatccttct tgttaatatg acatatatgg ctatacctat gtgttcaata gttagataaa
     2881 tgtattgcct gtaaggaaaa ataaacatca ttatgc
//
