LOCUS       NM_019197               2078 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus serpin family E member 2 (Serpine2), mRNA.
ACCESSION   NM_019197 XM_001060394 XM_343604
VERSION     NM_019197.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2078)
  AUTHORS   Longstaff,C. and Kolev,K.
  TITLE     Basic mechanisms and regulation of fibrinolysis
  JOURNAL   J Thromb Haemost 13 Suppl 1, S98-S105 (2015)
   PUBMED   26149056
  REMARK    Review article
REFERENCE   2  (bases 1 to 2078)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   3  (bases 1 to 2078)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 2078)
  AUTHORS   Bergeron,S., Lemieux,E., Durand,V., Cagnol,S., Carrier,J.C.,
            Lussier,J.G., Boucher,M.J. and Rivard,N.
  TITLE     The serine protease inhibitor serpinE2 is a novel target of ERK
            signaling involved in human colorectal tumorigenesis
  JOURNAL   Mol Cancer 9, 271 (2010)
   PUBMED   20942929
  REMARK    GeneRIF: data indicate that serpinE2 is up-regulated by oncogenic
            activation of Ras, BRAF and MEK1 and contributes to pro-neoplastic
            actions of ERK signaling in intestinal epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2078)
  AUTHORS   Zhang,Z.Y., Qi,J.P., Zhu,H., Song,Y.J., Wu,H., Jia,Y. and
            Zhang,G.M.
  TITLE     Expression of thrombin and its associated protein in cerebellum of
            human and rat after intracerebral hemorrhage
  JOURNAL   Chin Med J (Engl) 123 (15), 2077-2081 (2010)
   PUBMED   20819545
  REMARK    GeneRIF: In cerebellum, thrombin can activate PAR-1 expression
            after ICH, and PN-1 appears quickly after Intracerebral hemorrhage
            in order to control the deleterious effect of thrombin.
REFERENCE   6  (bases 1 to 2078)
  AUTHORS   Venuti,A., Romano,A., Pocobelli,D., Rumi,C. and Melaranci,C.
  TITLE     [Allergy to beta-lactam antibiotics in childhood. Diagnostic
            problems]
  JOURNAL   Pediatr Med Chir 14 (6), 565-569 (1992)
   PUBMED   1298926
  REMARK    Review article
REFERENCE   7  (bases 1 to 2078)
  AUTHORS   Rovelli,G., Stone,S.R., Guidolin,A., Sommer,J. and Monard,D.
  TITLE     Characterization of the heparin-binding site of glia-derived
            nexin/protease nexin-1
  JOURNAL   Biochemistry 31 (13), 3542-3549 (1992)
   PUBMED   1554734
REFERENCE   8  (bases 1 to 2078)
  AUTHORS   Evans,D.L., McGrogan,M., Scott,R.W. and Carrell,R.W.
  TITLE     Protease specificity and heparin binding and activation of
            recombinant protease nexin I
  JOURNAL   J Biol Chem 266 (33), 22307-22312 (1991)
   PUBMED   1939253
REFERENCE   9  (bases 1 to 2078)
  AUTHORS   Festoff,B.W., Rao,J.S. and Hantai,D.
  TITLE     Plasminogen activators and inhibitors in the neuromuscular system:
            III. The serpin protease nexin I is synthesized by muscle and
            localized at neuromuscular synapses
  JOURNAL   J Cell Physiol 147 (1), 76-86 (1991)
   PUBMED   2037625
REFERENCE   10 (bases 1 to 2078)
  AUTHORS   Cavanaugh,K.P., Gurwitz,D., Cunningham,D.D. and Bradshaw,R.A.
  TITLE     Reciprocal modulation of astrocyte stellation by thrombin and
            protease nexin-1
  JOURNAL   J Neurochem 54 (5), 1735-1743 (1990)
   PUBMED   1691280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK357674.1, M17784.1, CF110312.1, DV726078.1 and BQ199747.1.
            
            On or before Oct 12, 2007 this sequence version replaced
            XM_001060394.1, XM_343604.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN06680416 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               CK357674.1         1-692
            693-1018            M17784.1           569-894
            1019-1353           CF110312.1         177-511
            1354-1701           DV726078.1         234-581
            1702-2078           BQ199747.1         1-377               c
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..2078
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /note="serpin family E member 2"
                     /db_xref="GeneID:29366"
                     /db_xref="RGD:3748"
     exon            1..102
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     exon            103..383
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1318
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /note="Glia-derived nexin/protease nexin I; plasminogen
                     activator inhibitor type 1; protease nexin PN-1; GDN;
                     serpin peptidase inhibitor, clade E (nexin, plasminogen
                     activator inhibitor type 1), member 2; serpin E2; protease
                     nexin 1; peptidase inhibitor 7; serine (or cysteine)
                     proteinase inhibitor, clade E, member 2; serine protease
                     inhibitor 4; serine (or cysteine) peptidase inhibitor,
                     clade E, member 2; serpin peptidase inhibitor, clade E,
                     member 2; glia-derived nexin / preotease nexin I;
                     Clozapine Regulated Gene"
                     /codon_start=1
                     /product="glia-derived nexin precursor"
                     /protein_id="NP_062070.1"
                     /db_xref="GeneID:29366"
                     /db_xref="RGD:3748"
                     /translation="MNWHFPFFILTTVTLSSVYSQLNSLSLEELGSDTGIQVFNQIIK
                     SQPHENVVISPHGIASILGMLQLGADGRTKKQLSTVMRYNVNGVGKVLKKINKAIVSK
                     KNKDIVTVANAVFVRNGFKVEVPFAARNKEVFQCEVQSVNFQDPASACDAINFWVKNE
                     TRGMIDNLLSPNLIDSALTKLVLVNAVYFKGLWKSRFQPENTKKRTFVAGDGKSYQVP
                     MLAQLSVFRSGSTKTPNGLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKT
                     INSWMNTMVPKRMQLVLPKFTAVAQTDLKEPLKALGITEMFEPSKANFAKITRSESLH
                     VSHILQKAKIEVSEDGTKAAVVTTAILIARSSPPWFIVDRPFLFCIRHNPTGAILFLG
                     QVNKP"
     exon            384..611
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     exon            612..809
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1008
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1109
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1196
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1280
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..2063
                     /gene="Serpine2"
                     /gene_synonym="CRG; Gdnpn1; PI-7; Pn-1; Spin4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccggagcg cgggctgcaa gcgtcaccac cgcctgtccc ccaccgccgc gccgacctcc
       61 ttcccggctc cggccgccac ctggggatcc aagcgaggac gggctgtcct tgttggaagg
      121 aaccatgaat tggcattttc ccttcttcat cttgaccaca gtgactttat cctctgtgta
      181 ctcccagctc aactctctgt cactcgagga actaggctct gacacaggga tccaggtttt
      241 caatcagatc atcaaatcac agcctcatga gaacgttgtc atttctccgc acgggattgc
      301 gtccatcttg ggcatgctgc agctgggggc tgacggcagg acgaagaagc agctctcaac
      361 ggtgatgcga tacaatgtga acggagtcgg aaaagtgctg aagaagatca acaaggctat
      421 tgtctccaaa aagaataaag acattgtgac cgtggccaat gctgtgtttg tcaggaatgg
      481 ctttaaagtg gaagtgcctt ttgcagcaag gaacaaagag gtgtttcagt gtgaagtaca
      541 gagtgtgaac ttccaggacc cggcctctgc ttgtgatgcc atcaattttt gggtcaaaaa
      601 tgagacgagg ggcatgattg acaacctact ttccccaaat ctgatcgata gtgctcttac
      661 caaactggtc ctcgttaacg cagtgtattt caagggtttg tggaaatccc ggtttcaacc
      721 tgagaacacg aagaaacgga ccttcgtggc aggtgatgga aaatcctacc aagtacccat
      781 gctagcccag ctctccgtgt tccgctctgg gtctaccaaa accccaaatg gcttatggta
      841 caacttcatt gagctaccct accatggtga gagcatcagc atgttgatcg ccctgccaac
      901 agagagctcc accccactgt ccgccatcat ccctcacatc agtaccaaga ccatcaatag
      961 ctggatgaac accatggtac ccaagaggat gcagctggtc ctgcccaagt tcacagctgt
     1021 ggcacaaaca gatctgaagg agccactgaa agcccttggc attactgaga tgtttgaacc
     1081 gtcaaaggca aattttgcaa aaataacaag gtcagagagc cttcacgtct ctcacatctt
     1141 gcagaaagca aaaattgaag tcagcgaaga tgggaccaaa gccgcagtag tgacaactgc
     1201 aatcctaatt gcaaggtcat cgcctccctg gtttatagta gacaggcctt tcctgttctg
     1261 catccgacac aatcccacag gtgccatctt gttcctgggg caggtgaaca agccctgaag
     1321 gacggacaaa acaaaagcca cgcaaagcca agacgacttt gctccgaaga gagactccct
     1381 tccccacatc tttcatagtt ctgttaaata tttttataca ctgctttcct tttttgaaac
     1441 tggttcatgg cgacagttaa gtgacacaag tgtttctggt cagggctgtg tcagaagaaa
     1501 gggcaggatg gctgggatgc tgtacggaag aacgaagagg cgggtttcag gacgtctaga
     1561 agatttcttt aaactactga tcagttacct aggttaacaa ccctctcgag tatttgctgt
     1621 ctgtcgggtt cagcattttt gttccgttct tgtgtatatg tgtgacgttc cgggagaggt
     1681 ttaatcagtg tgataggagg ggggaaaaag acattttata gtagttttta tgtttttatg
     1741 gaaaacagta tcatttgcct ttttaattcc ttttctctca cttccacccg aaggccagaa
     1801 ggtggtgagg tggtgagggg tggagctaga aaagccgtag cctcttcgtg tgttgtttcc
     1861 gttgctgttg ctatcgctgt tttatatact gcatgtgttc actaaaataa agttggaaaa
     1921 ctaacgtctc gctggacaca atttgctgtc gagccacgtg cctgtcacta ctggtctgta
     1981 ctctttggat tggctttttt ttttttttgt attttgtata aagtaaaaag aaataaaagt
     2041 gttccgagta gtaaaaattt aaaaaaaaaa aaaaaaaa
//
