LOCUS       NM_001011892            2197 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus serpin family F member 2 (Serpinf2), mRNA.
ACCESSION   NM_001011892 XM_220709
VERSION     NM_001011892.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2197)
  AUTHORS   Ramlall V, Thangaraj PM, Meydan C, Foox J, Butler D, Kim J, May B,
            De Freitas JK, Glicksberg BS, Mason CE, Tatonetti NP and Shapira
            SD.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   2  (bases 1 to 2197)
  AUTHORS   Longstaff C and Kolev K.
  TITLE     Basic mechanisms and regulation of fibrinolysis
  JOURNAL   J Thromb Haemost 13 Suppl 1, S98-S105 (2015)
   PUBMED   26149056
  REMARK    Review article
REFERENCE   3  (bases 1 to 2197)
  AUTHORS   Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez
            L, Borras FE and Falcon-Perez JM.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 2197)
  AUTHORS   Kanno Y, Kawashita E, Minamida M, Kaneiwa A, Okada K, Ueshima S,
            Matsuo O and Matsuno H.
  TITLE     alpha2-antiplasmin is associated with the progression of fibrosis
  JOURNAL   Am J Pathol 176 (1), 238-245 (2010)
   PUBMED   20008146
  REMARK    Erratum:[Am J Pathol. 2014 Jul;184(7):2144]
REFERENCE   5  (bases 1 to 2197)
  AUTHORS   Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger
            B, Stubbe J, Jensen ON, Thiesson HC, Uhrenholt TR, Jespersen B,
            Jensen BL, Korbmacher C and Skott O.
  TITLE     Plasmin in nephrotic urine activates the epithelial sodium channel
  JOURNAL   J Am Soc Nephrol 20 (2), 299-310 (2009)
   PUBMED   19073825
  REMARK    GeneRIF: Plasmin in nephrotic urine activates the epithelial sodium
            channel
REFERENCE   6  (bases 1 to 2197)
  AUTHORS   Kopieczna-Grzebieniak E, Drozdz M, Grabowska-Bochenek R and
            Piekarski M.
  TITLE     [Activity of selected proteinase inhibitors in patients with
            disorders of lipid metabolism]
  JOURNAL   Pol Tyg Lek 47 (1-2), 12-14 (1992)
   PUBMED   1384011
REFERENCE   7  (bases 1 to 2197)
  AUTHORS   Mutoh S, Kobayashi M, Hirata J, Itoh N, Maki M, Komatsu Y, Yoshida
            A, Sasa H, Kuroda K, Kikuchi Y et al.
  TITLE     Urinary coagulation-fibrinolysis, kallirein-kinin systems and
            kininase in cases of preclampsia
  JOURNAL   Agents Actions Suppl 38 (Pt 2), 330-341 (1992)
   PUBMED   1334334
REFERENCE   8  (bases 1 to 2197)
  AUTHORS   Okazaki M, Suzuki M and Oguchi K.
  TITLE     Changes in coagulative and fibrinolytic activities in Triton
            WR-1339-induced hyperlipidemia in rats
  JOURNAL   Jpn J Pharmacol 52 (2), 353-361 (1990)
   PUBMED   2313941
REFERENCE   9  (bases 1 to 2197)
  AUTHORS   Hogstorp,H. and Carlin,G.
  TITLE     Two forms of alpha 2-antiplasmin: post-traumatic changes in the rat
  JOURNAL   Ups J Med Sci 92 (1), 79-83 (1987)
   PUBMED   2438835
REFERENCE   10 (bases 1 to 2197)
  AUTHORS   Moroi,M. and Aoki,N.
  TITLE     Isolation and characterization of alpha2-plasmin inhibitor from
            human plasma. A novel proteinase inhibitor which inhibits
            activator-induced clot lysis
  JOURNAL   J Biol Chem 251 (19), 5956-5965 (1976)
   PUBMED   134998
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079362.1.
            
            On Feb 11, 2005 this sequence version replaced XM_220709.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2197
                     /gene="Serpinf2"
                     /note="serpin family F member 2"
                     /db_xref="GeneID:287527"
                     /db_xref="RGD:1306692"
     exon            1..40
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            41..107
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1520
                     /gene="Serpinf2"
                     /note="serine (or cysteine) proteinase inhibitor, clade F,
                     member 2; alpha-2-antiplasmin; serine (or cysteine)
                     peptidase inhibitor, clade F, member 2; serpin peptidase
                     inhibitor, clade F (alpha-2 antiplasmin, pigment
                     epithelium derived factor), member 2"
                     /codon_start=1
                     /product="alpha-2-antiplasmin precursor"
                     /protein_id="NP_001011892.1"
                     /db_xref="GeneID:287527"
                     /db_xref="RGD:1306692"
                     /translation="MALLRGLLVLSLSCLQGPSSMFSPVSAMDLPGQQPVSEQAQQKL
                     PPLALLKLGNQDLGDHATLKRSPGDCKSAPTTEETRRLSQAMMAFTTDLFSLVAQTST
                     SSNLVLSPLSVALALSHLALGARNQTLENLQRVLHMNMGSCIPHLLSHFCQNLNPGTI
                     RLAARIYLQKGFPIKDDFLEQSEKLFGAKPVKLTGRQEEDLMNINKWVKEATEGKIED
                     FLSELPDNTVLLLLNAIHFHGFWRTKFDPSLTQKDSFHLDEQFTVPVAMMHAQSYPLR
                     WFLLEQPEIQVAHFPFQNNMSFVVIMPTYFGWNVSEVLANLTWDTLYQPSMREKPTKV
                     RLPKLHLEQHLDLVATLSKLGLQDLFQSPDLRGISDQSLVVSSVQHQSTMELSEAGVE
                     AAAATSTAMTRMSLSSFFLNRPFIFFIMEETIGIPLFVGSVRNPDPSAQPQPQEQQDS
                     PDNRRLDQNDKADIPGGKTFAPDLKLVPRLEEDYPQFSSPK"
     exon            108..146
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..209
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..411
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..555
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..759
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..902
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1107
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..2167
                     /gene="Serpinf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggagaac atcgtgtgct gcgctaagaa gcctgaagag gaacatggca ctgctccggg
       61 ggctcctggt acttagcttg tcctgtctgc aaggtcccag ttcaatgttc tctcctgtga
      121 gtgccatgga tctcccgggc cagcagccag tgagtgagca agcccagcag aagctgcccc
      181 cacttgccct cctcaagttg ggcaaccagg atcttggtga ccatgctacc ctgaagaggt
      241 ccccaggaga ttgcaagagt gccccaacta cagaggagac tcgcaggctg tctcaggcca
      301 tgatggcttt tactactgac ctgttctccc tggtggccca aacatccacc agctccaacc
      361 ttgtcctgtc accccttagt gtggccctag cactctctca cctggcacta ggtgctcgga
      421 accaaacact ggagaacctg caacgagtgc tgcacatgaa catgggatcc tgcatcccgc
      481 atctactgag ccatttctgc cagaacctaa accccgggac aatccgactg gcggccagaa
      541 tatacttgca gaaaggattt cccatcaaag atgatttcct ggagcaatcg gaaaagctct
      601 ttggcgcgaa gcccgtgaaa ctgactggaa ggcaggaaga agacctgatg aacatcaaca
      661 aatgggtgaa ggaggccaca gaagggaaga ttgaggattt cctctctgag ctgccggata
      721 acaccgtgct gctcctcctc aatgccatcc actttcacgg tttctggagg accaagtttg
      781 accccagcct cacccagaaa gactccttcc acctggacga gcagttcacg gtgccagtgg
      841 ccatgatgca cgcacagtca tacccccttc gatggttcct gctggagcaa cctgagatac
      901 aggtggctca tttcccattt cagaacaaca tgagcttcgt ggtcataatg cccacttact
      961 ttgggtggaa cgtgtccgag gtactagcca acctgacctg ggacactctg taccagccct
     1021 cgatgcggga gaagcccacc aaggtgcggc tgcctaaact tcatctggaa cagcatctgg
     1081 acctggtggc caccctcagc aagctgggcc tacaggactt gttccagagc ccagacctgc
     1141 gtgggatctc tgaccagagt ctggtggtgt ctagtgtgca gcaccagtct accatggagc
     1201 tcagtgaggc tggtgtggag gcagcggcag ctaccagcac agccatgact cgaatgtccc
     1261 tttcctcctt ctttttgaac cgaccattca tcttcttcat catggaggag accataggca
     1321 tacccctctt tgtgggaagt gtgagaaacc ctgaccccag tgcacagccc cagccccagg
     1381 aacagcaaga ctcccctgac aacaggcgct tagaccagaa tgacaaagct gacatccccg
     1441 gaggcaagac ctttgctcct gacttgaaac ttgtgccccg cctggaggaa gattatcccc
     1501 agtttagctc ccccaaatga ggaggggccc tggccagcag catcctgagt ccccacctgg
     1561 atcagcctct caactcctgt gactctttcc agccagcttt gtgggatagg gtgggacctg
     1621 ggggacagtc actggggatt ggaggcgggg tggggcctgg gaggaggcag gcccagggag
     1681 tcttcattgc ttcccaaggg gcccaggagg tgaccttttg tgggctggca ctcgtggata
     1741 gttttggcaa gaggtaggtt gggctagtcc ctaacttaga gtccctccac atttgtaagc
     1801 agaggctaga gaggccctct ttagacatat ccccagatgc ccgggtggga aaaagacaag
     1861 tgttggtctc ctgagcttag accggccttg gtgttctact ccatgggtgg aggcggacct
     1921 accctgactc tgatgtgcct tgctgaagac attcaggtcc ccaacctgtg tcctgccacc
     1981 caagccaccc ctctggtttt tggagatgcc agcactgcca ggagccttcc tccatcttcc
     2041 tctcgtcctc ctctgccagg aagctcaggg gctgaggcag ggaagggccc ctttagctcc
     2101 caagactctt ttgtaaggtt tttgtagtga tttttatgcc acctgaataa agaatgaatg
     2161 gatcgggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
