LOCUS       NM_199093               1791 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus serpin family G member 1 (Serping1), mRNA.
ACCESSION   NM_199093 XM_215766
VERSION     NM_199093.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Ramlall,V., Thangaraj,P.M., Meydan,C., Foox,J., Butler,D., Kim,J.,
            May,B., De Freitas,J.K., Glicksberg,B.S., Mason,C.E.,
            Tatonetti,N.P. and Shapira,S.D.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Zhang,S., Shaw-Boden,J., Banz,Y., Bongoni,A.K., Taddeo,A.,
            Spirig,R., Nolte,M.W., Cowan,P.J. and Rieben,R.
  TITLE     Effects of C1 inhibitor on endothelial cell activation in a rat
            hind limb ischemia-reperfusion injury model
  JOURNAL   J Vasc Surg 68 (6S), 209S-221S (2018)
   PUBMED   29395422
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Fornvik,K., Maddahi,A., Persson,O., Osther,K., Salford,L.G. and
            Nittby Redebrandt,H.
  TITLE     C1-inactivator is upregulated in glioblastoma
  JOURNAL   PLoS One 12 (9), e0183086 (2017)
   PUBMED   28880870
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Begieneman,M.P., Emmens,R.W., Rijvers,L., Woudstra,L., Paulus,W.J.,
            Kubat,B., Vonk,A.B., van Rossum,A.C., Wouters,D., Zeerleder,S., van
            Ham,M., Schalkwijk,C.G., Niessen,H.W. and Krijnen,P.A.
  TITLE     Myocardial infarction induces atrial inflammation that can be
            prevented by C1-esterase inhibitor
  JOURNAL   J Clin Pathol 69 (12), 1093-1099 (2016)
   PUBMED   27153875
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Emmens,R.W., Baylan,U., Juffermans,L.J., Karia,R.V., Ylstra,B.,
            Wouters,D., Zeerleder,S., Simsek,S., van Ham,M., Niessen,H.W. and
            Krijnen,P.A.
  TITLE     Endogenous C1-inhibitor production and expression in the heart
            after acute myocardial infarction
  JOURNAL   Cardiovasc Pathol 25 (1), 33-39 (2016)
   PUBMED   26476955
  REMARK    GeneRIF: Suggest that endogenous C1-inhibitor is likely involved in
            the regulation of complement activity in the myocardium following
            acute myocardial infarction.
REFERENCE   6  (bases 1 to 1791)
  AUTHORS   Kochilas,L., Campbell,B., Scalia,R. and Lefer,A.M.
  TITLE     Beneficial effects of C1 esterase inhibitor in murine traumatic
            shock
  JOURNAL   Shock 8 (3), 165-169 (1997)
   PUBMED   9377162
REFERENCE   7  (bases 1 to 1791)
  AUTHORS   Russell,J.A., Whaley,K. and Heaphy,S.
  TITLE     The sequence of a cDNA encoding functional murine C1-inhibitor
            protein
  JOURNAL   Biochim Biophys Acta 1352 (2), 156-160 (1997)
   PUBMED   9199246
REFERENCE   8  (bases 1 to 1791)
  AUTHORS   Yamaguchi,H., Weidenbach,H., Luhrs,H., Lerch,M.M., Dickneite,G. and
            Adler,G.
  TITLE     Combined treatment with C1 esterase inhibitor and antithrombin III
            improves survival in severe acute experimental pancreatitis
  JOURNAL   Gut 40 (4), 531-535 (1997)
   PUBMED   9176084
REFERENCE   9  (bases 1 to 1791)
  AUTHORS   Dickneite,G.
  TITLE     Influence of C1-inhibitor on inflammation, edema and shock
  JOURNAL   Behring Inst Mitt (93), 299-305 (1993)
   PUBMED   8172580
  REMARK    Review article
REFERENCE   10 (bases 1 to 1791)
  AUTHORS   Schwogler,S., Odenthal,M., Knittel,T., Meyer zum Buschenfelde,K.H.
            and Ramadori,G.
  TITLE     Fat-storing cells of the rat liver synthesize and secrete
            C1-esterase inhibitor; modulation by cytokines
  JOURNAL   Hepatology 16 (3), 794-802 (1992)
   PUBMED   1505923
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 30, 2024 this sequence was replaced by
            NM_199093.3.
            
            On Nov 27, 2020 this sequence version replaced NM_199093.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061860.1, SRR26643297.11930.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000003.1  90258613-90258717   c
            106-619             JAXUCZ010000003.1  90257019-90257532   c
            620-754             JAXUCZ010000003.1  90255604-90255738   c
            755-958             JAXUCZ010000003.1  90254451-90254654   c
            959-1095            JAXUCZ010000003.1  90254131-90254267   c
            1096-1315           JAXUCZ010000003.1  90251917-90252136   c
            1316-1791           JAXUCZ010000003.1  90249423-90249898   c
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1791
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /note="serpin family G member 1"
                     /db_xref="GeneID:295703"
                     /db_xref="RGD:735225"
     exon            1..105
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1569
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /note="plasma protease C1 inhibitor; serpin peptidase
                     inhibitor, clade G (C1 inhibitor), member 1; C1Inh; C1
                     Inh; C1-inhibiting factor; C1 esterase inhibitor; serpin
                     G1; serine (or cysteine) proteinase inhibitor, clade G (C1
                     inhibitor), member 1, (angioedema, hereditary); serine (or
                     cysteine) peptidase inhibitor, clade G, member 1; serpin
                     peptidase inhibitor, clade G, member 1; C1-inactivator"
                     /codon_start=1
                     /product="plasma protease C1 inhibitor precursor"
                     /protein_id="NP_954524.1"
                     /db_xref="GeneID:295703"
                     /db_xref="RGD:735225"
                     /translation="MASKLTPLTLLLLLLAGDRAFSDSEVTSHSSQDPLVVQEGSRDS
                     VPERDGSRSPIEHTGQSSTWPTTSGSTKISNDTMDQVANESFIQHVQPAAQLPEDSPS
                     QSPVNSSSPPSTASAPPTQAPTEPLCPEPLAWCSDSDRDSSEATLSEALTDFSVKLYH
                     AFSATKKAETNMAFSPFSIASLLTQVLLGAGDSTKSNLEDILSYPKDFACVHQTLKAF
                     SSKGVTSVSQIFHSPDLAIRDTYVNASLSLYGSSPRVLGPDGDANLKLINTWVAENTN
                     HKINELLDSLPSDTRLVLLNAVYLSAKWKKTFEQKKMMASFLYKNSMIKVPMLSSKKY
                     PLALFNDQTLKAKVGQLQLSHNLSFVIMVPQSPTHQLEDMEKALNPTVFKAILKKLEL
                     SKFQPTYVMMPRIKVKSSQDMLSIMEKLEFFDFTYDLNLCGLTEDPDLQVSSMKHETV
                     LELTETGVEAAAASTISVARNLLIFEVQQPFLFLLWDQRHKFPVFMGRVYDPRA"
     exon            106..619
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /inference="alignment:Splign:2.1.0"
     exon            620..754
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /inference="alignment:Splign:2.1.0"
     exon            755..958
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1095
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1315
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1791
                     /gene="Serping1"
                     /gene_synonym="C1-IA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctggctca gaggctaact ggcttcgtag gacgcagctg acatcgctgc ccagatggcc
       61 tccaagctga ccccactgac cctcctcctg ctgctgctag ctggggatag agccttctca
      121 gattctgaag tgaccagcca cagctcccag gatccactag tagttcaaga gggaagcagg
      181 gacagcgttc ctgaaagaga tggctcccgg agtcccattg agcacacagg acagtcttct
      241 acctggccaa caaccagtgg atccaccaaa atatcaaatg acaccatgga tcaagtagcc
      301 aacgagtcct tcatccagca tgtccaacca gctgctcagc tacctgagga ttctcccagc
      361 cagtctcccg tgaattcttc cagcccgccc tccacagcct cagcccctcc cacccaggct
      421 ccgactgagc ccctctgccc agagccactt gcttggtgct ctgattcaga cagagactcc
      481 tcagaggcta cgttgtcgga ggctttgaca gatttctctg tgaaactcta ccacgccttc
      541 tcggctacga agaaggctga gaccaacatg gccttttccc cattcagcat tgctagcctc
      601 ctcacgcagg tccttcttgg ggctggagac agcaccaaga gcaacttgga ggacatcctt
      661 tcctacccca aggattttgc ctgtgtccac cagacactaa aggctttttc atccaaaggt
      721 gtcacttctg tgtctcagat tttccacagc ccagatctag ccatacggga cacctatgtg
      781 aacgcctctc tgagcctgta tggaagcagc cccagagtcc tgggtccaga cggtgatgct
      841 aacttaaaac tcatcaacac ctgggtggcg gagaacacca accacaagat caatgagctg
      901 ctggacagcc tgccctctga cacccgcctc gtccttctca atgccgtcta cttgagtgcc
      961 aagtggaaga aaacctttga gcaaaagaag atgatggcat ctttcctcta caaaaactct
     1021 atgattaaag tgcccatgtt gagtagcaaa aagtaccctc tggccctttt caatgaccag
     1081 actttgaagg ccaaggtggg acagctgcag ctctctcaca acctgagctt tgtgatcatg
     1141 gtaccccaga gcccgacaca ccaacttgaa gacatggaaa aggcactcaa ccccactgtc
     1201 tttaaggcca tcctgaagaa gctagagctg tccaagtttc agcccactta cgtgatgatg
     1261 cctcgcatta aagtaaagag cagccaagac atgctgtcaa tcatggagaa actggaattc
     1321 tttgacttca cttacgatct caacctgtgt gggctgactg aggacccaga tcttcaggtg
     1381 tcttccatga aacacgagac ggtgttggaa ctgacagaga caggtgtgga agcagccgca
     1441 gcctccacca tctccgtggc ccgaaactta ctcatctttg aggtgcagca gcctttcctc
     1501 ttcctgctct gggaccagcg acacaagttc ccagtcttca tgggccgtgt atatgacccc
     1561 agggcctgag acaggcagga gtcaggcttg aagcactgcc acccaagctt cagctcatcc
     1621 agctatttcc tcgccactgc ctgccctagc cacttccagc cttaggaact ggcagaagga
     1681 acagtttcca cccaccaacc cccatggtat tgacatgctc tctaaaccac tgttttgcag
     1741 cttttatggt tcaagcttaa cagagtctac aaataaaact tgcagacact t
//
