LOCUS       NM_017173               2091 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Rattus norvegicus serpin family H member 1 (Serpinh1), mRNA.
ACCESSION   NM_017173 XM_346548
VERSION     NM_017173.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Wang,Y.J., Di,X.J., Zhang,P.P., Chen,X., Williams,M.P., Han,D.Y.,
            Nashmi,R., Henderson,B.J., Moss,F.J. and Mu,T.W.
  TITLE     Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the
            endoplasmic reticulum
  JOURNAL   Elife 13, e84798 (2024)
   PUBMED   38963323
  REMARK    GeneRIF: Hsp47 promotes biogenesis of multi-subunit neuroreceptors
            in the endoplasmic reticulum.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Wang,W. and lI,H.
  TITLE     Inhibition of heat shock protein 47 suppressed collagen production
            in Tenon's capsule fibroblasts
  JOURNAL   Folia Histochem Cytobiol 61 (3), 153-159 (2023)
   PUBMED   37724035
  REMARK    GeneRIF: Inhibition of heat shock protein 47 suppressed collagen
            production in Tenon's capsule fibroblasts.
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Da,J., Yang,Y., Dong,R., Shen,Y. and Zha,Y.
  TITLE     Therapeutic effect of 1,25(OH)2-VitaminD3 on fibrosis and
            angiogenesis of peritoneum induced by chlorhexidine
  JOURNAL   Biomed Pharmacother 129, 110431 (2020)
   PUBMED   32585450
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Huang,Y., Lu,J., Xu,Y., Xiong,C., Tong,D., Hu,N. and Yang,H.
  TITLE     Xiaochaihu decorction relieves liver fibrosis caused by Schistosoma
            japonicum infection via the HSP47/TGF-beta pathway
  JOURNAL   Parasit Vectors 13 (1), 254 (2020)
   PUBMED   32410640
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Yong-Hua,Z., Chen,X., Ying-Ying,Y., Cong-Jin,M., Pan-Pan,D.,
            Xue,S., Yong-Liang,X., Xiao-Lin,F., Jun-Qi,Y. and Li-Juan,S.
  TITLE     [Roles of transforming growth factor - beta1 and heat shock protein
            47 in progression of Schistosoma japonicum-induced hepatic
            fibrosis]
  JOURNAL   Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 31 (4), 382-387 (2019)
   PUBMED   31612672
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Koide,T., Aso,A., Yorihuzi,T. and Nagata,K.
  TITLE     Conformational requirements of collagenous peptides for recognition
            by the chaperone protein HSP47
  JOURNAL   J Biol Chem 275 (36), 27957-27963 (2000)
   PUBMED   10862616
REFERENCE   7  (bases 1 to 2091)
  AUTHORS   Nagai,N., Tetuya,Y., Hosokawa,N. and Nagata,K.
  TITLE     The human genome has only one functional hsp47 gene (CBP2) and a
            pseudogene (pshsp47)
  JOURNAL   Gene 227 (2), 241-248 (1999)
   PUBMED   10023073
REFERENCE   8  (bases 1 to 2091)
  AUTHORS   Shroff,B., Pileggi,R., Norris,K., Orbegoso,R., Wilson,T. and
            Sauk,J.J.
  TITLE     Dynamic variations in the expression of type I collagen and its
            molecular chaperone Hsp47 in cells of the mouse dental follicle
            during tooth eruption
  JOURNAL   Arch Oral Biol 39 (3), 231-243 (1994)
   PUBMED   8018053
REFERENCE   9  (bases 1 to 2091)
  AUTHORS   Clarke,E.P., Cates,G.A., Ball,E.H. and Sanwal,B.D.
  TITLE     A collagen-binding protein in the endoplasmic reticulum of
            myoblasts exhibits relationship with serine protease inhibitors
  JOURNAL   J Biol Chem 266 (26), 17230-17235 (1991)
   PUBMED   1654327
REFERENCE   10 (bases 1 to 2091)
  AUTHORS   Nandan,D., Cates,G.A., Ball,E.H. and Sanwal,B.D.
  TITLE     Partial characterization of a collagen-binding,
            differentiation-related glycoprotein from skeletal myoblasts
  JOURNAL   Arch Biochem Biophys 278 (2), 291-296 (1990)
   PUBMED   2158279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 24, 2020 this sequence version replaced NM_017173.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M69246.1, SRR22582416.528545.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000001.1  163062875-163062976 c
            103-764             JAXUCZ010000001.1  163058677-163059338 c
            765-863             JAXUCZ010000001.1  163057476-163057574 c
            864-1096            JAXUCZ010000001.1  163057150-163057382 c
            1097-2091           JAXUCZ010000001.1  163055630-163056624 c
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2091
                     /gene="Serpinh1"
                     /gene_synonym="Cbp2; HSP47; Serpinh2"
                     /note="serpin family H member 1"
                     /db_xref="GeneID:29345"
                     /db_xref="RGD:69302"
     exon            1..102
                     /gene="Serpinh1"
                     /gene_synonym="Cbp2; HSP47; Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            103..764
                     /gene="Serpinh1"
                     /gene_synonym="Cbp2; HSP47; Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1399
                     /gene="Serpinh1"
                     /gene_synonym="Cbp2; HSP47; Serpinh2"
                     /note="serine (or cysteine) proteinase inhibitor, clade H
                     (heat shock protein 47), member 1; serine proteinase
                     inhibitor, clade H (heat shock protein 47), member 1;
                     serpin H1; GP46; colligin; collagen-binding protein; 47
                     kDa heat shock protein; serine (or cysteine) proteinase
                     inhibitor, clade H, member 1; serine (or cysteine)
                     peptidase inhibitor, clade H, member 1; serpin peptidase
                     inhibitor, clade H, member 1; serpin peptidase inhibitor,
                     clade H (heat shock protein 47), member 1, (collagen
                     binding protein 1); collagen binding protein 2; serine (or
                     cysteine) proteinase inhibitor, clade H (heat shock
                     protein 47), member 2"
                     /codon_start=1
                     /product="serpin H1 precursor"
                     /protein_id="NP_058869.2"
                     /db_xref="GeneID:29345"
                     /db_xref="RGD:69302"
                     /translation="MRSLLLGTLCLLAVALAAEVKKPVEATAPGTAEKLSSKATTLAE
                     RSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLR
                     DEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKI
                     NFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMV
                     DNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQLVEMPLAHKLSSLIILMPHHVEP
                     LERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKA
                     DLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVR
                     DNQSGSLLFIGRLVRPKGDKMRDEL"
     exon            765..863
                     /gene="Serpinh1"
                     /gene_synonym="Cbp2; HSP47; Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1096
                     /gene="Serpinh1"
                     /gene_synonym="Cbp2; HSP47; Serpinh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..2091
                     /gene="Serpinh1"
                     /gene_synonym="Cbp2; HSP47; Serpinh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccagcca tatatagatc cagggcccgg ggcagtgagc tgagtagagc ctgcctgaga
       61 gcgagtgtcc cgtcggtccc ggagcagccc agcccggccc agccctcaca ggtcctctgt
      121 ggtgcacaca gcccacctcc cagccatgcg ctctctcctt ctgggcacct tatgcctcct
      181 ggctgtggcc ctggcagccg aggtgaagaa acctgtagag gccacagccc ctggtactgc
      241 ggagaagctg agttccaagg cgaccacact ggcagagcgc agcacaggcc tggccttcag
      301 cctgtatcag gcaatggcca aagatcaggc ggtggagaat atcctcctgt cacccttggt
      361 ggtggcctca tccctgggcc ttgtgtcact gggtggtaaa gccaccacag cttcgcaggc
      421 gaaggcagtg ctgagcgctg agaagctgcg ggatgaggag gtgcacacgg ggctgggcga
      481 gctgctgcgc tccctcagta actccactgc gcgcaatgtg acctggaaac tgggcagccg
      541 cctgtacggg cccagctccg tgagcttcgc cgatgacttc gtgcgcagca gtaagcaaca
      601 ctacaactgt gaacactcca agatcaactt ccgagacaag cgcagcgccc tgcagtccat
      661 caacgagtgg gcctcgcaga ccaccgacgg caagctgcca gaggtcacca aggatgtgga
      721 gcgcacggat ggggcactgc tcgttaatgc catgttcttt aagccgcact gggatgagaa
      781 gttccaccat aagatggtag acaaccgtgg cttcatggtg acccgctcct acactgtggg
      841 tgttacgatg atgcaccgga caggcctcta caactactat gacgacgaga aggagaagct
      901 gcagctggtg gagatgccct tggcccataa gctctccagc ctcatcatcc tcatgcccca
      961 ccacgtagaa ccgctcgagc gcctggagaa gttgctgacc aaggagcaac taaagacctg
     1021 gatggggaag atgcagaaga aggctgttgc catctccctg cccaagggag tggtggaggt
     1081 gacccatgac ctgcagaaac atctggccgg actgggcctg actgaggcca tcgacaagaa
     1141 caaggcagac ttatcgcgca tgtctggcaa gaaggatctg tacctggcca gtgtgttcca
     1201 cgccactgcc ttcgagtggg acacagaggg caaccccttc gaccaggaca tctacgggcg
     1261 tgaggagctg cgcagcccca agctgttcta tgccgaccac cccttcatct tcctggtgcg
     1321 agataatcag agcggctcct tgctgttcat tgggcgcctg gtccggccca agggagacaa
     1381 gatgcgagac gagttgtaga gtccaagagt gggcgtggcg tggcatggcg ggaagtagcc
     1441 agaggttcct gagacacatg ggtgctattg tggggggagg gggaggcacc aaccctggat
     1501 agtccacggg tggggggggg ttggcagtgc agatcggaat tcccataggt ctgagtaggt
     1561 atttttagac aagagtccac tccgttagga catggagccc agacactatg agaccaaatt
     1621 caggggtgtc acagccattc tgccctgccc cacaagtttt atatccaatc tgcctcaaca
     1681 gtcaatcagt gttcatattc gtggccaagc attctgtctg tgagacaatc gagttgggtg
     1741 ggggtagggc ggcctagccc tctctgtcac catgccctga gccctcggtt ttcctgttca
     1801 cctctgattc cctttaacca caaaactagg tgctgtggtc ccagaaccgc ccacccttaa
     1861 aatgattctt gccgagcagt gggagttggg agacaatgca taggaggggc tccttggcat
     1921 atcctgccct agagccatta cattggacat cacaatcatg aacttctgtt tttctccctt
     1981 ttttgagttt ttcaaggatg ggggtttggg gaaggggaag cctttattgc tttcaaaaca
     2041 agaacagttt gtacaatttt ttttgaataa aacttttcca atgaaatgtt a
//
