LOCUS       NM_024382               2093 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus serpin family D member 1 (Serpind1), mRNA.
ACCESSION   NM_024382
VERSION     NM_024382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 2093)
  AUTHORS   Noda,A., Wada,H., Kusiya,F., Sakakura,M., Onishi,K., Nakatani,K.,
            Gabazza,E.C., Asahara,N., Tsukada,M., Nobori,T. and Shiku,H.
  TITLE     Plasma levels of heparin cofactor II (HCII) and thrombin-HCII
            complex in patients with disseminated intravascular coagulation
  JOURNAL   Clin Appl Thromb Hemost 8 (3), 265-271 (2002)
   PUBMED   12361205
REFERENCE   3  (bases 1 to 2093)
  AUTHORS   Lind,B. and Thorsen,S.
  TITLE     A novel missense mutation in the human plasmin inhibitor
            (alpha2-antiplasmin) gene associated with a bleeding tendency
  JOURNAL   Br J Haematol 107 (2), 317-322 (1999)
   PUBMED   10583218
REFERENCE   4  (bases 1 to 2093)
  AUTHORS   Robbie,L.A., Booth,N.A., Brown,A.J. and Bennett,B.
  TITLE     Inhibitors of fibrinolysis are elevated in atherosclerotic plaque
  JOURNAL   Arterioscler Thromb Vasc Biol 16 (4), 539-545 (1996)
   PUBMED   8624776
REFERENCE   5  (bases 1 to 2093)
  AUTHORS   Kondo,S., Tokunaga,F., Kario,K., Matsuo,T. and Koide,T.
  TITLE     Molecular and cellular basis for type I heparin cofactor II
            deficiency (heparin cofactor II Awaji)
  JOURNAL   Blood 87 (3), 1006-1012 (1996)
   PUBMED   8562924
REFERENCE   6  (bases 1 to 2093)
  AUTHORS   Westrup,D. and Ragg,H.
  TITLE     Secondary thrombin-binding site, glycosaminoglycan binding domain
            and reactive center region of leuserpin-2 are strongly conserved in
            mammalian species
  JOURNAL   Biochim Biophys Acta 1217 (1), 90-92 (1994)
   PUBMED   8286422
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X74549.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74549.1, BC091145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2093
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /note="serpin family D member 1"
                     /db_xref="GeneID:79224"
                     /db_xref="RGD:619854"
     exon            1..43
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /inference="alignment:Splign:2.1.0"
     exon            44..100
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..948
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1559
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /note="heparin cofactor 2; HC-II; heparin cofactor II;
                     protease inhibitor leuserpin-2; serpin D1; serine (or
                     cysteine) peptidase inhibitor, clade D, member 1; serine
                     (or cysteine) proteinase inhibitor, clade D, member 1;
                     leuserpin 2; serpin peptidase inhibitor, clade D (heparin
                     cofactor), member 1"
                     /codon_start=1
                     /product="heparin cofactor 2 precursor"
                     /protein_id="NP_077358.1"
                     /db_xref="GeneID:79224"
                     /db_xref="RGD:619854"
                     /translation="MKHPAYTLLLSLIMSMCAGSKGLAEQLTKENLTVSLLPPNFHKE
                     NTVTNDWIPEGEEDDDYLDLEKLLSEDDDYIYVVDAVSPTDSESSAGNILQLFQGKSR
                     IQRLNILNAKFAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSV
                     LHFKDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKA
                     AMREFYFAEAQEADFSDPAFISKANSHILKLTKGLIKEALENTDSATQMMILNCIYFK
                     GAWMNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGIS
                     MLIVIPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSM
                     GITKLFNKNGNMSGISDQRIIIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQVRFT
                     VDRPFLFLVYEHRTSCLLFMGRVANPAKS"
     exon            949..1222
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1367
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..2083
                     /gene="Serpind1"
                     /gene_synonym="rls2var1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctggtctc atctctgcca cgccactgct cagaggcaca gagtgagcaa cagtttggta
       61 gcgctgagtc catccactgg aaattctcct cctgtctcag cggctttagc tctgcagaaa
      121 tgaagcatcc agcctacact ctccttctct ctctcatcat gtctatgtgt gctgggagca
      181 aaggccttgc tgagcagcta actaaggaaa acctgaccgt gtccctcctg cctcctaact
      241 tccacaaaga gaacacagtc accaatgact ggattccaga aggagaggaa gatgacgact
      301 acctggacct ggagaagctg ctcagtgaag atgacgacta catctatgtt gtcgatgcag
      361 tttccccaac agactcagaa tcaagtgctg gcaacatcct gcagcttttc caaggcaaaa
      421 gccggatcca gcgccttaac atcctcaatg caaagtttgc cttcaacctt taccgagtcc
      481 tgaaggacca ggctacctct tctgataaca ttttcatagc acccgttggc atttccactg
      541 ccatggggat gatctcctta ggtttgaggg gagagaccca tgaggaagta cactcagttc
      601 tacacttcaa agactttgtc aatgctagca gcaagtacga ggtgacaacc attcacaacc
      661 tctttcgaaa gctgacccat cgcctattca gaaggaattt tgggtacaca cttcagtcag
      721 ttaatgacct ttatattcag aagcagtttc ccatacggga ggacttcaaa gctgccatga
      781 gagagtttta ctttgctgag gcccaggagg ctgacttctc agatcctgcc ttcatatcaa
      841 aggcaaacag ccacattctg aagctcacca agggcctcat aaaagaagct ttggagaata
      901 cagactctgc tactcagatg atgattctga actgcatcta cttcaaagga gcttggatga
      961 ataaattccc agtagaaatg acgcataacc acaacttccg gctgaatgag agagaagtag
     1021 taaaagtctc catgatgcaa actaaaggga acttccttgc ggcaaatgac caggagctag
     1081 actgtgacat tctgcagctg gagtatgtag ggggcatcag catgctaatt gtaattccac
     1141 ggaagctgtc gggaatgaag actcttgaag cacagcttac accccaggta gtggagagat
     1201 ggcaaaaaag catgacaaac agaacccgag aggtacttct gcccaagttt aagcttgaga
     1261 agaattacaa cctggtggag gtcctcaagt ccatgggaat cacaaagctc ttcaacaaga
     1321 atggcaatat gtcaggcatc tcagaccaga ggatcatcat tgatctgttc aagcaccaga
     1381 gtaccatcac agtgaatgaa gagggtaccc aagctgcagc tgtaactaca gtggggttta
     1441 tgccgctgtc tacccaagtc agattcactg ttgaccgtcc cttcctgttc ctagtgtatg
     1501 agcaccgaac cagctgtctg ctgttcatgg gaagagtggc caaccctgcc aagtcttaat
     1561 ggtgctggtc tgggcacctg atgtagtttg gggacactct gtaatcctgt tttcattcta
     1621 agaggacaga gatattttga tattgataat ctatgtagtt tgagataata atctaacagt
     1681 aaacagtgtc ataagtgcac agatgttaat gcaactaatg gtcgtgccag ctattcccta
     1741 gaggtcctag acacagactg cctcagcgcc aacgcctctg tcactgagaa tgggcagagt
     1801 ggagctgaca ctttctcctc agttagccgt accagtcaag gtgtctcctc agccaggccc
     1861 ctccatatgg atggtactga ggaactctca cccttccagg gaggatgtcc aaggagcacc
     1921 attcttgcct agtggaaaag aaacctcaac atgtctgaga catttggact taattcaagg
     1981 ctgaaccttt taaattcatg taaatatcat ctgttctgct ttgtgtcaat agggctacca
     2041 tagcctattc tagagacaaa taaacaacca tatttactaa gcaaaaaaaa aaa
//
